Abstract:
:The cancer-prone and premature aging disease Werner syndrome is due to loss of WRN gene function. Cells lacking WRN demonstrate genomic instability, including telomeric abnormalities and undergo premature senescence, suggesting defects in telomere metabolism. This notion is strongly supported by our finding of physical and functional interactions between WRN and TRF2, a telomeric repeat binding factor essential for proper telomeric structure. TRF2 binds to DNA substrates containing telomeric repeats and facilitates their degradation specifically by WRN exonuclease activity. WRN and TRF2 also interact directly in the absence of DNA. These results suggest that TRF2 recruits WRN for accurate processing of telomeric structures in vivo. Thus, our findings link problems in telomere maintenance to both carcinogenesis and specific features of aging.
journal_name
Oncogenejournal_title
Oncogeneauthors
Machwe A,Xiao L,Orren DKdoi
10.1038/sj.onc.1206906subject
Has Abstractpub_date
2004-01-08 00:00:00pages
149-56issue
1eissn
0950-9232issn
1476-5594pii
1206906journal_volume
23pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::To dissect the p53-dependent apoptotic pathway, events following induction of temperature sensitive (ts) p53val138 were studied in a Ewing tumor cell line. Transcriptional deregulation of p53 targets first observable after 1 h at 32 degrees C preceded activation of caspases and the break-down of mitochondrial respirat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203780
更新日期:2000-08-24 00:00:00
abstract::Beta-catenin and plakoglobin are closely related armadillo family proteins with shared and distinct properties; Both are associated with cadherins in actin-containing adherens junctions. Plakoglobin is also found in desmosomes where it anchors intermediate filaments to the desmosomal plaques. Beta-catenin, on the othe...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203519
更新日期:2000-04-13 00:00:00
abstract::B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203618
更新日期:2000-06-15 00:00:00
abstract::Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208267
更新日期:2005-02-10 00:00:00
abstract::Breast carcinoma invasion is associated with prominent alterations in stromal fibroblasts. Carcinoma-associated fibroblasts (CAF) support and promote tumorigenesis, whereas normal mammary fibroblasts (NF) are thought to suppress tumor progression. Little is known about the difference in gene expression between CAF and...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.463
更新日期:2010-03-25 00:00:00
abstract::As part of a cloning strategy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with similar sequences to the Drosophila melanogaster gene goliath (gl) which is involved in the fate of mesodermal cells ultimately forming gut musculatures, fat body, and the heart. Praja1 is a 2...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201405
更新日期:1997-11-06 00:00:00
abstract::Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205426
更新日期:2002-05-02 00:00:00
abstract::It has been suggested that the embryonic microenvironment can control the survival and the transformed phenotype of tumour cells. Here, we addressed the hypothesis that the murine embryonic microenvironment can induce the differentiation of human tumour cells. To examine such interactions, we injected human leukaemic ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207134
更新日期:2003-12-11 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.70
更新日期:2017-08-01 00:00:00
abstract::The tumor suppressor p53 transcriptionally regulates a large number of target genes that may affect cell growth and cell death pathways. To better understand the role of p53 loss in tumorigenesis, we have developed a mouse mammary cancer model, the Wnt-1 TG/p53 model. Wnt-1 transgenic females that are p53-/- develop m...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203993
更新日期:2000-12-07 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is one of the most common and malignant carcinoma worldwide, and the incidence and mortality are increasing rapidly. Immunotherapy targeting programmed death 1/programmed death ligand 1 (PD-L1) signaling has shown prominent clinical effects in treating NSCLC; however, a poor understa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.217
更新日期:2017-11-09 00:00:00
abstract::The S-phase kinase-associated protein-2 (SKP2) plays a key role in ubiquitin-mediated proteolysis, which results in the progression of cells from a quiescence to proliferative state. SKP2 is overexpressed in a variety of tumors. In this study, we used small interfering RNAs (siRNAs) to inhibit the SKP2 expression in l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208459
更新日期:2005-05-12 00:00:00
abstract::The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0697-6
更新日期:2019-05-01 00:00:00
