当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.

ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.

Abstract：

:Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches to inhibit angiogenesis and metastasis may potentially lead to a better therapeutic option for ccRCC. Among all the types of cancer, renal cancer samples exhibited the maximum upregulation of ApoC1 as referred to in the Oncomine database. The expression of ApoC1 was increased accompanied by ccRCC progression. A high level of ApoC1 was closely related to poor survival time in ccRCC patients. Furthermore, ApoC1 was over-expressed in the highly invasive ccRCC cells as compared to that in the low-invasive ccRCC cells. Besides, ApoC1 promoted metastasis of ccRCC cells via EMT pathway, whereas depletion of ApoC1 alleviated these effects. ApoC1 as a novel pro-metastatic factor facilitates the activation of STAT3 and enhances the metastasis of ccRCC cells. Meanwhile, ApoC1 in the exosomes were transferred from the ccRCC cells to the vascular endothelial cells and promoted metastasis of the ccRCC cells via activating STAT3. Finally, the metastatic potential of the ccRCC cells driven by ApoC1 was suppressed by DPP-4 inhibition. Our study not only identifies a novel ApoC1-STAT3 pathway in ccRCC metastasis but also provides direction for the exploration of novel strategies to predict and treat metastatic ccRCC in the future.

journal_name

Oncogene

journal_title

Oncogene

authors

Li YL,Wu LW,Zeng LH,Zhang ZY,Wang W,Zhang C,Lin NM

doi

10.1038/s41388-020-01428-3

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

6203-6217

issue

39

eissn

0950-9232

issn

1476-5594

pii

10.1038/s41388-020-01428-3

journal_volume

39

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using Suppression Subtractive Hybridization.

    abstract：:Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209305

    authors： Colin C,Baeza N,Bartoli C,Fina F,Eudes N,Nanni I,Martin PM,Ouafik L,Figarella-Branger D

    更新日期：2006-05-04 00:00:00

  • Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas.

    abstract：:Expression of neurotrophin receptors of the tyrosine kinase receptor (Trk) family is an important prognostic factor in solid tumors including neuroblastoma. High expression of TrkA (NTRK1) is associated with a favorable biology and outcome of neuroblastoma, whereas TrkB (NTRK2) is expressed on aggressive neuroblastoma...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208000

    authors： Schulte JH,Schramm A,Klein-Hitpass L,Klenk M,Wessels H,Hauffa BP,Eils J,Eils R,Brodeur GM,Schweigerer L,Havers W,Eggert A

    更新日期：2005-01-06 00:00:00

  • High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities.

    abstract：:Soft tissue sarcomas are a heterogeneous group of neoplasms with various histological subtypes. Up to now, no individual causal molecular markers for prognosis and therapeutic success have been identified. A tumorigenic connection between the oncogene product Mdm2 and tumor suppressor p53 is generally accepted, but th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201646

    authors： Würl P,Meye A,Schmidt H,Lautenschläger C,Kalthoff H,Rath FW,Taubert H

    更新日期：1998-03-05 00:00:00

  • RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts.

    abstract：:The RNA-binding motif (RRM) gene on Y chromosome (RBMY), encoding a male germ cell-specific RNA-binding protein associated with spermatogenesis, was found inserted by hepatitis B virus (HBV) DNA in one childhood hepatocellular carcinoma (HCC). This study is aimed to explore the oncogenic potential of the RBMY protein....

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207773

    authors： Tsuei DJ,Hsu HC,Lee PH,Jeng YM,Pu YS,Chen CN,Lee YC,Chou WC,Chang CJ,Ni YH,Chang MH

    更新日期：2004-07-29 00:00:00

  • Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction.

    abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207219

    authors： Kuang C,Chen Y

    更新日期：2004-02-05 00:00:00

  • MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.

    abstract：:Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.123

    authors： Zhai Y,Iura A,Yeasmin S,Wiese AB,Wu R,Feng Y,Fearon ER,Cho KR

    更新日期：2011-10-06 00:00:00

  • Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).

    abstract：:The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Bougeret C,Rothhut B,Jullien P,Fischer S,Benarous R

    更新日期：1993-05-01 00:00:00

  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny.

    abstract：:Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or alterations of chromatin structure. There is a growing consensus tha...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Pandita TK,Hall EJ,Hei TK,Piatyszek MA,Wright WE,Piao CQ,Pandita RK,Willey JC,Geard CR,Kastan MB,Shay JW

