2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines.

abstract：:We have developed a transplantation system that allows us to introduce oncogenes into mouse mammary epithelial cells in culture and then to reconstitute an epithelial tree in vivo from the genetically altered cells. Introduction of the neu oncogene, a transforming homologue of the human proto-oncogene c-erbB-2, produc...

journal_title：Oncogene

authors： Bradbury JM,Arno J,Edwards PA

更新日期：1993-06-01 00:00:00

abstract：:The function of the class III histone deacetylase, Sir2, in promoting lifespan extension is well established in small model organisms. By analogy, SirT1, the mammalian orthologue of Sir2, is a candidate gene to slow down aging and forestall the onset of age-associated diseases. We have used SirT1-null mice to study th...

journal_title：Oncogene

authors： Boily G,He XH,Pearce B,Jardine K,McBurney MW

更新日期：2009-08-13 00:00:00

abstract：:Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signalling, perturbs differentiation and ultimately leads to neoplasia. Apc negatively regulates Wnt signalling but is also involved in organizing the cytoskeleton and may have a role in chromosome segregation. In vitro studies have implic...

journal_title：Oncogene

authors： Méniel V,Megges M,Young MA,Cole A,Sansom OJ,Clarke AR

更新日期：2015-07-30 00:00:00

abstract：:Wnt genes encode a set of structurally related cell surface glycoproteins that appear to have roles in cell-cell signalling. The ectopic expression of several murine Wnt genes has been implicated in the transformation of mammary epithelial and the onset of mammary tumours. Wnt11 is expressed in the developing embryo i...

journal_title：Oncogene

authors： Christiansen JH,Monkley SJ,Wainwright BJ

更新日期：1996-06-20 00:00:00

abstract：:Tat protein is an early nonstructural protein necessary for virus replication, which is secreted by infected cells and taken up by uninfected cells. Extensive evidence indicates that Tat may be a cofactor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may incl...

journal_title：Oncogene

authors： De Falco G,Bellan C,Lazzi S,Claudio P,La Sala D,Cinti C,Tosi P,Giordano A,Leoncini L

更新日期：2003-09-18 00:00:00

abstract：:We analysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic lesions, for genetic alterations at 15 microsatellite loci on the short arm of chromosome 8. Overall, loss of heterozygosity (LOH) was observed, in at least one informative locus, in 27% of the dysplastic lesions an...

journal_title：Oncogene

authors： El-Naggar AK,Coombes MM,Batsakis JG,Hong WK,Goepfert H,Kagan J

更新日期：1998-06-11 00:00:00

abstract：:Alterations in expression of c-myb can have profound effects on the growth and differentiation of hematopoietic cells. Thus, it is important to understand the mechanisms by which c-myb is regulated during hematopoietic cell differentiation. Previous studies pertaining to the regulation of c-myb have been carried out w...

journal_title：Oncogene

authors： Boise LH,Gorse KM,Westin EH

更新日期：1992-09-01 00:00:00

abstract：:Oncolytic adenoviruses, such as Delta-24-RGD (Δ24RGD), are replication-competent viruses that are genetically engineered to induce selective cancer cell lysis. In cancer cells, Δ24RGD induces massive autophagy, which is required for efficient cell lysis and adenoviral spread. Understanding the cellular mechanisms unde...

journal_title：Oncogene

authors： Klein SR,Piya S,Lu Z,Xia Y,Alonso MM,White EJ,Wei J,Gomez-Manzano C,Jiang H,Fueyo J

更新日期：2015-10-08 00:00:00

abstract：:In the search for retinoids active against Burkitt's lymphoma (BL), we found that the arotinoid mofarotene (Ro 40-8757) induced strong antiproliferative and apoptotic responses in most established BL cell lines as well as in primary BL cells. Ro 40-8757-induced apoptosis is associated with mitochondrial membrane depol...

journal_title：Oncogene

authors： Cariati R,Zancai P,Righetti E,Rizzo S,De Rossi A,Boiocchi M,Dolcetti R

更新日期：2003-02-13 00:00:00

abstract：:We have identified the mouse telomerase reverse transcriptase component (mTERT) and demonstrate both substantial sequence homology to the human ortholog (hTERT), and the presence of reverse transcriptase and telomerase specific motifs. Furthermore, we show functional interchangeability with hTERT in in vitro telomeras...

