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AP-1 complex is effector of Hox-induced cellular proliferation and transformation.

Abstract：

:Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of adult tissues. There is also a growing body of evidence that links Hox proteins to regulation of cellular proliferation/transformation. However, the underlying molecular mechanisms of Hox-associated transformation and tissue growth have yet to be elucidated. Using a well established model system for studying changes in cellular proliferation induced by Hoxb4, we show that AP-1 activity is markedly increased in Hoxb4-transduced cells due to significant upregulation of Jun-B and Fra-1 protein levels. Furthermore, we also show that the specific changes in AP-1 protein expression are necessary for the proliferation effects induced by Hoxb4, and that these changes converge to increase levels of cyclin D1, a known integrator of proliferation signals. Our observations thus link Hox gene products with key elements of the cell cycle machinery.

journal_name

Oncogene

journal_title

Oncogene

authors

Krosl J,Sauvageau G

doi

10.1038/sj.onc.1203897

subject

Has Abstract

pub_date

2000-10-26 00:00:00

pages

5134-41

issue

45

eissn

0950-9232

issn

1476-5594

journal_volume

19

pub_type

杂志文章

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