Molecular characterization and modular analysis of human MyD88.

abstract：:Prothymosin alpha (PT-alpha) is a nuclear protein involved in cell proliferation. Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro. We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library. Northern blot (messenger RNA) ana...

journal_title：Oncogene

authors： Mori M,Barnard GF,Staniunas RJ,Jessup JM,Steele GD Jr,Chen LB

更新日期：1993-10-01 00:00:00

abstract：:The fate of cells exposed to ionizing radiation (IR) may depend greatly on changes in gene expression, so that an improved view of gene induction profiles is important for understanding mechanisms of checkpoint control, repair and cell death following such exposures. We have used a quantitative fluorescent cDNA microa...

journal_title：Oncogene

authors： Amundson SA,Bittner M,Chen Y,Trent J,Meltzer P,Fornace AJ Jr

更新日期：1999-06-17 00:00:00

abstract：:To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure. NMuMG cells became proliferation-arrested and apoptotic after exposure to TGFbeta for 2-5 days, w...

journal_title：Oncogene

authors： Gal A,Sjöblom T,Fedorova L,Imreh S,Beug H,Moustakas A

更新日期：2008-02-21 00:00:00

abstract：:Previously, we showed that the BRCA1 protein interacts directly and functionally with estrogen receptor-alpha (ER-alpha), resulting in the inhibition of estradiol (E2)-stimulated ER-alpha transcriptional activity. The interaction sites were mapped to the N-terminus of BRCA1 (within amino acids (aa) 1-302) and the liga...

journal_title：Oncogene

authors： Ma YX,Tomita Y,Fan S,Wu K,Tong Y,Zhao Z,Song LN,Goldberg ID,Rosen EM

更新日期：2005-03-10 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...

journal_title：Oncogene

authors： Kranenburg O,Moolenaar WH

更新日期：2001-03-26 00:00:00

abstract：:Knowledge of tumour initiation in human epithelia is limited by sample availability and difficulty in experimental manipulation of human cells. The thyroid is a useful model since, in addition to multiple tumour stages, it presents two distinct 'pathways' of tumorigenesis: 'follicular' tumours, in which ras oncogene m...

journal_title：Oncogene

authors： Bond JA,Wyllie FS,Rowson J,Radulescu A,Wynford-Thomas D

更新日期：1994-01-01 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...

journal_title：Oncogene

authors： Dembowy J,Adissu HA,Liu JC,Zacksenhaus E,Woodgett JR

更新日期：2015-07-01 00:00:00

abstract：:CBF beta-SMMHC is expressed from the inv(16) chromosome in M4Eo AML. Mice lacking CBF subunits or expressing the CBF beta-SMMHC or AML1-ETO oncoproteins failed to develop definitive hematopoiesis. To investigate these effects on hematopoiesis, we expressed CBF beta-SMMHC from the metallothionein promoter, in both 32D ...

journal_title：Oncogene

authors： Cao W,Britos-Bray M,Claxton DF,Kelley CA,Speck NA,Liu PP,Friedman AD

更新日期：1997-09-01 00:00:00

abstract：:The c-Myb, A-Myb and B-Myb transcription factors have nearly identical DNA-binding domains, activate the same reporter gene constructs in animal cells, but have different biological roles. The Myb proteins are often coexpressed in the same cells, raising questions about whether they activate similar or distinct gene e...

journal_title：Oncogene

authors： Rushton JJ,Davis LM,Lei W,Mo X,Leutz A,Ness SA

更新日期：2003-01-16 00:00:00

abstract：:Glypican-3 (GPC3) is a membrane-bound heparan sulfate proteoglycan that is mutated in the Simpson-Golabi-Behmel syndrome. This is an X-linked condition characterized by overgrowth, and various visceral and skeletal dysmorphisms. The phenotype of the Simpson-Golabi-Behmel syndrome patients and GPC3-deficient mice, as w...

