Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells.

abstract：:The identification of target mRNAs is a key step for assessing the role of aberrantly expressed microRNAs in human cancer. MiR-221 is upregulated in human hepatocellular carcinoma (HCC) as well as in other malignancies. One proven target of miR-221 is CDKN1B/p27, whose downregulation affects HCC prognosis. Here, we pr...

journal_title：Oncogene

authors： Fornari F,Gramantieri L,Ferracin M,Veronese A,Sabbioni S,Calin GA,Grazi GL,Giovannini C,Croce CM,Bolondi L,Negrini M

更新日期：2008-09-25 00:00:00

abstract：:The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its beha...

journal_title：Oncogene

authors： Quimby BB,Yong-Gonzalez V,Anan T,Strunnikov AV,Dasso M

更新日期：2006-05-18 00:00:00

abstract：:Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...

journal_title：Oncogene

authors： Chadee DN,Peltier CP,Davie JR

更新日期：2002-12-05 00:00:00

abstract：:Many p53 mutants found in human cancer have an altered ability to bind DNA and transactivate gene expression. Re-expression of functional p53 in cells in which the endogenous TP53 gene is inactivated has been demonstrated to restore a non-tumorigenic phenotype. Pharmacological modulation of p53 mutant conformation may...

journal_title：Oncogene

authors： Maurici D,Monti P,Campomenosi P,North S,Frebourg T,Fronza G,Hainaut P

更新日期：2001-06-14 00:00:00

abstract：:Evidence from murine fibroblast models and human breast cancer cells indicates that c-Src and human EGF receptor (HER1) synergize to enhance neoplastic growth of mammary epithelial cells. To investigate whether interactions between c-Src and other HER family members may also play a role in breast tumor progression, we...

journal_title：Oncogene

authors： Belsches-Jablonski AP,Biscardi JS,Peavy DR,Tice DA,Romney DA,Parsons SJ

更新日期：2001-03-22 00:00:00

abstract：:The skin represents a physical and chemical barrier against invading pathogens, which is additionally supported by restriction factors that provide intrinsic cellular immunity. These factors detect viruses to block their replication cycle. Here, we uncover the Myb-related transcription factor, partner of profilin (MYP...

journal_title：Oncogene

authors： Wüstenhagen E,Boukhallouk F,Negwer I,Rajalingam K,Stubenrauch F,Florin L

更新日期：2018-11-01 00:00:00

abstract：:We have previously reported that carboxyl terminal truncations of the normal human fyn gene, a member of the src subfamily, can transform immortal mouse fibroblasts to full malignancy. In search of evidence which suggests the possible activation of the human fyn gene, we have screened DNAs and RNAs from a number of hu...

journal_title：Oncogene

authors： Kawakami Y,Furue M,Kawakami T

更新日期：1989-03-01 00:00:00

abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...

journal_title：Oncogene

authors： Denison SR,Wang F,Becker NA,Schüle B,Kock N,Phillips LA,Klein C,Smith DI

更新日期：2003-11-13 00:00:00

abstract：:Granulocyte macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and interleukin-5 (IL-5 belong to a family of cytokines that regulate proliferation, differentiation and function of haematopoietic cells. Their receptor consists of a ligand specific alpha-chain and a signal transducing beta-chain (betac)...

journal_title：Oncogene

authors： Geijsen N,Spaargaren M,Raaijmakers JA,Lammers JW,Koenderman L,Coffer PJ

更新日期：1999-09-09 00:00:00

abstract：:SIAH-1 and SIAH-2 are the human members of an evolutionary highly conserved E3 ligase family. SIAH-1 is a p53 and p21(Waf-1/Cip-1) induced gene during apoptosis and tumor suppression. In stable-transfected clones of MCF-7 cells, SIAH-1 overexpression was associated with apoptosis, mitotic alterations and p21(Waf-1/Cip...

journal_title：Oncogene

authors： Germani A,Prabel A,Mourah S,Podgorniak MP,Di Carlo A,Ehrlich R,Gisselbrecht S,Varin-Blank N,Calvo F,Bruzzoni-Giovanelli H

