Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach.

Abstract:

:Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used the public information of expressed sequence tags to systematically analyze gene expression patterns and identified a novel oncofetal-like gene, LRRC16B. It increased the proliferation, anchorage-independent growth and tumorigenesis of transformed cells in xenografts, possibly through its effects on cyclin B1 protein levels. These findings exemplify the feasibility of using bioinformatics to find new oncofetal-like genes and suggest that more genes with important functional roles will be uncovered in the candidate gene list.

journal_name

Oncogene

journal_title

Oncogene

authors

Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

doi

10.1038/onc.2010.451

subject

Has Abstract

pub_date

2011-02-10 00:00:00

pages

654-67

issue

6

eissn

0950-9232

issn

1476-5594

pii

onc2010451

journal_volume

30

pub_type

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