Interaction of ETS-1 and ERGB/FLI-1 proteins with DNA is modulated by spacing between multiple binding sites as well as phosphorylation.

abstract：:Recognition and elimination of malignant cells by cytotoxic T lymphocytes depends on antigenic peptides generated by proteasomes. It has been established that impairment of the immunoproteasome subunits, that is, PSMB8, PSMB9 and PSMB10 (PSMBs), is critical for malignant cells to escape immune recognition. We report h...

journal_title：Oncogene

authors： Yang XW,Wang P,Liu JQ,Zhang H,Xi WD,Jia XH,Wang KK

更新日期：2014-05-22 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...

journal_title：Oncogene

authors： Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

更新日期：2017-11-16 00:00:00

abstract：:YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes. The Amot-mediated retention of YAP in the cytoplasm results in the inhibition of its ...

journal_title：Oncogene

authors： Oka T,Schmitt AP,Sudol M

更新日期：2012-01-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Oncogene

authors： Wang K,Ji W,Yu Y,Li Z,Niu X,Xia W,Lu S

更新日期：2020-10-01 00:00:00

abstract：:Hepatocyte Growth Factor (HGF) exerts its biological effects via binding and activating a transmembrane protein tyrosine kinase receptor known as c-Met. Previous studies from our laboratory demonstrated that c-met gene expression is inducible by its own ligand (HGF). However, the molecular mechanism(s) involved in thi...

journal_title：Oncogene

authors： Seol DW,Chen Q,Zarnegar R

更新日期：2000-02-24 00:00:00

abstract：:Signet-ring cell carcinoma is classified in poorly differentiated adenocarcinoma with an aggressive nature and a poor prognosis. We have shown that the activation of PI 3-kinase in highly differentiated adenocarcinomas induces loss of cell-cell contact and formation of vacuoles, giving phenotypes similar to those of s...

journal_title：Oncogene

authors： Xu Q,Karouji Y,Kobayashi M,Ihara S,Konishi H,Fukui Y

更新日期：2003-08-28 00:00:00

abstract：:Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...

journal_title：Oncogene

authors： Zhou W,Sun W,Yung MMH,Dai S,Cai Y,Chen CW,Meng Y,Lee JB,Braisted JC,Xu Y,Southall NT,Shinn P,Huang X,Song Z,Chen X,Kai Y,Cai X,Li Z,Hao Q,Cheung ANY,Ngan HYS,Liu SS,Barak S,Hao J,Dai Z,Tzatsos A,Peng W

更新日期：2018-07-01 00:00:00

abstract：:Pancreatic cancer still remains one of the most lethal diseases and establishment of new therapy is needed. The purpose of this study is to find novel factors involved in pancreatic cancer progression by proteomic approach. We compared pre- and postoperative serum protein profiling obtained from pancreatic cancer pati...

journal_title：Oncogene

authors： Takano S,Yoshitomi H,Togawa A,Sogawa K,Shida T,Kimura F,Shimizu H,Tomonaga T,Nomura F,Miyazaki M

更新日期：2008-05-01 00:00:00

abstract：:Radiation therapy (RT) is useful for selectively killing cancer cells. However, because high levels of ionizing radiation (IR) are toxic to normal cells, RT cannot be applied repeatedly to cancer patients. Therefore, novel chemicals that enhance the efficacy of chemoradiotherapy (CRT) would be valuable. Here, we repor...

journal_title：Oncogene

authors： Ohno S,Naito Y,Mukai S,Yabuta N,Nojima H

更新日期：2015-12-03 00:00:00

abstract：:CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells. CDX2 is a marker of colon cancer, with strong staining in up to 90% of colonic adenocarcinomas. CDX2 heterozygous-null mice develop colonic neoplasms, which have sug...

journal_title：Oncogene

authors： Dang LH,Chen F,Ying C,Chun SY,Knock SA,Appelman HD,Dang DT

更新日期：2006-04-06 00:00:00

abstract：:Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast tumorigenesis and developing new diagnostic and therapeutic agents. In this study we have combined two powerful technologies, PCR-based cDNA subtraction and cDNA microa...

journal_title：Oncogene

authors： Jiang Y,Harlocker SL,Molesh DA,Dillon DC,Stolk JA,Houghton RL,Repasky EA,Badaro R,Reed SG,Xu J

更新日期：2002-03-28 00:00:00

abstract：:Despite the progress made in targeted anticancer therapies in recent years, challenges remain. The identification of new potential targets will ensure that the arsenal of cancer therapies continues to expand. FAM83B was recently discovered in a forward genetic screen for novel oncogenes that drive human mammary epithe...

journal_title：Oncogene

authors： Cipriano R,Bryson BL,Miskimen KL,Bartel CA,Hernandez-Sanchez W,Bruntz RC,Scott SA,Lindsley CW,Brown HA,Jackson MW

更新日期：2014-06-19 00:00:00

abstract：:Junctional adhesion molecule-A (JAM-A) is a membranous cell-cell adhesion protein involved in tight-junction formation in epithelial and endothelial cells. Its overexpression in breast tumors has recently been linked with increased risk of metastasis. We sought to identify if JAM-A overexpression was associated with s...

journal_title：Oncogene

authors： Brennan K,McSherry EA,Hudson L,Kay EW,Hill AD,Young LS,Hopkins AM

更新日期：2013-05-30 00:00:00

abstract：:Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations in cervical cancer initiation and progress has not been examined. Herein, we demonstrated that, in mouse embr...

journal_title：Oncogene

authors： Zeng Q,Chen J,Li Y,Werle KD,Zhao RX,Quan CS,Wang YS,Zhai YX,Wang JW,Youssef M,Cui R,Liang J,Genovese N,Chow LT,Li YL,Xu ZX

