Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay.

abstract：:Oncogene-induced senescence (OIS) is an intrinsic tumor suppression mechanism that requires the p53 and RB pathways and post-translational activation of C/EBPβ through the RAS-ERK cascade. We previously reported that in transformed/proliferating cells, C/EBPβ activation is inhibited by G/U-rich elements (GREs) in its ...

journal_title：Oncogene

authors： Basu SK,Gonit M,Salotti J,Chen J,Bhat A,Gorospe M,Viollet B,Claffey KP,Johnson PF

更新日期：2018-06-01 00:00:00

abstract：:YAP (Yes-associated protein) oncogene has been found to form a stable complex with members of the Angiomotin (Amot) family of proteins, which bind WW domains of YAP and sequester the protein in the cytoplasm and junctional complexes. The Amot-mediated retention of YAP in the cytoplasm results in the inhibition of its ...

journal_title：Oncogene

authors： Oka T,Schmitt AP,Sudol M

更新日期：2012-01-05 00:00:00

abstract：:p53 is a multifunctional protein that has been shown to inhibit the growth of transformed cells, arrest the cell cycle of normal cells, regulate gene transcription and influence cellular differentiation, apoptosis and senescence. This study was undertaken to determine if the expression of p53 in keratinocytes varied d...

journal_title：Oncogene

authors： Spandau DF

更新日期：1994-07-01 00:00:00

abstract：:Targeting altered cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable therapeutic strategy, but the effects of 2DG on lymphoma cells and the mechanism of action are unknown. Five T-cell lymphoma lines and two B-cell lymphoma lines were shown to be highly sensitive to 2DG. Examinatio...

journal_title：Oncogene

authors： Zagorodna O,Martin SM,Rutkowski DT,Kuwana T,Spitz DR,Knudson CM

更新日期：2012-05-31 00:00:00

abstract：:DNA double-stranded breaks (DSBs) elicit a checkpoint response that causes a delay in cell cycle progression. Early in the checkpoint response, histone H2AX is phosphorylated in the chromatin region flanking the DSB by ATM/ATR and DNA-PK kinases. The resulting foci of phosphorylated H2AX (gamma-H2AX) serve as a platfo...

journal_title：Oncogene

authors： Macůrek L,Lindqvist A,Voets O,Kool J,Vos HR,Medema RH

更新日期：2010-04-15 00:00:00

abstract：:Akt/PKB is a serine/threonine kinase that promotes tumor cell growth by phosphorylating transcription factors and cell cycle proteins. There is particular interest in finding tumor-specific substrates for Akt to understand how this protein functions in cancer and to provide new avenues for therapeutic targeting. Our l...

journal_title：Oncogene

authors： Sutherland BW,Kucab J,Wu J,Lee C,Cheang MC,Yorida E,Turbin D,Dedhar S,Nelson C,Pollak M,Leighton Grimes H,Miller K,Badve S,Huntsman D,Blake-Gilks C,Chen M,Pallen CJ,Dunn SE

更新日期：2005-06-16 00:00:00

abstract：:Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 ...

journal_title：Oncogene

authors： Zhan X,Culpepper A,Reddy M,Loveless J,Goldfarb M

更新日期：1987-01-01 00:00:00

abstract：:A potential role for 1-oleoyl-sn-glycero-3-phosphate or lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) in the regulation of malignant diseases has been widely considered. In this study, we found that in transformed astroglial cells, the expression profile of lysophospholipid receptor mRNA and the action...

journal_title：Oncogene

authors： Malchinkhuu E,Sato K,Horiuchi Y,Mogi C,Ohwada S,Ishiuchi S,Saito N,Kurose H,Tomura H,Okajima F

更新日期：2005-10-06 00:00:00

abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...

journal_title：Oncogene

authors： Xu X,Ehdaie B,Ohara N,Yoshino T,Deng CX

更新日期：2010-02-04 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is an inducible enzyme that contributes to the generation of chronic inflammation in response to chemical carcinogens and environmental stresses, including ultraviolet B (UVB) irradiation. Although post-translational histone modifications are believed to have an important role in modulating tr...