abstract::Paxillin is a focal-adhesion associated protein implicated in the regulation of integrin signaling and organization of the actin cytoskeleton. Paxillin associates with numerous signaling molecules including adaptor molecules (p130Cas, CRK), kinases (FAK, Pyk2, PAK and SRC), tyrosine phosphatases (PTP-PEST), ARF-GAP pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205013
更新日期:2002-01-03 00:00:00
abstract::The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive 'TGF-β paradox'. Herein, we identify a mechanism by which Six1 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.11
更新日期:2012-12-13 00:00:00
abstract::The recent identification of the mouse White spotting and Steel loci as genes encoding the c-kit receptor and its ligand, respectively, has shed light on the importance of this ligand and receptor in embryogenesis, melanogenesis and hematopoiesis. In order to determine if the c-kit proto-oncogene is involved in human ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic pathway characterized by episomal E2, E4, and E5 (E2/E4/E5) expression. Half of HPV positive cervical and pharyngeal cancers comprised a subtype wi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01431-8
更新日期:2020-10-01 00:00:00
abstract::The balance between acetylation and deacetylation of histone and nonhistone proteins controls gene expression in a variety of cellular processes, with transcription being activated by acetyltransferases and silenced by deacetylases. We report here the formation and enzymatic characterization of a complex between the a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207327
更新日期:2004-03-18 00:00:00
abstract::Rapamycin, a natural product inhibitor of the Raptor-mammalian target of rapamycin complex (mTORC1), is known to induce Protein kinase B (Akt/PKB) Ser-473 phosphorylation in a subset of human cancer cell lines through inactivation of S6K1, stabilization of insulin receptor substrate (IRS)-1, and increased signaling th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210343
更新日期:2007-08-16 00:00:00
abstract::Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202868
更新日期:1999-08-05 00:00:00
abstract::In the childhood cancer neuroblastoma (NB), the level of expression of the multidrug resistance-associated protein (MRP1) gene is strongly correlated with expression of the MYCN oncogene in primary NB tumors, suggesting that MRP1 may be a target for MYCN-mediated gene regulation. In this study, we show that MYCN induc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207151
更新日期:2004-01-22 00:00:00
abstract::In lung cancer, frequent loss of one allele of chromosome 3p is seen in both small cell lung cancer and non-small cell lung cancer (NSCLC), providing evidence of tumor suppressor genes (TSGs) in this chromosomal region. The mechanism of Fus1 tumor suppressor activity is unknown. We have found that a Fus1 peptide inhib...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210500
更新日期:2007-10-25 00:00:00
abstract::We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement. This rearrangement is similar to one we characterized recently in an independent adenoma. In these two, plus a third partially characterized adenoma, one allele of the PTH gene, on 11p...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract::Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evid...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1209942
更新日期:2006-10-30 00:00:00
abstract::Two thirds of breast cancers express estrogen receptors (ER). ER alpha (ERα) mediates breast cancer cell proliferation, and expression of ERα is the standard choice to indicate adjuvant endocrine therapy. ERbeta (ERβ) inhibits growth in vitro; its effects in vivo have been incompletely investigated and its role in bre...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.261
更新日期:2013-05-09 00:00:00
abstract::Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) m...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201123
更新日期:1997-06-05 00:00:00
abstract::Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208024
更新日期:2004-09-30 00:00:00
abstract::A 56 kDa protein kinase was molecularly cloned from human fetal brain. This protein kinase (p56 KKIAMRE) shares homology with p42 KKIALRE (Meyerson et al., 1992) and is related to the proline-directed protein kinase group of signal transducing enzymes. The p56 KKIAMRE and p42 KKIALRE protein kinases exhibit mutually e...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-12-19 00:00:00
abstract::Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppressed in HRAS-transfo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209502
更新日期:2006-08-10 00:00:00
abstract::By direct sequencing of cosmids using primers designed from the known cDNA sequence, we identified 19 exons in the human MET proto-oncogene, and sequenced the corresponding 5' and 3' exon-intron junctions. By homology search in the database of the Washington University Genome Sequence Center (GSC), we identified one a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201338
更新日期:1997-09-25 00:00:00