Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.

abstract：:The RAS/RAF mitogen-activated protein kinase pathway (MAPK) is highly active in many tumor types including the majority of high-grade gliomas and expression of activated RAS or RAF in neural progenitor cells combined with either AKT activation or Ink4a/Arf loss leads to the development of high-grade gliomas in vivo. T...

journal_title：Oncogene

authors： Robinson JP,Vanbrocklin MW,Lastwika KJ,McKinney AJ,Brandner S,Holmen SL

更新日期：2011-03-17 00:00:00

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:The gene for von Recklinghausen neurofibromatosis type 1 (NF1) was recently identified by positional cloning and found to encode a protein with sequence similarity to a family of eucaryotic GTPase-activating proteins (GAPs). Expression of the NF1-GAP-related domain (NF1GRD) has been shown to complement yeast strains d...

journal_title：Oncogene

authors： Gutmann DH,Boguski M,Marchuk D,Wigler M,Collins FS,Ballester R

更新日期：1993-03-01 00:00:00

abstract：:SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...

journal_title：Oncogene

authors： Murrell AM,Green AR

更新日期：1995-02-16 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...

journal_title：Oncogene

authors： Braig S,Bosserhoff AK

更新日期：2013-02-14 00:00:00

abstract：:To investigate the role of protein kinase C (PKC) in apoptotic signaling induced by cytokine withdrawal, we expressed PKC-alpha, -delta and -epsilon individually in the 32D myeloid progenitor cells. The parental and PKC-delta- and PKC-epsilon-transfected 32D cells underwent apoptosis within 24 h in the absence of inte...

journal_title：Oncogene

authors： Li W,Zhang J,Flechner L,Hyun T,Yam A,Franke TF,Pierce JH

更新日期：1999-11-11 00:00:00

abstract：:The role of thromboxane A(2) (TxA(2)) in smoking-associated lung cancer is poorly understood. This study was conducted to study the role of TxA(2) in smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-promoted cell survival and growth in human lung cancer cells. We found that NNK increased TxA(2) ...

journal_title：Oncogene

authors： Huang RY,Li MY,Hsin MK,Underwood MJ,Ma LT,Mok TS,Warner TD,Chen GG

更新日期：2011-01-06 00:00:00

abstract：:The myc proto-oncogenes are transcription factors that directly regulate the expression of other genes, by binding to the specific DNA sequence, CACGTG. Among the target genes for c-Myc regulation are ECA39, p53, ornithine decarboxylase (ODC), alpha-prothymosin and Cdc25A. In this study we examined the involvement of ...

journal_title：Oncogene

authors： Ben-Yosef T,Yanuka O,Halle D,Benvenisty N

更新日期：1998-07-16 00:00:00

abstract：:Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton's tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was confirmed by co-immunoprecipitation. BTK is expressed in neuroblastoma ce...

journal_title：Oncogene

authors： Li T,Deng Y,Shi Y,Tian R,Chen Y,Zou L,Kazi JU,Rönnstrand L,Feng B,Chan SO,Chan WY,Sun J,Zhao H

更新日期：2018-11-01 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men in the western world. Mutations in tumor suppressor genes and in oncogenes are important for PCa progression, whereas the role of stem cell proteins in prostate carcinogenesis is insufficiently examined. This study investigates the role o...

journal_title：Oncogene

authors： Queisser A,Hagedorn S,Wang H,Schaefer T,Konantz M,Alavi S,Deng M,Vogel W,von Mässenhausen A,Kristiansen G,Duensing S,Kirfel J,Lengerke C,Perner S

更新日期：2017-03-01 00:00:00

abstract：:Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppressed in HRAS-transfo...

journal_title：Oncogene

authors： Lund P,Weisshaupt K,Mikeska T,Jammas D,Chen X,Kuban RJ,Ungethüm U,Krapfenbauer U,Herzel HP,Schäfer R,Walter J,Sers C

更新日期：2006-08-10 00:00:00

abstract：:MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, but their role in head and neck cancer development and progression is not well defined. We aimed to determine whether specific miRNAs and their target mRNAs contribute to head and neck cancer pathogenesis and progression. To ide...

