当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Integrin-linked kinase: not so 'pseudo' after all.

Integrin-linked kinase: not so 'pseudo' after all.

Abstract：

:Integrin-linked kinase (ILK) is a highly evolutionarily conserved intracellular protein that was originally identified as an integrin-interacting protein, and extensive genetic and biochemical studies have shown that ILK expression is vital during both embryonic development and tissue homeostasis. At the cellular and tissue levels, ILK regulates signaling pathways for cell adhesion-mediated cell survival (anoikis), apoptosis, proliferation and mitosis, migration, invasion, and vascularization and tumor angiogenesis. ILK also has central roles in cardiac and smooth-muscle contractility, and ILK dysregulation causes cardiomyopathies in humans. ILK protein levels are increased in several human cancers and often the expression level predicts poor patient outcome. Abundant evidence has accumulated suggesting that, of the diverse functions of ILK, some may require kinase activity whereas others depend on protein-protein interactions and are, therefore, independent of kinase activity. However, the past several years have seen an ongoing debate about whether ILK indeed functions as a protein serine/threonine kinase. This debate centers on the atypical protein kinase domain of ILK, which lacks some amino-acid residues thought to be essential for phosphotransferase activity. However, similar deficiencies are present in the catalytic domains of other kinases now known to possess protein kinase activity. Numerous studies have shown that ILK phosphorylates peptide substrates in vitro, corresponding to ILK-mediated phosphorylations in intact cells, and a recent report characterizing in vitro phosphotransferase activity of highly purified, full-length ILK, accompanied by detailed enzyme kinetic analyses, shows that, at least in vitro, ILK is a bona fide protein kinase. However, several genetic studies suggest that, not all biological functions of ILK require kinase activity, and that it can function as an adaptor/scaffold protein. Here, we review evidence for and against ILK being an active kinase, and provide a framework for strategies to further analyze the kinase and adaptor functions of ILK in different cellular contexts.

journal_name

Oncogene

journal_title

Oncogene

authors

Hannigan GE,McDonald PC,Walsh MP,Dedhar S

doi

10.1038/onc.2011.177

subject

Has Abstract

pub_date

2011-10-27 00:00:00

pages

4375-85

issue

43

eissn

0950-9232

issn

1476-5594

pii

onc2011177

journal_volume

30

pub_type

杂志文章,评审

相关文献

ONCOGENE文献大全
  • SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells.

    abstract：:Here we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-associated secretory phenotype). Conditioned media from senescent MPM (malignant pleural mesothelioma) cells trig...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.485

    authors： Canino C,Mori F,Cambria A,Diamantini A,Germoni S,Alessandrini G,Borsellino G,Galati R,Battistini L,Blandino R,Facciolo F,Citro G,Strano S,Muti P,Blandino G,Cioce M

    更新日期：2012-06-28 00:00:00

  • HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas.

    abstract：:Amplified segments of the long arm of chromosome 12 are frequently observed in human sarcomas. In most cases there are separate amplified regions around the MDM2 and CDK4 genes. Here we show recurrent amplification of a third region encompassing HMGIC, a human architectural transcription factor gene. Reduced amplifica...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201135

    authors： Berner JM,Meza-Zepeda LA,Kools PF,Forus A,Schoenmakers EF,Van de Ven WJ,Fodstad O,Myklebost O

    更新日期：1997-06-19 00:00:00

  • Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cgamma.

    abstract：:Previous studies have demonstrated that activation of Kit by stem cell factor (SCF), its natural ligand, or by gain-of-function point mutation in its intracellular domain, confers significant protection against apoptosis induced by growth factor deprivation or radiation. However, the effects of Kit activation on the c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204877

    authors： Plo I,Lautier D,Casteran N,Dubreuil P,Arock M,Laurent G

    更新日期：2001-10-11 00:00:00

  • The concerted regulatory functions of the transcription factors nuclear factor-1 and upstream stimulatory factor on a composite element in the promoter of the hepatocyte growth factor gene.

