Abstract:
:Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB receptor family expression and found that the status of intercellular organization altered the receptor profile. We showed that HNSCC cells forced into tumor island-like 3D aggregates strongly upregulated ErbB3 at the level of transcription. Not only was the elevated ErbB3 responsive to HRG-β1-induced enhanced signaling mechanism, but also analysis by siRNA-knockdown and kinase inhibitor strategies revealed that the ErbB3/AKT signaling pathway was sufficient to enhance tumor cell survival and growth potential. Elevated ErbB3 expression in the high-density 3D culture system was strongly associated with hypoxia-induced HIF-1α. Hypoxia-regulated ErbB3 expression was mediated by the HIF-1α-binding consensus sequence in the ErbB3 proximal promoter. The findings show that the local 3D tumor microenvironment can trigger reprograming and switching of ErbB family members and thereby influence ErbB3-driven tumor growth.
journal_name
Oncogenejournal_title
Oncogeneauthors
Humtsoe JO,Pham E,Louie RJ,Chan DA,Kramer RHdoi
10.1038/onc.2015.220subject
Has Abstractpub_date
2016-03-24 00:00:00pages
1554-64issue
12eissn
0950-9232issn
1476-5594pii
onc2015220journal_volume
35pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210211
更新日期:2007-06-21 00:00:00
abstract::Transcription from the rat transforming growth factor alpha (TGF-alpha) promoter initiates at multiple sites within a 200-bp G+C-rich region that lacks TATA and CAAT motifs but contains multiple potential binding sites for the transcription factor Sp1. In the present study, we used deletion analysis to establish the 5...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.93
更新日期:2014-03-20 00:00:00
abstract::Spindle cell sarcomas consist of tumors with different biological features, of which distant metastasis is the most ominous sign for a poor prognosis. However, metastasis is difficult to predict on the basis of current histopathological analyses. We have identified actin filament-associated protein 1-like 1 (AFAP1L1) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.108
更新日期:2011-09-22 00:00:00
abstract::The role of thromboxane A(2) (TxA(2)) in smoking-associated lung cancer is poorly understood. This study was conducted to study the role of TxA(2) in smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-promoted cell survival and growth in human lung cancer cells. We found that NNK increased TxA(2) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.390
更新日期:2011-01-06 00:00:00
abstract::The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208924
更新日期:2005-08-29 00:00:00
abstract::The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207298
更新日期:2004-03-04 00:00:00
abstract::cDNA clones of the ski-related gene, sno, were isolated from a chicken cDNA library and sequenced. In contrast to the human system, from which two forms of sno cDNAs have been isolated, we obtained only one type of chicken sno cDNA, that encoding snoN. The coding region for chicken snoN was inserted into the retrovira...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::The role of cbl-b in signaling by the epidermal growth factor receptor (EGFR) was studied and compared with c-cbl. We demonstrate in vivo, that cbl-b, like c-cbl, is phosphorylated and recruited to the EGFR upon EGF stimulation and both cbl proteins can bind to the Grb2 adaptor protein. To investigate the functional r...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202499
更新日期:1999-03-11 00:00:00
abstract::Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-ca...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0170-y
更新日期:2018-06-01 00:00:00
abstract::We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-03-02 00:00:00
abstract::Homology PCR has been used to identify receptor tyrosine kinases (RTKs) expressed during activation of rat hepatic stellate cells, the key fibrogenic mesenchymal element in the liver. Partial cDNAs encoding several RTKs were cloned from stellate cells activated in vivo, including those of Flt-1, Flk-1, c-met, PDGFR, a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201912
更新日期:1998-07-09 00:00:00
abstract::To investigate the relationship between the local configuration of a gene and its level of expression, we constructed a rat cell line, Hy5, carrying a mutant polyomavirus middle T oncogene (pmt) whose overexpression converted the cells to the transformed state. The structure of the transgene was such that pmt was able...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Interferon (IFN)-beta induces S-phase slowing and apoptosis in human papilloma virus (HPV)-positive cervical carcinoma cell line ME-180. Here, we show that apoptosis is a consequence of the S-phase lengthening imposed by IFN-beta, demonstrating the functional correlation between S-phase alteration and apoptosis induct...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208403
更新日期:2005-04-07 00:00:00
