Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia.

abstract：:The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...

journal_title：Oncogene

authors： Shamanna RA,Hoque M,Pe'ery T,Mathews MB

更新日期：2013-10-24 00:00:00

abstract：:This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...

journal_title：Oncogene

authors： Noble JR,Rogan EM,Neumann AA,Maclean K,Bryan TM,Reddel RR

更新日期：1996-09-19 00:00:00

abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...

journal_title：Oncogene

authors： Furukawa Y,DeCaprio JA,Belvin M,Griffin JD

更新日期：1991-08-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; however, currently used biomarkers, such as, estrogen receptor-alpha/progesterone receptor (ERα/PR), predict only slightly more than half of the potential responders to AI treatment. To identify novel markers of AI responsi...

journal_title：Oncogene

authors： Moy I,Todorović V,Dubash AD,Coon JS,Parker JB,Buranapramest M,Huang CC,Zhao H,Green KJ,Bulun SE

更新日期：2015-01-15 00:00:00

abstract：:Prothymosin alpha (PT-alpha) is a nuclear protein involved in cell proliferation. Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro. We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library. Northern blot (messenger RNA) ana...

journal_title：Oncogene

authors： Mori M,Barnard GF,Staniunas RJ,Jessup JM,Steele GD Jr,Chen LB

更新日期：1993-10-01 00:00:00

abstract：:The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division...

journal_title：Oncogene

authors： Mishra L,Shetty K,Tang Y,Stuart A,Byers SW

更新日期：2005-08-29 00:00:00

abstract：:rho genes have been found in both lower and higher eucaryotes. They code for proteins of 21 kDa, highly conserved in evolution, which belong to the superfamily of ras GTPases. Among the members of this superfamily there are proteins with a regulatory function, such as ras, and proteins involved in vesicular traffickin...

journal_title：Oncogene

authors： Perona R,Esteve P,Jiménez B,Ballestero RP,Ramón y Cajal S,Lacal JC

更新日期：1993-05-01 00:00:00

abstract：:The p53 tumor suppressor protein is frequently mutated in human tumors. It is thought that the p53 pathway is indirectly impaired in the remaining tumors, for example by overexpression of its important regulators Mdm2 and Mdm4, making them attractive targets for the development of anti-cancer agents. Recent studies ha...

journal_title：Oncogene

authors： Lam S,Lodder K,Teunisse AF,Rabelink MJ,Schutte M,Jochemsen AG

更新日期：2010-04-22 00:00:00

abstract：:We have expressed wild-type and human tumour-derived mutant p53 cDNA genes in the fission yeast Schizosaccharomyces pombe. In the case of one mutant this resulted in a growth arrest of recipient yeast cells. In contrast, wild-type p53 and three other mutant proteins tested did not block outgrowth of colonies. Human an...

journal_title：Oncogene

authors： Wagner P,Simanis V,Maimets T,Keenan E,Addison C,Brain R,Grimaldi M,Sturzbecher HW,Jenkins J

更新日期：1991-09-01 00:00:00

abstract：:Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells (MSCs). The resulting lesions greatly contribute to patient morbidity and mortality, underscoring the need for defining how prostate metastases subvert the MSC-osteob...

journal_title：Oncogene

authors： Cook LM,Frieling JS,Nerlakanti N,McGuire JJ,Stewart PA,Burger KL,Cleveland JL,Lynch CC

更新日期：2019-10-01 00:00:00

abstract：:Our group recently identified Ras homolog member I (ARHI), a novel maternally imprinted tumor suppressor gene that encodes a 26 kDa GTP-binding protein with high homology to Ras and Rap. Unlike other Ras family members, ARHI exhibits several unusual structural and functional properties. ARHI contains a unique 34 amino...

journal_title：Oncogene

authors： Luo RZ,Fang X,Marquez R,Liu SY,Mills GB,Liao WS,Yu Y,Bast RC

更新日期：2003-05-15 00:00:00

abstract：:The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and hepatocellular carcinoma. Furthermore, the NF-kappaB signaling pathway is a potential target for development...

journal_title：Oncogene

authors： Sun B,Karin M

更新日期：2008-10-20 00:00:00

abstract：:SHP-2 protein tyrosine phosphatase plays an important role in activation of the RAS-dependent signaling. Gain-of-function mutations in the PTPN11 gene, which encodes SHP-2, have been found in the leukemia-prone developmental disorder Noonan syndrome as well as sporadic childhood leukemias, indicating that SHP-2 is a b...

journal_title：Oncogene

authors： Miyamoto D,Miyamoto M,Takahashi A,Yomogita Y,Higashi H,Kondo S,Hatakeyama M

更新日期：2008-06-05 00:00:00

abstract：:Transforming growth factor beta (TGFβ) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGFβ signaling maintains epithelial homeostasis, dysregulated TGFβ signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGFβ sign...

