MicroRNAs as potential cancer therapeutics.

abstract：:The NRG4 gene is a member of a family of four genes that encode a class of epidermal growth factors. This gene has been reported to express a protein designated here as NRG4A1. We describe here a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding ...

journal_title：Oncogene

authors： Hayes NV,Newsam RJ,Baines AJ,Gullick WJ

更新日期：2008-01-24 00:00:00

abstract：:The role of intracellular Ca2+ pools in the regulation of growth factor signal transduction pathways and mitogenesis is not well understood. We have examined the roles of basal and transiently mobilized Ca2+ in the regulation of MAP kinases by EGF. To assess the influence of Ca2+ transients we utilized Plcg1-/- and Pl...

journal_title：Oncogene

authors： Ji QS,Carpenter G

更新日期：2000-03-30 00:00:00

abstract：:Collagenase1 (MMP1) and stromelysin1 (MMP3) are extracellular proteolytic enzymes that degrade connective tissue macromolecules and basement membranes. Both genes are regulated by the Ets and Fos/Jun families of transcription factors/oncoproteins. Here, we show that two members of the Ets-family, Ets2 and Erg and thei...

journal_title：Oncogene

authors： Butticè G,Duterque-Coquillaud M,Basuyaux JP,Carrère S,Kurkinen M,Stéhelin D

更新日期：1996-12-05 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Activated TbetaRI then mediates TGF-beta signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize ...

journal_title：Oncogene

authors： Kleeff J,Ishiwata T,Maruyama H,Friess H,Truong P,Büchler MW,Falb D,Korc M

更新日期：1999-09-23 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) is a dynamic transcription factor that regulates important biological processes involved in cancer initiation and progression. Identifying regulators that control the half-life of NF-kappaB is important to understanding molecular processes that control the duration of transcriptional ...

journal_title：Oncogene

authors： Ramsey CS,Yeung F,Stoddard PB,Li D,Creutz CE,Mayo MW

更新日期：2008-06-05 00:00:00

abstract：:Two hepatocarcinoma cell lines, the Hepa-1 wild-type (c1c7) and the beta-subunit mutated (c4) lacking hypoxia-inducible factor-1 (HIF-1) activity, were differentially susceptible to apoptosis by hepatocyte growth factor (HGF). The c4 cells were 40% apoptotic 48 h after HGF treatment. On the contrary, the wild-type c1c...

journal_title：Oncogene

authors： Matteucci E,Modora S,Simone M,Desiderio MA

更新日期：2003-06-26 00:00:00

abstract：:The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding act...

journal_title：Oncogene

authors： Gilladoga AD,Edelhoff S,Blackwood EM,Eisenman RN,Disteche CM

更新日期：1992-06-01 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:Nerve growth factor (NGF)- and ras-induced neuronal differentiation of PC12 cells is accompanied by expression of transin, a secreted metalloproteinase. Retinoic acid (RA) is known to exert important effects on neural cell proliferation and differentiation. In this study we have analysed different PC12 sublines which ...

journal_title：Oncogene

authors： Cosgaya JM,Recio JA,Aranda A

更新日期：1997-04-10 00:00:00

abstract：:We recently reported the cloning and overexpression of full-length forms of human fibroblast growth factor (FGF) receptors, bek and flg. These receptors contain three immunoglobulin (Ig)-like domains and an unusual acidic motif in the extracellular region, a single transmembrane segment and a protein tyrosine kinase c...

journal_title：Oncogene

authors： Crumley G,Bellot F,Kaplow JM,Schlessinger J,Jaye M,Dionne CA

更新日期：1991-12-01 00:00:00

abstract：:Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemota...

journal_title：Oncogene

authors： Williams KC,Cepeda MA,Javed S,Searle K,Parkins KM,Makela AV,Hamilton AM,Soukhtehzari S,Kim Y,Tuck AB,Ronald JA,Foster PJ,Chambers AF,Leong HS

更新日期：2019-05-01 00:00:00

abstract：:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological ma...

journal_title：Oncogene

authors： Hawkins ED,Oliaro J,Ramsbottom KM,Newbold A,Humbert PO,Johnstone RW,Russell SM

更新日期：2016-03-03 00:00:00

abstract：:Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or alterations of chromatin structure. There is a growing consensus tha...

journal_title：Oncogene

authors： Pandita TK,Hall EJ,Hei TK,Piatyszek MA,Wright WE,Piao CQ,Pandita RK,Willey JC,Geard CR,Kastan MB,Shay JW

更新日期：1996-10-03 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. In order to investigate the role of p16 gene in the tumorigenesis of hepatocellular carcinoma (HCC), 48 cases of HCC were analysed for p16 alterations...

journal_title：Oncogene

authors： Liew CT,Li HM,Lo KW,Leow CK,Chan JY,Hin LY,Lau WY,Lai PB,Lim BK,Huang J,Leung WT,Wu S,Lee JC

更新日期：1999-01-21 00:00:00

abstract：:Recently, various cDNA sequences coding protein-tyrosine phosphatases (PTPs) have been reported and their extensive similarities in the catalytic domains clarified, but knowledge of the structures and organizations of their genes is still limited. In this study, a detailed structure and organization of the human intra...

