Abstract:
:MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of critical cell processes such as apoptosis, cell proliferation and differentiation. A small set of miRNAs is differentially expressed in hematopoietic cells and seemingly has an important role in granulopoiesis and lineage differentiation. In this study, we analysed, using a quantitative real-time PCR approach, the expression of 12 granulocytic differentiation signature miRNAs in a cohort of acute promyelocytic leukemia (APL) patients. We found nine miRNAs overexpressed and three miRNAs (miR-107, -342 and let-7c) downregulated in APL blasts as compared with normal promyelocytes differentiated in vitro from CD34+ progenitors. Patients successfully treated with all-trans-retinoic acid (ATRA) and chemotherapy showed downregulation of miR-181b and upregulation of miR-15b, -16, -107, -223, -342 and let-7c. We further investigated whether the APL-associated oncogene, promyelocytic leukemia gene (PML)/retinoic acid receptor alpha (RARalpha), might be involved in the transcriptional repression of miR-107, -342 and let-7c. We found that PML/RARalpha binds the regulatory sequences of the intragenic miR-342 and let-7c. In addition, we observed, in response to ATRA, the release of PML/RARalpha paralleled by their transcriptional activation, together with their host genes, EVL and C21orf34alpha. In conclusion, we show that a small subset of miRNAs is differentially expressed in APL and modulated by ATRA-based treatment.
journal_name
Oncogenejournal_title
Oncogeneauthors
Careccia S,Mainardi S,Pelosi A,Gurtner A,Diverio D,Riccioni R,Testa U,Pelosi E,Piaggio G,Sacchi A,Lavorgna S,Lo-Coco F,Blandino G,Levrero M,Rizzo MGdoi
10.1038/onc.2009.255subject
Has Abstractpub_date
2009-11-12 00:00:00pages
4034-40issue
45eissn
0950-9232issn
1476-5594pii
onc2009255journal_volume
28pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Gastric carcinogenesis is a multistep process involving genetic and epigenetic alteration of protein-coding proto-oncogenes and tumor-suppressor genes. Recent discoveries have shed new light on the involvement of a class of noncoding RNA known as microRNA (miRNA) in gastric cancer. A substantial number of miRNAs show ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.352
更新日期:2010-10-28 00:00:00
abstract::Next-generation sequencing (NGS) technology has demonstrated that the cancer genomes are peppered with mutations. Although most somatic tumour mutations are unlikely to have any role in the cancer process per se, the spectra of DNA sequence changes in tumour mutation catalogues have the potential to identify the mutag...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.192
更新日期:2017-01-12 00:00:00
abstract::Elevated expression of osteopontin (OPN), a secreted adhesive phosphoglycoprotein, is frequently associated with many transformed cell lines of epithelial and stromal origin. Moreover, several clonal lines of preneoplastic JB6 cells derived from Balb/c mouse epidermal cultures (Colburn et al., 1978, 1979), upon treatm...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Retinoic acid receptor-beta (RAR beta) and signal transducer and activator of transcription 1 (STAT1) are important mediators of the antiproliferative and apoptotic actions of retinoids and cytokines/growth factors, respectively. Expression of both RAR beta and STAT1 is lost in most breast cancer cell lines but it can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203084
更新日期:1999-11-18 00:00:00
abstract::Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determination of their pathog...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0968-2
更新日期:2020-01-01 00:00:00
abstract::The human ret proto-oncogene (proto-ret), encoding a receptor tyrosine kinase, is highly expressed in neuroblastomas, medullary thyroid carcinomas (MTCs) and pheochromocytomas, which are all tumors of cells originating from the neural crest. In studies on the transcription mechanism of proto-ret, we identified the tra...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::Transactivating proteins associated with complex onco-retroviruses including human T-cell leukemia virus-1 (HTLV-1) and bovine leukemia virus (BLV) mediate transformation using poorly understood mechanisms. To gain insight into the processes that govern tumor onset and progression, we have examined the impact of BLV-T...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206546
更新日期:2003-07-17 00:00:00
abstract::Interferon (IFN)-beta induces S-phase slowing and apoptosis in human papilloma virus (HPV)-positive cervical carcinoma cell line ME-180. Here, we show that apoptosis is a consequence of the S-phase lengthening imposed by IFN-beta, demonstrating the functional correlation between S-phase alteration and apoptosis induct...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208403
更新日期:2005-04-07 00:00:00
abstract::The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met recept...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.586
更新日期:2011-04-28 00:00:00
abstract::The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype wi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01431-8
更新日期:2020-10-01 00:00:00
abstract::Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the cDNA of human Fnk (FGF-inducible kinase) which codes for a serine/threonine kinase of 646 aa. Despite the homology to the proliferation-associated polo-like ki...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203845
