Abstract：
:Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-kappaB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-kappaB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-kappaB. Additionally, the effects of NF-kappaB activation in tumors relative to cancer therapy are also discussed.
journal_name
Oncogenejournal_title
Oncogeneauthors
Bassères DS,Baldwin ASdoi
10.1038/sj.onc.1209942subject
Has Abstractpub_date
2006-10-30 00:00:00pages
6817-30issue
51eissn
0950-9232issn
1476-5594pii
1209942journal_volume
25pub_type
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