更新日期：2017-03-02 00:00:00

abstract：:We report chromosome 3p deletion mapping of 32 cervical carcinoma (CC) biopsies using 26 microsatellite markers located in frequently deleted 3p regions to detect loss of heterozygosity and homozygous loss. In addition, two STS markers (NLJ-003 and NL3-001) located in the 3p21.3 telomeric (3p21.3T) and 3p21.3 centrome...

journal_title：Oncogene

authors： Senchenko V,Liu J,Braga E,Mazurenko N,Loginov W,Seryogin Y,Bazov I,Protopopov A,Kisseljov FL,Kashuba V,Lerman MI,Klein G,Zabarovsky ER

更新日期：2003-05-15 00:00:00

abstract：:Expression microarray analysis identified CITED1 among a group of genes specifically upregulated in the pubertal mouse mammary gland. At puberty, CITED1 localizes to the luminal epithelial cell population of the mammary ducts and the body cells of the terminal end buds. Generation of CITED1 gene knockout mice showed t...

journal_title：Oncogene

authors： Howlin J,McBryan J,Napoletano S,Lambe T,McArdle E,Shioda T,Martin F

更新日期：2006-03-09 00:00:00

abstract：:The 120 kD product of the c-cbl oncogene is rapidly tyrosine phosphorylated and recruited to the EGF receptor following ligand binding. Cbl's oncogenic potential is activated by a large carboxy-terminal truncation that generated v-cbl and removes the Ring finger and proline-rich SH3-binding domains. Here we show that ...

journal_title：Oncogene

authors： Thien CB,Langdon WY

更新日期：1997-05-08 00:00:00

abstract：:Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...

journal_title：Oncogene

authors： Sivak LE,Tai KF,Smith RS,Dillon PA,Brodeur GM,Carroll WL

更新日期：1997-10-16 00:00:00

abstract：:Recently, various cDNA sequences coding protein-tyrosine phosphatases (PTPs) have been reported and their extensive similarities in the catalytic domains clarified, but knowledge of the structures and organizations of their genes is still limited. In this study, a detailed structure and organization of the human intra...

journal_title：Oncogene

authors： Adachi M,Miyachi T,Sekiya M,Hinoda Y,Yachi A,Imai K

更新日期：1994-10-01 00:00:00

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype wi...

journal_title：Oncogene

authors： Ren S,Gaykalova DA,Guo T,Favorov AV,Fertig EJ,Tamayo P,Callejas-Valera JL,Allevato M,Gilardi M,Santos J,Fukusumi T,Sakai A,Ando M,Sadat S,Liu C,Xu G,Fisch KM,Wang Z,Molinolo AA,Gutkind JS,Ideker T,Koch WM,Cali

更新日期：2020-10-01 00:00:00

abstract：:Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...

journal_title：Oncogene

authors： Nguyen A,Chang AC,Reddel RR

更新日期：2009-05-07 00:00:00

abstract：:We have identified sequences in the 5' flanking region of the murine c-myc gene's P1 and P2 transcription initiation sites which form specific complexes with nuclear factors of murine and human origin and are also required for normal P1 and P2 usage. Four nuclear factor binding sites were identified within 400 bp 5' o...

journal_title：Oncogene

authors： Asselin C,Nepveu A,Marcu KB

更新日期：1989-05-01 00:00:00

abstract：:A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance t...

journal_title：Oncogene

authors： Casazza A,Di Conza G,Wenes M,Finisguerra V,Deschoemaeker S,Mazzone M

更新日期：2014-04-03 00:00:00

abstract：:Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in...

journal_title：Oncogene

authors： Robb L

更新日期：2007-10-15 00:00:00

abstract：:Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...

journal_title：Oncogene

authors： Kalari S,Jung M,Kernstine KH,Takahashi T,Pfeifer GP

更新日期：2013-07-25 00:00:00

abstract：:We screened cdc2 kinase inhibitors from cultured mediums of micro organisms using purified mouse cyclin B-cdc2 kinase and a specific substrate peptide for cdc2 kinase. A selective inhibitor of cdc2 kinase was isolated from the cultured medium of Aspergillus species F-25799, and identified as butyrolactone I. Butyrolac...

journal_title：Oncogene

authors： Kitagawa M,Okabe T,Ogino H,Matsumoto H,Suzuki-Takahashi I,Kokubo T,Higashi H,Saitoh S,Taya Y,Yasuda H

更新日期：1993-09-01 00:00:00

abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...

journal_title：Oncogene

authors： Gooding AJ,Zhang B,Gunawardane L,Beard A,Valadkhan S,Schiemann WP

更新日期：2019-03-01 00:00:00

abstract：:To explore the mechanism of estrogen-induced growth of normal endometrium, the transactivation system of the cyclin D1 gene was analysed using cultured normal endometrial glandular cells. Estradiol (E2) treatment of cultured normal endometrial glandular cells induced upregulation of c-Jun, and then cyclin D1 proteins,...

journal_title：Oncogene

authors： Shiozawa T,Miyamoto T,Kashima H,Nakayama K,Nikaido T,Konishi I

更新日期：2004-11-11 00:00:00

abstract：:Reovirus is a naturally oncolytic virus that preferentially replicates in Ras-transformed cells and is currently undergoing clinical trials as a cancer therapeutic. Ras transformation promotes reovirus oncolysis by enhancing virion disassembly during entry, viral progeny production, and virus release through apoptosis...

journal_title：Oncogene

authors： Garant KA,Shmulevitz M,Pan L,Daigle RM,Ahn DG,Gujar SA,Lee PW

更新日期：2016-02-11 00:00:00