journal_title：Oncogene

authors： Xiang YY,Ladeda V,Filmus J

更新日期：2001-11-01 00:00:00

abstract：:Amplified segments of the long arm of chromosome 12 are frequently observed in human sarcomas. In most cases there are separate amplified regions around the MDM2 and CDK4 genes. Here we show recurrent amplification of a third region encompassing HMGIC, a human architectural transcription factor gene. Reduced amplifica...

journal_title：Oncogene

authors： Berner JM,Meza-Zepeda LA,Kools PF,Forus A,Schoenmakers EF,Van de Ven WJ,Fodstad O,Myklebost O

更新日期：1997-06-19 00:00:00

abstract：:Two alternatively spliced mouse lymphocyte and brain ltk cDNAs predict small transmembrane tyrosine kinases that use CUG translational start codons and that differ upstream of their transmembrane segment. A recently isolated human neuroblastoma ltk cDNA, in contrast, includes a regular AUG start codon and predicts a m...

journal_title：Oncogene

authors： Snijders AJ,Haase VH,Bernards A

更新日期：1993-01-01 00:00:00

abstract：:The c-Met receptor is a potential therapeutic target for non-small cell lung cancer (NSCLC). Signaling interactions between c-Met and the mutant epidermal growth factor receptor (EGFR) have been studied extensively, but signaling intermediates and biological consequences of lateral signaling to c-Met in EGFR wild-type...

journal_title：Oncogene

authors： Dulak AM,Gubish CT,Stabile LP,Henry C,Siegfried JM

更新日期：2011-08-18 00:00:00

abstract：:Polyomavirus large T-antigen (PyLT-Ag), a nucleophosphoprotein essential for regulating viral gene expression, modulates the cell cycle by binding to the Rb tumor suppressor gene product. PyLT-Ag/Rb binding is essential for in vitro immortalization. However, the effect of PyLT-Ag on apoptosis has not been extensively ...

journal_title：Oncogene

authors： Rodier F,Bertrand R,Bossolasco M,Mes-Masson AM

更新日期：2000-12-14 00:00:00

abstract：:Bcl-2 or Bcl-X(L) confers resistance to chemotherapy in multiple myeloma (MM). Here we characterized the effects of ABT-737, a potent small-molecule inhibitor of antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w with markedly higher affinity than previously reported compounds, on human MM cells. ABT-737 induces apoptos...

journal_title：Oncogene

authors： Chauhan D,Velankar M,Brahmandam M,Hideshima T,Podar K,Richardson P,Schlossman R,Ghobrial I,Raje N,Munshi N,Anderson KC

更新日期：2007-04-05 00:00:00

abstract：:Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is highly overexpressed in invasive breast carcinomas. The function and reg...

journal_title：Oncogene

authors： Li T,Lu H,Shen C,Lahiri SK,Wason MS,Mukherjee D,Yu L,Zhao J

更新日期：2014-09-25 00:00:00

abstract：:The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation...

journal_title：Oncogene

authors： Myatt SS,Kongsema M,Man CW,Kelly DJ,Gomes AR,Khongkow P,Karunarathna U,Zona S,Langer JK,Dunsby CW,Coombes RC,French PM,Brosens JJ,Lam EW

更新日期：2014-08-21 00:00:00

abstract：:Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelia...

journal_title：Oncogene

authors： Beach S,Tang H,Park S,Dhillon AS,Keller ET,Kolch W,Yeung KC

更新日期：2008-04-03 00:00:00

abstract：:Myxoid and round-cell liposarcomas share the translocation t(12;16)(q13;p11) creating the TLS-CHOP fusion gene as a common genetic alteration. We previously reported several unique characteristics of genomic sequences around the breakpoints in the TLS and CHOP loci, and among them was the presence of consensus recogni...

journal_title：Oncogene

authors： Hosaka T,Kanoe H,Nakayama T,Murakami H,Yamamoto H,Nakamata T,Tsuboyama T,Oka M,Kasai M,Sasaki MS,Nakamura T,Toguchida J

更新日期：2000-11-23 00:00:00

abstract：:Many anticancer drugs exert their cytotoxicity through DNA damage and induction of apoptosis. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) have different sensitivity to treatment with radiation and chemotherapeutic agents with SCLC being more sensitive than NSCLC both in vitro and in vivo...

