Aurora-A-mediated phosphorylation of LKB1 compromises LKB1/AMPK signaling axis to facilitate NSCLC growth and migration.

abstract：:The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood. To address this, we compared the transcriptional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a TMPRSS2:ERG-positive PC cell line. This reveals that ERG re...

journal_title：Oncogene

authors： Mounir Z,Lin F,Lin VG,Korn JM,Yu Y,Valdez R,Aina OH,Buchwalter G,Jaffe AB,Korpal M,Zhu P,Brown M,Cardiff RD,Rocnik JL,Yang Y,Pagliarini R

更新日期：2015-07-01 00:00:00

abstract：:Recent analyses have revealed that RUNX family members play important roles in both normal developmental processes and carcinogenesis. Of the three known RUNX family members, RUNX3 has been shown to be involved in neurogenesis of the dorsal root ganglia, T-cell differentiation and tumorigenesis of gastric epithelium. ...

journal_title：Oncogene

authors： Bae SC,Choi JK

更新日期：2004-05-24 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

journal_title：Oncogene

authors： Simpson SC,Bolen JB,Veillette A

更新日期：1989-09-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Activated TbetaRI then mediates TGF-beta signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize ...

journal_title：Oncogene

authors： Kleeff J,Ishiwata T,Maruyama H,Friess H,Truong P,Büchler MW,Falb D,Korc M

更新日期：1999-09-23 00:00:00

abstract：:Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby delaying the onset of the majority of cancer types until post-reproductive age. Indeed, telomerase is silent in most differentiated human cells, predominantly due t...

journal_title：Oncogene

authors： Yuan X,Larsson C,Xu D

更新日期：2019-08-01 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:The HER-2/neu proto-oncogene is frequently amplified or overexpressed in many different types of human cancers, a phenomenon that has been shown to correlate with shorter survival time and lower survival rate in ovarian cancer patients. We previously reported that increased HER-2/neu expression led to more severe mali...

journal_title：Oncogene

authors： Yu D,Matin A,Xia W,Sorgi F,Huang L,Hung MC

更新日期：1995-10-05 00:00:00

abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...

journal_title：Oncogene

authors： Furukawa Y,DeCaprio JA,Belvin M,Griffin JD

更新日期：1991-08-01 00:00:00

abstract：:The W locus of mice encodes the c-kit receptor tyrosine kinase. Recently, we characterized a novel mutant allele, Wn, and demonstrated that the c-kit protein synthesized in Wn/Wn cultured mast cells (CMC) was reduced in size and not expressed on their surface (Tsujimura et al., 1993). In this study, we further examine...

journal_title：Oncogene

authors： Koshimizu U,Tsujimura T,Isozaki K,Nomura S,Furitsu T,Kanakura Y,Kitamura Y,Nishimune Y

更新日期：1994-01-01 00:00:00

abstract：:We analysed breast tumors and breast cancer cell lines for the expression of beta-parvin (ParvB), an adaptor protein that binds to the integrin-linked kinase (ILK). Quantitative RT-PCR indicated that ParvB mRNA was downregulated, by at least 60%, in four of nine breast tumors, relative to patient-matched normal mammar...

journal_title：Oncogene

authors： Mongroo PS,Johnstone CN,Naruszewicz I,Leung-Hagesteijn C,Sung RK,Carnio L,Rustgi AK,Hannigan GE

更新日期：2004-11-25 00:00:00

abstract：:MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has been studied in different tumor types, little is known about how they regulate nuclear factor κB (NF-κB) signaling in breast cancer. Here, we performed an unb...

journal_title：Oncogene

authors： Keklikoglou I,Koerner C,Schmidt C,Zhang JD,Heckmann D,Shavinskaya A,Allgayer H,Gückel B,Fehm T,Schneeweiss A,Sahin O,Wiemann S,Tschulena U

更新日期：2012-09-13 00:00:00

abstract：:The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its beha...

journal_title：Oncogene

authors： Quimby BB,Yong-Gonzalez V,Anan T,Strunnikov AV,Dasso M

更新日期：2006-05-18 00:00:00

abstract：:Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 rec...

journal_title：Oncogene

authors： Dirmeier U,Hoffmann R,Kilger E,Schultheiss U,Briseño C,Gires O,Kieser A,Eick D,Sugden B,Hammerschmidt W

更新日期：2005-03-03 00:00:00

abstract：:Germline LKB1 mutations cause Peutz-Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, however, a few reports showed the presence of somatic alterations in a considerable frac...

journal_title：Oncogene

authors： Matsumoto S,Iwakawa R,Takahashi K,Kohno T,Nakanishi Y,Matsuno Y,Suzuki K,Nakamoto M,Shimizu E,Minna JD,Yokota J