journal_title：Oncogene

authors： Greenberg RA,Allsopp RC,Chin L,Morin GB,DePinho RA

更新日期：1998-04-02 00:00:00

abstract：:LIM domain factors and associated cofactors are important developmental regulators in pattern formation and organogenesis. In addition, overexpression of two LIM-only factors (LMOs) causes acute lymphocytic leukemia. The more recently discovered LMO factor LMO4 is highly expressed in proliferating epithelial cells, an...

journal_title：Oncogene

authors： Wang N,Kudryavtseva E,Ch'en IL,McCormick J,Sugihara TM,Ruiz R,Andersen B

更新日期：2004-02-26 00:00:00

abstract：:Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective strategy to trigger an ...

journal_title：Oncogene

authors： Yang W,Li Y,Gao R,Xiu Z,Sun T

更新日期：2020-01-01 00:00:00

abstract：:Using a combination of raf and myc oncogenes co-expressed by the recombinant retrovirus J-2 we have generated and characterized a cell line which very efficiently supports the growth of B-cells and B-cell hybridomas. Murine spleen cells were cultured under in vitro immunization conditions favoring the short term proli...

journal_title：Oncogene

authors： Mischak H,Kolch W,Hofer F,Weissinger E,Gessl A,Davidson WF,Aiello FB,Blaas D,Rapp UR

更新日期：1990-09-01 00:00:00

abstract：:The NRG4 gene is a member of a family of four genes that encode a class of epidermal growth factors. This gene has been reported to express a protein designated here as NRG4A1. We describe here a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding ...

journal_title：Oncogene

authors： Hayes NV,Newsam RJ,Baines AJ,Gullick WJ

更新日期：2008-01-24 00:00:00

abstract：:Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...

journal_title：Oncogene

authors： Deblois G,St-Pierre J,Giguère V

更新日期：2013-07-25 00:00:00

abstract：:Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, characterized by childhood sarcoma, leukemia and early onset breast cancer and has occasionally been found also in familial breast-ovarian cancer. Most mutations found are of missense type and located in the central regio...

journal_title：Oncogene

authors： Sun XF,Johannsson O,Håkansson S,Sellberg G,Nordenskjöld B,Olsson H,Borg A

更新日期：1996-07-18 00:00:00

abstract：:The myb proto oncogene product (c-Myb) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis. It has been shown [Venturelli, D., Travali, S. & Calabretta, B. (1990). Proc. Natl. Acad. Sci. USA, 87, 5963-5967] that inhibition of T-cell pro...

journal_title：Oncogene

authors： Sudo T,Miyazawa H,Hanaoka F,Ishii S

更新日期：1992-10-01 00:00:00

abstract：:Omi is a mammalian serine protease that is localized in the mitochondria and released to the cytoplasm in response to apoptotic stimuli. Omi induces cell death in a caspase-dependent manner by interacting with the X-chromosome linked inhibitor of apoptosis protein, as well as in a caspase-independent way that relies o...

journal_title：Oncogene

authors： Junqueira D,Cilenti L,Musumeci L,Sedivy JM,Zervos AS

更新日期：2003-05-08 00:00:00

abstract：:We report chromosome 3p deletion mapping of 32 cervical carcinoma (CC) biopsies using 26 microsatellite markers located in frequently deleted 3p regions to detect loss of heterozygosity and homozygous loss. In addition, two STS markers (NLJ-003 and NL3-001) located in the 3p21.3 telomeric (3p21.3T) and 3p21.3 centrome...

journal_title：Oncogene

authors： Senchenko V,Liu J,Braga E,Mazurenko N,Loginov W,Seryogin Y,Bazov I,Protopopov A,Kisseljov FL,Kashuba V,Lerman MI,Klein G,Zabarovsky ER

更新日期：2003-05-15 00:00:00

abstract：:Recent explosive advances in next-generation sequencing technology and computational approaches to massive data enable us to analyze a number of cancer genome profiles by whole-genome sequencing (WGS). To explore cancer genomic alterations and their diversity comprehensively, global and local cancer genome-sequencing ...

journal_title：Oncogene

authors： Nakagawa H,Wardell CP,Furuta M,Taniguchi H,Fujimoto A

更新日期：2015-12-03 00:00:00

abstract：:There is an emerging body of evidence implicating iron in carcinogenesis and in particular colorectal cancer, but whether this involves Wnt signalling, a major oncogenic signalling pathway has not been studied. We aimed to determine the effect of iron loading on Wnt signalling using mutant APC (Caco-2 and SW480) and w...