journal_title：Oncogene

authors： Joseph B,Ekedahl J,Lewensohn R,Marchetti P,Formstecher P,Zhivotovsky B

更新日期：2001-05-24 00:00:00

abstract：:The v-myb oncogene of the avian myeloblastosis virus encodes a nuclear protein, p48v-myb, which binds to DNA in a sequence-specific manner. We have used wild type and mutant forms of this protein expressed in E. coli to study the protein and DNA determinants for sequence-specific DNA-binding. We have shown that only t...

journal_title：Oncogene

authors： Garcia A,LaMontagne K,Reavis D,Stober-Grässer U,Lipsick JS

更新日期：1991-02-01 00:00:00

abstract：:BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/- female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS) characterized by early-onset of breast cancer, even though LFS involves TP53 mutations, which ...

journal_title：Oncogene

authors： Böhringer M,Obermeier K,Griner N,Waldraff D,Dickinson E,Eirich K,Schindler D,Hagen M,Jerry DJ,Wiesmüller L

更新日期：2013-11-28 00:00:00

abstract：:The forkhead transcription factor FOXM1 has a key role in DNA damage response, and its deregulated overexpression is associated with genotoxic drug resistance in breast cancer. However, little is known about the posttranslational mechanisms by which FOXM1 expression is regulated by genotoxic agents and how they are de...

journal_title：Oncogene

authors： Karunarathna U,Kongsema M,Zona S,Gong C,Cabrera E,Gomes AR,Man EP,Khongkow P,Tsang JW,Khoo US,Medema RH,Freire R,Lam EW

更新日期：2016-03-17 00:00:00

abstract：:Protein-protein interaction can play an important role in the control of several biological events including gene transcription, replication and cell proliferation. E2F-1 is a DNA-binding transcription factor which, upon interaction with its target DNA sequence, induces expression of several S phase specific genes all...

journal_title：Oncogene

authors： Darbinian N,Gallia GL,Kundu M,Shcherbik N,Tretiakova A,Giordano A,Khalili K

更新日期：1999-11-04 00:00:00

abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

journal_title：Oncogene

authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

更新日期：2004-04-15 00:00:00

abstract：:The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression profiling have been proposed as alternatives. However, their reliability and clinical utility have been repeatedly questioned, notably because most of them were derive...

journal_title：Oncogene

authors： Guedj M,Marisa L,de Reynies A,Orsetti B,Schiappa R,Bibeau F,MacGrogan G,Lerebours F,Finetti P,Longy M,Bertheau P,Bertrand F,Bonnet F,Martin AL,Feugeas JP,Bièche I,Lehmann-Che J,Lidereau R,Birnbaum D,Bertucci F,de

更新日期：2012-03-01 00:00:00

abstract：:Evi5 is a common site of retroviral integration in T-cell lymphomas of AKXD mice. Mapping studies have localized Evi5 to a region approximately 18 kb upstream of another common viral integration site, Gfi1, on mouse chromosome 5 (Liao X, Jenkins NA and Copeland NG, (1995a). J. Virol., 69, 7132-7137). Gfi1 encodes a zi...

journal_title：Oncogene

authors： Liao X,Du Y,Morse HC 3rd,Jenkins NA,Copeland NG

更新日期：1997-03-06 00:00:00

abstract：:The E1a gene of group C adenoviruses is one of the most studied transforming genes of DNA tumor viruses. These transforming genes have been conventionally considered as dominant oncogenes since they transform cells in vitro and many of the resulting transformed cell lines induce tumors in experimental animals. It now ...

journal_title：Oncogene

authors： Chinnadurai G

更新日期：1992-07-01 00:00:00

abstract：:Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppressed in HRAS-transfo...

journal_title：Oncogene

authors： Lund P,Weisshaupt K,Mikeska T,Jammas D,Chen X,Kuban RJ,Ungethüm U,Krapfenbauer U,Herzel HP,Schäfer R,Walter J,Sers C

更新日期：2006-08-10 00:00:00