Nucleocytoplasmic transport of HTLV-1 RNA is regulated by two independent LTR encoded nuclear retention elements.

abstract：:Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to ...

journal_title：Oncogene

authors： Chen HZ,Li L,Wang WJ,Du XD,Wen Q,He JP,Zhao BX,Li GD,Zhou W,Xia Y,Yang QY,Hew CL,Liou YC,Wu Q

更新日期：2012-06-07 00:00:00

abstract：:A lot of effort has been done to study how cancer cells react to low-oxygen tension, a condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor are incapable to restore oxygenation, therefore perpetuating hypoxia, which, in turn, will fuel tumor progression, metastasis and resistance t...

journal_title：Oncogene

authors： Casazza A,Di Conza G,Wenes M,Finisguerra V,Deschoemaeker S,Mazzone M

更新日期：2014-04-03 00:00:00

abstract：:Retinoids have been shown to inhibit the growth of a number of human tumor cells, including several ovarian adenocarcinoma cell lines. All-trans retinoic acid (RA) is an effective growth suppressor of CA-OV3 cells but not SK-OV3 cells. Since the effects of RA are known to be mediated via the nuclear receptors (RARs an...

journal_title：Oncogene

authors： Wu S,Zhang D,Zhang ZP,Soprano DR,Soprano KJ

更新日期：1998-12-03 00:00:00

abstract：:Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...

journal_title：Oncogene

authors： Zhou W,Sun W,Yung MMH,Dai S,Cai Y,Chen CW,Meng Y,Lee JB,Braisted JC,Xu Y,Southall NT,Shinn P,Huang X,Song Z,Chen X,Kai Y,Cai X,Li Z,Hao Q,Cheung ANY,Ngan HYS,Liu SS,Barak S,Hao J,Dai Z,Tzatsos A,Peng W

更新日期：2018-07-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation in response to chemical carcinogens and environmental stresses, including ultraviolet B (UVB) irradiation. Although post-translational histone modifications are believed to have an important role in modulating tr...

journal_title：Oncogene

authors： Keum YS,Kim HG,Bode AM,Surh YJ,Dong Z

更新日期：2013-01-24 00:00:00

abstract：:In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the no...

journal_title：Oncogene

authors： Mäueler W,Raulf F,Schartl M

更新日期：1988-05-01 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, whic...

journal_title：Oncogene

authors： Fernández BG,Jezowska B,Janody F

更新日期：2014-04-17 00:00:00

abstract：:The myb proto oncogene product (c-Myb) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis. It has been shown [Venturelli, D., Travali, S. & Calabretta, B. (1990). Proc. Natl. Acad. Sci. USA, 87, 5963-5967] that inhibition of T-cell pro...

journal_title：Oncogene

authors： Sudo T,Miyazawa H,Hanaoka F,Ishii S

更新日期：1992-10-01 00:00:00

abstract：:To investigate the mechanisms by which p53 suppresses cell transformation, we used the simian virus 40 (SV40) large T antigen (LTag), the adenovirus E1a proteins, and an activated ras protein (EJ-ras), to examine different pathways of transformation for their susceptibility to suppression by p53: While p53 can suppres...

journal_title：Oncogene

authors： Hansen R,Reddel R,Braithwaite A

更新日期：1995-12-21 00:00:00

abstract：:Mammalian systems respond to environmental stress by either adapting or undergoing programmed cell death. While there is general agreement that the caspase family of proteases serve as the effectors of the apoptotic death response, the signaling apparatus involved in the decision to activate the caspase system is less...

journal_title：Oncogene

authors： Basu S,Kolesnick R

更新日期：1998-12-24 00:00:00

abstract：:Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD family of calcium-calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and PKD3. PKD2 is activated by many stimuli including growth factors, phorbol esters, and G-protein-coupled receptor agonists. PKD2 participation to uncontroll...

journal_title：Oncogene

authors： Azoitei N,Cobbaut M,Becher A,Van Lint J,Seufferlein T

更新日期：2018-03-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is a major risk factor worldwide for the development of hepatocellular carcinoma (HCC). Integrated HBV DNA fragments, often highly rearranged, are frequently detected in HCC. In woodchuck, the viral enhancer plays a central role in hepatocarcinogenesis, but in humans the mechanism of ...

journal_title：Oncogene

authors： Shamay M,Agami R,Shaul Y

更新日期：2001-10-18 00:00:00

abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...

journal_title：Oncogene

authors： Oehler MK,Hague S,Rees MC,Bicknell R

更新日期：2002-04-25 00:00:00

abstract：:Alpha-fetoprotein (AFP) producing gastric cancer (AFP-GC) is very malignant and highly metastatic compared with common gastric cancer. However, the causal relationship between AFP production and the high malignancy of AFP-GC is unclear. We investigated AFP gene regulation in AFP-GC by an active transcription factor, H...

journal_title：Oncogene

authors： Kataoka H,Miura Y,Joh T,Seno K,Tada T,Tamaoki T,Nakabayashi H,Kawaguchi M,Asai K,Kato T,Itoh M

更新日期：2001-02-15 00:00:00

abstract：:The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 with pSV2neo into the ben...

journal_title：Oncogene

authors： Lloyd BH,Platt-Higgins A,Rudland PS,Barraclough R

更新日期：1998-07-30 00:00:00

abstract：:Heregulins (neuregulins) are a family of proteins known to interact and activate the receptor tyrosine kinases ErbB2 in association with ErbB3 or ErbB4. Using immunofluorescence microscopy, electron microscopy autoradiography, and SDS-PAGE analysis of nuclear fractions, we show that the heregulin-beta1(1-244) isoform ...

