Abstract:
:Tat protein is an early nonstructural protein necessary for virus replication, which is secreted by infected cells and taken up by uninfected cells. Extensive evidence indicates that Tat may be a cofactor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may include deregulation of cellular genes. Among these genes, it has recently been shown that pRb2/p130 oncosuppressor protein is one of the targets in the interaction between HIV gene product Tat and host proteins. However, whether the HIV-1 gene product Tat may inactivate the oncosuppressive function of pRb2/p130 has not yet been elucidated. Here, we show that mRNA levels of pRb2/p130 increase in the presence of Tat, whereas no change in the phosphorylation status of pRb2/p130 is observed. In addition, Tat can inhibit the growth control activity exerted by pRb2/p130 in the T98G cell line. Finally, Tat does not compete with E2F-4 in binding to pRb2/p130. The interaction between Tat and pRb2/p130 seems to result in the deregulation of the control exerted by pRb2/p130 on the cell cycle. Taken together, these results open a window on the role of pRb2/p130 in AIDS-related oncogenesis.
journal_name
Oncogenejournal_title
Oncogeneauthors
De Falco G,Bellan C,Lazzi S,Claudio P,La Sala D,Cinti C,Tosi P,Giordano A,Leoncini Ldoi
10.1038/sj.onc.1206637subject
Has Abstractpub_date
2003-09-18 00:00:00pages
6214-9issue
40eissn
0950-9232issn
1476-5594pii
1206637journal_volume
22pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Induction of apoptosis by adenovirus E1A in rodent cells is stimulated by wild type (wt) p53 but completely suppressed by mutated p53. The suppression is overcome by coexpression with Id proteins (Ids). The cells expressing E1A and Ids undergo apoptosis after accumulation in S phase, suggesting that S phase events are...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203063
更新日期:1999-08-26 00:00:00
abstract::Induction of apoptosis in tumor cells is an important mechanism of chemotherapy-induced cell death. The tumor-suppressor gene p53 is required for the efficient activation of apoptosis following chemotherapy. However, the molecular mechanism regulating p53-associated apoptosis remains controversial. In this study, we s...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-05-18 00:00:00
abstract::Previous observations suggest expression of cyclooxygenase-2 to convey macrophage protection towards apoptotic cell death. We reasoned prostaglandin formation and in turn a cAMP increase as the underlying protective principle. Here we report that exposure of macrophages to lipopolysaccharide/interferon-gamma or lipoph...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201926
更新日期:1998-07-23 00:00:00
abstract::Transcriptomic screens in breast cancer cell lines have identified a protein named anterior gradient-2 (AGR2) as a potentially novel oncogene overexpressed in estrogen receptor (ER) positive tumours. As targeting the ER is responsible for major improvements in cure rates and prevention of breast cancers, we have evalu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.228
更新日期:2010-08-26 00:00:00
abstract::The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209997
更新日期:2007-03-22 00:00:00
abstract::Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201073
更新日期:1997-05-15 00:00:00
abstract::Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
abstract::Angiogenesis is essential for tumor growth and blocking this process might be a valid tool for the control of cancer growth. We showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of wild type animals and that over-expression of matrix metalloproteinase 9 (MMP-9) in the a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205045
更新日期:2002-01-10 00:00:00
abstract::The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. Little is yet known about the mode of action of hScrib, although recent reports suggest its role in the regulation of cell signalling. In this study we show that hScri...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.265
更新日期:2010-09-23 00:00:00
abstract::Prostate carcinoma (PCA) is the most frequently diagnosed malignancy in American men. PCA at advanced stages can both proliferate abnormally and resist apoptosis. Among the many known signal transduction pathways, phosphatidylinositide-3'OH kinase (PI3-kinase) has been shown to play an important role in cell survival ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202687
更新日期:1999-06-03 00:00:00
abstract::Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.123
更新日期:2008-08-14 00:00:00
abstract::Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of TEL-AML1-associated acute l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.148
更新日期:2015-04-16 00:00:00
abstract::Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.132
更新日期:2013-02-28 00:00:00
