Alu RNA accumulation induces epithelial-to-mesenchymal transition by modulating miR-566 and is associated with cancer progression.

abstract：:Anaplastic lymphoma kinase (ALK) was originally identified from a rare subtype of non-Hodgkin's lymphomas carrying t(2;5)(p23;q35) translocation, where ALK was constitutively activated as a result of a fusion with nucleophosmin (NPM). Aberrant ALK fusion proteins were also generated in inflammatory fibrosarcoma and a ...

journal_title：Oncogene

authors： Okubo J,Takita J,Chen Y,Oki K,Nishimura R,Kato M,Sanada M,Hiwatari M,Hayashi Y,Igarashi T,Ogawa S

更新日期：2012-11-01 00:00:00

abstract：:The p53 and MDM2 genes are part of a physiological pathway frequently impaired in human cancer. With the exception of tumours occasionally associated with hereditary predisposition, childhood malignancies have not been studied in detail yet. This is the first report on the analysis of p53 and MDM2 in a group of non-he...

journal_title：Oncogene

authors： Kovar H,Auinger A,Jug G,Aryee D,Zoubek A,Salzer-Kuntschik M,Gadner H

更新日期：1993-10-01 00:00:00

abstract：:Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epitheli...

journal_title：Oncogene

authors： Blaydes JP,Schlumberger M,Wynford-Thomas D,Wyllie FS

更新日期：1995-01-19 00:00:00

abstract：:To investigate the mechanisms by which p53 suppresses cell transformation, we used the simian virus 40 (SV40) large T antigen (LTag), the adenovirus E1a proteins, and an activated ras protein (EJ-ras), to examine different pathways of transformation for their susceptibility to suppression by p53: While p53 can suppres...

journal_title：Oncogene

authors： Hansen R,Reddel R,Braithwaite A

更新日期：1995-12-21 00:00:00

abstract：:The human RON and its mouse homologue stk are members of the MET family of tyrosine kinase receptors. We have previously shown that the RON gene is over-expressed in human breast carcinomas. As cat mammary tumours have been proposed as a suitable model for aggressive human breast cancer, we identified the feline stk g...

journal_title：Oncogene

authors： De Maria R,Maggiora P,Biolatti B,Prat M,Comoglio PM,Castagnaro M,Di Renzo MF

更新日期：2002-03-07 00:00:00

abstract：:The Abelson (Abl) family of non-receptor tyrosine kinases has an important role in cell morphogenesis, motility, and proliferation. Although the function of Abl has been extensively studied in leukemia, its role in epithelial cell invasion remains obscure. Using the Drosophila wing epithelium as an in vivo model syste...

journal_title：Oncogene

authors： Singh J,Aaronson SA,Mlodzik M

更新日期：2010-07-15 00:00:00

abstract：:Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma...

journal_title：Oncogene

authors： Damsky WE,Theodosakis N,Bosenberg M

更新日期：2014-05-08 00:00:00

abstract：:Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...

journal_title：Oncogene

authors： Smithgall TE,Briggs SD,Schreiner S,Lerner EC,Cheng H,Wilson MB

更新日期：2000-05-15 00:00:00

abstract：:Reversible acetylation on protein lysine residues has been shown to regulate the function of both nuclear proteins such as histones and p53 and cytoplasmic proteins such as alpha-tubulin. To identify novel acetylated proteins, we purified several proteins by the affinity to an anti-acetylated-lysine antibody from cell...

journal_title：Oncogene

authors： Shimazu T,Komatsu Y,Nakayama KI,Fukazawa H,Horinouchi S,Yoshida M

更新日期：2006-11-30 00:00:00

abstract：:Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical...

journal_title：Oncogene

authors： Louault K,Bonneaud TL,Séveno C,Gomez-Bougie P,Nguyen F,Gautier F,Bourgeois N,Loussouarn D,Kerdraon O,Barillé-Nion S,Jézéquel P,Campone M,Amiot M,Juin PP,Souazé F

