Abstract：
:We have determined the genomic structure of the mouse fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family. Fra-1 is expressed rather highly in the brain and testes of adult mice, and at low levels in most other tissues. Absence of c-Fos leads to significantly reduced serum stimulation of fra-1 expression in gene targeted mouse fibroblasts, demonstrating that mitogen induction of fra-1 is partially mediated by c-Fos/AP-1. A polymorphic (CA)n microsatellite marker was found in intron 2 of fra-1 and used to map the gene to the centromeric region of mouse chromosome 19. Since fra-1 maps to the same genomic region as oc (osteosclerosis), an autosomal recessive disorder leading to the bone remodelling disease osteopetrosis, we tested it as a candidate gene for oc. The segregation of fra-1 in two different crosses of mice carrying oc and an allelism test between oc and a targeted disruption of fra-1 demonstrate that fra-1 and oc are two distinct genes rather than oc being a mutant allele of fra-1.
journal_name
Oncogenejournal_title
Oncogeneauthors
Schreiber M,Poirier C,Franchi A,Kurzbauer R,Guenet JL,Carle GF,Wagner EFdoi
10.1038/sj.onc.1201460subject
Has Abstractpub_date
1997-09-04 00:00:00pages
1171-8issue
10eissn
0950-9232issn
1476-5594journal_volume
15pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:pp60c-src, a cellular tyrosine kinase homologous to the retroviral v-src oncogene, becomes transiently activated during mitosis. Activation is accompanied by phosphorylation of three sites in the amino-terminal regulatory domain of the protein, threonine 34, threonine 46 and serine 72. These sites can be phosphorylate...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-03-01 00:00:00
abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.637
更新日期：2011-06-09 00:00:00
abstract：:PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210033
更新日期：2007-04-12 00:00:00
abstract：:The human c-abl oncogene gives rise to different mRNA transcripts which vary primarily in that they possess alternative first exons. In the present study, we present the sequence for the human c-abl 3' untranslated region (3'utr) and show that while human and murine c-abl cDNA sequences are generally homologous, human...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological functions. Since one critical issue in cancer gene therapy is tumor specificity, we asked whether the tight p53 regula...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207042
更新日期：2004-01-15 00:00:00
abstract：:Overexpression of members of the myc family of oncogenes contributes to the development of many vertebrate malignancies. Although several functions for myc gene products have been proposed, the targets for Myc activity during oncogenesis or normal development remain to be identified. Oocytes of Xenopus laevis, which a...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Viruses have been engineered to replicate selectively in cancer cells, based on a number of innovative principles. Several of these viruses have entered clinical trials and have proven relatively safe, and have shown evidence of efficacy. However, further research is required to enable these agents to function systemi...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209064
更新日期：2005-11-21 00:00:00
abstract：:ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-01-04 00:00:00
abstract：:Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is noted for its transforming potential. Yet, it also acts as a cytostatic and growth-relenting factor in Burkitt's lymphoma (BL) cells. The underlying molecular mechanisms of the growth inhibitory property of LMP1 have remained largely unknown. In this...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.439
更新日期：2010-03-04 00:00:00
abstract：:The epithelium-specific transcription factor, ERT/ESX/ESE-1/ELF3, binds to the TGF-beta RII promoter in a sequence specific manner and regulates its expression. In this study, we investigated whether ERT could regulate endogenous TGF-beta RII expression in Hs578t breast cancer cells. Analyses of the Hs578t parental ce...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203252
更新日期：2000-01-06 00:00:00
abstract：:Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathw...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.423
更新日期：2013-08-29 00:00:00
abstract：:Heregulins are a group of growth factors that play diverse and critical roles in the signaling network of the human epidermal growth factor receptor (HER or EGFR) superfamily. Our earlier studies have shown that recombinant heregulinbeta1 (HRG) induces apoptosis in SKBr3 breast cancer cells that overexpress HER2. Here...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205039
更新日期：2001-12-13 00:00:00
abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.375
更新日期：2018-02-01 00:00:00
abstract：:Chromosomal region 8p11.2-p12 is consistently amplified in human breast cancer. We have constructed a 2.8 Mb YAC contig of this region, centered on the human Fibroblast Growth Factor Receptor 1 (FGFR1) locus and encompassing the Adrenergic beta 3 Receptor (ADRB3) locus. A smaller centromeric YAC contig spanning 1.4 Mb...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-03-02 00:00:00
abstract：:Successful treatment of multiple cancer types requires early detection and identification of reliable biomarkers present in specific cancer tissues. To test the feasibility of identifying proteins from archival cancer tissues, we have developed a methodology, termed direct tissue proteomics (DTP), which can be used to...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209755
更新日期：2007-01-04 00:00:00
abstract：:In this study we have investigated DNA-protein interactions at an AP1-like motif of the neuropeptide tyrosine (NPY) promoter during in vitro differentiation of human neuroblastoma cells SH-SY5Y to mature nonproliferative sympathetic neuron-like cells. These neuroblast-like cells originate from the parental cell line S...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:Knowledge of the type of biological reaction to chemotherapy is a prerequisite for its rational enhancement. We previously showed that irinotecan-induced DNA damage triggers in the HCT116p53(wt) colon carcinoma cell line a long-term cell cycle arrest and in HCT116p53(-/-) cells apoptosis (Magrini et al., 2002). To com...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209017
更新日期：2006-01-12 00:00:00
abstract：:Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to protect chromosome ends from cellular DNA-damage responses such as cell cycle arrest or apoptosis. This property of telomer...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1205082
更新日期：2002-01-21 00:00:00
abstract：:The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.44
更新日期：2013-11-21 00:00:00
abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204629
更新日期：2001-10-11 00:00:00
abstract：:Activation of the mitogen-activated protein kinase (MAPK) cascade is a well documented mechanism for the G-protein-coupled receptors. Here, we have analysed the requirements for ERKs and p38 MAPK activation by thrombin in Jurkat T cells. We show that thrombin-mediated ERKs activation requires both PTK and PKC activiti...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204266
更新日期：2001-04-12 00:00:00
abstract：:Activation of Stat5 by many cytokines implies that it cannot alone insure the specificity of the regulation of its target genes. We have evidenced a physical and functional interaction between members of two unrelated transcription factor families, Ets-1, Ets-2 and Stat5, which could contribute to the proliferative re...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203542
更新日期：2000-04-20 00:00:00
abstract：:Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.377
更新日期：2013-08-08 00:00:00
abstract：:Previously, we cloned two gene fragments encoding novel protein tyrosine phosphatases, termed PTP-U1 and PTP-U2. Here, we report the full-length sequence, expression, and chromosomal localization of the PTP-U2 gene. The cDNA for PTP-U2, which was obtained from a human normal kidney library, predicts a protein of 1216 ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-05-04 00:00:00
abstract：:There is now much evidence to suggest that the p53 tumour suppressor protein functions to monitor the integrity of the genome. When DNA damage is detected, p53 suppresses cell growth to allow repair or directs the cell into apoptosis. The mechanism of action of p53 is as yet unclear but recent evidence has accumulated...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-10-05 00:00:00
abstract：:Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is known to regulate cell growth and survival in multiple cancers; how...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-0927-y
更新日期：2019-10-01 00:00:00
abstract：:tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineage T-ALL with TcR-delta...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open reading frame encoding 469 amino acids. The ETS2 gene directs the synthe...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.451
更新日期：2011-02-10 00:00:00
abstract：:The Ewing family of tumors is characterized by recurrent reciprocal translocations that generate chimeric proteins, either EWS - FLI-1 or EWS - ERG. These proteins are potent transcriptional activators and are responsible for maintaining the oncogenic properties of tumor cells. Since apoptosis appears to be the main m...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203246
更新日期：2000-01-06 00:00:00