更新日期：2007-08-30 00:00:00

abstract：:Mxi1 is a basic region helix-loop-helix leucine zipper (bHLH/LZ) protein that, in association with Max, antagonizes Myc oncogenic activities. A possible mechanistic basis for Mxi1-mediated repression was provided by the recent demonstration that the repressive potential of Mxi1 correlates with its ability to physicall...

journal_title：Oncogene

authors： Rao G,Alland L,Guida P,Schreiber-Agus N,Chen K,Chin L,Rochelle JM,Seldin MF,Skoultchi AI,DePinho RA

更新日期：1996-03-07 00:00:00

abstract：:The role of the hepatitis B virus protein HBx in liver cell proliferation and apoptosis remains controversial. Using a transgenic mouse model, we have recently shown that HBx stimulates the apoptotic turnover of hepatocytes, independently of p53. In this paper, we tested whether the proapoptotic function of HBx can in...

journal_title：Oncogene

authors： Terradillos O,de La Coste A,Pollicino T,Neuveut C,Sitterlin D,Lecoeur H,Gougeon ML,Kahn A,Buendia MA

更新日期：2002-01-17 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) is a nuclear encoded and mitochondrial matrix-localized redox enzyme that is known to regulate the cellular redox environment. Cellular redox environment changes during transitions between quiescent and proliferative cycles. Human MnSOD has two poly(A) sites resulting in two tran...

journal_title：Oncogene

authors： Chaudhuri L,Nicholson AM,Kalen AL,Goswami PC

更新日期：2012-03-08 00:00:00

abstract：:The nuclear transport receptor importin-β/karyopherin-β1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic transport, importin-β regulates mitosis, but the programmes and pathways i...

journal_title：Oncogene

authors： Verrico A,Rovella P,Di Francesco L,Damizia M,Staid DS,Le Pera L,Schininà ME,Lavia P

更新日期：2020-01-01 00:00:00

abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

journal_title：Oncogene

authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

更新日期：2006-03-02 00:00:00

abstract：:While screening a chicken kidney cDNA library for the normal homolog of the yes oncogene, we isolated a clone that encodes a novel non-receptor type protein tyrosine kinase of the Src family. We named this gene product Yrk (York), as an acronym for Yes-related kinase. As predicted from the cDNA sequence, the Yrk prote...

journal_title：Oncogene

authors： Sudol M,Greulich H,Newman L,Sarkar A,Sukegawa J,Yamamoto T

更新日期：1993-04-01 00:00:00

abstract：:Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However, little is known about the molecular mechanisms of cell cycle regulation that discriminate between GSCs an...

journal_title：Oncogene

authors： Koyama-Nasu R,Nasu-Nishimura Y,Todo T,Ino Y,Saito N,Aburatani H,Funato K,Echizen K,Sugano H,Haruta R,Matsui M,Takahashi R,Manabe E,Oda T,Akiyama T

更新日期：2013-08-15 00:00:00

abstract：:Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF superfamily. This subset, which also includes Fas ligand and TNF-alpha, can activate the extrinsic apoptotic cell death pathway on binding to cognate death...

journal_title：Oncogene

authors： Gonzalvez F,Ashkenazi A

更新日期：2010-08-26 00:00:00

abstract：:The WARTS gene encodes a kinase that localizes to the mitotic apparatus of a dividing cell. Named WARTS after the growths that develop in the eyes of Drosophila in which the gene is deleted. WARTS is also implicated as a tumor suppressor in mice and humans. In this issue of Oncogene, Iida et al. describe experiments s...

journal_title：Oncogene

authors： Edwards KM,Münger K

更新日期：2004-07-08 00:00:00

abstract：:Cytokines can influence the interactions between members of the integrin cell adhesion receptor family and the extracellular matrix thereby potentially affecting cell function and promoting cell adhesion, growth and migration of malignant astrocytoma tumor cells. As malignant astrocytoma cells synthesize TGF-beta1 in ...

journal_title：Oncogene

authors： Han X,Stewart JE Jr,Bellis SL,Benveniste EN,Ding Q,Tachibana K,Grammer JR,Gladson CL

更新日期：2001-11-29 00:00:00

abstract：:Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

journal_title：Oncogene

authors： Zhang Y,Wang Z,Li X,Magnuson NS

更新日期：2008-08-14 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

journal_title：Oncogene

authors： Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

更新日期：1989-06-01 00:00:00

abstract：:The cysteinyl leukotriene1 (CysLT1) receptor (CysLT1R) enhances survival and proliferation of intestinal cells via distinct pathways. Here, we have demonstrated that there is significant endogenous production of CysLTs from both non-tumour- and tumour-derived intestinal epithelial cells. Treatment of two non-tumour ce...

journal_title：Oncogene

authors： Paruchuri S,Mezhybovska M,Juhas M,Sjölander A

更新日期：2006-10-26 00:00:00

abstract：:PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...

journal_title：Oncogene

authors： Huang W,Chang HY,Fei T,Wu H,Chen YG

更新日期：2007-04-12 00:00:00