PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion.

abstract：:In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...

journal_title：Oncogene

authors： Bianchi T,Rufer N,MacDonald HR,Migliaccio M

更新日期：2006-07-06 00:00:00

abstract：:RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal transduction, differentiation and apoptosis. Most of the RING-finger proteins have E3-ubiquitin ligase activity. RNF11 is a small RING-finger protein and harbors a RING-H2 domain and a PY motif that...

journal_title：Oncogene

authors： Li H,Seth A

更新日期：2004-03-11 00:00:00

abstract：:Transcription from the rat TGF alpha promoter initiates at two predominant sites (-188 and -58) in a G+C-rich region that does not contain TATA or CAAT motifs. Previous studies using transfected reporter constructs implicated the transcription factor Sp1 in active expression from the promoter, particularly from the -5...

journal_title：Oncogene

authors： Chen X,Wright KL,Berkowitz EA,Azizkhan JC,Ting JP,Lee DC

更新日期：1994-11-01 00:00:00

abstract：:The eph gene encodes a putative receptor tyrosine kinase for an as yet unknown ligand. Some human cancer cells have been found to overexpress eph mRNAs without gene amplification. We show here that NIH3T3 cells acquire tumorigenic ability in nude mice and make colonies in soft agar with a viral LTR (Long Terminal Repe...

journal_title：Oncogene

authors： Maru Y,Hirai H,Takaku F

更新日期：1990-03-01 00:00:00

abstract：:The point mutation that substitutes lysine with arginine at position 120 of human p53 has been characterized as a missense mutation. The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation an...

journal_title：Oncogene

authors： Lee SY,Park JH,Jeong S,Kim BY,Kang YK,Xu Y,Chung SK

更新日期：2019-03-01 00:00:00

abstract：:The transforming potential of adenovirus E1A oncogene products derives largely from the formation of complexes with cellular proteins, including the p105Rb tumor suppressor and a related p107 species, p130 and p300 proteins, and cyclin A (p60cycA). Extensive quantitative analyses using E1A deletion mutants identified ...

journal_title：Oncogene

authors： Barbeau D,Charbonneau R,Whalen SG,Bayley ST,Branton PE

更新日期：1994-02-01 00:00:00

abstract：:Amplification and overexpression of the E2F3 gene at 6p22 in human bladder cancer is associated with increased tumour stage, grade and proliferation index, and in prostate cancer E2F3 overexpression is linked to tumour aggressiveness. We first used small interfering RNA technology to confirm the potential importance o...

journal_title：Oncogene

authors： Olsson AY,Feber A,Edwards S,Te Poele R,Giddings I,Merson S,Cooper CS

更新日期：2007-02-15 00:00:00

abstract：:Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...

journal_title：Oncogene

authors： Park TJ,Curran T

更新日期：2014-10-23 00:00:00

abstract：:B7-H4, a member of B7 family, is a transmembrane protein and inhibits T-cells immunity. However, in a variety of tumor cells, B7-H4 was detected predominantly in intracellular compartments with unknown mechanism and functions. In this study, we analyzed B7-H4 expression and subcellular distribution by immunohistochemi...

journal_title：Oncogene

authors： Zhang L,Wu H,Lu D,Li G,Sun C,Song H,Li J,Zhai T,Huang L,Hou C,Wang W,Zhou B,Chen S,Lu B,Zhang X

更新日期：2013-11-14 00:00:00

abstract：:The ability of tumour cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of tumour elimination. An important effector of apoptosis is the CD95/CD95 ligand system (APO-1/Fas) that mediates perforin-independent cytotoxic T-cell killing of tumour cells. We propose a new stra...

journal_title：Oncogene

authors： Strand S,Vollmer P,van den Abeelen L,Gottfried D,Alla V,Heid H,Kuball J,Theobald M,Galle PR,Strand D

更新日期：2004-04-29 00:00:00

abstract：:Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...

journal_title：Oncogene

authors： Urbanucci A,Sahu B,Seppälä J,Larjo A,Latonen LM,Waltering KK,Tammela TL,Vessella RL,Lähdesmäki H,Jänne OA,Visakorpi T

更新日期：2012-04-26 00:00:00

abstract：:Rac1-GTPases serve as intermediary cellular switches, which conduct transient and constitutive signals from upstream cues, including those from Ras oncoproteins. Although the sirtuin1 (SIRT1) deacetylase is overexpressed in several human cancers and has recently been linked to cancer cell motility as a context-depende...

journal_title：Oncogene

authors： Saxena M,Dykes SS,Malyarchuk S,Wang AE,Cardelli JA,Pruitt K

更新日期：2015-01-08 00:00:00

abstract：:A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...

journal_title：Oncogene

authors： Reynolds AB,Herbert L,Cleveland JL,Berg ST,Gaut JR

更新日期：1992-12-01 00:00:00

abstract：:Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta under normal physiological conditions. Although MAGEA1's expression levels have been evaluated as one of the cancer testis (CT) antigens for immunotherapy in melanoma and several other cance...

journal_title：Oncogene

authors： Zhao J,Wang Y,Mu C,Xu Y,Sang J

更新日期：2017-08-31 00:00:00

abstract：:Internal tandem duplication (ITD) of the juxtamembrane (JM) domain of FLT3 is the most frequent mutation in human acute myeloid leukemia, and is significantly associated with leukocytosis and a poor prognosis. Previously we reported that FLT3 with ITD (FLT3/ITD) formed a homodimer and was autophosphorylated on tyrosin...

journal_title：Oncogene

authors： Kiyoi H,Ohno R,Ueda R,Saito H,Naoe T

更新日期：2002-04-11 00:00:00

abstract：:Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains ill-defined. The evidence for a role of energy balance, physical inactivity, and obesity has st...