更新日期：2019-04-01 00:00:00

abstract：:We compared the regulation of gamma-glutamyl transferase (gamma GT) and glutathione-S-transferase-P (GST-P) expression in rat liver epithelial cells (228 cells) and a line derived from them (C5 cells) by stable transfection with a metallothionein-activated ras fusion gene (MTrasT24). Earlier studies demonstrated that ...

journal_title：Oncogene

authors： Li YC,Lieberman MW

更新日期：1989-06-01 00:00:00

abstract：:The c-myc oncogene is the most extensively studied member of the myc gene family which now consists of three characterized members, namely the c-myc, N-myc and L-myc genes. These genes are often found amplified in cell lines from small cell carcinomas of the lung (SCLC). In this study the L-myc gene was examined in a ...

journal_title：Oncogene

authors： Saksela K

更新日期：1987-01-01 00:00:00

abstract：:We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response...

journal_title：Oncogene

authors： Haapasalo A,Saarelainen T,Moshnyakov M,Arumäe U,Kiema TR,Saarma M,Wong G,Castrén E

更新日期：1999-02-11 00:00:00

abstract：:Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for Cav1 has been suggested; however, Cav1 is frequently overexpressed in aggressive breast cancer subtypes, ...

journal_title：Oncogene

authors： Rao X,Evans J,Chae H,Pilrose J,Kim S,Yan P,Huang RL,Lai HC,Lin H,Liu Y,Miller D,Rhee JK,Huang YW,Gu F,Gray JW,Huang TM,Nephew KP

更新日期：2013-09-19 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00

abstract：:The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, whic...

journal_title：Oncogene

authors： Fernández BG,Jezowska B,Janody F

更新日期：2014-04-17 00:00:00

abstract：:Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gen...

journal_title：Oncogene

authors： Lin HM,Pestell RG,Raz A,Kim HR

更新日期：2002-11-14 00:00:00

abstract：:Steroid receptor co-activator-3 (SRC-3/AIB1) is an oncogene that is amplified and overexpressed in many human cancers. However, the molecular mechanisms that regulate 'activated SRC-3 oncoprotein' turnover during tumorigenesis remain to be elucidated. Here, we report that speckle-type POZ protein (SPOP), a cullin 3 (C...

journal_title：Oncogene

authors： Li C,Ao J,Fu J,Lee DF,Xu J,Lonard D,O'Malley BW

更新日期：2011-10-20 00:00:00

abstract：:The molecular interactions implicated in the mammalian G1/S cell cycle phase transition comprise a highly nonlinear network which can produce seemingly paradoxical results and make intuitive interpretations unreliable. A new approach to this problem is presented, consisting of (1) a convention of unambiguous reaction ...

journal_title：Oncogene

authors： Kohn KW

更新日期：1998-02-26 00:00:00

abstract：:Diffuse intrinsic pontine glioma (or DIPG) are pediatric high-grade gliomas associated with a dismal prognosis. They harbor specific substitution in histone H3 at position K27 that induces major epigenetic dysregulations. Most clinical trials failed so far to increase survival, and radiotherapy remains the most effici...

journal_title：Oncogene

authors： Silva-Evangelista C,Barret E,Ménez V,Merlevede J,Kergrohen T,Saccasyn A,Oberlin E,Puget S,Beccaria K,Grill J,Castel D,Debily MA

更新日期：2019-09-01 00:00:00

abstract：:Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we show that specific microRNAs (miRNAs) target the 3'-UTR of Axl. Luciferase-reporter assays with wild-type and deleted miR-34 and miR-199a/b seed sequences of Axl 3'-UTR confirmed the specificity of targeting. An inverse c...

journal_title：Oncogene

authors： Mudduluru G,Ceppi P,Kumarswamy R,Scagliotti GV,Papotti M,Allgayer H

更新日期：2011-06-23 00:00:00

abstract：:Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure-activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and Q, led to the discovery of Cuc Q, which inhibits the activation of STAT3 but not JAK2; Cuc A which inhibits J...

