A human tumour-derived mutant p53 protein induces a p34cdc2 reversible growth arrest in fission yeast.

abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...

journal_title：Oncogene

authors： Green AL,DeSisto J,Flannery P,Lemma R,Knox A,Lemieux M,Sanford B,O'Rourke R,Ramkissoon S,Jones K,Perry J,Hui X,Moroze E,Balakrishnan I,O'Neill AF,Dunn K,DeRyckere D,Danis E,Safadi A,Gilani A,Hubbell-Engler B,Nus

更新日期：2020-03-01 00:00:00

abstract：:Most colorectal carcinomas harbor genetic alterations that result in stabilization of beta-catenin. A colorectal carcinoma cell line, HCT116, which has both mutated and wild-type beta-catenin genes, was engineered by homologous recombination to investigate the significance of beta-catenin gene mutation. As expected, t...

journal_title：Oncogene

authors： Sekine S,Shibata T,Sakamoto M,Hirohashi S

更新日期：2002-08-29 00:00:00

abstract：:After publication of this Article, the Authors noticed errors in some of the Figures. In Figures 2e, 2f-g, 4a, 4j, 5a and 6b, unmatched β-actin was inadvertently used as loading control for the immunoblots. These have been corrected using repeat data from a similar set of samples and the revised Figures containing mat...

journal_title：Oncogene

authors： Vantaku V,Putluri V,Bader DA,Maity S,Ma J,Arnold JM,Rajapakshe K,Donepudi SR,von Rundstedt FC,Devarakonda V,Dubrulle J,Karanam B,McGuire SE,Stossi F,Jain AK,Coarfa C,Cao Q,Sikora AG,Villanueva H,Kavuri SM,Lotan Y

更新日期：2020-10-01 00:00:00

abstract：:The molecular basis for the resistance of tumor cells to cell-mediated cytotoxicity remains poorly understood and thus poses a major challenge for cancer immunotherapy. The present study was designed to determine whether the WNT1-inducible signaling pathway protein 2 (WISP2, also referred to as CCN5), a key regulator ...

journal_title：Oncogene

authors： Akalay I,Tan TZ,Kumar P,Janji B,Mami-Chouaib F,Charpy C,Vielh P,Larsen AK,Thiery JP,Sabbah M,Chouaib S

更新日期：2015-04-23 00:00:00

abstract：:A variety of factors cooperate to regulate neovessel formation and persistence. Proangiogenic growth factors have remained an area of intense interest due to their capacity to promote endothelial cell (EC) proliferation and to initiate the angiogenic program. These growth factors are associated with increased cell sur...

journal_title：Oncogene

authors： Stupack DG,Cheresh DA

更新日期：2003-12-08 00:00:00

abstract：:In Dictyostelium discoideum, three ras genes (rasD, rasG and rasB) and one ras-related gene (rap1) have been previously isolated and characterized, and the deduced amino acid sequence of their predicted protein products share at least 50% sequence identity with the human H-Ras protein. We have now cloned and character...

journal_title：Oncogene

authors： Daniel J,Bush J,Cardelli J,Spiegelman GB,Weeks G

更新日期：1994-02-01 00:00:00

abstract：:Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...

journal_title：Oncogene

authors： Cohen N,Shani O,Raz Y,Sharon Y,Hoffman D,Abramovitz L,Erez N

更新日期：2017-08-01 00:00:00

abstract：:The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...

journal_title：Oncogene

authors： Yu X,Wang R,Zhang Y,Zhou L,Wang W,Liu H,Li W

更新日期：2019-12-01 00:00:00

abstract：:The VN-11 recombinant retroviruses, originally generated by co-transfection of the avian MH2 and AKRv viral genomes, were molecularly cloned from an infected mouse cell line named N11. The analysis of the proviral genome sequence from one of these recombinants showed a possible envAKR-mycMH2 fusion. Point mutations we...

journal_title：Oncogene

authors： Sassano M,Granucci F,Seveso M,Marconi G,Foti M,Ricciardi-Castagnoli P

更新日期：1994-05-01 00:00:00

abstract：:The REL gene is amplified in many human B-cell lymphomas and we have previously shown that expression of REL from a retroviral vector can malignantly transform chicken spleen cells in vitro. To identify REL protein functions necessary for malignant transformation, we have performed deletion analysis on REL sequences e...