journal_title：Oncogene

authors： White RA,Malkoski SP,Wang XJ

更新日期：2010-10-07 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with tumours of both lymphoid and epithelial origin. Whilst a role for EBV latent genes in the development of these malignancies is accepted, it is also possible that viral proteins involved in EBV replication may influence the oncogenic process. BHRF1 is an immediate early prote...

journal_title：Oncogene

authors： Dawson CW,Eliopoulos AG,Dawson J,Young LS

更新日期：1995-01-05 00:00:00

abstract：:In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...

journal_title：Oncogene

authors： Bianchi T,Rufer N,MacDonald HR,Migliaccio M

更新日期：2006-07-06 00:00:00

abstract：:A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci. The deduced amino acid sequence of tek predicts that it encodes a putative receptor tyrosine kinase that ...

journal_title：Oncogene

authors： Dumont DJ,Yamaguchi TP,Conlon RA,Rossant J,Breitman ML

更新日期：1992-08-01 00:00:00

abstract：:We have evaluated the transcriptional activation of a human p21 promoter reporter construct by transfection of BRCA1 expression constructs into tumorigenic and nontumorigenic human breast cell lines. Two cell lines with wildtype p53 (MCF-7 and MCF10A) demonstrated transcriptional activation of the p21 promoter by full...

journal_title：Oncogene

authors： Lu M,Arrick BA

更新日期：2000-12-14 00:00:00

abstract：:Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...

journal_title：Oncogene

authors： Ferreira LM,Hebrant A,Dumont JE

更新日期：2012-09-06 00:00:00

abstract：:Tyrosine kinase receptors have an essential role in various aspects of tumor progression. In particular, epidermal growth factor receptor (EGFR) and its ligands have been implicated in the growth and dissemination of a wide array of human carcinomas. Here, we describe an EGFR-mediated signaling pathway that regulates ...

journal_title：Oncogene

authors： Huang M,Anand S,Murphy EA,Desgrosellier JS,Stupack DG,Shattil SJ,Schlaepfer DD,Cheresh DA

更新日期：2012-05-31 00:00:00

abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...

journal_title：Oncogene

authors： Shtrichman R,Sharf R,Kleinberger T

更新日期：2000-08-03 00:00:00

abstract：:The management of pain and morbidity due to the spreading and growth of cancer within bone remains to be a paramount problem in clinical care. Cancer cells actively transform bone, however, the molecular requirements and mechanisms of this process remain unclear. This study shows that functional modulation of the alph...

journal_title：Oncogene

authors： McCabe NP,De S,Vasanji A,Brainard J,Byzova TV

更新日期：2007-09-13 00:00:00

abstract：:Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at high risk for the disease. The genetic background has been shown t...

journal_title：Oncogene

authors： Wang L,Soria JC,Chang YS,Lee HY,Wei Q,Mao L

更新日期：2003-10-16 00:00:00

abstract：:The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protei...

journal_title：Oncogene

authors： Chikamori M,Fujimoto J,Tokai-Nishizumi N,Yamamoto T

更新日期：2007-05-03 00:00:00

abstract：:The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour-promoting transcription factor. Here we report the surprising result that c-rel-/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lymphoma. c-Rel loss als...

journal_title：Oncogene

authors： Hunter JE,Butterworth JA,Zhao B,Sellier H,Campbell KJ,Thomas HD,Bacon CM,Cockell SJ,Gewurz BE,Perkins ND

更新日期：2016-06-30 00:00:00

abstract：:The family of tripartite-motif (TRIM) proteins are involved in diverse cellular processes, but are often characterized by critical protein-protein interactions necessary for their function. TRIM16 is induced in different cancer types, when the cancer cell is forced to proceed down a differentiation pathway. We have id...

journal_title：Oncogene

authors： Marshall GM,Bell JL,Koach J,Tan O,Kim P,Malyukova A,Thomas W,Sekyere EO,Liu T,Cunningham AM,Tobias V,Norris MD,Haber M,Kavallaris M,Cheung BB

更新日期：2010-11-18 00:00:00

abstract：:Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in estrogen receptor (ER) positive tumours. As targeting the ER is responsible for major improvements in cure rates and prevention of breast cancers, we have evalu...

journal_title：Oncogene

authors： Hrstka R,Nenutil R,Fourtouna A,Maslon MM,Naughton C,Langdon S,Murray E,Larionov A,Petrakova K,Muller P,Dixon MJ,Hupp TR,Vojtesek B

更新日期：2010-08-26 00:00:00

abstract：:NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kappaB prevented TNF-a...

journal_title：Oncogene

authors： Delhalle S,Deregowski V,Benoit V,Merville MP,Bours V

更新日期：2002-05-30 00:00:00

abstract：:Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. Immunoblotting or immunoprecipitation of fusion protein or in vitro translated protein, respect...

journal_title：Oncogene

authors： Drané P,Barel M,Balbo M,Frade R

更新日期：1997-12-18 00:00:00

abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

journal_title：Oncogene

authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

更新日期：2017-03-30 00:00:00