journal_title：Oncogene

authors： Li W,Park JW,Nuijens A,Sliwkowski MX,Keller GA

更新日期：1996-06-06 00:00:00

abstract：:Imatinib-acquired resistance related to the presence of secondary point mutations has become a frequent event in gastrointestinal stromal tumors. Here, transient transfection experiments with plasmids carrying two different KIT-acquired point mutations were performed along with immunoprecipitation of total protein ext...

journal_title：Oncogene

authors： Tamborini E,Pricl S,Negri T,Lagonigro MS,Miselli F,Greco A,Gronchi A,Casali PG,Ferrone M,Fermeglia M,Carbone A,Pierotti MA,Pilotti S

更新日期：2006-10-05 00:00:00

abstract：:We have shown that one of the principle mechanisms of chemotherapy resistance involves the activation of nuclear factor kappa-B (NF-kappaB). In an effort to identify NF-kappaB-regulated chemotherapy response genes, we performed a microarray assay and observed that heparin-binding EGF-like growth factor (HB-EGF) was si...

journal_title：Oncogene

authors： Wang F,Liu R,Lee SW,Sloss CM,Couget J,Cusack JC

更新日期：2007-03-29 00:00:00

abstract：:The maintenance of genome stability is essential for the cell as the integrity of genomic information guaranties reproduction of a whole organism. DNA damage occurring in response to different natural and nonnatural stimuli (errors in DNA replication, UV radiation, chemical agents, etc.) is normally detected by specia...

journal_title：Oncogene

authors： Prokhorova EA,Egorshina AY,Zhivotovsky B,Kopeina GS

更新日期：2020-01-01 00:00:00

abstract：:WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint and to be involved in tumour progression in different malignant tumours. Here we analysed the expression levels of WEE1 in a series of melanoma patient samples and melanoma cell lines using immunoblotting, quantitative real-time PCR ...

journal_title：Oncogene

authors： Bhattacharya A,Schmitz U,Wolkenhauer O,Schönherr M,Raatz Y,Kunz M

更新日期：2013-06-27 00:00:00

abstract：:The cysteinyl leukotriene1 (CysLT1) receptor (CysLT1R) enhances survival and proliferation of intestinal cells via distinct pathways. Here, we have demonstrated that there is significant endogenous production of CysLTs from both non-tumour- and tumour-derived intestinal epithelial cells. Treatment of two non-tumour ce...

journal_title：Oncogene

authors： Paruchuri S,Mezhybovska M,Juhas M,Sjölander A

更新日期：2006-10-26 00:00:00

abstract：:We have studied the role of the HPV-16 E5 protein in apoptosis, using HaCaT cell lines stably transfected with either E5 (HaCaT/E5) or the empty vector (HaCaT/pMSG) as control. When subjected to a hyperosmolar concentration of sorbitol, HaCaT/E5 cells respond with cytochrome c release, activation of caspase-3, -8, and...

journal_title：Oncogene

authors： Kabsch K,Alonso A

更新日期：2002-01-31 00:00:00

abstract：:Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent mechanisms. As cell migration is studied in vitro, it is important to identify genes that both drive cell migration and are biologically relevant in promoting inv...

journal_title：Oncogene

authors： Wu Y,Siadaty MS,Berens ME,Hampton GM,Theodorescu D

更新日期：2008-11-06 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT), marked by the dissolution of cell-cell junctions, loss of cell polarity and increased cell motility, is one of the essential steps for prostate cancer metastasis. However, the underlying mechanism has not been fully explored. We report in this study that Shp2 is upregulated ...

journal_title：Oncogene

authors： Zhang K,Zhao H,Ji Z,Zhang C,Zhou P,Wang L,Chen Q,Wang J,Zhang P,Chen Z,Zhu HH,Gao WQ

更新日期：2016-03-10 00:00:00

abstract：:The p21WAF1/CIP1 protein was shown to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. We investigated the effects of exogenous p21WAF1/CIP1 in two different human breast carcinoma (HBC) cell lines MCF-7 and T47D. p21WAF1/CIP1 transfected cells formed significantly reduced n...

journal_title：Oncogene

authors： Sheikh MS,Rochefort H,Garcia M

更新日期：1995-11-02 00:00:00

abstract：:Human WWOX gene encodes a proapoptotic WW domain-containing oxidoreductase WOX1 (also named WWOX, FOR2 or WWOXv1). Apoptotic and stress stimuli activate WOX1 via Tyr33 phosphorylation and nuclear translocation. WOX1 possesses a tetrad NSYK motif in the C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domai...

journal_title：Oncogene

authors： Chang NS,Schultz L,Hsu LJ,Lewis J,Su M,Sze CI

更新日期：2005-01-20 00:00:00

abstract：:Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelia...

journal_title：Oncogene

authors： Beach S,Tang H,Park S,Dhillon AS,Keller ET,Kolch W,Yeung KC

更新日期：2008-04-03 00:00:00

abstract：:Mouse malignant T-lymphoma CS-21 cells grow in vitro in the presence of CA-12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA-12 stromal cells. In the course of examining the nursing effects of CA-12 stromal cells, we found that these cells provided some soluble factors that supp...

journal_title：Oncogene

authors： Lee SH,Fujita N,Mashima T,Tsuruo T

更新日期：1996-11-21 00:00:00

abstract：:Observations that genome-wide DNA hypomethylation induces genome instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that allows the quantifi...

journal_title：Oncogene

authors： Maslov AY,Lee M,Gundry M,Gravina S,Strogonova N,Tazearslan C,Bendebury A,Suh Y,Vijg J

更新日期：2012-12-13 00:00:00