当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells.

Abstract：

:It has recently been shown that an adenovirus mutant lacking expression of the large E1B protein (deltaE1B) selectively replicates in p53 deficient cells. However, apart from the large E1B protein the adenovirus early region encodes the E1A and E4orf6 proteins which also have been reported to affect p53 expression as well as its functioning. After infection with wild-type adenovirus we observed a dramatic decrease in wild-type p53 expression while no down-regulation of p53 could be detected after infection with the deltaE1B virus. The different effects of the wild-type and deltaE1B adenovirus on p53 expression were not only found in cells expressing wild-type p53 but were also observed when tumor cells expressing highly stabilized mutant p53 were infected with these two viruses. Infection with different adenovirus mutants indicated the importance of a direct interaction between p53 and the large E1B protein for reduced p53 expression after infection. Moreover, coexpression of the E4orf6 protein was found to be required for this phenomenon, while expression of E1A is dispensable. In addition, we provide evidence that p53 is actively degraded in wild-type adenovirus-infected cells but not in deltaE1B-infected cells.

journal_name

Oncogene

journal_title

Oncogene

authors

Steegenga WT,Riteco N,Jochemsen AG,Fallaux FJ,Bos JL

doi

10.1038/sj.onc.1201540

subject

Has Abstract

pub_date

1998-01-22 00:00:00

pages

349-57

issue

3

eissn

0950-9232

issn

1476-5594

journal_volume

16

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Frequent hypermethylation of the RASSF1A gene in prostate cancer.

    abstract：:Recently, we have cloned and characterized the Ras association domain family 1A gene (RASSF1A) at 3p21.3, from which loss of genetic material is one of the most frequent events in several types of human solid tumors. The CpG island promoter region of this gene is highly methylated in several human cancers, most notabl...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205814

    authors： Liu L,Yoon JH,Dammann R,Pfeifer GP

    更新日期：2002-10-03 00:00:00

  • SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia.

    abstract：:Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-01495-6

    authors： Chu Y,Chen Y,Guo H,Li M,Wang B,Shi D,Cheng X,Guan J,Wang X,Xue C,Cheng T,Shi J,Yuan W

    更新日期：2020-12-01 00:00:00

  • Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells.

    abstract：:Stimulation of resting W53 cells (lymphoid murine cells expressing prolactin (PRL) receptor) by PRL induced expression of growth-related immediate-early genes (IEG), and proliferation through activation of the Src kinases. Since IEG are essential for cell cycle progression, we have studied how PRL controls expression ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208002

    authors： Domínguez-Cáceres MA,García-Martínez JM,Calcabrini A,González L,Porque PG,León J,Martín-Pérez J

    更新日期：2004-09-23 00:00:00

  • The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization.

    abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208088

    authors： Slee EA,Gillotin S,Bergamaschi D,Royer C,Llanos S,Ali S,Jin B,Trigiante G,Lu X

    更新日期：2004-12-02 00:00:00

  • Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21.

    abstract：:The death mediator caspase acts as the dominant regulator during cell death induction. The CPP32 subfamily, including caspase 3 (CPP32/Yama/Apopain), is essential for the cell death signaling. We recently reported that activation of caspase 3 is regulated by complex formation with p21 or ILP. In the present study, we ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202409

    authors： Suzuki A,Tsutomi Y,Miura M,Akahane K

    更新日期：1999-02-04 00:00:00

  • The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another.

    abstract：:Chromosomal translocation t(X;14)(q28;q11) has been observed in patients with pro-lymphocytic T-cell leukaemia (T-PLL). In two cases of T-PLL, one of which was associated with Ataxia telangiectasia (AT), the chromosomal break occurred in two different introns of a gene c6.1A, located at the Xq28 locus. Fusion transcri...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Fisch P,Forster A,Sherrington PD,Dyer MJ,Rabbitts TH

    更新日期：1993-12-01 00:00:00

  • Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway.

    abstract：:Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated the role of TUFT1 in hepatocellular carcinoma (HCC). qRT-PCR, immunohistochemistry and western blot were employed to evaluate TUFT1 level in HCC. MT...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0505-8

    authors： Dou C,Zhou Z,Xu Q,Liu Z,Zeng Y,Wang Y,Li Q,Wang L,Yang W,Liu Q,Tu K

    更新日期：2019-02-01 00:00:00

  • The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses.

    abstract：:The skin represents a physical and chemical barrier against invading pathogens, which is additionally supported by restriction factors that provide intrinsic cellular immunity. These factors detect viruses to block their replication cycle. Here, we uncover the Myb-related transcription factor, partner of profilin (MYP...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0398-6

    authors： Wüstenhagen E,Boukhallouk F,Negwer I,Rajalingam K,Stubenrauch F,Florin L