    更新日期：1996-10-03 00:00:00

  • ACTL6A suppresses p21Cip1 expression to enhance the epidermal squamous cell carcinoma phenotype.

    abstract：:Epidermal squamous cell carcinoma (SCC) is a common and highly invasive form of cancer. SCC arises due to ultraviolet light exposure and is associated with increased expression of pro-cancer genes and reduced expression of cancer suppressors. Actin-Like Protein 6A (ACTL6A, BAF53a) is an important protein subunit of th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-1371-8

    authors： Shrestha S,Adhikary G,Xu W,Kandasamy S,Eckert RL

    更新日期：2020-09-01 00:00:00

  • p23rab2, a ras-like GTPase with a -GGGCC C-terminus, is isoprenylated but not detectably carboxymethylated in NIH3T3 cells.

    abstract：:With the development of a specific anti-rab2 antiserum, p23rab2, a ras-like GTPase with a -GGGCC C-terminus, has been localized mainly to the particulate (P100) fraction in NIH3T3 cells, although a small amount of this protein also appears in the soluble fraction. The endogenous p23rab2 is isoprenylated in intact cell...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Wei C,Lutz R,Sinensky M,Macara IG

    更新日期：1992-03-01 00:00:00

  • Isolation of expressed sequences that include a gene for familial breast cancer (BRCA2) and other novel transcripts from a five megabase region on chromosome 13q12.

    abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

    journal_title：Oncogene

    pub_type：

    doi：

    authors： Jacob AN,Kandpal G,Kandpal RP

    更新日期：1996-07-04 00:00:00

  • The role of Gads in hematopoietic cell signalling.

    abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1204771

    authors： Liu SK,Berry DM,McGlade CJ

    更新日期：2001-10-01 00:00:00

  • Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium.

    abstract：:The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overe...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201731

    authors： Sun L,Carpenter G

    更新日期：1998-04-23 00:00:00

  • Binding of the corepressor TLE1 to Qin enhances Qin-mediated transformation of chicken embryo fibroblasts.

    abstract：:The oncoprotein Qin is a member of the winged helix family of transcriptional regulators. The region C-terminal to its winged helix DNA-binding domain is required for transformation of chicken embryo fibroblasts. We isolated the corepressor TLE1 as a binding partner for Qin in a yeast two-hybrid screen and localized t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206308

    authors： Sonderegger CK,Vogt PK

    更新日期：2003-03-27 00:00:00

  • Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma.

    abstract：:Tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (TRAIL-R1) and tumor necrosis factor-related apoptosis-inducing ligand-receptor 2 (TRAIL-R2) are cell-surface receptors involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. TRAIL-R1 and TRAIL-R2 gene...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204103

    authors： Lee SH,Shin MS,Kim HS,Lee HK,Park WS,Kim SY,Lee JH,Han SY,Park JY,Oh RR,Kang CS,Kim KM,Jang JJ,Nam SW,Lee JY,Yoo NJ

    更新日期：2001-01-18 00:00:00

  • Chromosomal imbalances in human lung cancer.

    abstract：:A wealth of cytogenetic data has demonstrated that numerous somatic genetic changes are involved in the pathogenesis of human lung cancer. Despite the complexity of the genomic changes observed in these neoplasms, recurrent chromosomal patterns have emerged. In this review, we summarize chromosomal alterations identif...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1205836

    authors： Balsara BR,Testa JR

    更新日期：2002-10-07 00:00:00

  • Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.

    abstract：:Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.338

    authors： Schoeneberger H,Belz K,Schenk B,Fulda S

    更新日期：2015-07-30 00:00:00

  • Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.

    abstract：:The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine kinases. The two SH3 domains are separated by a 54 amino acid linker region, whose length is highly conserved in xenopus, chicken, and mamalian Crk II proteins. To g...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204173

    authors： Zvara A,Fajardo JE,Escalante M,Cotton G,Muir T,Kirsch KH,Birge RB

    更新日期：2001-02-22 00:00:00

  • Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.

    abstract：:The candidate proto-oncogene BCL3 was isolated through its involvement in the t(14;19) found in chronic lymphocytic leukemia and other B-cell neoplasms. As a member of the I kappaB family, BCL3 plays a role in the immune response by interactions with the NF-kappaB family of transcription factors. In order to study the...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201771

    authors： Ong ST,Hackbarth ML,Degenstein LC,Baunoch DA,Anastasi J,McKeithan TW

    更新日期：1998-05-07 00:00:00

  • Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells.

