Abstract:
:We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement. This rearrangement is similar to one we characterized recently in an independent adenoma. In these two, plus a third partially characterized adenoma, one allele of the PTH gene, on 11p15, is rearranged with DNA from the D11S287 region on 11q13. This region contains a transcribed sequence, D11S287E, distinct from known 11q13 oncogenes, that is expressed in all parathyroid tissues examined, but is overexpressed dramatically in all three tumours with PTH gene-D11S287 rearrangements. These findings suggest that overexpression of D11S287E, perhaps driven by the misplaced PTH gene's regulatory elements, contributed to the development of these benign tumors. D11S287E is a new candidate oncogene with potential importance in parathyroid adenomas and perhaps other tumors with 11q13 abnormalities.
journal_name
Oncogenejournal_title
Oncogeneauthors
Rosenberg CL,Kim HG,Shows TB,Kronenberg HM,Arnold Asubject
Has Abstractpub_date
1991-03-01 00:00:00pages
449-53issue
3eissn
0950-9232issn
1476-5594journal_volume
6pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::It is well known that intracellular antioxidant glutathione (GSH) plays major roles in the maintenance of redox status and defense of oxidative stress. Ras, a small GTP-binding protein, may send growth-stimulating message to the nucleus through downstream Rac oncoprotein and superoxide (O(2*-)). These findings led us ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206289
更新日期:2003-03-06 00:00:00
abstract::Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209541
更新日期:2006-09-07 00:00:00
abstract::The activating transcription factor, ATF-2, is a target of p38 and JNK that are involved in stress-induced apoptosis. Heterozygous Atf-2 mutant (Atf-2+/-) mice are highly prone to mammary tumors. The apoptosis-regulated gene GADD45alpha and the breast cancer suppressor gene Maspin, both of which are known to be p53 ta...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210727
更新日期:2008-02-14 00:00:00
abstract::The LoVo colon carcinoma cell line that presents two wild type p53 alleles was used as the recipient for a series of transfections with p53 expression vectors coding for wild-type or three different mutants (143ala, 175his or 273his). The parental cell line as well as all clones that had rearranged the plasmid with co...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-02-15 00:00:00
abstract::The tumor-stroma crosstalk is a dynamic process fundamental in tumor development. In hepatocellular carcinoma (HCC), the progression of malignant hepatocytes frequently depends on transforming growth factor (TGF)-beta provided by stromal cells. TGF-beta induces an epithelial to mesenchymal transition (EMT) of oncogeni...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.253
更新日期:2009-11-12 00:00:00
abstract::Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, possesses significant anti-inflammatory and cancer chemopreventive properties. Studies have shown the photochemopreventive effects of green tea and EGCG in cell culture, animal models, and human skin. The molecular mechanism(s) of photochemoprevent...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206206
更新日期:2003-02-20 00:00:00
abstract::Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.32
更新日期:2016-09-15 00:00:00
abstract::Glioblastoma is the most common and lethal primary malignant brain tumor in adults. The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in more than 60% of glioblastoma cases resulting in hyperactivation of the phosphoinositide 3-kinase pathway, which leads to sustained PI(3,4,5)P3 signaling, and the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.303
更新日期:2015-07-01 00:00:00
abstract::Knowledge of the type of biological reaction to chemotherapy is a prerequisite for its rational enhancement. We previously showed that irinotecan-induced DNA damage triggers in the HCT116p53(wt) colon carcinoma cell line a long-term cell cycle arrest and in HCT116p53(-/-) cells apoptosis (Magrini et al., 2002). To com...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209017
更新日期:2006-01-12 00:00:00
abstract::It has recently been shown that an adenovirus mutant lacking expression of the large E1B protein (deltaE1B) selectively replicates in p53 deficient cells. However, apart from the large E1B protein the adenovirus early region encodes the E1A and E4orf6 proteins which also have been reported to affect p53 expression as ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201540
更新日期:1998-01-22 00:00:00
abstract::Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.261
更新日期:2012-02-02 00:00:00
abstract::The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-04-18 00:00:00
