Protein phosphatase 1 regulatory subunit 1A in ewing sarcoma tumorigenesis and metastasis.

abstract：:Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...

journal_title：Oncogene

authors： Zheng X,Chi J,Zhi J,Zhang H,Yue D,Zhao J,Li D,Li Y,Gao M,Guo J

更新日期：2018-01-25 00:00:00

abstract：:The oligomerization chain reaction (OCR) strategy is a recently described technique for inactivation of target proteins that function as homoassociate complexes. This novel strategy is based on the fusion of self-associating coiled-coil (CC) domain of the nuclear factor promyelocytic leukemia (PML) to target proteins....

journal_title：Oncogene

authors： Napolitano G,Mazzocco A,Fraldi A,Majello B,Lania L

更新日期：2003-07-31 00:00:00

abstract：:The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...

journal_title：Oncogene

authors： Zörnig M,Schmidt T,Karsunky H,Grzeschiczek A,Möröy T

更新日期：1996-04-18 00:00:00

abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

journal_title：Oncogene

authors： Liu SK,Berry DM,McGlade CJ

更新日期：2001-10-01 00:00:00

abstract：:Heat shock protein (Hsp)90 regulates many key pathways in oncogenesis, including Akt and mammalian target of rapamycin (mTOR). The strengths of disruption of Hsp90 in cancer therapy include their versatility in inhibiting a wide range of oncogenic pathways. The present study demonstrated that synuclein γ (SNCG) protec...

journal_title：Oncogene

authors： Liang W,Miao S,Zhang B,He S,Shou C,Manivel P,Krishna R,Chen Y,Shi YE

更新日期：2015-04-30 00:00:00

abstract：:The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell lung cancer A549 and H460 cells, and knockdown of TR3 by RNA interference (siTR3) inhibited cancer cell growth...

journal_title：Oncogene

authors： Lee SO,Andey T,Jin UH,Kim K,Singh M,Safe S

更新日期：2012-07-05 00:00:00

abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...

journal_title：Oncogene

authors： Varga AE,Stourman NV,Zheng Q,Safina AF,Quan L,Li X,Sossey-Alaoui K,Bakin AV

更新日期：2005-07-28 00:00:00

abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

journal_title：Oncogene

authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

更新日期：1998-03-26 00:00:00

abstract：:Fanconi anemia is a hereditary cancer susceptibility disorder characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents such as mitomycin C. This phenotype suggests a possible role for the Fanconi anemia proteins in the repair of DNA lesions in...

journal_title：Oncogene

authors： Godthelp BC,Artwert F,Joenje H,Zdzienicka MZ

更新日期：2002-07-25 00:00:00

abstract：:Bladder cancer is one of the most common causes of death in industrialized countries. New tumor markers and therapeutic approaches are still needed to improve the management of bladder cancer patients. Choline kinase-alpha (ChoKalpha) is a metabolic enzyme that has a role in cell proliferation and transformation. Inhi...

journal_title：Oncogene

authors： Hernando E,Sarmentero-Estrada J,Koppie T,Belda-Iniesta C,Ramírez de Molina V,Cejas P,Ozu C,Le C,Sánchez JJ,González-Barón M,Koutcher J,Cordón-Cardó C,Bochner BH,Lacal JC,Ramírez de Molina A

更新日期：2009-07-02 00:00:00

abstract：:The Epstein-Barr virus latency-associated membrane protein LMP2A has been shown to activate the survival kinase Akt in epithelial and B cells in a phosphoinositide 3-kinase-dependent fashion. In this study, we demonstrate that the signalling scaffold Shb associates through SH2 and PTB domain interactions with phosphor...

journal_title：Oncogene

authors： Matskova LV,Helmstetter C,Ingham RJ,Gish G,Lindholm CK,Ernberg I,Pawson T,Winberg G

更新日期：2007-07-26 00:00:00

abstract：:The t(12;21) translocation, generating the TEL/AML1 fusion protein, is the most common genetic lesion in childhood cancer. Using a bone marrow transplantation model, we demonstrate that TEL/AML1 expression impinges on normal hematopoietic differentiation, leading to the in vivo accumulation and persistence of an early...

journal_title：Oncogene

authors： Fischer M,Schwieger M,Horn S,Niebuhr B,Ford A,Roscher S,Bergholz U,Greaves M,Löhler J,Stocking C

更新日期：2005-11-17 00:00:00

abstract：:Cells from patients with the human genetic disorder ataxia-telangiectasia (A-T) are defective in the activation of cell cycle checkpoints in response to ionizing radiation damage. In order to understand the role of ATM in checkpoint control we investigated whether Schizosaccaromyces pombe chk1, a protein kinase implic...

journal_title：Oncogene

authors： Chen P,Gatei M,O'Connell MJ,Khanna KK,Bugg SJ,Hogg A,Scott SP,Hobson K,Lavin MF

更新日期：1999-01-07 00:00:00

abstract：:Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are d...

journal_title：Oncogene

authors： Sciamanna I,Landriscina M,Pittoggi C,Quirino M,Mearelli C,Beraldi R,Mattei E,Serafino A,Cassano A,Sinibaldi-Vallebona P,Garaci E,Barone C,Spadafora C

更新日期：2005-06-02 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there is little data regarding the contribution of post-transcriptional processing to this regula...

