Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor.

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function. Cells lacking WRN demonstrate genomic instability, including telomeric abnormalities and undergo premature senescence, suggesting defects in telomere metabolism. This notion is strongly supported by our finding of physica...

journal_title：Oncogene

authors： Machwe A,Xiao L,Orren DK

更新日期：2004-01-08 00:00:00

abstract：:BRAF mutations occur in ~10% of colorectal cancer (CRC) and are associated with poor prognosis. Inhibitors selective for the BRAFV600E oncoprotein, the most common BRAF mutant, elicit only poor response rates in BRAF-mutant CRC as single agents. This unresponsiveness was mechanistically attributed to the loss of negat...

journal_title：Oncogene

authors： Herr R,Halbach S,Heizmann M,Busch H,Boerries M,Brummer T

更新日期：2018-03-01 00:00:00

abstract：:Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells...

journal_title：Oncogene

authors： Tait S

更新日期：2013-10-31 00:00:00

abstract：:We have shown that one of the principle mechanisms of chemotherapy resistance involves the activation of nuclear factor kappa-B (NF-kappaB). In an effort to identify NF-kappaB-regulated chemotherapy response genes, we performed a microarray assay and observed that heparin-binding EGF-like growth factor (HB-EGF) was si...

journal_title：Oncogene

authors： Wang F,Liu R,Lee SW,Sloss CM,Couget J,Cusack JC

更新日期：2007-03-29 00:00:00

abstract：:We show that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells (HBEC) by expression of K-Ras(G12V) and knockdown of p53. Further investigation demonstrates that this is due to the K-Ras/ERK1/2 MAPK pathway, as loss of p53 had little...

journal_title：Oncogene

authors： Zaganjor E,Osborne JK,Weil LM,Diaz-Martinez LA,Gonzales JX,Singel SM,Larsen JE,Girard L,Minna JD,Cobb MH

更新日期：2014-11-20 00:00:00

abstract：:Injection of the human neurotropic polyomavirus, JCV, into neonatal hamsters causes tumors of glial origin. Previously, a rapidly proliferating cell line, HJC-15, which expresses high levels of the viral T-antigen, had been established from JCV-induced hamster glial tumors. In our analyses of the mechanisms involved i...

journal_title：Oncogene

authors： Raj GV,Ansari SA,Khalili K

更新日期：1996-03-21 00:00:00

abstract：:Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evid...

journal_title：Oncogene

authors： Bassères DS,Baldwin AS

更新日期：2006-10-30 00:00:00

abstract：:The trans-activator protein, tax, from the human T leukemia virus type 1 (HTLV-1) trans-activates both viral and cellular genes. It has previously been shown that granulocyte macrophage-colony stimulating factor (GM-CSF) is constitutively expressed in HTLV-1 infected cells and in cells artificially expressing tax. We ...

journal_title：Oncogene

authors： Himes SR,Coles LS,Katsikeros R,Lang RK,Shannon MF

更新日期：1993-12-01 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta 1) inhibits most epithelial cell types by blocking cell cycle progression during the G1 phase. D cyclins are normally expressed during G1 and are regulators of G1 progression. One of the crucial functions of D cyclins is their ability to bind to a cyclin-dependent kinase (Cd...

journal_title：Oncogene

authors： Ko TC,Sheng HM,Reisman D,Thompson EA,Beauchamp RD

更新日期：1995-01-05 00:00:00

abstract：:It has recently been shown that an adenovirus mutant lacking expression of the large E1B protein (deltaE1B) selectively replicates in p53 deficient cells. However, apart from the large E1B protein the adenovirus early region encodes the E1A and E4orf6 proteins which also have been reported to affect p53 expression as ...

journal_title：Oncogene

authors： Steegenga WT,Riteco N,Jochemsen AG,Fallaux FJ,Bos JL

更新日期：1998-01-22 00:00:00

abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...

journal_title：Oncogene

authors： Ego T,Tanaka Y,Shimotohno K

更新日期：2005-03-10 00:00:00

abstract：:Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxxb families encode splice variants of VEGF-A that differ only at the level of six amino acids in their C-terminal part. The expression level of VEGFxxx splice...

journal_title：Oncogene

authors： Boudria A,Abou Faycal C,Jia T,Gout S,Keramidas M,Didier C,Lemaître N,Manet S,Coll JL,Toffart AC,Moro-Sibilot D,Albiges-Rizo C,Josserand V,Faurobert E,Brambilla C,Brambilla E,Gazzeri S,Eymin B

更新日期：2019-02-01 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:Downregulation of the cellular retinol-binding protein-I (CRBP-I) occurs in breast and other human cancers, but its significance is not well understood. Recently, we showed that restoration of CRBP-I expression in transformed MTSV1-7 breast epithelial cells increased retinoic receptor activity, inhibited anoikis, prom...

journal_title：Oncogene

authors： Farias EF,Marzan C,Mira-y-Lopez R

更新日期：2005-02-24 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:The co-chaperone protein, BAG3, which belongs to the BAG protein family, has an established antiapoptotic function in different tumor cell lines. Here we demonstrated that treatment of the human neuroblastoma cell line, SK-N-MC, with fibroblast growth factor-2 (FGF-2) results in induction of BAG3 expression. Induction...

journal_title：Oncogene

authors： Gentilella A,Passiatore G,Deshmane S,Turco MC,Khalili K

更新日期：2008-08-28 00:00:00

abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...

