Cdc25B activity is regulated by 14-3-3.

abstract：:Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen l...

journal_title：Oncogene

authors： Xiao W,Zhang Q,Habermacher G,Yang X,Zhang AY,Cai X,Hahn J,Liu J,Pins M,Doglio L,Dhir R,Gingrich J,Wang Z

更新日期：2008-03-06 00:00:00

abstract：:Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here, we demonstrate a unique protumorigenic niche in the livers of Ncoa5...

journal_title：Oncogene

authors： Williams M,Liu X,Zhang Y,Reske J,Bahal D,Gohl TG,Hollern D,Ensink E,Kiupel M,Luo R,Das R,Xiao H

更新日期：2020-05-01 00:00:00

abstract：:Alterations affecting the epidermal growth factor (EGF)/transforming growth factor alpha (TGF alpha)-responsive mitogenic pathway are frequently detected in malignancies. In particular, the EGF-receptor (EGFR) molecule has been found overexpressed in a number of human tumors, and TGF alpha is produced by a large array...

journal_title：Oncogene

authors： Di Marco E,Pierce JH,Fleming TP,Kraus MH,Molloy CJ,Aaronson SA,Di Fiore PP

更新日期：1989-07-01 00:00:00

abstract：:Sex-determining region Y box 6 (SOX6) has been described as a tumor-suppressor gene in several cancers. Our previous work has suggested that SOX6 upregulated p21(Waf1/Cip1)(p21) expression in a p53-dependent manner; however, the underlying mechanism has remained elusive. In this study, we confirmed that SOX6 can suppr...

journal_title：Oncogene

authors： Wang J,Ding S,Duan Z,Xie Q,Zhang T,Zhang X,Wang Y,Chen X,Zhuang H,Lu F

更新日期：2016-03-31 00:00:00

abstract：:The mouse pancreatic amylase Amy-2.2 gene was fused to the structural gene for SV40 T antigen, and 51 independent transgenic founder mice carrying the fusion gene were generated. The majority of the founders and 100% of their offspring in the derived transgenic lines developed pancreatic acinar cell carcinomas and sto...

journal_title：Oncogene

authors： Ceci JD,Kovatch RM,Swing DA,Jones JM,Snow CM,Rosenberg MP,Jenkins NA,Copeland NG,Meisler MH

更新日期：1991-02-01 00:00:00

abstract：:The serine threonine checkpoint kinase 2 (CHK2) is a critical protein involved in the DNA damage-response pathway, which is activated by phosphorylation inducing cellular response such as DNA repair, cell-cycle regulation or apoptosis. Although CHK2 activation mechanisms have been amply described, very little is known...

journal_title：Oncogene

authors： García-Limones C,Lara-Chica M,Jiménez-Jiménez C,Pérez M,Moreno P,Muñoz E,Calzado MA

更新日期：2016-08-18 00:00:00

abstract：:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular ada...

journal_title：Oncogene

authors： Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan G

更新日期：2001-10-01 00:00:00

abstract：:One of the key events in tumor initiation in mouse skin is mutational activation of the H-ras gene. Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. We describe he...

journal_title：Oncogene

authors： Chakravarti D,Mailander P,Franzen J,Higginbotham S,Cavalieri EL,Rogan EG

更新日期：1998-06-18 00:00:00

abstract：:Assessment of the genetic instability of a microsatellite has indicated a new mechanism in human carcinogenesis. Examination was made to determine whether microsatellite instability is associated with the onset of prostate cancer. Twenty-nine DNA samples from 24 primary prostate cancer, two metastatic lymph-node and t...

journal_title：Oncogene

authors： Uchida T,Wada C,Wang C,Ishida H,Egawa S,Yokoyama E,Ohtani H,Koshiba K

更新日期：1995-03-02 00:00:00

abstract：:In mammalian cells, the p53 protein is a key regulator of the cell cycle following DNA damage. In the present study, we investigated the function of p53 in the A6 amphibian cell line. Using various specific Xenopus p53 monoclonal antibodies, we showed that Xenopus p53 accumulates after DNA damage, including gamma and ...

journal_title：Oncogene

authors： Bensaad K,Rouillard D,Soussi T

更新日期：2001-06-28 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:cDNA clones of the ski-related gene, sno, were isolated from a chicken cDNA library and sequenced. In contrast to the human system, from which two forms of sno cDNAs have been isolated, we obtained only one type of chicken sno cDNA, that encoding snoN. The coding region for chicken snoN was inserted into the retrovira...

journal_title：Oncogene

authors： Boyer PL,Colmenares C,Stavnezer E,Hughes SH

更新日期：1993-02-01 00:00:00

abstract：:The post-translational modifications ubiquitination and sumoylation have been implicated in regulating many critical cellular pathways. Like ubiquitination, sumoylation is a multistep process involving maturation, activation, conjugation and deconjugation. Ubc9 is a sole E2-conjugating enzyme essential for sumoylation...

journal_title：Oncogene

authors： Mo YY,Yu Y,Theodosiou E,Ee PL,Beck WT

更新日期：2005-04-14 00:00:00

abstract：:Recently, constitutive activation of JAK kinases (JAKs) and/or signal transducers and activators of transcription (STATs) has been reported in growing numbers of human cancer cells as well as oncogene-transformed cells. JAB/SOCS-1 has been shown to be an intrinsic JAK tyrosine kinase inhibitor and to suppress the cyto...

