The PGC-1/ERR signaling axis in cancer.

abstract：:The T-box transcription factor TBX3 has been implicated in the patterning and differentiation of a number of tissues during embryonic development, and is overexpressed in a variety of cancers; however, the precise function of TBX3 in papillary thyroid carcinoma (PTC) development remains to be determined. In the curren...

journal_title：Oncogene

authors： Li X,Ruan X,Zhang P,Yu Y,Gao M,Yuan S,Zhao Z,Yang J,Zhao L

更新日期：2018-05-01 00:00:00

abstract：:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...

journal_title：Oncogene

authors： Yang W,Li Y,Gao R,Xiu Z,Sun T

更新日期：2020-01-01 00:00:00

abstract：:The p53 protein is a multifunctional transcription factor which orchestrates cellular responses to DNA damage, so helping to conserve genomic stability. It may also regulate genes involved in intercellular signalling, such as thrombospondin, a negative regulator of angiogenesis and metastatic spread. Activation of p53...

journal_title：Oncogene

authors： Rolley N,Butcher S,Milner J

更新日期：1995-08-17 00:00:00

abstract：:Colon cancer is the most aggressive tumor in both men and women globally. As many the chemotherapeutic regimens have adverse side effects and contribute to the resistance and recurrence, therefore, finding novel therapeutic targets and developing effective agents are urgent. Based on the TCGA and GTEx database analysi...

journal_title：Oncogene

authors： Jin G,Yan M,Liu K,Yao K,Chen H,Zhang C,Yi Y,Reddy K,Gorja DR,Laster KV,Guo Z,Dong Z

更新日期：2020-10-01 00:00:00

abstract：:Cytokines can influence the interactions between members of the integrin cell adhesion receptor family and the extracellular matrix thereby potentially affecting cell function and promoting cell adhesion, growth and migration of malignant astrocytoma tumor cells. As malignant astrocytoma cells synthesize TGF-beta1 in ...

journal_title：Oncogene

authors： Han X,Stewart JE Jr,Bellis SL,Benveniste EN,Ding Q,Tachibana K,Grammer JR,Gladson CL

更新日期：2001-11-29 00:00:00

abstract：:Defining apoptosis-regulatory cascades of the epithelium is important for understanding carcinogenesis, since cancer cells are considered to arise as a result of the collapse of the cascades. We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lin...

journal_title：Oncogene

authors： Saeki N,Kim DH,Usui T,Aoyagi K,Tatsuta T,Aoki K,Yanagihara K,Tamura M,Mizushima H,Sakamoto H,Ogawa K,Ohki M,Shiroishi T,Yoshida T,Sasaki H

更新日期：2007-10-04 00:00:00

abstract：:The c-myb gene is the normal cellular homolog of v-myb, the oncogenic component of Avian Myeloblastosis Virus (AMV). The c-myb gene has previously been shown to code for a single protein species of about 75 kd. However, accumulating evidence indicates that this gene could code for multiple mRNAs as a result of differe...

journal_title：Oncogene

authors： Dudek H,Reddy EP

更新日期：1989-09-01 00:00:00

abstract：:Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signalling, perturbs differentiation and ultimately leads to neoplasia. Apc negatively regulates Wnt signalling but is also involved in organizing the cytoskeleton and may have a role in chromosome segregation. In vitro studies have implic...

journal_title：Oncogene

authors： Méniel V,Megges M,Young MA,Cole A,Sansom OJ,Clarke AR

更新日期：2015-07-30 00:00:00

abstract：:dMax, a naturally occurring splice variant of the Myc binding protein Max, lacks the DNA binding basic region and helix 1 of the Helix-Loop-Helix domain; dMax interacts with c-Myc in vitro and in vivo, and inhibits E-box Myc site driven transcription in transient transfection assays. Here we have investigated the expr...

journal_title：Oncogene

authors： FitzGerald MJ,Arsura M,Bellas RE,Yang W,Wu M,Chin L,Mann KK,DePinho RA,Sonenshein GE

更新日期：1999-04-15 00:00:00

abstract：:Radiation therapy (RT) is useful for selectively killing cancer cells. However, because high levels of ionizing radiation (IR) are toxic to normal cells, RT cannot be applied repeatedly to cancer patients. Therefore, novel chemicals that enhance the efficacy of chemoradiotherapy (CRT) would be valuable. Here, we repor...

journal_title：Oncogene

authors： Ohno S,Naito Y,Mukai S,Yabuta N,Nojima H

更新日期：2015-12-03 00:00:00

abstract：:Bcl-2 and Bcl-XL serve as critical inhibitors of apoptosis triggered by a broad range of stimuli, mainly acting on the mitochondria. We identified two members of the reticulon (RTN) family as Bcl-XL binding proteins, i.e., NSP-C (RTN1-C) and a new family member, RTN-XS, both of which did not belong to the Bcl-2 family...

journal_title：Oncogene

authors： Tagami S,Eguchi Y,Kinoshita M,Takeda M,Tsujimoto Y

更新日期：2000-11-23 00:00:00

abstract：:Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...

journal_title：Oncogene

authors： Yin D,Ogawa S,Kawamata N,Leiter A,Ham M,Li D,Doan NB,Said JW,Black KL,Phillip Koeffler H

更新日期：2013-02-28 00:00:00

abstract：:The cytoplasmic tyrosine kinase Src has been implicated in signal transduction induced by growth factors and integrins. Src also shows oncogenic activity when deregulated. Accumulating evidence indicates that the tyrosine kinase Abl is an important substrate for Src signalling in normal cells. Here we show that Abl is...