journal_title：Oncogene

authors： Nakanishi H,Taccioli C,Palatini J,Fernandez-Cymering C,Cui R,Kim T,Volinia S,Croce CM

更新日期：2014-02-06 00:00:00

abstract：:High-grade serous carcinoma, accounts for up to 70% of all ovarian cases. Furin, a proprotein convertase, is highly expressed in high-grade serous carcinoma of ovarian cancer patients, and its expression is even higher in tumor omentum than in normal omentum, the preferred site of ovarian cancer metastasis. The proteo...

journal_title：Oncogene

authors： Chen C,Gupta P,Parashar D,Nair GG,George J,Geethadevi A,Wang W,Tsaih SW,Bradley W,Ramchandran R,Rader JS,Chaluvally-Raghavan P,Pradeep S

更新日期：2020-04-01 00:00:00

abstract：:AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously shown that AP-1 complexes are activated by peptide and steroid growth factors in both normal and malignant breas...

journal_title：Oncogene

authors： Liu Y,Ludes-Meyers J,Zhang Y,Munoz-Medellin D,Kim HT,Lu C,Ge G,Schiff R,Hilsenbeck SG,Osborne CK,Brown PH

更新日期：2002-10-31 00:00:00

abstract：:The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes. However, it is not clear which genes are the biological targets of WT1, nor which cellular pathway(s) is critically altered in tumors as a result of WT1 muta...

journal_title：Oncogene

authors： Udtha M,Lee SJ,Alam R,Coombes K,Huff V

更新日期：2003-06-12 00:00:00

abstract：:The matricellular protein CCN5/WISP-2 represents a promising target in triple-negative breast cancer (TNBC) because treatment or induced activation of CCN5 in TNBC cells promotes cell growth arrest at the G0/G1 phase, reduces cell proliferation and delays tumor growth in the xenograft model. Our studies found that the...

journal_title：Oncogene

authors： Haque I,Banerjee S,De A,Maity G,Sarkar S,Majumdar M,Jha SS,McGragor D,Banerjee SK

更新日期：2015-06-11 00:00:00

abstract：:Using Southern blot analysis of DNA from mouse-hamster somatic cell hybrids, we have mapped Lmyc and Bmyc, two members of the myc family of genes, to mouse chromosomes 4 and 2, respectively. Furthermore, we have compared the regulation of Lmyc and Bmyc expression under different growth conditions and during in vitro d...

journal_title：Oncogene

authors： Ingvarsson S,Sundaresan S,Jin P,Francke U,Asker C,Sümegi J,Klein G,Sejersen T

更新日期：1988-12-01 00:00:00

abstract：:RAS is a small GTP binding protein mutated in approximately 30% human cancer. Despite its important role in the initiation and progression of human cancer, the underlying mechanism of RAS-induced human epithelial transformation remains elusive. In this study, we probe the cellular and molecular mechanisms of RAS-media...

journal_title：Oncogene

authors： Young T,Mei F,Liu J,Bast RC Jr,Kurosky A,Cheng X

更新日期：2005-09-08 00:00:00

abstract：:The metastasis-associated protein 1 (MTA1) is overexpressed in various human cancers and is closely connected with aggressive phenotypes; however, little is known about the transcriptional regulation of the MTA1 gene. This study identified the MTA1 gene as a target of p53-mediated transrepression. The MTA1 promoter co...

journal_title：Oncogene

authors： Lee MH,Na H,Kim EJ,Lee HW,Lee MO

更新日期：2012-12-06 00:00:00

abstract：:Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is noted for its transforming potential. Yet, it also acts as a cytostatic and growth-relenting factor in Burkitt's lymphoma (BL) cells. The underlying molecular mechanisms of the growth inhibitory property of LMP1 have remained largely unknown. In this...

journal_title：Oncogene

authors： Anastasiadou E,Boccellato F,Vincenti S,Rosato P,Bozzoni I,Frati L,Faggioni A,Presutti C,Trivedi P

