p53, mutation frequency and apoptosis in the murine small intestine.

abstract：:Overexpression of the receptor tyrosine kinase ERBB2 (also known as HER2) occurs in around 15% of breast cancers and is driven by amplification of the ERBB2 gene. ERBB2 amplification is a marker of poor prognosis, and although anti-ERBB2-targeted therapies have shown significant clinical benefit, de novo and acquired ...

journal_title：Oncogene

authors： Shiu KK,Wetterskog D,Mackay A,Natrajan R,Lambros M,Sims D,Bajrami I,Brough R,Frankum J,Sharpe R,Marchio C,Horlings H,Reyal F,van der Vijver M,Turner N,Reis-Filho JS,Lord CJ,Ashworth A

更新日期：2014-01-30 00:00:00

abstract：:ID4 gene is a member of the inhibitor of DNA-binding (ID) family, which inhibits DNA binding of basic helix-loop-helix transcription factors. Certain human primary breast cancers reportedly have low or no expression of ID4 protein, but its role in carcinogenesis and cancer progression is unknown. To determine its poss...

journal_title：Oncogene

authors： Umetani N,Mori T,Koyanagi K,Shinozaki M,Kim J,Giuliano AE,Hoon DS

更新日期：2005-07-07 00:00:00

abstract：:EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...

journal_title：Oncogene

authors： Squatrito M,Mancino M,Donzelli M,Areces LB,Draetta GF

更新日期：2004-05-27 00:00:00

abstract：:Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Ju...

journal_title：Oncogene

authors： Venugopal R,Jaiswal AK

更新日期：1998-12-17 00:00:00

abstract：:Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...

journal_title：Oncogene

authors： Qing J,Wei D,Maher VM,McCormick JJ

更新日期：1999-01-14 00:00:00

abstract：:The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes three members, Rb/p105, p107 ...

journal_title：Oncogene

authors： Giacinti C,Giordano A

更新日期：2006-08-28 00:00:00

abstract：:The maintenance of genomic stability is one of the most important defenses against neoplastic transformation. This objective must be accomplished despite a constant barrage of spontaneous DNA double strand breaks. These dangerous lesions are corrected by two primary pathways of double strand break repair; non homologo...

journal_title：Oncogene

authors： Ferguson DO,Alt FW

更新日期：2001-09-10 00:00:00

abstract：:Loss of RASSF1A leads to several mitotic abnormalities, including cytokinesis failure and tetraploidization. Uncontrolled proliferation of tetraploid cells is known to trigger genomic instability and tumor development and is normally prevented through activation of a p53-dependent tetraploidy checkpoint. RASSF1A is th...

journal_title：Oncogene

authors： Tommasi S,Besaratinia A,Wilczynski SP,Pfeifer GP

更新日期：2011-02-10 00:00:00

abstract：:Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...

journal_title：Oncogene

authors： Rea S,Xouri G,Akhtar A

更新日期：2007-08-13 00:00:00

abstract：:The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...

journal_title：Oncogene

authors： Yu L,Dong L,Li H,Liu Z,Luo Z,Duan G,Dai X,Lin Z

更新日期：2020-05-01 00:00:00

abstract：:Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...

journal_title：Oncogene

authors： Sivak LE,Tai KF,Smith RS,Dillon PA,Brodeur GM,Carroll WL

更新日期：1997-10-16 00:00:00

abstract：:The p53 transcription factor has a critical role in cell stress response and in tumor suppression. Wild-type p53 protein is a growth modulator and its inactivation is a critical event in malignant transformation. It has been recently demonstrated that wild-type p53 has developmental and differentiation functions. Inde...

journal_title：Oncogene

authors： Terrinoni A,Pagani IS,Zucchi I,Chiaravalli AM,Serra V,Rovera F,Sirchia S,Dionigi G,Miozzo M,Frattini A,Ferrari A,Capella C,Pasquali F,Curto FL,Albertini A,Melino G,Porta G

更新日期：2011-07-07 00:00:00

abstract：:Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...

journal_title：Oncogene

authors： Chatain N,Ziegler P,Fahrenkamp D,Jost E,Moriggl R,Schmitz-Van de Leur H,Müller-Newen G

更新日期：2013-08-01 00:00:00

abstract：:Activation of hypoxia-inducible factor (HIF) is due to loss of von Hippel-Lindau protein (pVHL) function in most clear cell renal cell carcinomas (ccRCCs). Here we describe a novel pVHL-independent mechanism of HIF regulation and identify nuclear factor (NF)-κB essential modulator (NEMO) as a hitherto unknown oncogeni...

journal_title：Oncogene

authors： Nowicka AM,Häuselmann I,Borsig L,Bolduan S,Schindler M,Schraml P,Heikenwalder M,Moch H