    abstract：:Hepatocyte growth factor (HGF) is an important multifunctional cytokine whose gene expression is regulated mainly at the transcriptional level. Previous studies using transgenic mice as well as in vitro analyses showed that a potential regulatory element(s) exists between -260 to -230 bp in the upstream region of the ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203581

    authors： Jiang JG,Gao B,Zarnegar R

    更新日期：2000-05-25 00:00:00

  • CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling.

    abstract：:Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be the initial event associated with cancer metastasis and how it occurred is still a mystery. CtBP is known as a co-repre...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0570-z

    authors： Zhao Z,Hao D,Wang L,Li J,Meng Y,Li P,Wang Y,Zhang C,Zhou H,Gardner K,Di LJ

    更新日期：2019-03-01 00:00:00

  • Accumulated helix-destabilizing mutations in the leucine zipper of c-Fos leads to attenuation and temperature sensitivity of function.

    abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Nicklin MJ,Zechner D,Kislyakova T

    更新日期：1993-07-01 00:00:00

  • ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma.

    abstract：:Oligodendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain tumor. Many LGGs eventually transform into a more aggressive or malignant type. Enhanced angiogenesis is a characteristic of malignantly transformed oligodendroglioma (m-oligodendroglioma). However, the pathogenesis...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-01411-y

    authors： Qi L,Wang ZY,Shao XR,Li M,Chen SN,Liu XQ,Yan S,Zhang B,Zhang XD,Li X,Zhao W,Pan JA,Zhao B,Zhang XD

    更新日期：2020-09-01 00:00:00

  • p53, mutation frequency and apoptosis in the murine small intestine.

    abstract：:Normal function of the p53 gene is integral to the cellular response to genotoxic stress. One prediction arising from this is that p53 deficiency results in an increased mutation frequency. However, limited evidence has been produced in support of this idea. In order to further investigate the in vivo role of p53 in s...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201040

    authors： Clarke AR,Howard LA,Harrison DJ,Winton DJ

    更新日期：1997-05-01 00:00:00

  • HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.

    abstract：:Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209191

    authors： Wu X,Jia HL,Wang YF,Ren N,Ye QH,Sun HC,Wang L,Liu YK,Tang ZY,Qin LX

    更新日期：2006-03-16 00:00:00

  • Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT.

    abstract：:Ubiquitin-dependent mechanisms have emerged as essential regulatory elements controlling cellular levels of Smads and TGFβ-dependent biological outputs such as epithelial-mesenchymal transition (EMT). In this study, we identify a HECT E3 ubiquitin ligase known as WWP2 (Full-length WWP2-FL), together with two WWP2 isof...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.617

    authors： Soond SM,Chantry A

    更新日期：2011-05-26 00:00:00

  • The amplicons in HL60 cells contain novel cellular sequences linked to MYC locus DNA.

    abstract：:We have previously determined that the amplified DNA present in the HL60 promyelocytic leukaemia cell line contained 70 kb of continuous DNA sequences around the c-myc gene. In the work presented here we have further defined the HL60 amplicon and find it to be of the order of 160 kb and to contain a large region of DN...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Feo S,Di Liegro C,Mangano R,Read M,Fried M

    更新日期：1996-10-03 00:00:00

  • siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors.

    abstract：:BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/- female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS) characterized by early-onset of breast cancer, even though LFS involves TP53 mutations, which ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.38

    authors： Böhringer M,Obermeier K,Griner N,Waldraff D,Dickinson E,Eirich K,Schindler D,Hagen M,Jerry DJ,Wiesmüller L

    更新日期：2013-11-28 00:00:00

  • Transforming activities of human CSF-1 receptors with different point mutations at codon 301 in their extracellular domains.

    abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Roussel MF,Downing JR,Sherr CJ

    更新日期：1990-01-01 00:00:00

  • Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha.

