Abstract:
:Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However, little is known about the molecular mechanisms of cell cycle regulation that discriminate between GSCs and differentiated glioblastoma cells. Here we show that cyclin D2 is the cyclin that is predominantly expressed in GSCs and suppression of its expression by RNA interference causes G1 arrest in vitro and growth retardation of GSCs xenografted into immunocompromised mice in vivo. We also demonstrate that the expression of cyclin D2 is suppressed upon serum-induced differentiation similar to what was observed for the cancer stem cell marker CD133. Taken together, our results demonstrate that cyclin D2 has a critical role in cell cycle progression and the tumorigenicity of GSCs.
journal_name
Oncogenejournal_title
Oncogeneauthors
Koyama-Nasu R,Nasu-Nishimura Y,Todo T,Ino Y,Saito N,Aburatani H,Funato K,Echizen K,Sugano H,Haruta R,Matsui M,Takahashi R,Manabe E,Oda T,Akiyama Tdoi
10.1038/onc.2012.399subject
Has Abstractpub_date
2013-08-15 00:00:00pages
3840-5issue
33eissn
0950-9232issn
1476-5594pii
onc2012399journal_volume
32pub_type
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