abstract::Mammalian Mip/LIN-9 is a cell cycle regulatory protein that is negatively regulated by CDK4/cyclin D. It has been demonstrated that Mip/LIN-9 collaborates with B-Myb during S and G(2)/M in the induction of cyclins A and B, and CDK1. The ortholog of Mip/LIN-9 in Drosophila, Mip130, is part of a large multisubunit prote...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210562
更新日期:2007-11-29 00:00:00
abstract::Appropriate expression of HTLV-1 genes requires transcriptional transactivation by Tax and post-transcriptional regulation by Rex, both mediated by LTR encoded RNA sequences. Using a combination of deletion mutagenesis, Rex-reporter CAT assays, fluorescence in situ hybridization (FISH) and confocal laser scanning micr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201884
更新日期:1998-06-25 00:00:00
abstract::Imatinib-acquired resistance related to the presence of secondary point mutations has become a frequent event in gastrointestinal stromal tumors. Here, transient transfection experiments with plasmids carrying two different KIT-acquired point mutations were performed along with immunoprecipitation of total protein ext...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209639
更新日期:2006-10-05 00:00:00
abstract::Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair, can lead to functional deficiencies of the FEN1 protein and a predisposition to cancer. We identified a FEN1 germline mutation that changed residue E359 to K in a patient whose family had a hi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.19
更新日期:2015-02-12 00:00:00
abstract::p53 and DNA methylation play key roles in the maintenance of genome stability. In this work, we demonstrate that the two mechanisms are linked and that p53 plays a role in the maintenance of the DNA methylation levels. The loss of p53 was shown to induce loss of DNA methylation in the TROP1 gene, a human cancer-expres...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206248
更新日期:2003-03-20 00:00:00
abstract::Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (Cdk6) blocks chondrocyte differentiation without affecting cell-cycle progression in vitro. To investigate whether Cdk6 inhibits chondrocyte differentiation in vivo, we generated ch...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.130
更新日期:2014-04-03 00:00:00
abstract::SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204698
更新日期:2001-08-30 00:00:00
abstract::The orphan nuclear receptor TR3 (NR41A and Nur77) is overexpressed in most lung cancer patients and is a negative prognostic factor for patient survival. The function of TR3 was investigated in non-small-cell lung cancer A549 and H460 cells, and knockdown of TR3 by RNA interference (siTR3) inhibited cancer cell growth...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.504
更新日期:2012-07-05 00:00:00
abstract::Heat shock protein (Hsp)90 regulates many key pathways in oncogenesis, including Akt and mammalian target of rapamycin (mTOR). The strengths of disruption of Hsp90 in cancer therapy include their versatility in inhibiting a wide range of oncogenic pathways. The present study demonstrated that synuclein γ (SNCG) protec...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.126
更新日期:2015-04-30 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its clinical inhibition has significant limitations. Our previous studies suggested that NRARP, a negative regulator o...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-1042-9
更新日期:2020-01-01 00:00:00
abstract::The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1298-0
更新日期:2020-05-01 00:00:00
abstract::Poor-prognosis oestrogen receptor-positive breast cancer is characterised by the presence of high-level focal amplifications. We utilised a focused small interfering RNA screen in 14 breast cancer cell lines to define genes that were pathogenic in three genomic regions focally amplified in oestrogen receptor-positive ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.202
更新日期:2014-05-08 00:00:00
abstract::Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203616
更新日期:2000-06-08 00:00:00
abstract::Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely related ErbB2, has been associated with a more aggressive clinical behavior. Further, transfection or activation of high levels of these tw...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204082
更新日期:2000-12-27 00:00:00
abstract::With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00
abstract::The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209997
更新日期:2007-03-22 00:00:00
abstract::Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0995-z
更新日期:2020-01-01 00:00:00
abstract::The epidermis is continually exposed to harmful mutagens that have the potential to cause DNA damage. To protect the skin from accumulating mutated cells, keratinocytes have developed a highly regulated mechanism of eliminating damaged cells through apoptosis. Bcl-xL is a well-described cell survival protein that when...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202836
更新日期:1999-08-05 00:00:00