    abstract：:A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207723

    authors： Sumigama S,Ito T,Kajiyama H,Shibata K,Tamakoshi K,Kikkawa F,Williams T,Tainsky MA,Nomura S,Mizutani S

    更新日期：2004-07-15 00:00:00

  • Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21.

    abstract：:The death mediator caspase acts as the dominant regulator during cell death induction. The CPP32 subfamily, including caspase 3 (CPP32/Yama/Apopain), is essential for the cell death signaling. We recently reported that activation of caspase 3 is regulated by complex formation with p21 or ILP. In the present study, we ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202409

    authors： Suzuki A,Tsutomi Y,Miura M,Akahane K

    更新日期：1999-02-04 00:00:00

  • Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein.

    abstract：:Cell cycle checkpoints and tumor suppressor gene functions appear to be required for the maintenance of a stable genome in proliferating cells. In this study chromosomal destabilization was monitored in relation to telomere structure, lifespan control and G2 checkpoint function. Replicative senescence was inactivated ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201711

    authors： Filatov L,Golubovskaya V,Hurt JC,Byrd LL,Phillips JM,Kaufmann WK

    更新日期：1998-04-09 00:00:00

  • The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix.

    abstract：:The cellular transcription factor Brn-3a differentially regulates different human papilloma virus (HPV)-16 variants that are associated with different risks of progression to cervical carcinoma in infected humans. The upstream regulatory regions (URRs) of high- and intermediate-risk HPV-16 variants are activated by th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.33

    authors： Ndisang D,Khan A,Lorenzato F,Sindos M,Singer A,Latchman DS

    更新日期：2010-05-06 00:00:00

  • Hypervariable allelic expression patterns of the imprinted IGF2 gene in tumor cells.

    abstract：:The IGF2 gene, which encodes a growth factor, is subject to genomic imprinting. The frequently observed loss of IGF2 imprinting in a variety of tumors has been suggested to contribute to neoplasia. Since these reports have not documented the imprinting status of IGF2 at the cellular level, it cannot be excluded that t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201501

    authors： He L,Cui H,Walsh C,Mattsson R,Lin W,Anneren G,Pfeifer-Ohlsson S,Ohlsson R

    更新日期：1998-01-08 00:00:00

  • The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus.

    abstract：:BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA). Here we report that transcription inhibition can be alleviated by interferon treatment and the degradati...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209245

    authors： Marchetti B,Ashrafi GH,Dornan ES,Araibi EH,Ellis SA,Campo MS

    更新日期：2006-04-06 00:00:00

  • Cloning and structural analysis of the human c-kit gene.

    abstract：:The recent identification of the mouse White spotting and Steel loci as genes encoding the c-kit receptor and its ligand, respectively, has shed light on the importance of this ligand and receptor in embryogenesis, melanogenesis and hematopoiesis. In order to determine if the c-kit proto-oncogene is involved in human ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Vandenbark GR,deCastro CM,Taylor H,Dew-Knight S,Kaufman RE

    更新日期：1992-07-01 00:00:00

  • Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.

    abstract：:Activating mutations of K-ras are frequent in colon tumors and aberrant crypt foci, and may play important roles in colon carcinogenesis. Here, we investigated the effects of a K-ras codon 12 mutation on inducible nitric oxide synthase (iNOS) expression. When rat intestinal epithelial cells (IEC-6) were transfected wi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207051

    authors： Takahashi M,Mutoh M,Shoji Y,Kamanaka Y,Naka M,Maruyama T,Sugimura T,Wakabayashi K

    更新日期：2003-10-23 00:00:00

  • Lineage specific demethylation of tal-1 gene breakpoint region determines the frequency of tal-1 deletions in alpha beta lineage T-cells.

    abstract：:tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineage T-ALL with TcR-delta...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Breit TM,Wolvers-Tettero IL,van Dongen JJ

