Abstract:
:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellular distribution of v-rel protein complexes after biochemical fractionation of [35S]methionine and [32P]orthophosphate labeled cells. Our results demonstrate that the v-rel protein coprecipitates with a characteristic set of proteins, some of which are distinct to nuclear or cytoplasmic fractions. We also demonstrate that the normal cellular homolog of the viral rel protein, c-rel, coprecipitates with several cellular proteins from normal chick hematopoietic tissue. These cellular proteins have apparent molecular weights similar to those which are coprecipitated with v-rel from cytoplasmic fractions. Our results demonstrate that both v-rel and c-rel interact with a variety of cellular proteins and suggest that this association is important for the function or regulation of the rel protein.
journal_name
Oncogenejournal_title
Oncogeneauthors
Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJsubject
Has Abstractpub_date
1989-06-01 00:00:00pages
677-83issue
6eissn
0950-9232issn
1476-5594journal_volume
4pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The retinoblastoma protein (pRB) has the dual capability to negatively regulate both E2F-induced cell cycle entry and E2F1-induced apoptosis. In this report, we characterize a unique pRB-E2F1 interaction. Using mutagenesis to disrupt E2F1 binding, we find that the ability of pRB to regulate E2F1-induced apoptosis is d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210803
更新日期:2008-03-06 00:00:00
abstract::Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The transcriptional activation is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric member of the basic helix-loop-helix PAS family, composed of alpha and beta ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203938
更新日期:2000-11-16 00:00:00
abstract::The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205221
更新日期:2002-03-07 00:00:00
abstract::The mechanism by which the p53 family of proteins coordinately regulates select target genes after various types of cell stress is not well understood. To further define factors that dictate regulation of target genes, we examined the binding of p53, DeltaNp63alpha and RNA polymerase II (pol II) to the regulatory regi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210441
更新日期:2007-09-13 00:00:00
abstract::Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the BMP3B promoter is associated with downregulation of BMP3B transcripti...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207441
更新日期:2004-04-29 00:00:00
abstract::Nuclear Foxc2 is a transcriptional regulator of mesenchymal transformation during developmental epithelial-mesenchymal transition (EMT) and has been associated with EMT in malignant epithelia. Our laboratory has shown that in normal epithelial cells Foxc2 is maintained in the cytoplasm where it promotes an epithelial ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.395
更新日期:2015-09-03 00:00:00
abstract::E2F transcription factors are important regulators of the cell cycle, and unrestrained activation of E2F-dependent transcription is considered to be an important driver of tumor formation and progression. Although highly expressed in normal skin and skin cancer, the role of the atypical E2Fs, E2F7 and E2F8, in keratin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.251
更新日期:2017-02-09 00:00:00
abstract::The BNLF-1 protein is the only non-nuclear Epstein-Barr virus (EBV) encoded protein that has been detected in B-lymphocytes immortalized by EBV. We demonstrate that the BNLF-1 gene induces anchorage-independent growth and tumorigenic transformation of the murine cell-line, Balb/3T3. This demonstration extends the earl...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract::Trichostatin A (TSA), a histone deacetylase inhibitor, strongly increases acetylation of the N-terminal tails of histone H3. Many studies have correlated the function of TSA with the hyperacetylation of histone. Although histone H3 is known to be phosphorylated, the effect of acetylation on phosphorylation is not know...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206507
更新日期:2003-08-14 00:00:00
abstract::Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::Ultraviolet light (UV) induced DNA lesions efficiently block transcript elongation and induce the p53 response. Although p53 contributes to transcriptional activation of the p21waf1 and bax genes, accumulation of these proteins requires that these genes are free of UV induced pyrimidine dimers. We assessed the level o...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201963
更新日期:1998-08-06 00:00:00
abstract::Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. However, our understanding of the regulatory mechanisms of AR-V7-driven transcription ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0047-5
更新日期:2018-03-01 00:00:00
abstract::Eukaryotic translation can be initiated either by a cap-dependent mechanism or by internal ribosome entry, a process by which ribosomes are directly recruited to structured regions of mRNA upstream of the initiation codon. Here we report the finding of an internal ribosome entry site (IRES) in the untranslated region ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206149
更新日期:2003-01-30 00:00:00
abstract::The v-myb oncogene of the avian myeloblastosis virus encodes a nuclear protein, p48v-myb, which binds to DNA in a sequence-specific manner. We have used wild type and mutant forms of this protein expressed in E. coli to study the protein and DNA determinants for sequence-specific DNA-binding. We have shown that only t...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::The c-Myb transcriptional regulator is crucial to the development and functioning of haemopoietic cells, so much so that mouse embryos homozygous for an inactivated c-myb allele die from anaemia at about day 15 of gestation. By analysing c-myb(-/-) chimaeras we show that no mature cells of any lymphoid or myeloid line...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203660
更新日期:2000-07-13 00:00:00
abstract::The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208924
更新日期:2005-08-29 00:00:00
abstract::Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that cause their misregulation in cancers are largely unknown. In this study, we investigate the mechanism by which the Six1 homeobox protein, which has a crucial role d...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.233
更新日期:2010-09-02 00:00:00
abstract::Metastasis is the chief cause of mortality from cancer, but the mechanisms leading to metastasis are poorly understood. We used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 (CRMP4) expression was inversely associated with the lymph node metasta...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.213
更新日期:2010-08-12 00:00:00
abstract::A hallmark of plasma cells is the expression of syndecan-1, which has major functions in epithelial cells, in particular as the coreceptor of heparin-binding growth factors. We previously found that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a growth factor for malignant plasma cells. As am...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208536
更新日期:2005-05-12 00:00:00
abstract::Ataxia Telangiectasia Mutated (ATM) kinase, a central regulator of the DNA damage response, regulates the activity of several E3-ubiquitin ligases, and the ubiquitination-proteasome system is a consistent target of ATM. ITCH is an E3-ubiquitin ligase that modulates the ubiquitination of several targets, therefore part...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.52
更新日期:2014-02-27 00:00:00
abstract::Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.73
更新日期:2010-06-03 00:00:00
abstract::Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastoma...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208000
更新日期:2005-01-06 00:00:00
abstract::Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.397
更新日期:2015-08-27 00:00:00
abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Oncogene
pub_type: 已发布勘误
doi:10.1038/s41388-019-0835-1
更新日期:2019-07-01 00:00:00
abstract::Oncoprotein C-MYC is overexpressed in human metastatic melanomas and melanoma-derived cells where it is required for the suppression of oncogene-induced senescence (OIS). The genetic events that maintain high levels of C-MYC in melanoma cells and their role in OIS are unknown. Here we report that C-MYC in cells from s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.339
更新日期:2012-03-22 00:00:00
abstract::Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202290
更新日期:1999-01-14 00:00:00
abstract::p27Kip1 plays an important role in cell cycle progression by negatively regulating the activity of cyclin-Cdk complexes. To understand how p27Kip1 functions, the level and subcellular location of p27Kip1 in Swiss/3T3 cells following serum stimulation of quiescent cells was examined. Surprisingly, p27Kip1 was observed ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202912
更新日期:1999-09-16 00:00:00
abstract::The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210766
更新日期:2007-10-15 00:00:00
abstract::The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.600
更新日期:2011-05-12 00:00:00