更新日期：2003-12-04 00:00:00

abstract：:To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respect...

journal_title：Oncogene

authors： Di Giandomenico S,Frapolli R,Bello E,Uboldi S,Licandro SA,Marchini S,Beltrame L,Brich S,Mauro V,Tamborini E,Pilotti S,Casali PG,Grosso F,Sanfilippo R,Gronchi A,Mantovani R,Gatta R,Galmarini CM,Sousa-Faro JM,D'Incalc

更新日期：2014-10-30 00:00:00

abstract：:Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-...

journal_title：Oncogene

authors： Ueno H,Honda H,Nakamoto T,Yamagata T,Sasaki K,Miyagawa K,Mitani K,Yazaki Y,Hirai H

更新日期：1997-06-26 00:00:00

abstract：:The ability of glioma cells to migrate great distances from a primary tumor mass is the primary cause of tumor recurrence. The urokinase-type plasminogen activator (uPA) is a serine protease that can initiate proteolytic cascades, which result in remodeling of extracellular matrix and basement membrane, allowing cells...

journal_title：Oncogene

authors： Chandrasekar N,Mohanam S,Gujrati M,Olivero WC,Dinh DH,Rao JS

更新日期：2003-01-23 00:00:00

abstract：:Rearrangements of the NFKB2 gene are associated with lymphoid malignancies, but the functional significance of these alterations is not known. Here we characterize structurally and functionally a rearranged NFKB2 gene identified at the T cell lymphoma line, HUT78. The rearrangement has truncated NFKB2 sequences within...

journal_title：Oncogene

authors： Zhang J,Chang CC,Lombardi L,Dalla-Favera R

更新日期：1994-07-01 00:00:00

abstract：:T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by an accumulation of immature T cells. Although patient outcomes have improved, novel targeted therapies are needed to reduce the intensity of chemotherapy and improve the prognosis of high-risk patients. Interleukin-7...

journal_title：Oncogene

authors： Buffière A,Uzan B,Aucagne R,Hermetet F,Mas M,Nassurdine S,Aznague A,Carmignac V,Tournier B,Bouchot O,Ballerini P,Barata JT,Bastie JN,Delva L,Pflumio F,Quéré R

更新日期：2019-11-01 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00

abstract：:Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy. As such, DAMPs may...

journal_title：Oncogene

authors： Hernandez C,Huebener P,Schwabe RF

更新日期：2016-11-17 00:00:00

abstract：:Radicicol, an inhibitor of Src-family protein-tyrosine kinases, causes morphological reversion of v-src- and v-Ha-ras-transformed fibroblasts and arrest of the cell cycle at both the G1 and the G2 phases. Radicicol was found to inhibit the growth of several other oncogene-transformed cell lines and human carcinoma cel...

journal_title：Oncogene

authors： Kwon HJ,Yoshida M,Nagaoka R,Obinata T,Beppu T,Horinouchi S

更新日期：1997-11-20 00:00:00

abstract：:TGF-β is a multifunctional cytokine affecting many cell types and implicated in tissue remodeling processes. Due to its many functions and cell-specific effects, the consequences of TGF-β signaling are process-and stage-dependent, and it is not uncommon that TGF-β exerts distinct and sometimes opposing effects on a di...

journal_title：Oncogene

authors： Muppala S,Xiao R,Krukovets I,Verbovetsky D,Yendamuri R,Habib N,Raman P,Plow E,Stenina-Adognravi O

更新日期：2017-09-07 00:00:00

abstract：:In Dictyostelium discoideum, three ras genes (rasD, rasG and rasB) and one ras-related gene (rap1) have been previously isolated and characterized, and the deduced amino acid sequence of their predicted protein products share at least 50% sequence identity with the human H-Ras protein. We have now cloned and character...

journal_title：Oncogene

authors： Daniel J,Bush J,Cardelli J,Spiegelman GB,Weeks G

更新日期：1994-02-01 00:00:00

abstract：:Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be the initial event associated with cancer metastasis and how it occurred is still a mystery. CtBP is known as a co-repre...

