c-Jun causes focus formation and anchorage-independent growth in culture but is non-tumorigenic.

abstract：:PIKE-A (phosphoinositide 3-kinases (PI 3)-kinase enhancer) is a ubiquitously expressed GTPase, which binds to and enhances protein kinase B (Akt) kinase activity in a guanine nucleotide-dependent manner. PIKE-A is one of the components of the CDK4 amplicon that is amplified in numerous human cancers. However, whether ...

journal_title：Oncogene

authors： Liu X,Hu Y,Hao C,Rempel SA,Ye K

更新日期：2007-07-26 00:00:00

abstract：:The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...

journal_title：Oncogene

authors： Miyata Y,Yahara I

更新日期：2000-03-09 00:00:00

abstract：:Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent mechanisms. As cell migration is studied in vitro, it is important to identify genes that both drive cell migration and are biologically relevant in promoting inv...

journal_title：Oncogene

authors： Wu Y,Siadaty MS,Berens ME,Hampton GM,Theodorescu D

更新日期：2008-11-06 00:00:00

abstract：:Jun : Fos and Jun : ATF complexes represent two classes of AP-1 dimers that (1) preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are differently regulated by cellular signaling pathways and oncogene products. To discriminate between the functions of Jun : Fos, Jun : ATF and Jun : Jun, ...

journal_title：Oncogene

authors： van Dam H,Castellazzi M

更新日期：2001-04-30 00:00:00

abstract：:Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules mediating cytoskeletal reorganization. The cortactin gene, EMS1, maps to chromosome 11q13, a region amplified in head and neck squamous cell carcinoma...

journal_title：Oncogene

authors： Patel AS,Schechter GL,Wasilenko WJ,Somers KD

更新日期：1998-06-25 00:00:00

abstract：:SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...

journal_title：Oncogene

authors： Claudio JO,Zhu YX,Benn SJ,Shukla AH,McGlade CJ,Falcioni N,Stewart AK

更新日期：2001-08-30 00:00:00

abstract：:The PLZF gene was identified first by its fusion with the retinoic acid receptor alpha gene in the t(11;17) translocation associated with a retinoic acid resistant form of acute promyelocytic leukemia (APL). It encodes a krüppel-like zinc finger protein with a POZ domain shared with a subset of regulatory proteins inc...

journal_title：Oncogene

authors： David G,Alland L,Hong SH,Wong CW,DePinho RA,Dejean A

更新日期：1998-05-14 00:00:00

abstract：:Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosph...

journal_title：Oncogene

authors： Wang W,Liao P,Shen M,Chen T,Chen Y,Li Y,Lin X,Ge X,Wang P

更新日期：2016-01-28 00:00:00

abstract：:CD44 is a transmembrane glycoprotein known to bind hyaluronic acid (HA) in its extracellular domain and to contain at least one ankyrin-binding site in its cytoplasmic domain. In this study we have examined CD44 expression in a mouse fibroblast cell line transfected with the pl85(neu) oncogene cDNA. The results of RT-...

journal_title：Oncogene

authors： Zhu D,Bourguignon L

更新日期：1996-06-06 00:00:00

abstract：:Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive brea...

journal_title：Oncogene

authors： Walter M,Liang S,Ghosh S,Hornsby PJ,Li R

更新日期：2009-07-30 00:00:00

abstract：:In Dictyostelium discoideum, three ras genes (rasD, rasG and rasB) and one ras-related gene (rap1) have been previously isolated and characterized, and the deduced amino acid sequence of their predicted protein products share at least 50% sequence identity with the human H-Ras protein. We have now cloned and character...

journal_title：Oncogene

authors： Daniel J,Bush J,Cardelli J,Spiegelman GB,Weeks G

更新日期：1994-02-01 00:00:00

abstract：:The maintenance of genomic stability is one of the most important defenses against neoplastic transformation. This objective must be accomplished despite a constant barrage of spontaneous DNA double strand breaks. These dangerous lesions are corrected by two primary pathways of double strand break repair; non homologo...

