Abstract：
:We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concentrations: mutants not able to oligomerize are neither able to suppress transactivation, although these transactivating properties can be untouched.
journal_name
Oncogenejournal_title
Oncogeneauthors
Kristjuhan A,Jaks V,Rimm I,Tooming T,Maimets Tdoi
10.1038/sj.onc.1201749subject
Has Abstractpub_date
1998-05-07 00:00:00pages
2413-8issue
18eissn
0950-9232issn
1476-5594journal_volume
16pub_type
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