    abstract：:The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 with pSV2neo into the ben...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201948

    authors： Lloyd BH,Platt-Higgins A,Rudland PS,Barraclough R

    更新日期：1998-07-30 00:00:00

  • PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors.

    abstract：:Transmembrane tyrosine kinases are involved in the control of cell growth and differentiation by extracellular signals. To enable identification of new receptor tyrosine kinases we developed a method that selectively amplifies segments of receptor genes. The method is based on a combination of polymerase chain reactio...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Raz V,Kelman Z,Avivi A,Neufeld G,Givol D,Yarden Y

    更新日期：1991-05-01 00:00:00

  • The p53 knowledgebase: an integrated information resource for p53 research.

    abstract：:The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in one of several ways, that is, cell cycle arrest, senescence or programmed cell death (apoptosis). Mutations in...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209952

    authors： Lim YP,Lim TT,Chan YL,Song AC,Yeo BH,Vojtesek B,Coomber D,Rajagopal G,Lane D

    更新日期：2007-03-08 00:00:00

  • DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways.

    abstract：:Mammalian Vav signal transducer proteins couple receptor tyrosine kinase signals to the activation of the Rho/Rac GTPases, leading to cell differentiation and/or proliferation. The unique and complex structure of mammalian Vav proteins is preserved in the Drosophila melanogaster homologue, DroVav. We demonstrate that ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207027

    authors： Hornstein I,Mortin MA,Katzav S

    更新日期：2003-10-02 00:00:00

  • Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer.

    abstract：:Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells, overactivation of mTOR has been reported. In addition, mTOR inhibitors, such as rapamycin and its derivatives, are being evaluated ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.28

    authors： Sato T,Nakashima A,Guo L,Coffman K,Tamanoi F

    更新日期：2010-05-06 00:00:00

  • Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP.

    abstract：:YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes. The Amot-mediated retention of YAP in the cytoplasm results in the inhibition of its ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.216

    authors： Oka T,Schmitt AP,Sudol M

    更新日期：2012-01-05 00:00:00

  • The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter.

    abstract：:We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201660

    authors： Voz ML,Aström AK,Kas K,Mark J,Stenman G,Van de Ven WJ

    更新日期：1998-03-01 00:00:00

  • New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin.

    abstract：:Telomeres are stabilized, and telomeric DNA is replenished, by the action of the ribonucleoprotein reverse transcriptase telomerase. Telomere capping functions include the ability of telomeres to protect chromosome ends from cellular DNA-damage responses such as cell cycle arrest or apoptosis. This property of telomer...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1205082

    authors： Chan SW,Blackburn EH

    更新日期：2002-01-21 00:00:00

  • Rearrangements of minisatellites in the human telomerase reverse transcriptase gene are not correlated with its expression in colon carcinomas.

    abstract：:Telomerase activation is crucial in human carcinogenesis. The limiting component of telomerase, the catalytic subunit (hTERT), is undetectable in normal somatic cells but present in most tumor cells, including the earliest stages of colon carcinoma. The mechanisms involved in the differential expression in normal and ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204346

    authors： Szutorisz H,Palmqvist R,Roos G,Stenling R,Schorderet DF,Reddel R,Lingner J,Nabholz M

    更新日期：2001-05-03 00:00:00

  • p53 compound heterozygosity in a severely affected child with Li-Fraumeni syndrome.

    abstract：:The Li-Fraumeni Syndrome (LFS) is a rare, dominantly inherited syndrome that features high risk of cancers in childhood and early adulthood. Affected families tend to develop bone and soft tissue sarcomas, breast cancers, brain tumors, leukemias, and adrenocortical carcinomas. In some kindreds, the genetic abnormality...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202783

    authors： Quesnel S,Verselis S,Portwine C,Garber J,White M,Feunteun J,Malkin D,Li FP

    更新日期：1999-07-08 00:00:00

  • Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling.

    abstract：:Tumors of low malignant potential (LMP) represent 20% of epithelial ovarian cancers (EOCs) and are associated with a better prognosis than the invasive tumors (TOV). Defining the relationship between LMPs and TOVs remains an important goal towards understanding the molecular pathways that contribute to prognosis, as w...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208214

    authors： Ouellet V,Provencher DM,Maugard CM,Le Page C,Ren F,Lussier C,Novak J,Ge B,Hudson TJ,Tonin PN,Mes-Masson AM

    更新日期：2005-07-07 00:00:00