Adenovirus E4orf4 protein interacts with both Balpha and B' subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Balpha.

abstract：:Amplification and rearrangements of the epidermal growth factor receptor (EGFR) gene are frequently found in glioblastoma multiforme (GBM). The most common variant is EGFR variant III (EGFRvIII). Research suggests that EGFRvIII could be a marker for a cancer stem cell or tumor-initiating population. If amplification a...

journal_title：Oncogene

authors： Del Vecchio CA,Giacomini CP,Vogel H,Jensen KC,Florio T,Merlo A,Pollack JR,Wong AJ

更新日期：2013-05-23 00:00:00

abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

journal_title：Oncogene

authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

更新日期：1996-08-15 00:00:00

abstract：:Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and as...

journal_title：Oncogene

authors： Angelastro JM,Canoll PD,Kuo J,Weicker M,Costa A,Bruce JN,Greene LA

更新日期：2006-02-09 00:00:00

abstract：:The putative tumor suppressor CDKN1C is an imprinted gene at 11p15.5, a well-known imprinted region often deleted in tumors. The absence of somatic mutations and the frequent diminished expression in tumors would suggest that CDKN1C expression is regulated epigenetically. It has been, however, controversial whether th...

journal_title：Oncogene

authors： Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T

更新日期：2004-05-27 00:00:00

abstract：:Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells...

journal_title：Oncogene

authors： Tait S

更新日期：2013-10-31 00:00:00

abstract：:The aspartic protease cathepsin D (cath-D) is a key mediator of induced-apoptosis and its proteolytic activity has been generally involved in this event. During apoptosis, cath-D is translocated to the cytosol. Because cath-D is one of the lysosomal enzymes that requires a more acidic pH to be proteolytically active r...

journal_title：Oncogene

authors： Beaujouin M,Baghdiguian S,Glondu-Lassis M,Berchem G,Liaudet-Coopman E

更新日期：2006-03-23 00:00:00

abstract：:The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...

journal_title：Oncogene

authors： David-Pfeuty T

更新日期：1999-12-09 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:Axl is a receptor that induces proliferation, migration and invasion in cancer. In this study, we show that specific microRNAs (miRNAs) target the 3'-UTR of Axl. Luciferase-reporter assays with wild-type and deleted miR-34 and miR-199a/b seed sequences of Axl 3'-UTR confirmed the specificity of targeting. An inverse c...

journal_title：Oncogene

authors： Mudduluru G,Ceppi P,Kumarswamy R,Scagliotti GV,Papotti M,Allgayer H

更新日期：2011-06-23 00:00:00

abstract：:Oncogenic Ras is known to drive both the Rac and Raf-MAP-kinase pathways, which act in concert to cause cell transformation. Unlike the Raf-MAP-kinase cascade, however, the downstream elements of Rac pathway are not fully understood. Previously, we showed that cytosolic phospholipase A2 (cPLA2) and subsequent metaboli...

journal_title：Oncogene

authors： Yoo MH,Song H,Woo CH,Kim H,Kim JH

更新日期：2004-12-09 00:00:00

abstract：:Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...

journal_title：Oncogene

authors： Rea S,Xouri G,Akhtar A

更新日期：2007-08-13 00:00:00

abstract：:Immunopurified mouse p53 proteins were used to gain experimental access to the mechanisms underlying nonprimate p53 directed suppression of SV40 origin directed DNA replication in vivo. In replication competent HeLa cell extracts containing exogenous T antigen, mouse p53 blocks T antigen dependent DNA synthesis as in ...

journal_title：Oncogene

authors： Stürzbecher HW,Brain R,Maimets T,Addison C,Rudge K,Jenkins JR

更新日期：1988-10-01 00:00:00

abstract：:The product of the retinoblastoma susceptibility gene, pRb, is a negative regulator of cell growth. It functions by regulating the activity of transcription factors. Rb represses some genes by sequestering or inactivating the positive transcription factor E2F and seems to activate some others by interacting with facto...

journal_title：Oncogene

authors： Rohde M,Warthoe P,Gjetting T,Lukas J,Bartek J,Strauss M

更新日期：1996-06-06 00:00:00

abstract：:We have previously demonstrated that the expression of FGFR3 is frequently downregulated in colorectal carcinoma cells. Here we have shown that FGFR1 is overexpressed in colorectal carcinoma cells and the gene expressions between FGFR1 and FGFR3 are mutually exclusive. Moreover, we have also shown that the disruption ...

journal_title：Oncogene

authors： Jang JH

更新日期：2005-01-27 00:00:00

abstract：:Pancreatic cancer still remains one of the most lethal diseases and establishment of new therapy is needed. The purpose of this study is to find novel factors involved in pancreatic cancer progression by proteomic approach. We compared pre- and postoperative serum protein profiling obtained from pancreatic cancer pati...

journal_title：Oncogene

authors： Takano S,Yoshitomi H,Togawa A,Sogawa K,Shida T,Kimura F,Shimizu H,Tomonaga T,Nomura F,Miyazaki M

更新日期：2008-05-01 00:00:00

abstract：:Genetic amplification at chromosome 8p23.1 has been reported in some solid tumors. Translocation of 8p23.1 has also been reported in hematological malignancies and head and neck squamous cell cancer. In an attempt to clarify whether this translocation is implicated in lymphomagenesis, we performed FISH analysis of the...

journal_title：Oncogene

authors： Tagawa H,Karnan S,Kasugai Y,Tuzuki S,Suzuki R,Hosokawa Y,Seto M

更新日期：2004-04-01 00:00:00

abstract：:Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent mechanisms. As cell migration is studied in vitro, it is important to identify genes that both drive cell migration and are biologically relevant in promoting inv...