journal_title：Oncogene

authors： Doçi CL,Zhou G,Lingen MW

更新日期：2013-09-12 00:00:00

abstract：:To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure. NMuMG cells became proliferation-arrested and apoptotic after exposure to TGFbeta for 2-5 days, w...

journal_title：Oncogene

authors： Gal A,Sjöblom T,Fedorova L,Imreh S,Beug H,Moustakas A

更新日期：2008-02-21 00:00:00

abstract：:It has recently been shown that the high-risk human papillomavirus (HPV) E6 proteins can target the PDZ-domain containing proteins, Dlg, MUPP-1, MAGI-1 and hScrib for proteasome-mediated degradation. However, the E6 proteins from HPV-16 and HPV-18 (the two most common high-risk virus types) differ in their ability to ...

journal_title：Oncogene

authors： Thomas M,Glaunsinger B,Pim D,Javier R,Banks L

更新日期：2001-09-06 00:00:00

abstract：:Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...

journal_title：Oncogene

authors： Beyne-Rauzy O,Recher C,Dastugue N,Demur C,Pottier G,Laurent G,Sabatier L,Mansat-De Mas V

更新日期：2004-09-30 00:00:00

abstract：:Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...

journal_title：Oncogene

authors： Adnane J,Bizouarn FA,Chen Z,Ohkanda J,Hamilton AD,Munoz-Antonia T,Sebti SM

更新日期：2000-11-16 00:00:00

abstract：:Tumor suppressor p53 has been shown to repress expression of vascular endothelial growth factor (VEGF), an endothelial cell-specific mitogen and a key mediator of tumor angiogenesis. The p63 gene, recently identified as a p53-relative, encodes multiple isoforms with structural and functional similarities and differenc...

journal_title：Oncogene

authors： Senoo M,Matsumura Y,Habu S

更新日期：2002-04-11 00:00:00

abstract：:Met tyrosine kinase has been implicated in tumorigenesis and metastasis; its overexpression and deregulation is often observed in cancer. Although Met's functions in cell motility has been studied extensively, its involvement in bleb-based, amoeboid motility is yet to be determined. The aim of this work is to study th...

journal_title：Oncogene

authors： Laser-Azogui A,Diamant-Levi T,Israeli S,Roytman Y,Tsarfaty I

更新日期：2014-04-03 00:00:00

abstract：:As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...

journal_title：Oncogene

authors： Mishra L,Tully RE,Monga SP,Yu P,Cai T,Makalowski W,Mezey E,Pavan WJ,Mishra B

更新日期：1997-11-06 00:00:00

abstract：:The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....

journal_title：Oncogene

authors： Liu Y,Jovanovic B,Pins M,Lee C,Bergan RC

更新日期：2002-11-28 00:00:00

abstract：:CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA. We show here that CD97 was expressed in a majority of thyroid cancers but not normal thyroid epithelium and that the level of CD97...

journal_title：Oncogene

authors： Ward Y,Lake R,Martin PL,Killian K,Salerno P,Wang T,Meltzer P,Merino M,Cheng SY,Santoro M,Garcia-Rostan G,Kelly K

更新日期：2013-05-30 00:00:00

abstract：:The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform myelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such...

journal_title：Oncogene

authors： Schlichter U,Burk O,Worpenberg S,Klempnauer KH

更新日期：2001-01-11 00:00:00

abstract：:Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we show that specific microRNAs (miRNAs) target the 3'-UTR of Axl. Luciferase-reporter assays with wild-type and deleted miR-34 and miR-199a/b seed sequences of Axl 3'-UTR confirmed the specificity of targeting. An inverse c...

journal_title：Oncogene

authors： Mudduluru G,Ceppi P,Kumarswamy R,Scagliotti GV,Papotti M,Allgayer H

更新日期：2011-06-23 00:00:00

abstract：:Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF superfamily. This subset, which also includes Fas ligand and TNF-alpha, can activate the extrinsic apoptotic cell death pathway on binding to cognate death...

journal_title：Oncogene

authors： Gonzalvez F,Ashkenazi A

更新日期：2010-08-26 00:00:00

abstract：:Three-dimensional explant cultures of muscle tissue were used to characterize secreted proteins regulated by endogenous levels of the angiogenesis modulator thrombospondin (TSP)-1. Explants from TSP1 null mice exhibit enhanced neovascularization associated with increased endothelial outgrowth but decreased outgrowth o...

journal_title：Oncogene

authors： Zhou L,Isenberg JS,Cao Z,Roberts DD

更新日期：2006-01-26 00:00:00

abstract：:Medulloblastoma (MB) results from aberrant development of cerebellar neurons in which altered hedgehog (Hh) signalling plays a major role. We investigated the possible influence of Hh signalling on ErbB-receptor expression in MB, in particular that of the ErbB-4 CYT-1 and CYT-2 isoforms generated by alternative splici...

journal_title：Oncogene

authors： Ferretti E,Di Marcotullio L,Gessi M,Mattei T,Greco A,Po A,De Smaele E,Giangaspero F,Riccardi R,Di Rocco C,Pazzaglia S,Maroder M,Alimandi M,Screpanti I,Gulino A

更新日期：2006-11-23 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...

journal_title：Oncogene

authors： Sastry KJ,Marin MC,Nehete PN,McConnell K,el-Naggar AK,McDonnell TJ

更新日期：1996-08-01 00:00:00