journal_title：Oncogene

authors： Sun J,Blaskovich MA,Jove R,Livingston SK,Coppola D,Sebti SM

更新日期：2005-05-05 00:00:00

abstract：:We recently reported an interaction between the p14(ARF) protein and human topoisomerase I (Topo I) resulting in the stimulation of the relaxation activity of Topo I. Our data showed that the complex between the two proteins was located within the nucleolus. In the present work, we have investigated the regions of p14...

journal_title：Oncogene

authors： Ayrault O,Karayan L,Riou JF,Larsen CJ,Séité P

更新日期：2003-04-03 00:00:00

abstract：:Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the development of a variety of tumors in mice without significantly affecting survival rates, suggesting a modulating role for the MutSβ (MSH2-MSH3) complex in late-onset tumorigenesis. To better study the role of MSH3 in tumor progression, we crossed Msh3(-...

journal_title：Oncogene

authors： van Oers JM,Edwards Y,Chahwan R,Zhang W,Smith C,Pechuan X,Schaetzlein S,Jin B,Wang Y,Bergman A,Scharff MD,Edelmann W

更新日期：2014-07-24 00:00:00

abstract：:Ovarian cancer is currently the second leading cause of gynecological malignancy and cisplatin or cisplatin-based regimens have been the standard of care for the treatment of advance epithelial ovarian cancers. However, the efficacy of cisplatin treatment is often limited by the development of drug resistance either t...

journal_title：Oncogene

authors： Leong CT,Ong CK,Tay SK,Huynh H

更新日期：2007-02-08 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p27 is a key regulator of cell-cycle progression. Its expression and localization are altered in several types of malignancies, which has prognostic significance in cancers such as renal cell carcinoma (RCC). S-phase kinase-associated protein 2 (SKP-2) is an F-box protein that is ...

journal_title：Oncogene

authors： Shanmugasundaram K,Block K,Nayak BK,Livi CB,Venkatachalam MA,Sudarshan S

更新日期：2013-04-18 00:00:00

abstract：:The role of thromboxane A(2) (TxA(2)) in smoking-associated lung cancer is poorly understood. This study was conducted to study the role of TxA(2) in smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-promoted cell survival and growth in human lung cancer cells. We found that NNK increased TxA(2) ...

journal_title：Oncogene

authors： Huang RY,Li MY,Hsin MK,Underwood MJ,Ma LT,Mok TS,Warner TD,Chen GG

更新日期：2011-01-06 00:00:00

abstract：:Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...

journal_title：Oncogene

authors： Urbanucci A,Sahu B,Seppälä J,Larjo A,Latonen LM,Waltering KK,Tammela TL,Vessella RL,Lähdesmäki H,Jänne OA,Visakorpi T

更新日期：2012-04-26 00:00:00

abstract：:The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) (Nanbru et al., 1997; Stoneley et al., 1998) and thus c-myc protein synthesis can be initiated by a cap-independent as well as a cap-dependent mechanism (Stoneley et al., 2000). In cell lines derived from patients...

journal_title：Oncogene

authors： Chappell SA,LeQuesne JP,Paulin FE,deSchoolmeester ML,Stoneley M,Soutar RL,Ralston SH,Helfrich MH,Willis AE

更新日期：2000-09-07 00:00:00

abstract：:Although p73alpha induces many of the same cellular events as p53, it is structurally distinct from p53 in that it possesses a unique COOH-terminal domain. To dissect the function of this domain, we performed yeast two-hybrid screening of a HeLa cDNA library using residues 552-636 of p73alpha as bait. Among the clones...

journal_title：Oncogene

authors： Lee YG,Lee SW,Sin HS,Kim EJ,Um SJ

更新日期：2009-02-19 00:00:00