    更新日期：1994-07-01 00:00:00

  • Loss of heterozygosity of chromosome 17 in human borderline and invasive epithelial ovarian tumors.

    abstract：:Polymerase chain reaction (PCR) analysis of microsatellite polymorphisms corresponding to four loci which map to chromosome 17p and 11 loci which map to chromosome 17q was performed to screen for loss of heterozygosity (LOH) in paired normal and tumor tissues from 27 cases of borderline epithelial ovarian tumors (BEOT...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Wertheim I,Tangir J,Muto MG,Welch WR,Berkowitz RS,Chen WY,Mok SC

    更新日期：1996-05-16 00:00:00

  • Random mutagenesis of PDZ(Omi) domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis.

    abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206359

    authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

    更新日期：2003-05-08 00:00:00

  • NF-kB2 induces senescence bypass in melanoma via a direct transcriptional activation of EZH2.

    abstract：:Enhancer of Zeste homologue 2 (EZH2) belongs to the polycomb repressive complex 2 and catalyzes the methylation of histone H3 lysine 27. These pivotal epigenetic marks are altered in many cancers, including melanoma, as a result of EZH2 overexpression. Here, we show that the non-canonical-NF-kB pathway accounts for mo...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.331

    authors： De Donatis GM,Le Pape E,Pierron A,Cheli Y,Hofman V,Hofman P,Allegra M,Zahaf K,Bahadoran P,Rocchi S,Bertolotto C,Ballotti R,Passeron T

    更新日期：2016-05-01 00:00:00

  • Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase.

    abstract：:We have identified a novel mechanism of cross-talk between cell signaling and metabolic pathways, whereby the signaling kinase p21-activated kinase 1 (Pak1) binds to, phosphorylates and enhances the enzymatic activity of phosphoglucomutase 1 (PGM), an important regulatory enzyme in cellular glucose utilization and ene...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207969

    authors： Gururaj A,Barnes CJ,Vadlamudi RK,Kumar R

    更新日期：2004-10-21 00:00:00

  • The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein.

    abstract：:The products of the proto-oncogenes c-jun and c-fos are known to form a complex in vivo. Complex formation appears to stabilize protein-DNA interactions and is thought to play an important functional role in transcriptional regulation. Here we show that the viral Jun oncoprotein, which differs structurally from cellul...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Bos TJ,Rauscher FJ 3rd,Curran T,Vogt PK

    更新日期：1989-02-01 00:00:00

  • A 5'-CG-3'-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues.

    abstract：:In a large proportion of familial and sporadic cases of Hirschsprung disease (HSCR) mutations in the RET (rearranged during transfection) protooncogene have been described. We have investigated the structure of the RET gene promoter and have analysed a region of approximately 1000 nucleotides in its promoter and 5'-up...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202165

    authors： Munnes M,Patrone G,Schmitz B,Romeo G,Doerfler W

    更新日期：1998-11-19 00:00:00

  • Dominant negative Met reduces tumorigenicity-metastasis and increases tubule formation in mammary cells.

    abstract：:Activation of the Met tyrosine kinase growth factor receptor by its ligand HGF/SF has been shown to increase in vitro invasiveness in epithelial cell lines. To study the effect of Met-HGF/SF signaling in breast cancer cells, we transfected met, hgf/sf and dominant negative (DN) forms of met into the poorly differentia...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203557

    authors： Firon M,Shaharabany M,Altstock RT,Horev J,Abramovici A,Resau JH,Vande Woude GF,Tsarfaty I

    更新日期：2000-05-11 00:00:00

  • Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.

    abstract：:The nuclear transport receptor importin-β/karyopherin-β1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic transport, importin-β regulates mitosis, but the programmes and pathways i...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0989-x

    authors： Verrico A,Rovella P,Di Francesco L,Damizia M,Staid DS,Le Pera L,Schininà ME,Lavia P

    更新日期：2020-01-01 00:00:00