journal_title：Oncogene

authors： Wu Y,Siadaty MS,Berens ME,Hampton GM,Theodorescu D

更新日期：2008-11-06 00:00:00

abstract：:Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...

journal_title：Oncogene

authors： Dembowy J,Adissu HA,Liu JC,Zacksenhaus E,Woodgett JR

更新日期：2015-07-01 00:00:00

abstract：:Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To define the nature of the interaction between rhuMAb HER2 and other classes of cytotoxic drugs, we applied multiple drug effect/combination index (CI) isobologra...

journal_title：Oncogene

authors： Pegram M,Hsu S,Lewis G,Pietras R,Beryt M,Sliwkowski M,Coombs D,Baly D,Kabbinavar F,Slamon D

更新日期：1999-04-01 00:00:00

abstract：:In the G2 phase cell cycle checkpoint arrest, the cdc25-dependent activation of cyclin B/cdc2, a critical step in regulating entry into mitosis, is blocked. Studies in yeast have demonstrated that the inhibition of cdc25 function involves 14-3-3 binding to cdc25. In humans, two cdc25 isoforms have roles in G2/M progre...

journal_title：Oncogene

authors： Forrest A,Gabrielli B

更新日期：2001-07-19 00:00:00

abstract：:Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localize...

journal_title：Oncogene

authors： Hornigold N,Devlin J,Davies AM,Aveyard JS,Habuchi T,Knowles MA

更新日期：1999-04-22 00:00:00

abstract：:An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting functional analysis. He...

journal_title：Oncogene

authors： Lauring J,Cosgrove DP,Fontana S,Gustin JP,Konishi H,Abukhdeir AM,Garay JP,Mohseni M,Wang GM,Higgins MJ,Gorkin D,Reis M,Vogelstein B,Polyak K,Cowherd M,Buckhaults PJ,Park BH

更新日期：2010-04-22 00:00:00

abstract：:We have cloned a cDNA from the Drosophila elg gene, a new member of the ets family of genes. The D-elg gene is located at 97D on chromosome 3R and is expressed as a 2.0kb RNA in the embryos, pupae and adults, with no detectable expression in third instar larvae. D-elg expression is observed in all cells of early stage...

journal_title：Oncogene

authors： Pribyl LJ,Watson DK,Schulz RA,Papas TS

更新日期：1991-07-01 00:00:00

abstract：:The tumor suppressor gene p53 is a potent transcriptional regulator of genes which are involved in many cellular activities including cell cycle arrest, apoptosis, and angiogenesis. Recent studies have demonstrated that the activation of the transcriptional factor nuclear factor kappaB (NF-kappaB) plays an essential r...

journal_title：Oncogene

authors： Shao J,Fujiwara T,Kadowaki Y,Fukazawa T,Waku T,Itoshima T,Yamatsuji T,Nishizaki M,Roth JA,Tanaka N

更新日期：2000-02-10 00:00:00

abstract：:The vast majority of cancer cells have defective checkpoints that permit the cell cycle to progress in the presence of double-strand DNA breaks (DSBs) caused by ionizing radiation (IR) and radiomimetic drugs. ATR (ataxia telangiectasia-mutated and Rad3-related) has recently been shown to be activated by DSBs, although...

journal_title：Oncogene

authors： Hurley PJ,Wilsker D,Bunz F

更新日期：2007-04-19 00:00:00

abstract：:Wilms tumor is one of the most frequent neoplasias in children. Our previous microarray screening in a large series of Wilms tumors revealed several candidate genes that are deregulated in advanced tumors and are part of the retinoic acid signaling pathway. To investigate whether retinoic acid could be employed as a n...

journal_title：Oncogene

authors： Zirn B,Samans B,Spangenberg C,Graf N,Eilers M,Gessler M

更新日期：2005-08-04 00:00:00

abstract：:Many cells die with apoptotic morphology and with documented activation of an effector caspase, but there are also many exceptions. Cells frequently display activation of other proteases, including granzymes, lysosomal cathepsins, matrix metalloproteinases, and proteasomal proteases, and others display morphologies th...

journal_title：Oncogene

authors： Lockshin RA,Zakeri Z

更新日期：2004-04-12 00:00:00

abstract：:There is now much evidence to suggest that the p53 tumour suppressor protein functions to monitor the integrity of the genome. When DNA damage is detected, p53 suppresses cell growth to allow repair or directs the cell into apoptosis. The mechanism of action of p53 is as yet unclear but recent evidence has accumulated...

journal_title：Oncogene

authors： Perrem K,Rayner J,Voss T,Sturzbecher H,Jackson P,Braithwaite A

更新日期：1995-10-05 00:00:00

abstract：:Radicicol, a macrocyclic anti-fungal antibiotic, has the ability to suppress transformation by diverse oncogenes such as Src, Ras and Mos. Despite this useful property, the mechanism by which radicicol exerts its anti-transformation effects is currently unknown. To understand the transformation-suppressing effects of ...

journal_title：Oncogene

authors： Sharma SV,Agatsuma T,Nakano H

更新日期：1998-05-01 00:00:00

abstract：:The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLr). Ubiquitin-dependent degradation of the PRLr that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLr on Ser349 followed by the recruitment of the beta-transducin ...

journal_title：Oncogene

authors： Li Y,Clevenger CV,Minkovsky N,Kumar KG,Raghunath PN,Tomaszewski JE,Spiegelman VS,Fuchs SY

更新日期：2006-03-23 00:00:00