    更新日期：2018-11-01 00:00:00

  • Recurrent allelic deletions at mouse chromosomes 4 and 14 in Myc-induced liver tumors.

    abstract：:Transgenic mice expressing the c-Myc oncogene driven by woodchuck hepatitis virus (WHV) regulatory sequences develop hepatocellular carcinoma with a high frequency. To investigate genetic lesions that cooperate with Myc in liver carcinogenesis, we conducted a genome-wide scan for loss of heterozygosity (LOH) and mutat...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205208

    authors： Wu Y,Renard CA,Apiou F,Huerre M,Tiollais P,Dutrillaux B,Buendia MA

    更新日期：2002-02-28 00:00:00

  • Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines.

    abstract：:Overexpression of the nuclear phosphoprotein p53 has been detected in many different transformed human cell lines and primary adult tumors. Elevated steady-state levels of p53 appear to be the result of an increase in the stability of the protein and, in adult cancers, high levels of the protein are associated with mu...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Davidoff AM,Pence JC,Shorter NA,Iglehart JD,Marks JR

    更新日期：1992-01-01 00:00:00

  • Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells.

    abstract：:Constitutive telomerase activity maintains telomere length and confers immortal phenotypes to human cancers. The prevalence of telomerase, rather than a homologous recombination-based mechanism, in telomere length maintenance suggests that telomerase also has auxiliary roles in tumorigenesis. Here, we investigate grow...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.292

    authors： Fleisig HB,Wong JM

    更新日期：2012-02-23 00:00:00

  • The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein.

    abstract：:The products of the proto-oncogenes c-jun and c-fos are known to form a complex in vivo. Complex formation appears to stabilize protein-DNA interactions and is thought to play an important functional role in transcriptional regulation. Here we show that the viral Jun oncoprotein, which differs structurally from cellul...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Bos TJ,Rauscher FJ 3rd,Curran T,Vogt PK

    更新日期：1989-02-01 00:00:00

  • mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.

    abstract：:Cancer cells harboring oncogenic BRaf mutants, but not oncogenic KRas mutants, are sensitive to MEK inhibitors (MEKi). The mechanism underlying the intrinsic resistance to MEKi in KRas-mutant cells is under intensive investigation. Here, we pursued this mechanism by live imaging of extracellular signal-regulated kinas...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.16

    authors： Komatsu N,Fujita Y,Matsuda M,Aoki K

    更新日期：2015-11-05 00:00:00

  • pRb and Cdk regulation by N-(4-hydroxyphenyl)retinamide.

    abstract：:The cancer chemopreventive synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR) can inhibit the growth and induce apoptosis of tumor cells. In this study we analysed the growth suppressive effect of HPR on human breast cancer cell lines in vitro and the role of the retinoblastoma protein (pRb) in this response. Trea...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203743

    authors： Panigone S,Debernardi S,Taya Y,Fontanella E,Airoldi R,Delia D

    更新日期：2000-08-17 00:00:00

  • c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis.

    abstract：:c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II,...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206800

    authors： Kanazawa S,Soucek L,Evan G,Okamoto T,Peterlin BM

    更新日期：2003-08-28 00:00:00

  • A comprehensive profile of recurrent glioblastoma.

    abstract：:In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these tumors. Many therapeutic agents are first tested in clinical trials involving recurrent glioblastomas. Remarkably, however, fundament...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2016.85

    authors： Campos B,Olsen LR,Urup T,Poulsen HS

    更新日期：2016-11-10 00:00:00

  • Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).

    abstract：:An elevated proteasome activity contributes to tumorigenesis, particularly by providing cancer cells with antiapoptotic protection and efficient clearance from irregular proteins. Still, the underlying mechanisms are poorly known. In this study, we report that in colon cancer patients, higher proteasome activity was d...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.264

    authors： Arlt A,Bauer I,Schafmayer C,Tepel J,Müerköster SS,Brosch M,Röder C,Kalthoff H,Hampe J,Moyer MP,Fölsch UR,Schäfer H

    更新日期：2009-11-12 00:00:00

  • Tumour regression in a ligand inducible manner mediated by a chimeric tumour suppressor derived from p53.

    abstract：:The p53 tumour suppressor induces cell cycle arrest and apoptosis in response to cellular stresses. p53 is inactivated by various cellular and viral factors. We set out to generate regulatable p53 derivatives that are highly inducible by synthetic ligands, escape inactivation and efficiently induce apoptosis. We have ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203256

    authors： Sengupta S,Ralhan R,Wasylyk B

    更新日期：2000-01-20 00:00:00

  • Molecular pathology in basal cell cancer with p53 as a genetic marker.