abstract::Although there is indirect genetic evidence that MEN1, the gene for multiple endocrine neoplasia type 1, is a tumor suppressor gene, little is known about the MEN1-encoded protein, menin. Menin was stably overexpressed in a well-characterized murine tumor cell line, (valine-12)-RAS-transformed NIH3T3 cells. Menin over...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203005
更新日期:1999-10-21 00:00:00
abstract::ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.162
更新日期:2009-08-20 00:00:00
abstract::SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in malignant rhabdoid tumors (MRT) and atypical teratoid/rhabdoid tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. SMARCB1 is a core subunit of Swi/Snf chromatin remodeling complexes, and loss ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.261
更新日期:2014-06-05 00:00:00
abstract::Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell metabolism also directly influences genetic, epigenetic and signaling events associated with tumor progression. Many cancer cells are addicted to glut...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.364
更新日期:2017-04-01 00:00:00
abstract::Expression of constitutively activated M-Ras in normal murine bone-marrow cells was sufficient to induce the factor-independent, in vitro growth and differentiation of colonies of macrophages and neutrophils, and the generation of immortal lines of factor-independent mast cells, and, upon in vivo injection of the tran...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208441
更新日期:2005-03-31 00:00:00
abstract::Activation of the EGF receptor (c-erbB) tyrosine kinase has been implicated in tumorigenesis, either by overexpression of the normal receptor in the presence of EGF, or through expression of a truncated receptor lacking the EGF binding domain as in the viral oncogene v-erbB. Here, normal and truncated human EGF recept...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules mediating cytoskeletal reorganization. The cortactin gene, EMS1, maps to chromosome 11q13, a region amplified in head and neck squamous cell carcinoma...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201850
更新日期:1998-06-25 00:00:00
abstract::The human c-abl oncogene gives rise to different mRNA transcripts which vary primarily in that they possess alternative first exons. In the present study, we present the sequence for the human c-abl 3' untranslated region (3'utr) and show that while human and murine c-abl cDNA sequences are generally homologous, human...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS). Seventy-five percent of ARMS harbor reciprocal chromosomal translocations leading to fusion genes of the forkhead transcriptio...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.368
更新日期:2010-12-02 00:00:00
abstract::Integrin α3β1 regulates adhesive interactions of cells with laminins and have a critical role in adhesion-dependent cellular responses. Here, we examined the role of α3β1-integrin in ErbB2-dependent proliferation of breast cancer cells in three-dimensional laminin-rich extracellular matrix (3D lr-ECM). Depletion of α3...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.231
更新日期:2014-05-22 00:00:00
abstract::T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.481
更新日期:2016-08-04 00:00:00
abstract::Recently, we have cloned and characterized the Ras association domain family 1A gene (RASSF1A) at 3p21.3, from which loss of genetic material is one of the most frequent events in several types of human solid tumors. The CpG island promoter region of this gene is highly methylated in several human cancers, most notabl...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205814
更新日期:2002-10-03 00:00:00
abstract::BCL11 genes play crucial roles in lymphopoiesis and have been associated with hematopoietic malignancies. Specifically, disruption of the BCL11B (B-cell chronic lymphocytic leukemia/lymphoma 11B) locus is linked to T-cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T-cell lymphoma. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208904
更新日期:2005-10-13 00:00:00
abstract::Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::Amplified in breast cancer 1 (AIB1) is a transcriptional coactivator for nuclear receptors and other transcription factors. AIB1 has an important role in malignancy of several cancers such as breast and prostate cancers. However, its involvement in human hepatocellular carcinoma (HCC) progression remains unclear. Here...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.90
更新日期:2010-06-10 00:00:00
abstract::Ataxia telangiectasia (AT) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (ATM) protein kinase, is involved in multiple intracellular signaling pathways. We demonstrated previously that AT fibroblasts are defective in intracellular Ca(2+) mobilization in response to both st...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206167
更新日期:2003-01-23 00:00:00