Abstract:
:Leukemic lymphoblasts within different immunophenotypic populations possess stem cell properties. However, whether or not the self-renewal program is retained from stem cells or conferred on progenitors by leukemogenic molecules remains unknown. We have addressed the issue in the context of TEL-AML1-associated acute lymphoblastic leukemia (ALL) by profiling a refined program edited from genes essential for self-renewal of hematopoietic stem cells and B-cell development. Bioinformatic analysis shows that ALL populations are loosely clustered and close to the normal population that contains stem and primitive progenitor cells. This finding indicates that immunophenotypes do not reflect maturation stages in ALL and that the self-renewal program may be retained from stem cells. Results of assessing 'first hit' function of TEL-AML1 in different populations of normal cells demonstrate the molecular model. Therefore, the current study shows a leukemogenic scenario of human ALL in which programs of stem cells are sustained in distinct fractions by leukemogenic mutations.
journal_name
Oncogenejournal_title
Oncogeneauthors
Fan D,Zhou X,Li Z,Li ZQ,Duan C,Liu T,Zhang F,Huang Y,Zhang Y,Gao F,Guo Y,Gupta R,Chen G,Enver T,Tang J,Hong Ddoi
10.1038/onc.2014.148subject
Has Abstractpub_date
2015-04-16 00:00:00pages
2083-93issue
16eissn
0950-9232issn
1476-5594pii
onc2014148journal_volume
34pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205737
更新日期:2002-09-05 00:00:00
abstract::The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes. However, it is not clear which genes are the biological targets of WT1, nor which cellular pathway(s) is critically altered in tumors as a result of WT1 muta...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206597
更新日期:2003-06-12 00:00:00
abstract::Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence of metastases. We and others demonstrated that nuclear ErbB-2 (NErbB-2) also plays a key role in BC and is a poor prognostic factor in ErbB...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.281
更新日期:2016-04-28 00:00:00
abstract::Ras-genes encode for proteins important for transmitting extracellular signals from the cytoplasm to the nucleus. In this study we investigated the impact of Ras on cell cycle progression after hepatectomy by using adenoviral vectors (adv) expressing beta-galactosidase (beta-gal), a dominant-negative (Ras N17) or a do...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204690
更新日期:2001-08-30 00:00:00
abstract::Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target gene...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207892
更新日期:2004-11-04 00:00:00
abstract::Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct oncogenic activity by signaling through protease-activated receptor-1 (PAR1) in car...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.157
更新日期:2014-04-24 00:00:00
abstract::Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.377
更新日期:2013-08-08 00:00:00
abstract::Aromatase inhibitors (AIs) are the standard endocrine therapy for postmenopausal breast cancer; however, currently used biomarkers, such as, estrogen receptor-alpha/progesterone receptor (ERα/PR), predict only slightly more than half of the potential responders to AI treatment. To identify novel markers of AI responsi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.553
更新日期:2015-01-15 00:00:00
abstract::The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204910
更新日期:2001-10-25 00:00:00
abstract::Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208081
更新日期:2004-10-18 00:00:00
abstract::To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0238-8
更新日期:2018-07-01 00:00:00
abstract::The function of Bcl-2 family members on the endoplasmic reticulum has received increasing attention in recent years. The endoplasmic reticulum is the major organelle involved in intracellular calcium homeostasis and calcium signaling, including calcium signals that mediate apoptosis induction by anticancer drugs. But ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207519
更新日期:2004-04-12 00:00:00
abstract::Reexpression of hypermethylated tumor suppressor genes using DNA methyltransferase (DNMT) and histone deacetylase inhibitors occurs by a mechanism whereby promoter demethylation is the dominant event. In support of this model, we found in acute myeloid leukemia cells with hypermethylated p15INK4B and E-cadherin promot...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.361
更新日期:2010-01-28 00:00:00
abstract::The p53/p21Cip1/Waf1-dependent checkpoint control of G1/S and G2/M phases of the cell cycle in response to DNA damage is an important mechanism of genome stability maintenance in normal cells. In many tumor cells, due to frequent point mutations and deletions of p53, the stringent control of the cell cycle and apoptos...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202945