    abstract：:Human basal cell cancer (BCC) has unique growth characteristics with virtual inability to metastasize. We investigated clonality and genetic progression using p53 mutations as marker. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. From 11 BCC tumors 78 sam...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201435

    authors： Pontén F,Berg C,Ahmadian A,Ren ZP,Nistér M,Lundeberg J,Uhlén M,Pontén J

    更新日期：1997-08-28 00:00:00

  • Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions.

    abstract：:To appreciate the involvement of known or potential susceptibility genes in sporadic breast tumors, we have searched for chromosomal deletions by studying loss of heterozygosity (LOH) at 43 microsatellite (CA)n markers from human chromosomes 10, 11 and 17, in 115 unselected consecutive samples of breast carcinoma with...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1200818

    authors： Kerangueven F,Eisinger F,Noguchi T,Allione F,Wargniez V,Eng C,Padberg G,Theillet C,Jacquemier J,Longy M,Sobol H,Birnbaum D

    更新日期：1997-01-23 00:00:00

  • Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells.

    abstract：:Although Kruppel-like factor 5 (KLF5) is a transcription factor that has been implicated in pathways critical to carcinogenesis, controversy persists as to whether it functions as a tumor suppressor or as an oncogene. Here, we describe a novel role for KLF5 in a p53-independent apoptotic pathway. Using RNA-interferenc...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210625

    authors： Zhao Y,Hamza MS,Leong HS,Lim CB,Pan YF,Cheung E,Soo KC,Iyer NG

    更新日期：2008-01-03 00:00:00

  • Wnts as ligands: processing, secretion and reception.

    abstract：:Cell to cell communication is vital throughout the development of multicellular organisms and during adult homeostasis. One way in which communication is achieved is through the secretion of signaling molecules that are received by neighboring responding cells. Wnt ligands comprise a large family of secreted, hydropho...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1210053

    authors： Mikels AJ,Nusse R

    更新日期：2006-12-04 00:00:00

  • Post-transcriptional inactivation of p53 in immortalized murine embryo fibroblast cells.

    abstract：:The steady-state levels of p53 mRNA and protein were barely detectable by Northern and Western blot analysis in spontaneously immortalized (10)3 and (10)7 murine embryo fibroblast (MEF) cells. But when cells were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observed in primary ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204423

    authors： Kim H,You S,Farris J,Foster LK,Foster DN

    更新日期：2001-05-31 00:00:00

  • Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes.

    abstract：:Mechanisms underlying multidrug resistance (MDR), one of the major causes of cancer treatment failure, are still poorly understood. We selected the osteosarcoma MDR HosDXR150 cell line by culturing Hos cells in the presence of increasing doxorubicin doses and showed that it is crossresistant to vinblastine. Similarly ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206487

    authors： La Sala D,Macaluso M,Trimarchi C,Giordano A,Cinti C

    更新日期：2003-06-05 00:00:00

  • Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks.

    abstract：:The diverse checkpoint responses to DNA damage may reflect differential sensitivities by molecular components of the damage-signalling network to the type and amount of lesions. Here, we determined the kinetics of activation of the checkpoint kinases ATM and Chk2 (the latter substrate of ATM) in relation to the initia...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207986

    authors： Buscemi G,Perego P,Carenini N,Nakanishi M,Chessa L,Chen J,Khanna K,Delia D

    更新日期：2004-10-07 00:00:00

  • Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer.

    abstract：:The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT-PCR in 123 sp...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206040

    authors： Span PN,Manders P,Heuvel JJ,Thomas CM,Bosch RR,Beex LV,Sweep CG

    更新日期：2002-12-05 00:00:00

  • Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer.

    abstract：:Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we show that specific microRNAs (miRNAs) target the 3'-UTR of Axl. Luciferase-reporter assays with wild-type and deleted miR-34 and miR-199a/b seed sequences of Axl 3'-UTR confirmed the specificity of targeting. An inverse c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.13

    authors： Mudduluru G,Ceppi P,Kumarswamy R,Scagliotti GV,Papotti M,Allgayer H

    更新日期：2011-06-23 00:00:00

  • Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice.

    abstract：:Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially r...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201670

    authors： Feldman BJ,Reid TR,Cleary ML

    更新日期：1997-11-27 00:00:00

  • Histone H1(S)-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts.

    abstract：:Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206029

    authors： Chadee DN,Peltier CP,Davie JR

    更新日期：2002-12-05 00:00:00

  • Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB.

    abstract：:Epstein-Barr virus (EBV) transforms resting primary human B lymphocytes into indefinitely proliferating lymphoblastoid cell lines in vitro and is associated with several human malignancies in vivo. Recombinant EBV genetic analyses combined with in vitro B lymphocyte transformation assays demonstrate that latent infect...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1203217

    authors： Cahir McFarland ED,Izumi KM,Mosialos G

    更新日期：1999-11-22 00:00:00