abstract::Mouse Developmental Kinase 1 (MDK1) is a receptor tyrosine kinase of the eck/eph subfamily expressed in a variety of tissues during early mouse embryogenesis. To obtain further insight into the function of MDK1, we determined identity and localisation of its physiological ligand(s). Staining whole embryos with fusion ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200800
更新日期:1997-01-09 00:00:00
abstract::Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0665-6
更新日期:2019-05-01 00:00:00
abstract::Exposure of CV-1P cells to hypoxic conditions results in reversible cell cycle arrest concomitant with accumulation of pRB in the hypophosphorylated, growth suppressive form. Similar to cell cycle arrest induced by serum starvation, we show here that hypoxia-induced arrest is accompanied by a decrease in pRB-directed ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202159
更新日期:1998-11-05 00:00:00
abstract::Cell lines derived from cervical neoplasias, as well as cells from normal cervix and neonatal foreskin were examined in an in vitro culture system (raft system) that allows for stratification and differentiation of epithelial cells at an air-liquid interface. Epithelial cells from human foreskin and ectocervix were ob...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::Tumor cells are characterized by deregulated proliferation and resistance to proapoptotic stimuli. The Bcl-2 family of antiapoptotic proteins is overexpressed in a large number of chemoresistant tumors. Downregulation or inhibition of antiapoptotic proteins might result in the sensitization of cancer cells to chemothe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209832
更新日期:2007-02-01 00:00:00
abstract::The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-01-18 00:00:00
abstract::Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.65
更新日期:2009-05-07 00:00:00
abstract::Chromosomal region 8p11.2-p12 is consistently amplified in human breast cancer. We have constructed a 2.8 Mb YAC contig of this region, centered on the human Fibroblast Growth Factor Receptor 1 (FGFR1) locus and encompassing the Adrenergic beta 3 Receptor (ADRB3) locus. A smaller centromeric YAC contig spanning 1.4 Mb...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-03-02 00:00:00
abstract::Ewing sarcoma (ES) is an aggressive bone and soft tissue tumor of children and young adults in which finding effective new targeted therapies is imperative. Here, we report an in-depth preclinical study of the investigational cullin-RING ubiquitin ligase (CRL) inhibitor MLN4924 in ES, as we have recently demonstrated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.153
更新日期:2013-03-14 00:00:00
abstract::The microenvironment of glioblastoma (GBM) contains high levels of inflammatory cytokine interleukin 6 (IL-6), which contributes to promote tumour progression and invasion. The common epidermal growth factor receptor variant III (EGFRvIII) mutation in GBM is associated with significantly higher levels of IL-6. Further...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.225
更新日期:2015-05-28 00:00:00
abstract::Apoptin, a protein of the chicken anemia virus (CAV), represents a novel potential anticancer therapeutic, because it induces apoptotic death specifically in tumor but not normal cells. The cellular localization appears to be crucial for apoptin's selective toxicity. In normal cells apoptin remains in the cytoplasm, w...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209923
更新日期:2007-03-08 00:00:00
abstract::Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/s41388-020-01459-w
更新日期:2020-10-01 00:00:00
abstract::Low-grade glial neoplasms (astrocytomas) represent one of the most common brain tumors in the pediatric population. These tumors frequently form in the optic pathway (optic pathway gliomas, OPGs), especially in children with the neurofibromatosis type 1 (NF1)-inherited tumor predisposition syndrome. To model these tum...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.580
更新日期:2014-01-16 00:00:00
abstract::N-cadherin is a cell-cell adhesion molecule that plays a role in breast cancer metastasis. Here, we show that in vivo expression of N-cadherin in the PyMT mouse model, which enhances mammary tumor metastasis, results in selective inhibition of Akt3 expression and phosphorylation. Similarly, exogenous expression of N-c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.65
更新日期:2013-01-24 00:00:00
abstract::DNA methylation alterations are now widely recognized as a contributing factor in human tumorigenesis. A significant number of tumor suppressor genes are transcriptionally silenced by promoter hypermethylation, and recent research implicates alterations in chromatin structure as the mechanistic basis for this repressi...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1205602
更新日期:2002-08-12 00:00:00
abstract::We have determined the genomic structure of the mouse fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family. Fra-1 is expressed rather highly in the brain and testes of adult mice, and at low levels in most other tissues. Absence of c-Fos leads t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201460
更新日期:1997-09-04 00:00:00