journal_title：Oncogene

authors： Starczynowski DT,Reynolds JG,Gilmore TD

更新日期：2003-10-09 00:00:00

abstract：:We have cloned and characterised the murine gene encoding c-Mpl, a receptor for thrombopoietin and member of the hematopoietin receptor superfamily. The gene encompasses 15 kb of the mouse genome and the organisation of its 12 exons conforms closely to the pattern observed for the genes of other hematopoietin receptor...

journal_title：Oncogene

authors： Alexander WS,Dunn AR

更新日期：1995-02-16 00:00:00

abstract：:Human Papillomavirus (HPV) type 16 is the most frequently detected HPV in cervical cancer. Although epidemiologic and experimental evidence indicates a prominent role for HPV infection in the development of this disease, other factors are also involved. Altered expression of the ets family transcription factors erg an...

journal_title：Oncogene

authors： Simpson S,Woodworth CD,DiPaolo JA

更新日期：1997-05-08 00:00:00

abstract：:Tumor suppressor p53 is a nuclear transcription factor that blocks cell cycle progression and induces apoptosis. We have previously shown that the MCF7 resistance to the cytotoxic action of TNF correlates with p53 mutations. In the present study, we used a recombinant adenovirus carrying a wild-type p53 gene (Adwtp53)...

journal_title：Oncogene

authors： Ameyar M,Shatrov V,Bouquet C,Capoulade C,Cai Z,Stancou R,Badie C,Haddada H,Chouaib S

更新日期：1999-09-23 00:00:00

abstract：:Overexpression of members of the myc family of oncogenes contributes to the development of many vertebrate malignancies. Although several functions for myc gene products have been proposed, the targets for Myc activity during oncogenesis or normal development remain to be identified. Oocytes of Xenopus laevis, which a...

journal_title：Oncogene

authors： Gibson AW,Ye R,Johnston RN,Browder LW

更新日期：1992-11-01 00:00:00

abstract：:Chromosomal aberrations are a hallmark of human cancers, with complex cytogenetic rearrangements leading to genetic changes permissive for cancer initiation and progression. Protection of Telomere 1 (POT1) is an essential component of the shelterin complex and functions to maintain chromosome stability by repressing t...

journal_title：Oncogene

authors： Gu P,Wang Y,Bisht KK,Wu L,Kukova L,Smith EM,Xiao Y,Bailey SM,Lei M,Nandakumar J,Chang S

更新日期：2017-04-06 00:00:00

abstract：:Long-lived species Homo sapiens have evolved robust protection mechanisms against cancer by repressing telomerase and maintaining short telomeres, thereby delaying the onset of the majority of cancer types until post-reproductive age. Indeed, telomerase is silent in most differentiated human cells, predominantly due t...

journal_title：Oncogene

authors： Yuan X,Larsson C,Xu D

更新日期：2019-08-01 00:00:00

abstract：:We previously reported cloning the rLot1 gene, and its human homolog (hLOT1), through analysis of differential gene expression in normal and malignant rat ovarian surface epithelial cells. Both human and rat ovarian carcinoma cell lines exhibited lost or decreased expression of this gene. Interestingly, the LOT1 gene ...

journal_title：Oncogene

authors： Abdollahi A,Bao R,Hamilton TC

更新日期：1999-11-11 00:00:00

abstract：:p53 is involved in several DNA repair pathways. Some of these require the specific transactivation of p53-dependent genes and others involve direct interactions between the p53 protein and DNA repair associated proteins. Previously, we have shown that p53 acts directly in Base Excision Repair (BER) when assayed under ...

journal_title：Oncogene

authors： Offer H,Milyavsky M,Erez N,Matas D,Zurer I,Harris CC,Rotter V

更新日期：2001-02-01 00:00:00

abstract：:The products of two cellular proto-oncogenes c-fos and c-jun form a heterodimeric complex that contribute to the DNA-binding activity referred to as AP-1 (activator protein-1). Two domains have been proposed to be required for heterodimer formation and protein-DNA complex formation. The leucine zipper domain mediated ...

journal_title：Oncogene

authors： Cohen DR,Curran T

更新日期：1990-06-01 00:00:00

abstract：:Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the tre...

