Abstract:
:The products of the proto-oncogenes c-jun and c-fos are known to form a complex in vivo. Complex formation appears to stabilize protein-DNA interactions and is thought to play an important functional role in transcriptional regulation. Here we show that the viral Jun oncoprotein, which differs structurally from cellular Jun, is also capable of complex formation with Fos. Thus the oncogenic potency of viral Jun is unlikely to be due to an altered affinity for Fos. We have also defined, by deletion analysis, the domain of v-Jun responsible for complex formation to reside in the carboxy terminus encompassing the leucine zipper motif. We find that complex formation with c-Fos does not occur with v-Jun deletions affecting one or more leucine residues in the zipper domain. Our results are consistent with the hypothesis that the leucine zipper mediates Jun-Fos interaction.
journal_name
Oncogenejournal_title
Oncogeneauthors
Bos TJ,Rauscher FJ 3rd,Curran T,Vogt PKsubject
Has Abstractpub_date
1989-02-01 00:00:00pages
123-6issue
2eissn
0950-9232issn
1476-5594journal_volume
4pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Artemis is a multifunctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage. Here, we describe a new function of Artemis as a negative regulator of p53 in response to oxidative stress in both prima...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.100
更新日期:2009-06-04 00:00:00
abstract::The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsib...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Interleukin-8 (IL-8), a chemokine implicated in the metastasis and angiogenesis of a variety of cancers, has been reported to be overexpressed in prostate cancer. In this study, we ascribe a new role for IL-8 in prostate cancer progression using LNCaP cells. We demonstrate that IL-8 activates the androgen receptor and...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207344
更新日期:2004-03-18 00:00:00
abstract::Mouse Developmental Kinase 1 (MDK1) is a receptor tyrosine kinase of the eck/eph subfamily expressed in a variety of tissues during early mouse embryogenesis. To obtain further insight into the function of MDK1, we determined identity and localisation of its physiological ligand(s). Staining whole embryos with fusion ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200800
更新日期:1997-01-09 00:00:00
abstract::Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/s41388-020-01459-w
更新日期:2020-10-01 00:00:00
abstract::Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205973
更新日期:2002-10-24 00:00:00
abstract::SHP-2 protein tyrosine phosphatase plays an important role in activation of the RAS-dependent signaling. Gain-of-function mutations in the PTPN11 gene, which encodes SHP-2, have been found in the leukemia-prone developmental disorder Noonan syndrome as well as sporadic childhood leukemias, indicating that SHP-2 is a b...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1211019
更新日期:2008-06-05 00:00:00
abstract::Paxillin is a focal-adhesion associated protein implicated in the regulation of integrin signaling and organization of the actin cytoskeleton. Paxillin associates with numerous signaling molecules including adaptor molecules (p130Cas, CRK), kinases (FAK, Pyk2, PAK and SRC), tyrosine phosphatases (PTP-PEST), ARF-GAP pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205013
更新日期:2002-01-03 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0985-1
更新日期:2020-01-01 00:00:00
abstract::Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of apoptosis at the level of mitochondria, an important role for BCL-2 proteins at the end...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2008.309
更新日期:2008-10-27 00:00:00
abstract::Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localize...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202854
更新日期:1999-04-22 00:00:00
abstract::The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201980
更新日期:1998-08-13 00:00:00
abstract::The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has a significant role in initiating EBV-associated lymphoproliferative disease and EBV-related malignancies. In view of clinical features related to the type of EBV latency, LMP1 may influence invasiveness of EBV associated tumors categorized as ty...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203502
更新日期:2000-03-30 00:00:00
abstract::We have recently developed an allele titration assay (ATA) to assess the sensitivity and influence of normal cell admixture in loss of heterozygosity (LOH) studies based on CA-repeat. The assay showed that these studies are biased by the size-dependent differential sensitivity of allele detection. Based on these data,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203449
更新日期:2000-03-09 00:00:00
abstract::Mouse embryonic stem (ES) cells are known to express D-type cyclins at very low levels and these levels increase dramatically during in vitro and in vivo differentiation. Here, we investigate some of the signalling pathways regulating expression of cyclin D1 and progression to S phase, the Ras/Extracellular signal-reg...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205728