journal_title：Oncogene

authors： Colombo MP,Ferrari G,Parmiani G,Wettstein PJ

更新日期：1988-04-01 00:00:00

abstract：:BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible expression of BRCA1 to evaluate its role in mediating the cellular response to various chemotherapeutic drugs commonly used in the treatment of breast and ovarian can...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Gilmore PM,McWilliams S,Andrews H,Gervin C,McCabe N,McKenna S,White P,Song YH,Maheswaran S,Liu E,Haber DA,Johnston PG,Harkin DP

更新日期：2001-09-27 00:00:00

abstract：:Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis. Aberrant STC1 expression has been reported in breast, ovarian and prostate cancers, but the significance of this is not well understood. Here, we report that oxidative stress caused a 40-...

journal_title：Oncogene

authors： Nguyen A,Chang AC,Reddel RR

更新日期：2009-05-07 00:00:00

abstract：:BTG2, a p53-inducible antiproliferative gene, is stimulated in breast cancer cells by activation of nuclear factor kappa B (NF-kappaB). In rat mammary glands, BTG2 is expressed in epithelial cells and levels decreased during pregnancy and lactation but recovered during involution. Estrogen and progestin suppress BTG2 ...

journal_title：Oncogene

authors： Kawakubo H,Carey JL,Brachtel E,Gupta V,Green JE,Walden PD,Maheswaran S

更新日期：2004-10-28 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/AKT and RAS oncogenic signalling modules are frequently mutated in sporadic human cancer. Although each of these pathways has been shown to play critical roles in driving tumour growth and proliferation, their activation in normal human cells can also promote cell senescence. A...

journal_title：Oncogene

authors： Astle MV,Hannan KM,Ng PY,Lee RS,George AJ,Hsu AK,Haupt Y,Hannan RD,Pearson RB

更新日期：2012-04-12 00:00:00

abstract：:c-Abl is a nuclear and cytoplasmic tyrosine kinase involved in a variety of cellular growth and differentiation processes. In contrast to its oncogenic counterparts, like BCR-Abl, c-Abl is not constitutively tyrosine phosphorylated and its catalytic activity is very low. Here we report tyrosine phosphorylation of endo...

journal_title：Oncogene

authors： Dorey K,Engen JR,Kretzschmar J,Wilm M,Neubauer G,Schindler T,Superti-Furga G

更新日期：2001-12-06 00:00:00

abstract：:Guanine nucleotide exchange factors from the Dbl family are proto-oncogenic proteins that activate small GTPases of the Rho family. Here we report the characterization of GEF720, a novel Dbl-like protein related to p115Rho-GEF. GEF720 activated RhoA both in our recently developed Yeast Exchange Assay and in biochemica...

journal_title：Oncogene

authors： De Toledo M,Coulon V,Schmidt S,Fort P,Blangy A

更新日期：2001-11-01 00:00:00

abstract：:Constitutive expression of the activated Rap1A protein inhibits differentiation of myogenic C2 cells whereas the inactivated Rap1A protein favours cell differentiation and induces late endocytic compartments clustering. Although the role of Rap1A in MAPK activation has been analysed in various cell types, the signalli...

journal_title：Oncogene

authors： Pizon V,Baldacci G

更新日期：2000-12-07 00:00:00

abstract：:The viral mitochondrial inhibitor of apoptosis (vMIA) encoded by the human cytomegalovirus exerts cytopathic effects and neutralizes the proapoptotic endogenous Bcl-2 family member Bax by recruiting it to mitochondria, inducing its oligomerization and membrane insertion. Using a combination of computational modeling a...

journal_title：Oncogene

authors： Pauleau AL,Larochette N,Giordanetto F,Scholz SR,Poncet D,Zamzami N,Goldmacher VS,Kroemer G

更新日期：2007-11-01 00:00:00

abstract：:We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses an in-frame PTEN::ADE2 chimera protein. An allele of nonsense mutati...

journal_title：Oncogene

authors： Zhang CL,Tada M,Kobayashi H,Nozaki M,Moriuchi T,Abe H

更新日期：2000-09-07 00:00:00

abstract：:Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment. ANKDD1A directly interacts with FIH1 and inhibits the transcriptional activity of HIF1α by upregulating FIH1. In ...

journal_title：Oncogene

authors： Feng J,Zhang Y,She X,Sun Y,Fan L,Ren X,Fu H,Liu C,Li P,Zhao C,Liu Q,Liu Q,Li G,Wu M

更新日期：2019-01-01 00:00:00

abstract：:Nuclear activated β-catenin plays a causative role in colorectal cancers (CRC) but remains an elusive therapeutic target. Using human CRC cells harboring different Wnt/β-catenin pathway mutations in APC/KRAS or β-catenin/KRAS genes, and both genetic and pharmacological knockdown approaches, we show that oncogenic β-ca...

journal_title：Oncogene

authors： Saponaro C,Sergio S,Coluccia A,De Luca M,La Regina G,Mologni L,Famiglini V,Naccarato V,Bonetti D,Gautier C,Gianni S,Vergara D,Salzet M,Fournier I,Bucci C,Silvestri R,Passerini CG,Maffia M,Coluccia AML

更新日期：2018-06-01 00:00:00

abstract：:The status of the p53 gene in lymphoblastoid cell lines (LCLs) and Burkitt lymphoma cell lines (BLs) was investigated. Southern blot analysis demonstrated that no major deletions or rearrangements had occurred in the p53 gene in any of the cell lines. The p53 protein was examined by immunoprecipitation using two monoc...

journal_title：Oncogene

authors： Wiman KG,Magnusson KP,Ramqvist T,Klein G

更新日期：1991-09-01 00:00:00