NF-kappaB signaling, liver disease and hepatoprotective agents.

abstract：:LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion a...

journal_title：Oncogene

authors： Reiss K,Wang JY,Romano G,Tu X,Peruzzi F,Baserga R

更新日期：2001-01-25 00:00:00

abstract：:Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. Similarly, mice that contain a single mutant APC gene encoding a protein truncated at residue 716 (Apc(Δ716...

journal_title：Oncogene

authors： Mohammad HP,Zhang W,Prevas HS,Leadem BR,Zhang M,Herman JG,Hooker CM,Watkins DN,Karim B,Huso DL,Baylin SB

更新日期：2011-06-09 00:00:00

abstract：:Most colorectal carcinomas harbor genetic alterations that result in stabilization of beta-catenin. A colorectal carcinoma cell line, HCT116, which has both mutated and wild-type beta-catenin genes, was engineered by homologous recombination to investigate the significance of beta-catenin gene mutation. As expected, t...

journal_title：Oncogene

authors： Sekine S,Shibata T,Sakamoto M,Hirohashi S

更新日期：2002-08-29 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is known to regulate cell growth and survival in multiple cancers; how...

journal_title：Oncogene

authors： Nitta RT,Bolin S,Luo E,Solow-Codero DE,Samghabadi P,Purzner T,Aujla PS,Nwagbo G,Cho YJ,Li G

更新日期：2019-10-01 00:00:00

abstract：:To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed IkappaBbeta, a specific inhibitor of NF-kappaB, in two human lung adenocarcinoma cell lines, A549 and H441. Expression of IkappaBbeta significantly reduced NF-kappaB activation induced by cotransfection with p65/RelA or T...

journal_title：Oncogene

authors： Jiang Y,Cui L,Yie TA,Rom WN,Cheng H,Tchou-Wong KM

更新日期：2001-04-26 00:00:00

abstract：:We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo fibroblasts. In accordance with previous work, we found that several functions were required. These include activities that map to the p53 binding domain and the...

journal_title：Oncogene

authors： Powell AJ,Darmon AJ,Gonos ES,Lam EW,Peden KW,Jat PS

更新日期：1999-12-02 00:00:00

abstract：:Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive ...

journal_title：Oncogene

authors： Kurisetty VV,Johnston PG,Johnston N,Erwin P,Crowe P,Fernig DG,Campbell FC,Anderson IP,Rudland PS,El-Tanani MK

更新日期：2008-12-04 00:00:00

abstract：:Breast cancer is a heterogeneous genetic disease driven by the accumulation of individual mutations per tumor. Whole-genome sequencing approaches have identified numerous genes with recurrent mutations in primary tumors. Although mutations in well characterized tumor suppressors and oncogenes are overrepresented in th...

journal_title：Oncogene

authors： Block I,Müller C,Sdogati D,Pedersen H,List M,Jaskot AM,Syse SD,Lund Hansen P,Schmidt S,Christiansen H,Casella C,Bering Olsen S,Blomstrøm MM,Riedel A,Thomassen M,Kruse TA,Karlskov Hansen SW,Kioschis P,Mollenhauer J

更新日期：2019-06-01 00:00:00

abstract：:The mechanisms of ras activation by mutations in residue 61 and in the NKXD guanine nucleotide-binding consensus sequence (ras residues 116-119) have been evaluated. Weakly transforming mutations that either reduce intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activities (61P) or enhance guanine nucl...

journal_title：Oncogene

authors： Patel G,MacDonald MJ,Khosravi-Far R,Hisaka MM,Der CJ

更新日期：1992-02-01 00:00:00

abstract：:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological ma...

journal_title：Oncogene

authors： Hawkins ED,Oliaro J,Ramsbottom KM,Newbold A,Humbert PO,Johnstone RW,Russell SM

更新日期：2016-03-03 00:00:00

abstract：:Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence of metastases. We and others demonstrated that nuclear ErbB-2 (NErbB-2) also plays a key role in BC and is a poor prognostic factor in ErbB...

journal_title：Oncogene

authors： Venturutti L,Romero LV,Urtreger AJ,Chervo MF,Cordo Russo RI,Mercogliano MF,Inurrigarro G,Pereyra MG,Proietti CJ,Izzo F,Díaz Flaqué MC,Sundblad V,Roa JC,Guzmán P,Bal de Kier Joffé ED,Charreau EH,Schillaci R,Elizalde PV

更新日期：2016-04-28 00:00:00

abstract：:Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer hallmarks. While conventional anticancer therapies usually target one pathway at a time, targeting key RBP would affect multiple genes and thus overcome drug resistance....

journal_title：Oncogene

authors： Rataj F,Planel S,Denis J,Roelants C,Filhol O,Guyon L,Feige JJ,Cherradi N

更新日期：2019-06-01 00:00:00

abstract：:Reversible acetylation on protein lysine residues has been shown to regulate the function of both nuclear proteins such as histones and p53 and cytoplasmic proteins such as alpha-tubulin. To identify novel acetylated proteins, we purified several proteins by the affinity to an anti-acetylated-lysine antibody from cell...

journal_title：Oncogene

authors： Shimazu T,Komatsu Y,Nakayama KI,Fukazawa H,Horinouchi S,Yoshida M

更新日期：2006-11-30 00:00:00

abstract：:D-type cyclins are important cell cycle regulators that promote cellular proliferation in response to growth factors by inactivation of the retinoblastoma protein (Rb). Cyclin D1 has been shown to be overexpressed in several cancer types and to act as an oncogene in breast cancers. As D-type cyclins are rate limiting ...