journal_title：Oncogene

authors： McCullough ML,Giovannucci EL

更新日期：2004-08-23 00:00:00

abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

journal_title：Oncogene

authors： Han SW,Roman J

更新日期：2006-07-20 00:00:00

abstract：:Tat protein is an early nonstructural protein necessary for virus replication, which is secreted by infected cells and taken up by uninfected cells. Extensive evidence indicates that Tat may be a cofactor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may incl...

journal_title：Oncogene

authors： De Falco G,Bellan C,Lazzi S,Claudio P,La Sala D,Cinti C,Tosi P,Giordano A,Leoncini L

更新日期：2003-09-18 00:00:00

abstract：:Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...

journal_title：Oncogene

authors： Lee Y,Kim SJ,Park HD,Park EH,Huang SM,Jeon SB,Kim JM,Lim DS,Koh SS

更新日期：2010-01-07 00:00:00

abstract：:Integrin-linked kinase (ILK) is a highly evolutionarily conserved intracellular protein that was originally identified as an integrin-interacting protein, and extensive genetic and biochemical studies have shown that ILK expression is vital during both embryonic development and tissue homeostasis. At the cellular and ...

journal_title：Oncogene

authors： Hannigan GE,McDonald PC,Walsh MP,Dedhar S

更新日期：2011-10-27 00:00:00

abstract：:Poor-prognosis oestrogen receptor-positive breast cancer is characterised by the presence of high-level focal amplifications. We utilised a focused small interfering RNA screen in 14 breast cancer cell lines to define genes that were pathogenic in three genomic regions focally amplified in oestrogen receptor-positive ...

journal_title：Oncogene

authors： Garcia-Murillas I,Sharpe R,Pearson A,Campbell J,Natrajan R,Ashworth A,Turner NC

更新日期：2014-05-08 00:00:00

abstract：:The human trk oncogene (originally identified in a colon carcinoma) was activated by a genetic rearrangement which resulted in replacement of the extracellular ligand-binding domain of the proto-trk transmembrane receptor by non-muscle tropomyosin sequences. The product of the trk oncogene, a protein of 70 kDa (p70trk...

journal_title：Oncogene

authors： Mitra G

更新日期：1991-12-01 00:00:00

abstract：:To appreciate the involvement of known or potential susceptibility genes in sporadic breast tumors, we have searched for chromosomal deletions by studying loss of heterozygosity (LOH) at 43 microsatellite (CA)n markers from human chromosomes 10, 11 and 17, in 115 unselected consecutive samples of breast carcinoma with...

journal_title：Oncogene

authors： Kerangueven F,Eisinger F,Noguchi T,Allione F,Wargniez V,Eng C,Padberg G,Theillet C,Jacquemier J,Longy M,Sobol H,Birnbaum D

更新日期：1997-01-23 00:00:00

abstract：:Signal transduction and activator of transcription 3(STAT3) signaling is constitutively activated in various tumors, and is involved in cell survival and proliferation during oncogenesis. There are few reports, however, on the role of STAT3 signaling in gastric cancer. The aim of the present study was to clarify the r...

journal_title：Oncogene

authors： Kanda N,Seno H,Konda Y,Marusawa H,Kanai M,Nakajima T,Kawashima T,Nanakin A,Sawabu T,Uenoyama Y,Sekikawa A,Kawada M,Suzuki K,Kayahara T,Fukui H,Sawada M,Chiba T

更新日期：2004-06-17 00:00:00

abstract：:Skeletrophin (mindbomb homolog 2 (MIB2)) is a RING (Really Interesting New Gene) finger-dependent ubiquitin ligase, which targets the intracellular region of Notch ligands. A previous immunohistochemical study demonstrated that skeletrophin was downregulated in many melanomas. In the present study, we have identified ...

journal_title：Oncogene

authors： Takeuchi T,Adachi Y,Sonobe H,Furihata M,Ohtsuki Y

更新日期：2006-11-09 00:00:00

abstract：:Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular pathogenesis of NETs. In addition, NETs have become one of the most exciting settings for drug development. Two targeted agents for the management of advanced pancreat...

journal_title：Oncogene

authors： Capdevila J,Casanovas O,Salazar R,Castellano D,Segura A,Fuster P,Aller J,García-Carbonero R,Jimenez-Fonseca P,Grande E,Castaño JP

更新日期：2017-04-06 00:00:00

abstract：:Early growth response-1 (Egr-1) is overexpressed in human prostate tumors and contributes to cancer progression. On the other hand, mutation of p53 is associated with advanced prostate cancer, as well as with metastasis and hormone independence. This study shows that in prostate cell lines in culture, Egr-1 overexpres...

journal_title：Oncogene

authors： Sauer L,Gitenay D,Vo C,Baron VT

更新日期：2010-05-06 00:00:00

abstract：:I briefly review the discovery and characterization of the first human retrovirus, human T-cell leukemia virus type 1, focusing on contributions from Japanese researchers. The unique regulatory mechanisms for the viral regulation with Tax and Rex, etiology of ATL and possible leukemogenic mechanism with Tax are also d...

journal_title：Oncogene

authors： Yoshida M

更新日期：2005-09-05 00:00:00

abstract：:Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth...

journal_title：Oncogene

authors： Pérez-Caro M,Gutierrez-Cianca N,González-Herrero I,López-Hernández I,Flores T,Orfao A,Sánchez-Martín M,Gutiérrez-Adán A,Pintado B,Sánchez-García I

更新日期：2007-03-15 00:00:00

abstract：:Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas af...

journal_title：Oncogene

authors： Wang Y,Sugiyama H,Axelson H,Panda CK,Babonits M,Ma A,Steinberg JM,Alt FW,Klein G,Wiener F

更新日期：1992-06-01 00:00:00