journal_title：Oncogene

authors： Adachi M,Miyachi T,Sekiya M,Hinoda Y,Yachi A,Imai K

更新日期：1994-10-01 00:00:00

abstract：:Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...

journal_title：Oncogene

authors： Chu Y,Chen Y,Guo H,Li M,Wang B,Shi D,Cheng X,Guan J,Wang X,Xue C,Cheng T,Shi J,Yuan W

更新日期：2020-12-01 00:00:00

abstract：:Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway i...

journal_title：Oncogene

authors： Zhang X,Yang L,Szeto P,Abali GK,Zhang Y,Kulkarni A,Amarasinghe K,Li J,Vergara IA,Molania R,Papenfuss AT,McLean C,Shackleton M,Harvey KF

更新日期：2020-07-01 00:00:00

abstract：:Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One way they do this is by increasing the expression of anti-apoptotic BCL-2 proteins. Anti-apoptotic BCL-2 family proteins antagonize death signaling by forming he...

journal_title：Oncogene

authors： Ni Chonghaile T,Letai A

更新日期：2008-12-01 00:00:00

abstract：:p27Kip1 is a regulator of the mammalian cell cycle and a putative tumor suppressor. Distinct altered patterns of p27Kip1 protein expression are found in a variety of human carcinomas, and p27Kip1 expression levels usually correlate directly with disease-free survival. The mechanism(s) by which p27Kip1 expression is re...

journal_title：Oncogene

authors： Worm J,Bartkova J,Kirkin AF,Straten P,Zeuthen J,Bartek J,Guldberg P

更新日期：2000-10-19 00:00:00

abstract：:Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 rec...

journal_title：Oncogene

authors： Dirmeier U,Hoffmann R,Kilger E,Schultheiss U,Briseño C,Gires O,Kieser A,Eick D,Sugden B,Hammerschmidt W

更新日期：2005-03-03 00:00:00

abstract：:Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, a...

journal_title：Oncogene

authors： Dawson DW,Hong JS,Shen RR,French SW,Troke JJ,Wu YZ,Chen SS,Gui D,Regelson M,Marahrens Y,Morse HC 3rd,Said J,Plass C,Teitell MA

更新日期：2007-06-21 00:00:00

abstract：:The p160 nuclear receptor co-activators represent a family of molecules, which are recruited by steroid nuclear receptors as well as other transcription factors that are overexpressed in several tumors. We investigated the role of one member of this family on the sensitivity of cells to apoptosis. We observed that ove...

journal_title：Oncogene

authors： Colo GP,Rubio MF,Nojek IM,Werbajh SE,Echeverría PC,Alvarado CV,Nahmod VE,Galigniana MD,Costas MA

更新日期：2008-04-10 00:00:00

abstract：:The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...

journal_title：Oncogene

authors： Nguyen-Lefebvre AT,Leprun G,Morin V,Viñuelas J,Couté Y,Madjar JJ,Gandrillon O,Gonin-Giraud S

更新日期：2014-03-20 00:00:00

abstract：:The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo. T...

journal_title：Oncogene

authors： Robinson JP,Vanbrocklin MW,Lastwika KJ,McKinney AJ,Brandner S,Holmen SL

更新日期：2011-03-17 00:00:00

abstract：:Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatments while minimizing injury to surrounding normal tissue is an important clinical goal. Due to their sequence-derived specificity and properties as gene regulators in IR-affected pathways, microRNAs (miRNAs) coul...

journal_title：Oncogene

authors： Metheetrairut C,Adams BD,Nallur S,Weidhaas JB,Slack FJ

更新日期：2017-01-26 00:00:00

abstract：:B-Myb, a highly conserved member of the Myb oncoprotein family, is a 110 kDa sequence-specific DNA binding protein expressed in virtually all proliferating cells. B-myb expression reaches its maximum at the G1/S phase boundary and during the S phase of the cell cycle. We have previously shown that B-Myb activity is ce...

journal_title：Oncogene

authors： Charrasse S,Carena I,Brondani V,Klempnauer KH,Ferrari S

更新日期：2000-06-15 00:00:00

abstract：:Ras is a major signaling molecule activated by interleukin-6. There have been no published reports, however, that specifically examine the kinetics and percentage of Ras activation in response to IL-6. Model cell lines were used to study activation of N- and K-ras induced by IL-6. All of the myeloma cell lines we test...

journal_title：Oncogene

authors： Rowley M,Van Ness B

更新日期：2002-12-12 00:00:00

abstract：:Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, ...

journal_title：Oncogene

authors： Wang Z,Shi Y,Ying C,Jiang Y,Hu J

更新日期：2021-01-08 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiological processes ranging from neurotransmission to cancer signaling. These receptors are activated by the neurotransmitter, acetylcholine, and the tobacco alkaloid, nicotine. Recently, the gene cluster encoding the alpha3...

journal_title：Oncogene

authors： Improgo MR,Scofield MD,Tapper AR,Gardner PD

更新日期：2010-09-02 00:00:00