journal_title：Oncogene

authors： Sirvent A,Boureux A,Simon V,Leroy C,Roche S

更新日期：2007-11-15 00:00:00

abstract：:The regulation of cell adhesion and motility in human prostate is not well understood. We have previously shown that the endoglin gene is differently expressed during changes in prostate cell adhesion. Endoglin is a transmembrane transforming growth factor beta binding protein typically expressed by endothelial cells....

journal_title：Oncogene

authors： Liu Y,Jovanovic B,Pins M,Lee C,Bergan RC

更新日期：2002-11-28 00:00:00

abstract：:This issue attempts to give a 'state of the art' overview of the AP-1 transcription factor family, a fundamental class of transcriptional regulators. The AP-1 family consists of several bZIP (basic region leucine zipper) domain proteins, the Jun, the Fos, and the ATF subfamilies, which all have to dimerize before they...

journal_title：Oncogene

authors： Wagner EF

更新日期：2001-04-30 00:00:00

abstract：:Polyoma virus (Py) causes neoplastic transformation in vitro and multiple tumors in vivo. The role played by large and middle T antigens (LT, MT) and their mechanisms of action are focused here. Py-transformed Balb-3T3 cells become independent of platelet-derived growth factor (PDGF) for growth. JE, c-fos, c-jun and c...

journal_title：Oncogene

authors： Rameh LE,Armelin MC

更新日期：1991-06-01 00:00:00

abstract：:YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes. The Amot-mediated retention of YAP in the cytoplasm results in the inhibition of its ...

journal_title：Oncogene

authors： Oka T,Schmitt AP,Sudol M

更新日期：2012-01-05 00:00:00

abstract：:Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...

journal_title：Oncogene

authors： Zheng X,Chi J,Zhi J,Zhang H,Yue D,Zhao J,Li D,Li Y,Gao M,Guo J

更新日期：2018-01-25 00:00:00

abstract：:Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) cell growth and prog...

journal_title：Oncogene

authors： Li N,Truong S,Nouri M,Moore J,Al Nakouzi N,Lubik AA,Buttyan R

更新日期：2018-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...

journal_title：Oncogene

authors： Zhao X,Reebye V,Hitchen P,Fan J,Jiang H,Sætrom P,Rossi J,Habib NA,Huang KW

更新日期：2019-05-01 00:00:00

abstract：:The MLL (HRX/ALL-1 gene is frequently disrupted in infantile leukemias and therapy-related leukemias and fused to various translocation partner genes. We previously showed that chimeric MLL proteins localize in the nuclei in a fashion similar to that of MLL protein even if the partner gene encodes a cytoplasmic protei...

journal_title：Oncogene

authors： Joh T,Hosokawa Y,Suzuki R,Takahashi T,Seto M

更新日期：1999-01-28 00:00:00

abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

journal_title：Oncogene

authors： Simpson SC,Bolen JB,Veillette A

更新日期：1989-09-01 00:00:00

abstract：:A cDNA encoding a complete human c-fos protein was isolated and inserted into two different murine MoMuLV-derived recombinant retroviruses allowing expression of c-fos protein in different cell types. One c-fos-expressing retrovirus, chosen for its ability to express high levels of proteins in fibroblast-like cells, w...

journal_title：Oncogene

authors： Roux P,Verrier B,Klein B,Niccolino M,Marty L,Alexandre C,Piechaczyk M

更新日期：1991-11-01 00:00:00

abstract：:We previously reported the presence of mitotic check-point impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mut...

journal_title：Oncogene

authors： Nomoto S,Haruki N,Takahashi T,Masuda A,Koshikawa T,Takahashi T,Fujii Y,Osada H,Takahashi T

更新日期：1999-11-25 00:00:00

abstract：:Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be the initial event associated with cancer metastasis and how it occurred is still a mystery. CtBP is known as a co-repre...

journal_title：Oncogene

authors： Zhao Z,Hao D,Wang L,Li J,Meng Y,Li P,Wang Y,Zhang C,Zhou H,Gardner K,Di LJ

更新日期：2019-03-01 00:00:00

abstract：:Wild-type p53 protein displays a spectrum of activities including the ability to suppress transformed cell growth to direct apoptotic cell death and to mediate G1 checkpoint in response to cellular DNA damage. Earlier work showed that a self-association defective p53 protein retained transformation suppressor activity...

journal_title：Oncogene

authors： Tarunina M,Grimaldi M,Ruaro E,Pavlenko M,Schneider C,Jenkins JR

更新日期：1996-08-01 00:00:00

abstract：:Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...

journal_title：Oncogene

authors： Ghamrasni SE,Cardoso R,Li L,Guturi KK,Bjerregaard VA,Liu Y,Venkatesan S,Hande MP,Henderson JT,Sanchez O,Hickson ID,Hakem A,Hakem R

更新日期：2016-09-15 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy because of its relative tumor selectivity. However, many cancers including pancreatic cancer remain resistant towards TRAIL. To develop TRAIL for cancer therapy of pancreatic carcinoma, it will therefore b...

journal_title：Oncogene

authors： Vogler M,Dürr K,Jovanovic M,Debatin KM,Fulda S

更新日期：2007-01-11 00:00:00

abstract：:Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...

journal_title：Oncogene

authors： Haley JD,Hsuan JJ,Waterfield MD

更新日期：1989-03-01 00:00:00

abstract：:Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen. Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is most often increased in tumour cells. HKII and phosphoglucose isomerase (PGI) have mainly an antiapoptotic effect; PGI and glyceraldehyde-...

journal_title：Oncogene

authors： Lincet H,Icard P

更新日期：2015-07-01 00:00:00