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And-1 is required for the stability of histone acetyltransferase Gcn5.

Abstract：

:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins are regulated remains largely unknown. Here we show that acidic nucleoplasmic DNA-binding protein (And-1, a high mobility group domain-containing protein) has remarkable capability to regulate the stability of Gcn5 proteins and thereby histone H3 acetylation. We find that And-1 forms a complex with both histone H3 and Gcn5. Downregulation of And-1 results in Gcn5 degradation, leading to the reduction of H3K9 and H3K56 acetylation. And-1 overexpression stabilizes Gcn5 through protein-protein interactions in vivo. Furthermore, And-1 expression is increased in cancer cells in a manner correlating with increased Gcn5 and H3K9Ac and H3K56Ac. Thus, our data reveal not only a functional link between Gcn5 and And-1 that is essential for Gcn5 protein stability and histone H3 acetylation, but also a potential role of And-1 in cancer.

journal_name

Oncogene

journal_title

Oncogene

authors

Li Y,Jaramillo-Lambert AN,Yang Y,Williams R,Lee NH,Zhu W

doi

10.1038/onc.2011.261

subject

Has Abstract

pub_date

2012-02-02 00:00:00

pages

643-52

issue

5

eissn

0950-9232

issn

1476-5594

pii

onc2011261

journal_volume

31

pub_type

杂志文章

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