journal_title：Oncogene

authors： Keum YS,Kim HG,Bode AM,Surh YJ,Dong Z

更新日期：2013-01-24 00:00:00

abstract：:The ability of glioma cells to migrate great distances from a primary tumor mass is the primary cause of tumor recurrence. The urokinase-type plasminogen activator (uPA) is a serine protease that can initiate proteolytic cascades, which result in remodeling of extracellular matrix and basement membrane, allowing cells...

journal_title：Oncogene

authors： Chandrasekar N,Mohanam S,Gujrati M,Olivero WC,Dinh DH,Rao JS

更新日期：2003-01-23 00:00:00

abstract：:Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. Biological effects of the RAS are media...

journal_title：Oncogene

authors： Renziehausen A,Wang H,Rao B,Weir L,Nigro CL,Lattanzio L,Merlano M,Vega-Rioja A,Del Carmen Fernandez-Carranco M,Hajji N,Matin R,Harwood C,Li S,Sim VR,O'Neill K,Evans A,Thompson A,Szlosarek P,Fleming C,Stebbing J,Pr

更新日期：2019-03-01 00:00:00

abstract：:The cellular response to DNA damage is a crucial surveillance mechanism that maintains genomic integrity and prevents cancer progression. Previous studies identified multiple Ser/Thr protein kinases that have pivotal roles in the activation of this response. It is interesting that a growing body of evidence suggests t...

journal_title：Oncogene

authors： Peng A,Maller JL

更新日期：2010-11-11 00:00:00

abstract：:SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown. In this study, we demonstrated that SALL4 was aberrantly expressed at both mRNA and protein...

journal_title：Oncogene

authors： Zhang L,Xu Z,Xu X,Zhang B,Wu H,Wang M,Zhang X,Yang T,Cai J,Yan Y,Mao F,Zhu W,Shao Q,Qian H,Xu W

更新日期：2014-11-27 00:00:00

abstract：:Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...

journal_title：Oncogene

authors： Urbanucci A,Sahu B,Seppälä J,Larjo A,Latonen LM,Waltering KK,Tammela TL,Vessella RL,Lähdesmäki H,Jänne OA,Visakorpi T

更新日期：2012-04-26 00:00:00

abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...

journal_title：Oncogene

authors： Oehler MK,Hague S,Rees MC,Bicknell R

更新日期：2002-04-25 00:00:00

abstract：:B7-H4, a member of B7 family, is a transmembrane protein and inhibits T-cells immunity. However, in a variety of tumor cells, B7-H4 was detected predominantly in intracellular compartments with unknown mechanism and functions. In this study, we analyzed B7-H4 expression and subcellular distribution by immunohistochemi...

journal_title：Oncogene

authors： Zhang L,Wu H,Lu D,Li G,Sun C,Song H,Li J,Zhai T,Huang L,Hou C,Wang W,Zhou B,Chen S,Lu B,Zhang X

更新日期：2013-11-14 00:00:00

abstract：:Seventy lung tumors from 53 patients were analysed for alterations of myc family oncogenes, c-myc, N-myc and L-myc, to evaluate when activation of these genes occurs during tumor development. The 53 cases were 17 small cell carcinomas (SCCs), 18 adenocarcinomas, 12 squamous cell carcinomas (SqCs), 4 large cell carcino...

journal_title：Oncogene

authors： Yokota J,Wada M,Yoshida T,Noguchi M,Terasaki T,Shimosato Y,Sugimura T,Terada M

更新日期：1988-06-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential in which distant metastasis is the main reason for treatment failure. Till present, the underlying molecular mechanisms of NPC metastasis remains poorly understood. Here, we identified S100 calcium-binding p...

journal_title：Oncogene

authors： Meng DF,Sun R,Liu GY,Peng LX,Zheng LS,Xie P,Lin ST,Mei Y,Qiang YY,Li CZ,Xu L,Peng XS,Hu H,Lang YH,Liu ZJ,Wang MD,Guo LL,Xie DH,Shu DT,Li HF,Luo FF,Niu XT,Huang BJ,Qian CN