journal_title：Oncogene

authors： Iwamoto T,Senga T,Naito Y,Matsuda S,Miyake Y,Yoshimura A,Hamaguchi M

更新日期：2000-09-28 00:00:00

abstract：:Aggrus (also known as T1alpha/podoplanin) is a membrane sialoglycoprotein whose function in tumors is unknown. We recently determined that Aggrus possessed the ability of inducing platelet aggregation and that its expression was frequently upregulated in colorectal tumors. Thus, Aggrus expression might be associated w...

journal_title：Oncogene

authors： Kato Y,Sasagawa I,Kaneko M,Osawa M,Fujita N,Tsuruo T

更新日期：2004-11-04 00:00:00

abstract：:In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...

journal_title：Oncogene

authors： Munnes M,Patrone G,Schmitz B,Romeo G,Doerfler W

更新日期：1998-11-19 00:00:00

abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...

journal_title：Oncogene

authors： García P,Calés C

更新日期：1996-08-15 00:00:00

abstract：:MicroRNAs (miRNAs) may function as either oncogenes or tumor suppressors in the malignant progression of different tumor types. MiR-663 was recently reported to be decreased and identified as a tumor suppressor in gastric cancer. We also verified its role in repressing cell proliferation of a gastric cancer cell line....

journal_title：Oncogene

authors： Yi C,Wang Q,Wang L,Huang Y,Li L,Liu L,Zhou X,Xie G,Kang T,Wang H,Zeng M,Ma J,Zeng Y,Yun JP

更新日期：2012-10-11 00:00:00

abstract：:Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...

journal_title：Oncogene

authors： Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

更新日期：2017-11-16 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:Ret is a receptor tyrosine kinase predominantly expressed in tissue derived from the neuroectoderm and is involved in multiple endocrine neoplasia type 2A and 2B, familiar medullary thyroid carcinoma, and Hirschsprung's disease. The ligand for the receptor is still unknown. Previously, using a human epidermal growth f...

journal_title：Oncogene

authors： van Weering DH,Medema JP,van Puijenbroek A,Burgering BM,Baas PD,Bos JL

更新日期：1995-12-07 00:00:00

abstract：:To investigate the relationship between the local configuration of a gene and its level of expression, we constructed a rat cell line, Hy5, carrying a mutant polyomavirus middle T oncogene (pmt) whose overexpression converted the cells to the transformed state. The structure of the transgene was such that pmt was able...

journal_title：Oncogene

authors： St-Onge L,Bastin M

更新日期：1994-03-01 00:00:00

abstract：:Mutant p53 frequently accumulates in cancer cells and promotes tumor cell invasion, as part of its gain of function. Its accumulation is partially due to enhanced stability, but little is known about how the mRNA levels of mutant p53 can be regulated. Likewise, the impact of cancer therapy on the levels of mutant p53 ...

journal_title：Oncogene

authors： Bug M,Dobbelstein M

更新日期：2011-08-18 00:00:00

abstract：:The marine alkaloid ascididemin (ASC) was shown to exert cytotoxicity even against multidrug-resistant cancer cells. Here, we address the signaling pathways utilized by ASC to trigger apoptosis in Jurkat leukemia T cells. We show that ASC (0.5-20 microM) induces a mitochondrial pathway that requires the activation of ...

journal_title：Oncogene

authors： Dirsch VM,Kirschke SO,Estermeier M,Steffan B,Vollmar AM

更新日期：2004-02-26 00:00:00

abstract：:c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II,...

journal_title：Oncogene

authors： Kanazawa S,Soucek L,Evan G,Okamoto T,Peterlin BM

更新日期：2003-08-28 00:00:00

abstract：:Recent explosive advances in next-generation sequencing technology and computational approaches to massive data enable us to analyze a number of cancer genome profiles by whole-genome sequencing (WGS). To explore cancer genomic alterations and their diversity comprehensively, global and local cancer genome-sequencing ...

journal_title：Oncogene

authors： Nakagawa H,Wardell CP,Furuta M,Taniguchi H,Fujimoto A

更新日期：2015-12-03 00:00:00

abstract：:We have previously shown that exogenous wild type p53 induces apoptosis in the Burkitt lymphoma line BL41 that carries endogenous mutant p53, using a temperature sensitive p53 construct expressed as mutant p53 at 37 degrees C and wild type p53 at 32 degrees C (Ramqvist et al., Oncogene, 8, 1495-1500, 1993). We also fo...

journal_title：Oncogene

authors： Okan I,Wang Y,Chen F,Hu LF,Imreh S,Klein G,Wiman KG

更新日期：1995-09-21 00:00:00

abstract：:Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle. Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary. In this study, ...

journal_title：Oncogene

authors： Ohtani K,Iwanaga R,Nakamura M,Ikeda M,Yabuta N,Tsuruga H,Nojima H

更新日期：1999-04-08 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastasis is largely responsible for HCC-associated recurrence and mortality. We aimed to identify metastasis-related long non-coding RNAs (lncRNAs) to understand the molecular mechanism of HCC metastasis. We first identified that miR-1258 was downregulated in HCC tissues both in The Ca...

journal_title：Oncogene

authors： Huang WJ,Tian XP,Bi SX,Zhang SR,He TS,Song LY,Yun JP,Zhou ZG,Yu RM,Li M

更新日期：2020-06-01 00:00:00

abstract：:RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli...

journal_title：Oncogene

authors： Bren GD,Solan NJ,Miyoshi H,Pennington KN,Pobst LJ,Paya CV

更新日期：2001-11-22 00:00:00