更新日期：2010-03-04 00:00:00

abstract：:Previous observations suggest expression of cyclooxygenase-2 to convey macrophage protection towards apoptotic cell death. We reasoned prostaglandin formation and in turn a cAMP increase as the underlying protective principle. Here we report that exposure of macrophages to lipopolysaccharide/interferon-gamma or lipoph...

journal_title：Oncogene

authors： von Knethen A,Lotero A,Brüne B

更新日期：1998-07-23 00:00:00

abstract：:Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry because of insuffici...

journal_title：Oncogene

authors： Bower JJ,Karaca GF,Zhou Y,Simpson DA,Cordeiro-Stone M,Kaufmann WK

更新日期：2010-08-26 00:00:00

abstract：:The phosphatase Cdc25A was shown to be a target of the transcription factor c-Myc. Myc-induced apoptosis appeared dependent on Cdc25A expression and Cdc25A over-expression could substitute for Myc-triggered apoptosis. These findings suggested that an important downstream component of Myc-mediated apoptosis was identif...

journal_title：Oncogene

authors： Fuhrmann G,Leisser C,Rosenberger G,Grusch M,Huettenbrenner S,Halama T,Mosberger I,Sasgary S,Cerni C,Krupitza G

更新日期：2001-07-27 00:00:00

abstract：:RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas. We used RasGRP1 trans...

journal_title：Oncogene

authors： Klinger MB,Guilbault B,Goulding RE,Kay RJ

更新日期：2005-04-14 00:00:00

abstract：:Tbx3 is a member of the T-box family of transcription factors. Mutations in Tbx3 cause ulnar-mammary syndrome, an autosomal dominant disorder characterized by upper limb defects, apocrine-gland defects including mammary hypoplasia, and tooth, hair and genital defects. In cell culture, Tbx3 and its close relative Tbx2 ...

journal_title：Oncogene

authors： Carlson H,Ota S,Song Y,Chen Y,Hurlin PJ

更新日期：2002-05-30 00:00:00

abstract：:Fos-related antigen-1 (Fra-1) is a member of the Activator Protein-1 (AP-1) transcription factor superfamily that is overexpressed in a variety of cancers, including colon, breast, lung, bladder and brain. High Fra-1 levels are associated with enhanced cell proliferation, survival, migration and invasion. Despite its ...

journal_title：Oncogene

authors： Pakay JL,Diesch J,Gilan O,Yip YY,Sayan E,Kolch W,Mariadason JM,Hannan RD,Tulchinsky E,Dhillon AS

更新日期：2012-04-05 00:00:00

abstract：:The introduction of new therapies against particular genetic mutations in non-small-cell lung cancer is a promising avenue for improving patient survival, but the target population is small. There is a need to discover new potential actionable genetic lesions, to which end, non-conventional cancer pathways, such as RN...

journal_title：Oncogene

authors： Anadón C,Guil S,Simó-Riudalbas L,Moutinho C,Setien F,Martínez-Cardús A,Moran S,Villanueva A,Calaf M,Vidal A,Lazo PA,Zondervan I,Savola S,Kohno T,Yokota J,Ribas de Pouplana L,Esteller M

更新日期：2016-08-18 00:00:00

abstract：:Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...

journal_title：Oncogene

authors： Blanco MJ,Moreno-Bueno G,Sarrio D,Locascio A,Cano A,Palacios J,Nieto MA

更新日期：2002-05-09 00:00:00

abstract：:All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for many developmental process as well as homeostasis in the adult. Many lines of evidence also suggest that RA, acting through the RA receptors (RARs), can also suppress growth of tumors of diverse origin. To assess direct...

journal_title：Oncogene

authors： Chen CF,Goyette P,Lohnes D

更新日期：2004-07-08 00:00:00

abstract：:Ectopic expression of the intracellular domain of NOTCH-4/INT-3 leads to tumorigenesis in the mouse mammary gland. This results from a gain-of-function mutation. To evaluate gain-of-function NOTCH-4/INT-3 activity in human cancers we have surveyed human breast, lung, and colon carcinoma tissue culture cell lines for e...

journal_title：Oncogene

authors： Imatani A,Callahan R

更新日期：2000-01-13 00:00:00