更新日期:2000-10-05 00:00:00
abstract::Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon ti...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-16 00:00:00
abstract::Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::The 2;13 chromosomal translocation occurs in most cases of the cancer alveolar rhabdomyosarcoma (ARMS), and juxtaposes the genes encoding the PAX3 and FKHR transcription factors. The resulting chimeric protein PAX3-FKHR is a potent transcriptional activator, and is hypothesized to function as a dominant acting oncogen...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207850
更新日期:2004-09-09 00:00:00
abstract::Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal transition (EMT) by...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.369
更新日期:2018-02-01 00:00:00
abstract::In this study, we investigated the regulation of FOXM1 expression by estrogen receptor alpha (ERalpha) and its role in hormonal therapy and endocrine resistance. FOXM1 protein and mRNA expression was regulated by ER-ligands, including estrogen, tamoxifen (OHT) and fulvestrant (ICI182780; ICI) in breast carcinoma cell ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.47
更新日期:2010-05-20 00:00:00
abstract::Myristoylated Alanine-Rich C Kinase Substrate (MARCKS), a substrate of protein kinase C, is a key regulatory molecule controlling mucus granule secretion by airway epithelial cells as well as directed migration of leukocytes, stem cells and fibroblasts. Phosphorylation of MARKCS may be involved in these responses. How...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.336
更新日期:2014-07-10 00:00:00
abstract::The understanding of the organisation of cell cycle events is of utmost importance to devise effective therapeutic strategies for cancer. In this article we gather evidences from the literature in support of a system model of the cell cycle, in which a growth-sensitive threshold controls entry into S phase and the seq...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204263
更新日期:2001-03-01 00:00:00
abstract::A dominant negative mutant of Ras, M17 Ras, was used to study the role of Ras in receptor coupling of Raf-1 and B-Raf protein serine/threonine kinases (PSKs). We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf P...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract::BRCA1 mutation carriers have an 85% lifetime risk of breast cancer and 60% for ovarian cancer. BRCA1 facilitates DNA double-strand break repair, and dysfunction of BRCA1 leads to hypersensitivity to DNA damaging agents and consequently genomic instability of cells. In this communication, we have examined the tumor inc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210451
更新日期:2007-09-13 00:00:00
abstract::Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210958
更新日期:2008-05-08 00:00:00
abstract::Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1371-8
更新日期:2020-09-01 00:00:00
abstract::Numerous reports suggest that use of nonsteroidal anti-inflammatory drugs (NSAIDs) decrease mortality from colorectal cancer. To better understand all of the mechanisms underlying this effect, the global pattern of gene expression in colon carcinoma cells following treatment with NS-398, a selective cyclo-oxygenase-2 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204588
更新日期:2001-07-27 00:00:00
abstract::ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix-loop-helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its poss...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208538
更新日期:2005-07-07 00:00:00
abstract::Previous observations suggest expression of cyclooxygenase-2 to convey macrophage protection towards apoptotic cell death. We reasoned prostaglandin formation and in turn a cAMP increase as the underlying protective principle. Here we report that exposure of macrophages to lipopolysaccharide/interferon-gamma or lipoph...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201926
更新日期:1998-07-23 00:00:00
abstract::We analysed the involvement of proteases during taxol-mediated cell death of human A549 non-small-cell lung carcinoma cells using a proteomics approach that specifically targets protein N termini and further detects newly formed N termini that are the result of protein processing. Our analysis revealed 27 protease-med...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.96
更新日期:2008-07-31 00:00:00
abstract::Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200910
更新日期:1997-02-27 00:00:00
abstract::The present study was designed to elucidate the relationship between p53 and ceramide, both of which are involved in apoptotic signaling. Treatment of human glioma cells with etoposide caused apoptosis only in cells expressing functional p53. p53 activation was followed by the formation of reactive oxygen species (ROS...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204207
更新日期:2001-03-15 00:00:00
abstract::Interleukin-6 (IL-6) inhibits the growth of melanocytes and of early stage melanoma cells, but not that of advanced melanoma cells. The in vitro IL-6 response can be restored in the highly metastatic melanoma B16-F10.9 by addition of recombinant soluble IL-6 receptor alpha-chain (sIL-6R). The F10.9 cells then undergo ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201213
更新日期:1997-07-31 00:00:00
abstract::The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206117
更新日期:2002-11-28 00:00:00