更新日期:1999-10-07 00:00:00
abstract::Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) has been suggested to be involved in tumor metastasis. However, the molecular mechanism of LMP1-induced metastasis is largely unknown. In this study, we investigated the effect of LMP1 on the expression of RECK, a metastasis suppressor gene, in an EBV-negative ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207157
更新日期:2003-11-13 00:00:00
abstract::RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal transduction, differentiation and apoptosis. Most of the RING-finger proteins have E3-ubiquitin ligase activity. RNF11 is a small RING-finger protein and harbors a RING-H2 domain and a PY motif that...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207319
更新日期:2004-03-11 00:00:00
abstract::The sirtuins (SIRT 1-7) comprise a family of NAD⁺-dependent protein-modifying enzymes with activities in lysine deacetylation, adenosinediphospho(ADP)-ribosylation, and/or deacylation. These enzymes are involved in the cell's stress response systems and in regulating gene expression, DNA damage repair, metabolism and ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.120
更新日期:2014-03-27 00:00:00
abstract::Cancer is classically considered as a genetic and, more recently, epigenetic multistep disease. Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. This review aims to provide a histori...
journal_title:Oncogene
pub_type: 历史文章,杂志文章,评审
doi:10.1038/onc.2011.576
更新日期:2012-09-06 00:00:00
abstract::Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive brea...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.130
更新日期:2009-07-30 00:00:00
abstract::The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.304
更新日期:2014-07-03 00:00:00
abstract::Recent evidence suggests that squamous cell carcinoma of the vulva may have more than one etiology, with only some tumors associated with human papillomavirus (HPV). Cells infected with HPV produce a viral protein (E6) which binds to and causes rapid degradation of p53, possibly contributing to cellular transformation...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::BRCA1 mutation carriers have an increased susceptibility to breast and ovarian cancer. Excision of exon 11 of Brca1 in the mouse, using a conditional knockout (Cre-loxP) approach, results in mammary tumor formation after long latency. To characterize the genomic instability observed in these tumors, to establish a com...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205636
更新日期:2002-08-01 00:00:00
abstract::Pancreatic cancer is characterized by early metastatic spread, but the process of tumor cell dissemination is largely unknown. In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. Variations in the lev...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.298
更新日期:2010-01-07 00:00:00
abstract::Expression of the avian E26-derived Gag-Myb-Ets fusion oncogene in interleukin-3(IL3)-dependent murine hematopoietic cell lines results in a pattern of cell line dependent changes in growth factor-induced proliferation and apoptosis. A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-01-18 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0985-1
更新日期:2020-01-01 00:00:00
abstract::Previous studies have documented that Tumor necrosis factor alpha (TNFalpha) is a potent negative regulator of normal hematopoiesis. However, the mechanism by which TNFalpha acts at the cellular level is not totally understood. Although apoptotic cell killing appears to be the most common cellular effect of TNFalpha, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208024
更新日期:2004-09-30 00:00:00
abstract::SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling. The potential role of this enzyme in hepatocarcinogenesis has now been investigated by examining its expression in 32 su...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206588
更新日期:2003-07-24 00:00:00
abstract::Deletion or loss-of-function mutation of LKB1, frequently occurring in non-small cell lung cancers (NSCLCs), is a predominant caution of NSCLC initiation and progression. However, the upstream signaling pathways governing LKB1 activation are largely unknown. Here, we report that LKB1 undergoes Aurora kinase A (AURKA)-...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.354
更新日期:2018-01-25 00:00:00
abstract::Previously, we showed that the BRCA1 protein interacts directly and functionally with estrogen receptor-alpha (ER-alpha), resulting in the inhibition of estradiol (E2)-stimulated ER-alpha transcriptional activity. The interaction sites were mapped to the N-terminus of BRCA1 (within amino acids (aa) 1-302) and the liga...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208190
更新日期:2005-03-10 00:00:00