更新日期:2002-08-15 00:00:00
abstract::Evidence from murine fibroblast models and human breast cancer cells indicates that c-Src and human EGF receptor (HER1) synergize to enhance neoplastic growth of mammary epithelial cells. To investigate whether interactions between c-Src and other HER family members may also play a role in breast tumor progression, we...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204205
更新日期:2001-03-22 00:00:00
abstract::We compared the regulation of gamma-glutamyl transferase (gamma GT) and glutathione-S-transferase-P (GST-P) expression in rat liver epithelial cells (228 cells) and a line derived from them (C5 cells) by stable transfection with a metallothionein-activated ras fusion gene (MTrasT24). Earlier studies demonstrated that ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::Within the superfamily of ras-related GTP-binding proteins, only ras itself has been shown to act as an oncogene. Seven other proteins, however, have greater than 50% amino acid identity to ras and one of them, rap1A, has been shown to interact with the ras GTPase activating protein, ras-GAP, and to inhibit ras functi...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::We have recently identified ZNF185 as a gene that is downregulated in prostate cancer (PCa), in part via epigenetic alteration, and maybe associated with disease progression. In this study, we cloned the ZNF185 cDNA from normal human prostate tissues and investigated its biological function. We show that ZNF185 is a n...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209769
更新日期:2007-01-04 00:00:00
abstract::The leukemia-associated fusion proteins share several structural or functional similarities, suggesting that they may impart a leukemic phenotype through common modes of transcriptional dysregulation. The fusion proteins generated by these translocations usually contain a DNA-binding domain, domains responsible for ho...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1205315
更新日期:2002-05-13 00:00:00
abstract::Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::The WARTS gene encodes a kinase that localizes to the mitotic apparatus of a dividing cell. Named WARTS after the growths that develop in the eyes of Drosophila in which the gene is deleted. WARTS is also implicated as a tumor suppressor in mice and humans. In this issue of Oncogene, Iida et al. describe experiments s...
journal_title:Oncogene
pub_type: 评论,杂志文章
doi:10.1038/sj.onc.1207686
更新日期:2004-07-08 00:00:00
abstract::Expression of the avian E26-derived Gag-Myb-Ets fusion oncogene in interleukin-3(IL3)-dependent murine hematopoietic cell lines results in a pattern of cell line dependent changes in growth factor-induced proliferation and apoptosis. A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-01-18 00:00:00
abstract::Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, characterized by childhood sarcoma, leukemia and early onset breast cancer and has occasionally been found also in familial breast-ovarian cancer. Most mutations found are of missense type and located in the central regio...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-07-18 00:00:00
abstract::A yeast two-hybrid screen has identified HBP1 as a transcription factor capable of interacting with the pocket protein family. We show that HBP1 can interact with one of these, RB, both in vitro and in mammalian cells. Two distinct RB binding sites are present within HBP1--a high affinity binding site, mediated by an ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201243
更新日期:1997-06-05 00:00:00
abstract::The viability of rat embryo cells immortalized by thermosensitive mutants of SV40 or polyoma Large T antigen is impaired at the non-permissive temperature thus demonstrating that the immortal phenotype is dominantly maintained by Large T antigens. We have observed that exposing these cells to the restrictive temperatu...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::Murine double minute (MDM2) binding protein (MTBP) has been implicated in cancer progression. Here, we demonstrate one mechanism by which MTBP inhibits cancer metastasis. Overexpression of MTBP in human osteosarcoma cell lines lacking wild-type p53 did not alter primary tumor growth in mice, but significantly inhibite...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.69
更新日期:2013-01-24 00:00:00
abstract::AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that p53 could bind...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207909
更新日期:2004-09-02 00:00:00
abstract::Wild-type p53 protein displays a spectrum of activities including the ability to suppress transformed cell growth to direct apoptotic cell death and to mediate G1 checkpoint in response to cellular DNA damage. Earlier work showed that a self-association defective p53 protein retained transformation suppressor activity...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.545
更新日期:2012-08-09 00:00:00