journal_title：Oncogene

authors： Ferguson DO,Alt FW

更新日期：2001-09-10 00:00:00

abstract：:The SNAIL-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to contribute to piebaldism and Waardenburg syndrome type 2 in a dose-dependent fashion. While aberrant induction of SLUG has been ...

journal_title：Oncogene

authors： Pérez-Mancera PA,González-Herrero I,Pérez-Caro M,Gutiérrez-Cianca N,Flores T,Gutiérrez-Adán A,Pintado B,Sánchez-Martín M,Sánchez-García I

更新日期：2005-04-28 00:00:00

abstract：:The p21WAF1/CIP1 protein was shown to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. We investigated the effects of exogenous p21WAF1/CIP1 in two different human breast carcinoma (HBC) cell lines MCF-7 and T47D. p21WAF1/CIP1 transfected cells formed significantly reduced n...

journal_title：Oncogene

authors： Sheikh MS,Rochefort H,Garcia M

更新日期：1995-11-02 00:00:00

abstract：:Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast tumorigenesis and developing new diagnostic and therapeutic agents. In this study we have combined two powerful technologies, PCR-based cDNA subtraction and cDNA microa...

journal_title：Oncogene

authors： Jiang Y,Harlocker SL,Molesh DA,Dillon DC,Stolk JA,Houghton RL,Repasky EA,Badaro R,Reed SG,Xu J

更新日期：2002-03-28 00:00:00

abstract：:The Ets family of transcription factors is one of a growing number of master regulators of development. This family was originally defined by the presence of a conserved DNA binding domain, the Ets domain. To date, nearly 30 members of this family have been identified and implicated in a wide range of physiological an...

journal_title：Oncogene

authors： Bartel FO,Higuchi T,Spyropoulos DD

更新日期：2000-12-18 00:00:00

abstract：:Matrilysin (MMP-7) is thought to contribute to invasive growth and metastasis of colon carcinoma and many other human cancers. The present study demonstrates that treatment of human colon carcinoma cells with active matrilysin induces cell aggregation in vitro and promotes liver metastasis in nude mice. When two kinds...

journal_title：Oncogene

authors： Kioi M,Yamamoto K,Higashi S,Koshikawa N,Fujita K,Miyazaki K

更新日期：2003-11-27 00:00:00

abstract：:Oncostatin M (OM) is a polypeptide cytokine that induces autocrine and paracrine effects on AIDS-Kaposi's sarcoma (KS) cells (Nair et al., Science, 255, 1430-1432, 1992; Miles et al., Science, 255, 1432-1434, 1992). The signalling pathways underlying this activation are largely unknown. We have found that OM binding t...

journal_title：Oncogene

authors： Soldi R,Graziani A,Benelli R,Ghigo D,Bosia A,Albini A,Bussolino F

更新日期：1994-08-01 00:00:00

abstract：:Treatment with retinoic acid (RA) is effective to restore radioactive iodine uptake in metastases of a small fraction of thyroid cancer patients. In order to find predictive markers of response, we took advantage of two thyroid cancer cell lines, FTC133 and FTC238, with low RA-receptor (RAR)beta expression but differi...

journal_title：Oncogene

authors： Cras A,Darsin-Bettinger D,Balitrand N,Cassinat B,Soulié A,Toubert ME,Delva L,Chomienne C

更新日期：2007-06-07 00:00:00

abstract：:The tumor microenvironment plays a critical role in prostate cancer (PC) development and progression. Inappropriate activation of the stroma potentiates the growth and transformation of epithelial tumor cells. Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine...

journal_title：Oncogene

authors： Li J,Pu T,Yin L,Li Q,Liao CP,Wu BJ

更新日期：2020-04-01 00:00:00

abstract：:A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP) pathway as well as the canonical Wnt signaling pathway. Although both pathways require a cytoplasmic protein, dishevelled, the molecular mechanism by which frizzled regulates intracellular signaling remains to be elucidated. I...