journal_title：Oncogene

authors： Brookes MJ,Boult J,Roberts K,Cooper BT,Hotchin NA,Matthews G,Iqbal T,Tselepis C

更新日期：2008-02-07 00:00:00

abstract：:Bcl-2 is a key inhibitor of a broad range of apoptotic pathways, yet neither the mechanism of action nor the role of Bcl-2 subcellular localization are well understood. The subcellular localization of Bcl-2 includes the mitochondrial membrane as well as the contiguous membrane of the endoplasmic reticulum and nuclear ...

journal_title：Oncogene

authors： Lee ST,Hoeflich KP,Wasfy GW,Woodgett JR,Leber B,Andrews DW,Hedley DW,Penn LZ

更新日期：1999-06-10 00:00:00

abstract：:Loss of the tumor suppressive effect of transforming growth factor-beta (TGF-beta) has been commonly found at later stages in carcinogenic progression. Although the genes encoding TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutation in Smad3 has been observed. Therefor...

journal_title：Oncogene

authors： Han SU,Kim HT,Seong DH,Kim YS,Park YS,Bang YJ,Yang HK,Kim SJ

更新日期：2004-02-19 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a kind of adult stem cells that can be isolated easily from bone marrow, adipose tissue, umbilical cord and many other tissues. MSCs have been shown to specifically migrate to inflammatory sites, including tumors, and hold great promise as tumor-specific vectors to deliver antitumor a...

journal_title：Oncogene

authors： Xu C,Lin L,Cao G,Chen Q,Shou P,Huang Y,Han Y,Wang Y,Shi Y

更新日期：2014-10-16 00:00:00

abstract：:A growing body of literature suggests that the ubiquitously expressed Src family kinases (Src, Fyn and Yes) are required for agents such as platelet-derived growth factor (PDGF) to stimulate DNA synthesis. Yet Klinghoffer and colleagues recently presented evidence that fibroblasts derived from mice null for Src, Fyn a...

journal_title：Oncogene

authors： Broome MA,Courtneidge SA

更新日期：2000-06-01 00:00:00

abstract：:One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly e...

journal_title：Oncogene

authors： Yang J,Zhang Z,Chen C,Liu Y,Si Q,Chuang TH,Li N,Gomez-Cabrero A,Reisfeld RA,Xiang R,Luo Y

更新日期：2014-06-05 00:00:00

abstract：:Ectopic expression of the intracellular domain of NOTCH-4/INT-3 leads to tumorigenesis in the mouse mammary gland. This results from a gain-of-function mutation. To evaluate gain-of-function NOTCH-4/INT-3 activity in human cancers we have surveyed human breast, lung, and colon carcinoma tissue culture cell lines for e...

journal_title：Oncogene

authors： Imatani A,Callahan R

更新日期：2000-01-13 00:00:00

abstract：:One of the key events in tumor initiation in mouse skin is mutational activation of the H-ras gene. Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. We describe he...

journal_title：Oncogene

authors： Chakravarti D,Mailander P,Franzen J,Higginbotham S,Cavalieri EL,Rogan EG

更新日期：1998-06-18 00:00:00

abstract：:Nuclear-enriched RNA-binding proteins (RBPs) are mainly involved in transcriptional regulation, which is a critical checkpoint to tune gene diversity and expression levels. We analyzed nuclear RBPs in human HCC tissues and matched normal control tissues. Based on the gene expression levels, PTBP3 was identified as top...

journal_title：Oncogene

authors： Yang X,Qu S,Wang L,Zhang H,Yang Z,Wang J,Dai B,Tao K,Shang R,Liu Z,Li X,Zhang Z,Xia C,Ma B,Liu W,Li H,Dou K

更新日期：2018-12-01 00:00:00

abstract：:We have isolated a gene (WS5) that is specifically expressed at the mRNA and protein level in avian fibroblasts transformed by the v-myc oncogene of avian acute leukemia virus MC29. In a conditional cell transformation system, WS5 gene expression was tightly correlated with v-myc activation. The WS5 gene contains 11 e...

journal_title：Oncogene

authors： Reiter F,Hartl M,Karagiannidis AI,Bister K

更新日期：2007-03-15 00:00:00