journal_title：Oncogene

authors： Zhao Z,Hao D,Wang L,Li J,Meng Y,Li P,Wang Y,Zhang C,Zhou H,Gardner K,Di LJ

更新日期：2019-03-01 00:00:00

abstract：:Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damaging aspects of ROS. Here, we show that MutT Homolog 1 (MTH1), the mam...

journal_title：Oncogene

authors： Patel A,Burton DG,Halvorsen K,Balkan W,Reiner T,Perez-Stable C,Cohen A,Munoz A,Giribaldi MG,Singh S,Robbins DJ,Nguyen DM,Rai P

更新日期：2015-05-14 00:00:00

abstract：:Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberra...

journal_title：Oncogene

authors： Johnson CE,Dunlop EA,Seifan S,McCann HD,Hay T,Parfitt GJ,Jones AT,Giles PJ,Shen MH,Sampson JR,Errington RJ,Davies DM,Tee AR

更新日期：2018-11-01 00:00:00

abstract：:TrkA is the receptor tyrosine kinase (RTK) for nerve growth factor (NGF) and stimulates NGF-dependent cell survival and differentiation in primary neurons. TrkA expression in neuronal tumors also supports NGF-dependent differentiation of neuroblastomas and apoptosis of medulloblastomas. Phosphorylation of the activati...

journal_title：Oncogene

authors： Gryz EA,Meakin SO

更新日期：2000-01-20 00:00:00

abstract：:To investigate the mechanisms of colorectal carcinogenesis, we searched for genes regulated by adenomatous polyposis coli gene product (APC) and identified a novel gene, termed HELAD1 (helicase, APC down-regulated 1). A recombinant polypeptide representing the ATPases associated with cellular activities (AAA) domain o...

journal_title：Oncogene

authors： Ishiguro H,Shimokawa T,Tsunoda T,Tanaka T,Fujii Y,Nakamura Y,Furukawa Y

更新日期：2002-09-12 00:00:00

abstract：:Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial growth factor signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale i...

journal_title：Oncogene

authors： Chen CH,Fong LWR,Yu E,Wu R,Trott JF,Weiss RH

更新日期：2017-06-22 00:00:00

abstract：:Despite the fact that objective response rates to 5-FU are as low as 20%, 5-FU remains the most commonly used drug for the treatment of colorectal cancer. The lack of understanding of resistance to 5-FU, therefore, remains a significant impediment in maximizing its efficacy. We used intestinal epithelial cells with an...

journal_title：Oncogene

authors： Klampfer L,Swaby LA,Huang J,Sasazuki T,Shirasawa S,Augenlicht L

更新日期：2005-06-02 00:00:00

abstract：:We show that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells (HBEC) by expression of K-Ras(G12V) and knockdown of p53. Further investigation demonstrates that this is due to the K-Ras/ERK1/2 MAPK pathway, as loss of p53 had little...

journal_title：Oncogene

authors： Zaganjor E,Osborne JK,Weil LM,Diaz-Martinez LA,Gonzales JX,Singel SM,Larsen JE,Girard L,Minna JD,Cobb MH

更新日期：2014-11-20 00:00:00

abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L, BAG-1M and BAG-1S. BAG-1L contains a nuclear localization signal, which is not present in the other isoforms, and is pr...

journal_title：Oncogene

authors： Cutress RI,Townsend PA,Sharp A,Maison A,Wood L,Lee R,Brimmell M,Mullee MA,Johnson PW,Royle GT,Bateman AC,Packham G

更新日期：2003-08-07 00:00:00

abstract：:The CD4 T-cell surface antigen and the lymphocyte-specific tyrosine-protein kinase p56lck form a stable noncovalent complex in CD4+ T-lymphocytes. In this report, we demonstrate that these two gene products can also associate when co-expressed in NIH3T3 fibroblasts, therefore implying that other lymphoid specific comp...

journal_title：Oncogene

authors： Simpson SC,Bolen JB,Veillette A

更新日期：1989-09-01 00:00:00