journal_title：Oncogene

authors： Hao N,Behar M,Elston TC,Dohlman HG

更新日期：2007-05-14 00:00:00

abstract：:SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-kappaB. Here we have examined a role of SCC-S2 in cell growth regulation in vitro and in vivo. Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa c...

journal_title：Oncogene

authors： Kumar D,Gokhale P,Broustas C,Chakravarty D,Ahmad I,Kasid U

更新日期：2004-01-15 00:00:00

abstract：:Breast cancer cells that overexpress HER-2/neu are more resistant to chemotherapeutic agents such as paclitaxel (Taxol) and docetaxel (Taxotere) than those that do not overexpress HER-2/neu. In previous work, we showed that the adenovirus type 5 E1A can repress HER-2/neu expression at the transcriptional level. Here w...

journal_title：Oncogene

authors： Ueno NT,Yu D,Hung MC

更新日期：1997-08-18 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) was originally identified from a rare subtype of non-Hodgkin's lymphomas carrying t(2;5)(p23;q35) translocation, where ALK was constitutively activated as a result of a fusion with nucleophosmin (NPM). Aberrant ALK fusion proteins were also generated in inflammatory fibrosarcoma and a ...

journal_title：Oncogene

authors： Okubo J,Takita J,Chen Y,Oki K,Nishimura R,Kato M,Sanada M,Hiwatari M,Hayashi Y,Igarashi T,Ogawa S

更新日期：2012-11-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by the thiazolidinedione (TZD) class of antidiabetic drugs elicits growth inhibition in a variety of malignant tumors. We clarified the effects of TZDs on growth of human non-small cell lung carcinoma (NSCLC) cells that express endogenous PPAR-gamma...

journal_title：Oncogene

authors： Satoh T,Toyoda M,Hoshino H,Monden T,Yamada M,Shimizu H,Miyamoto K,Mori M

更新日期：2002-03-28 00:00:00

abstract：:The mouse mammary epithelial cell hierarchy contains both multipotent stem cell as well as lineage-limited duct and lobular progenitor cell functions. The latter-also termed parity-identified mammary epithelial cells (PI-MECs)-are marked by beta-galactosidase (β Gal) expression following pregnancy and involution in wh...

journal_title：Oncogene

authors： Bruno RD,Boulanger CA,Smith GH

更新日期：2012-01-05 00:00:00

abstract：:We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concen...

journal_title：Oncogene

authors： Kristjuhan A,Jaks V,Rimm I,Tooming T,Maimets T

更新日期：1998-05-07 00:00:00

abstract：:We have developed a transplantation system that allows us to introduce oncogenes into mouse mammary epithelial cells in culture and then to reconstitute an epithelial tree in vivo from the genetically altered cells. Introduction of the neu oncogene, a transforming homologue of the human proto-oncogene c-erbB-2, produc...

journal_title：Oncogene

authors： Bradbury JM,Arno J,Edwards PA

更新日期：1993-06-01 00:00:00

abstract：:Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of adult tissues. There is also a growing body of evidence that links Hox proteins to regulation of cellular proliferation/transformation. However, the underlying molecular mechanisms of Ho...

journal_title：Oncogene

authors： Krosl J,Sauvageau G

更新日期：2000-10-26 00:00:00

abstract：:The MET oncogene encodes the receptor for HGF/Scatter Factor, known to control cell motility and invasion in epithelial cells. We report that the Met/HGF receptor, absent in differentiated adult skeletal muscles, is aberrantly expressed in clinical samples and in established cell lines of human rhadbomyosarcomas. In b...

journal_title：Oncogene

authors： Ferracini R,Olivero M,Di Renzo MF,Martano M,De Giovanni C,Nanni P,Basso G,Scotlandi K,Lollini PL,Comoglio PM

更新日期：1996-04-18 00:00:00

abstract：:In contrast to the hereditary form of medullary thyroid carcinoma (MTC), little is known about the etiology of sporadic MTC. Somatic gain-of-function mutations in the RET proto-oncogene, encoding a receptor tyrosine kinase, are found in an average of 40% of sporadic MTC. We analysed 31 sporadic MTC for somatic and ger...

journal_title：Oncogene

authors： Gimm O,Dziema H,Brown J,Hoang-Vu C,Hinze R,Dralle H,Mulligan LM,Eng C

更新日期：2001-04-19 00:00:00