journal_title：Oncogene

authors： Yao R,Natsume Y,Noda T

更新日期：2004-08-12 00:00:00

abstract：:Apoptin, a small protein from the chicken anemia virus, has attracted attention because of its specificity in killing tumor cells. Localization of apoptin in the nucleus of tumor cells has been shown to be vital for proapoptotic activity, however, targeted expression of apoptin in the nucleus of normal cells does not ...

journal_title：Oncogene

authors： Maddika S,Wiechec E,Ande SR,Poon IK,Fischer U,Wesselborg S,Jans DA,Schulze-Osthoff K,Los M

更新日期：2008-05-08 00:00:00

abstract：:Hedgehog pathway activity has been demonstrated in malignant glioma. However, its role in tumor growth has not been determined. Here we demonstrate that pharmacological inhibition of the Hedgehog pathway in established orthotopic malignant glioma xenografts confers a survival advantage. Pathway inhibition is measured ...

journal_title：Oncogene

authors： Sarangi A,Valadez JG,Rush S,Abel TW,Thompson RC,Cooper MK

更新日期：2009-10-01 00:00:00

abstract：:The WARTS gene encodes a kinase that localizes to the mitotic apparatus of a dividing cell. Named WARTS after the growths that develop in the eyes of Drosophila in which the gene is deleted. WARTS is also implicated as a tumor suppressor in mice and humans. In this issue of Oncogene, Iida et al. describe experiments s...

journal_title：Oncogene

authors： Edwards KM,Münger K

更新日期：2004-07-08 00:00:00

abstract：:The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open reading frame encoding 469 amino acids. The ETS2 gene directs the synthe...

journal_title：Oncogene

authors： Watson DK,Mavrothalassitis GJ,Jorcyk CL,Smyth FE,Papas TS

更新日期：1990-10-01 00:00:00

abstract：:The retinoblastoma protein (pRB) has the dual capability to negatively regulate both E2F-induced cell cycle entry and E2F1-induced apoptosis. In this report, we characterize a unique pRB-E2F1 interaction. Using mutagenesis to disrupt E2F1 binding, we find that the ability of pRB to regulate E2F1-induced apoptosis is d...

journal_title：Oncogene

authors： Julian LM,Palander O,Seifried LA,Foster JE,Dick FA

更新日期：2008-03-06 00:00:00

abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...

journal_title：Oncogene

authors： Denison SR,Wang F,Becker NA,Schüle B,Kock N,Phillips LA,Klein C,Smith DI

更新日期：2003-11-13 00:00:00

abstract：:A dominant negative mutant of Ras, M17 Ras, was used to study the role of Ras in receptor coupling of Raf-1 and B-Raf protein serine/threonine kinases (PSKs). We found that mutant Ras blocks serum- and 12-O-tetradecanoyl phorbol 13-acetate-induced activation of Raf-1 kinase in NIH3T3 cells and Raf-1 as well as B-Raf P...

journal_title：Oncogene

authors： Troppmair J,Bruder JT,App H,Cai H,Liptak L,Szeberényi J,Cooper GM,Rapp UR

更新日期：1992-09-01 00:00:00

abstract：:Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...

journal_title：Oncogene

authors： Zhang X,Yang L,Szeto P,Abali GK,Zhang Y,Kulkarni A,Amarasinghe K,Li J,Vergara IA,Molania R,Papenfuss AT,McLean C,Shackleton M,Harvey KF

更新日期：2020-07-01 00:00:00

abstract：:Uveal melanoma (UM) is a currently untreatable form of melanoma with a 50% mortality rate. Characterization of the essential signaling pathways driving this cancer is critical to develop target therapies. Activating mutations in the Gαq signaling pathway at the level of GNAQ, GNA11, or rarely CYSLTR2 or PLCβ4 are cons...

journal_title：Oncogene

authors： Ma J,Weng L,Bastian BC,Chen X

更新日期：2021-01-01 00:00:00