Abstract:
:Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon tissues, expression varied remarkably in colon carcinoma-derived cell lines. CCK-4 cDNA encodes a chicken KLG-related, 1071 amino acid-long transmembrane glycoprotein containing several genetic alterations within the RTK consensus sequences. These define CCK-4 as a catalytically inactive member of the RTK family of proteins and, in analogy to HER3, suggest a potentially tumor-characteristic role as a signal amplifier or modulator for an as yet unidentified kinase-competent partner.
journal_name
Oncogenejournal_title
Oncogeneauthors
Mossie K,Jallal B,Alves F,Sures I,Plowman GD,Ullrich Asubject
Has Abstractpub_date
1995-11-16 00:00:00pages
2179-84issue
10eissn
0950-9232issn
1476-5594journal_volume
11pub_type
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