更新日期：2020-07-01 00:00:00

abstract：:Tumors consistently mimic wound-generating chronic inflammation; however, why they do not heal like wounds with fibrotic scars remains unknown. The components of the tumor microenvironment, such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGFs), may account for this phenomenon. Tumor formati...

journal_title：Oncogene

authors： Zhang HR,Wang XD,Yang X,Chen D,Hao J,Cao R,Wu XZ

更新日期：2017-07-06 00:00:00

abstract：:In the childhood cancer neuroblastoma (NB), the level of expression of the multidrug resistance-associated protein (MRP1) gene is strongly correlated with expression of the MYCN oncogene in primary NB tumors, suggesting that MRP1 may be a target for MYCN-mediated gene regulation. In this study, we show that MYCN induc...

journal_title：Oncogene

authors： Manohar CF,Bray JA,Salwen HR,Madafiglio J,Cheng A,Flemming C,Marshall GM,Norris MD,Haber M,Cohn SL

更新日期：2004-01-22 00:00:00

abstract：:During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...

journal_title：Oncogene

authors： Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC

更新日期：2018-02-22 00:00:00

abstract：:A flow cytometric assay was developed to examine the expression of the cellular myc oncogene in relation to cell cycle in individual cells. C-myc-oncoprotein was detected by indirect immunofluorescence using a purified sheep polyclonal antibody, anti-human-myc. Specific binding of anti-human-myc was measured by flow c...

journal_title：Oncogene

authors： Mohamed AN,Nakeff A,Mohammad RM,KuKuruga M,al-Katib A

更新日期：1988-10-01 00:00:00

abstract：:We have examined the mitogenic potential of platelet-derived growth factor (PDGF) on AIDS (acquired immune deficiency syndrome)-related and sporadic Kaposi's sarcoma cells in comparison to fibroblasts at physiological and subphysiological calcium concentrations of the culture medium. At low calcium concentrations in t...

journal_title：Oncogene

authors： Roth WK,Werner S,Schirren CG,Hofschneider PH

更新日期：1989-04-01 00:00:00

abstract：:The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recu...

journal_title：Oncogene

authors： Özeş AR,Miller DF,Özeş ON,Fang F,Liu Y,Matei D,Huang T,Nephew KP

更新日期：2016-10-13 00:00:00

abstract：:Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partia...

journal_title：Oncogene

authors： May D,Itin A,Gal O,Kalinski H,Feinstein E,Keshet E

更新日期：2005-02-03 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Two promoters, 1A and 1B, have been recognized in APC, and 1B is thought to have a minor role in the regulation of the gene. We have identified a novel deletion encompassing half of this promoter in the l...

journal_title：Oncogene

authors： Rohlin A,Engwall Y,Fritzell K,Göransson K,Bergsten A,Einbeigi Z,Nilbert M,Karlsson P,Björk J,Nordling M

更新日期：2011-12-15 00:00:00

abstract：:The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pe...

journal_title：Oncogene

authors： Khan KA,Naylor AJ,Khan A,Noy PJ,Mambretti M,Lodhia P,Athwal J,Korzystka A,Buckley CD,Willcox BE,Mohammed F,Bicknell R

更新日期：2017-11-02 00:00:00

abstract：:Heregulins (neuregulins) are a family of proteins known to interact and activate the receptor tyrosine kinases ErbB2 in association with ErbB3 or ErbB4. Using immunofluorescence microscopy, electron microscopy autoradiography, and SDS-PAGE analysis of nuclear fractions, we show that the heregulin-beta1(1-244) isoform ...

journal_title：Oncogene

authors： Li W,Park JW,Nuijens A,Sliwkowski MX,Keller GA

更新日期：1996-06-06 00:00:00

abstract：:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...

journal_title：Oncogene

authors： Yang W,Li Y,Gao R,Xiu Z,Sun T

更新日期：2020-01-01 00:00:00