journal_title：Oncogene

authors： Russell A,Thompson MA,Hendley J,Trute L,Armes J,Germain D

更新日期：1999-03-18 00:00:00

abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

journal_title：Oncogene

authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

更新日期：2015-08-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...

journal_title：Oncogene

authors： Zhao X,Reebye V,Hitchen P,Fan J,Jiang H,Sætrom P,Rossi J,Habib NA,Huang KW

更新日期：2019-05-01 00:00:00

abstract：:The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Spec...

journal_title：Oncogene

authors： Davis LJ,Halazonetis TD

更新日期：1993-01-01 00:00:00

abstract：:Max is a small helix-loop-helix protein which forms heterodimers with members of the Myc protein family. Myc/Max heterodimers exhibit sequence-specific DNA binding with much greater affinity than Myc homodimers. The Xenopus laevis homologue of Max, XMax, is shorter than the equivalent mammalian protein. This differenc...

journal_title：Oncogene

authors： Tonissen KF,Krieg PA

更新日期：1994-01-01 00:00:00

abstract：:Myeloproliferative disorders (MPDs) are clonal malignancies that arise from hematopoietic progenitors and characterized by overproduction of mature, functional blood cells. These disorders can be broadly characterized into Philadelphia chromosome-positive (Ph(+)) or negative (Ph(-)) genetic groupings. Chronic myeloid ...

journal_title：Oncogene

authors： Kumar C,Purandare AV,Lee FY,Lorenzi MV

更新日期：2009-06-18 00:00:00

abstract：:The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division...

journal_title：Oncogene

authors： Mishra L,Shetty K,Tang Y,Stuart A,Byers SW

更新日期：2005-08-29 00:00:00

abstract：:Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell...

journal_title：Oncogene

authors： Tada Y,Yamaguchi Y,Kinjo T,Song X,Akagi T,Takamura H,Ohta T,Yokota T,Koide H

更新日期：2015-02-05 00:00:00

abstract：:MEMO1 (mediator of ErbB2-driven cell motility 1) regulates HER2-dependent cell migration. Increased MEMO1 expression is associated with cancer aggressiveness. Here, we found that MEMO1 is also involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. We showed t...

journal_title：Oncogene

authors： Sorokin AV,Chen J

更新日期：2013-06-27 00:00:00

abstract：:Ataxia-Telangiectasia (A-T) is an autosomal recessive human disease characterized by genetic instability, radiosensitivity, immunodeficiency and cancer predisposition, because of mutation in both alleles of the ATM (ataxia-telangiectasia mutated) gene. The role of Atm heterozygosity in cancer susceptibility is controv...

journal_title：Oncogene

authors： Mao JH,Wu D,DelRosario R,Castellanos A,Balmain A,Perez-Losada J

更新日期：2008-11-20 00:00:00

abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

journal_title：Oncogene

authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

更新日期：1996-08-15 00:00:00

abstract：:Clear cell renal cell cancer (CC-RCC) is a highly chemoresistant tumor characterized by frequent inactivation of the von Hippel-Lindau (VHL) gene. The prognosis is reportedly worse in patients whose tumors express immunoreactive type I insulin-like growth factor receptor (IGF1R), a key mediator of tumor cell survival....

journal_title：Oncogene

authors： Yuen JS,Cockman ME,Sullivan M,Protheroe A,Turner GD,Roberts IS,Pugh CW,Werner H,Macaulay VM

更新日期：2007-10-04 00:00:00

abstract：:Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...

journal_title：Oncogene

authors： Maurici D,Monti P,Campomenosi P,North S,Frebourg T,Fronza G,Hainaut P

更新日期：2001-06-14 00:00:00

abstract：:Expression of the c-myc gene is often elevated in human colorectal tumors, but reported amplification of the locus is rare. Here we demonstrate that modest amplification of c-myc is frequently found in aggressive subtypes of colorectal cancer. Careful quantitation of c-myc copy number has shown amplification in 53.8% ...

journal_title：Oncogene

authors： Heerdt BG,Molinas S,Deitch D,Augenlicht LH

更新日期：1991-01-01 00:00:00

abstract：:Checkpoint kinase 2 (Chk2) is known to mediate diverse cellular responses to genotoxic stress. The fundamental role of Chk2 is to regulate the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both...

journal_title：Oncogene

authors： Park HU,Jeong SJ,Jeong JH,Chung JH,Brady JN

更新日期：2006-01-19 00:00:00

abstract：:Ki-1 lymphoma is a subtype of human malignant lymphoma characterized by the expression of CD30 (Ki-1) and a peculiar morphology. It is occasionally accompanied by a unique reciprocal chromosomal translocation t(2;5)(p23;q35). A Ki-1 lymphoma cell line, AMS3, was established by maintaining biopsied tumor cells in SCID ...

journal_title：Oncogene

authors： Shiota M,Fujimoto J,Semba T,Satoh H,Yamamoto T,Mori S

更新日期：1994-06-01 00:00:00

abstract：:Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth...

journal_title：Oncogene

authors： Pérez-Caro M,Gutierrez-Cianca N,González-Herrero I,López-Hernández I,Flores T,Orfao A,Sánchez-Martín M,Gutiérrez-Adán A,Pintado B,Sánchez-García I

更新日期：2007-03-15 00:00:00