更新日期：2016-06-16 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:The p53 protein is known to play a central role in mediating G1 arrest or apoptosis in response to ionizing radiation in some cell types. It has been proposed that the link between p53 and induction of apoptosis is provided in part by p53-mediated upregulation of BAX. In this study, we used the human SW626 ovarian can...

journal_title：Oncogene

authors： Strobel T,Swanson L,Korsmeyer S,Cannistra SA

更新日期：1997-06-12 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-...

journal_title：Oncogene

authors： Clark J,Benjamin H,Gill S,Sidhar S,Goodwin G,Crew J,Gusterson BA,Shipley J,Cooper CS

更新日期：1996-01-18 00:00:00

abstract：:E1A of human adenovirus type 5 (Ad5) encodes proteins of 289 and 243 residues (289R and 243R) which differ only by the 46 amino acid CR3 region known to activate expression of certain cellular and early viral genes. E1A proteins also induce DNA synthesis and cell transformation, but as well can stimulate apoptosis. Tw...

journal_title：Oncogene

authors： Teodoro JG,Shore GC,Branton PE

更新日期：1995-08-03 00:00:00

abstract：:Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ...

journal_title：Oncogene

authors： Fukuzawa R,Anaka MR,Weeks RJ,Morison IM,Reeve AE

更新日期：2009-02-26 00:00:00

abstract：:Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is highly overexpressed in invasive breast carcinomas. The function and reg...

journal_title：Oncogene

authors： Li T,Lu H,Shen C,Lahiri SK,Wason MS,Mukherjee D,Yu L,Zhao J

更新日期：2014-09-25 00:00:00

abstract：:The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...

journal_title：Oncogene

authors： Tsuchida R,Das B,Yeger H,Koren G,Shibuya M,Thorner PS,Baruchel S,Malkin D

更新日期：2008-06-26 00:00:00

abstract：:Members of the ErbB family of receptors have been implicated in regulation of androgen receptor (AR) activity. Ebp1, an ErbB-3 binding protein recently cloned in our laboratory, possesses an LXXLL motif important in mediating interactions with nuclear hormone receptors. Therefore, we sought to determine if Ebp1 could ...

journal_title：Oncogene

authors： Zhang Y,Fondell JD,Wang Q,Xia X,Cheng A,Lu ML,Hamburger AW

更新日期：2002-08-15 00:00:00

abstract：:Osteoclasts are multinuclear bone-resorbing cells that differentiate from hematopoietic precursor cells. Prostate cancer cells frequently spread to bone and secrete soluble signaling factors to accelerate osteoclast differentiation and bone resorption. However, processes and mechanisms that govern the expression of os...

journal_title：Oncogene

authors： Kim JM,Shin Y,Lee S,Kim MY,Punj V,Shin HI,Kim K,Koh JM,Jeong D,An W

更新日期：2018-10-01 00:00:00

abstract：:Defining apoptosis-regulatory cascades of the epithelium is important for understanding carcinogenesis, since cancer cells are considered to arise as a result of the collapse of the cascades. We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lin...

journal_title：Oncogene

authors： Saeki N,Kim DH,Usui T,Aoyagi K,Tatsuta T,Aoki K,Yanagihara K,Tamura M,Mizushima H,Sakamoto H,Ogawa K,Ohki M,Shiroishi T,Yoshida T,Sasaki H

更新日期：2007-10-04 00:00:00

abstract：:Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we positioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted region. We now report a high frequency (>65%) of missense mutation at codon 235 in the DNA-bin...

journal_title：Oncogene

authors： Suraweera N,Meijne E,Moody J,Carvajal-Carmona LG,Yoshida K,Pollard P,Fitzgibbon J,Riches A,van Laar T,Huiskamp R,Rowan A,Tomlinson IP,Silver A

更新日期：2005-05-19 00:00:00

abstract：:To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive hybridization and cDNA microarray to analyse the expression profiles of 2400 cDNAs clones. Genes that are over-expressed in SCLC were identified using 32 pairs of fluoresce...

journal_title：Oncogene

authors： Bangur CS,Switzer A,Fan L,Marton MJ,Meyer MR,Wang T

更新日期：2002-05-23 00:00:00

abstract：:ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain...

journal_title：Oncogene

authors： Hodge DR,Robinson L,Watson D,Lautenberger J,Zhang XK,Venanzoni M,Seth A

更新日期：1996-01-04 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...

journal_title：Oncogene

authors： Li YL,Wu LW,Zeng LH,Zhang ZY,Wang W,Zhang C,Lin NM

更新日期：2020-09-01 00:00:00

abstract：:We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protein during murine erythroleukemia (MEL) cell differentiation. In the present work, we demonstrated that YY-1 and...

journal_title：Oncogene

authors： Zhao JH,Inoue T,Shoji W,Nemoto Y,Obinata M

更新日期：1998-08-27 00:00:00