Abstract:
:T-cell acute lymphoblastic leukemia (T-ALL) frequently involves aberrant expression of TAL1 (T-cell acute lymphocytic leukemia 1) and LMO2, oncogenic members of the TAL1 transcriptional complex. Transcriptional activity of the TAL1-complex is thought to have a pivotal role in the transformation of thymocytes and is associated with a differentiation block and self-renewal. The transcription factor Forkhead Box P3 (FOXP3) was recently described to be expressed in a variety of malignancies including T-ALL. Here we show that increased FOXP3 levels negatively correlate with expression of genes regulated by the oncogenic TAL1-complex in human T-ALL patient samples as well as a T-ALL cell line ectopically expressing FOXP3. In these cells, FOXP3 expression results in altered regulation of cell cycle progression and reduced cell viability. Finally, we demonstrate that FOXP3 binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1, providing a molecular mechanism for FOXP3-mediated transcriptional modulation in T-ALL. Collectively, our findings provide initial evidence for a novel role of FOXP3 as a tumor suppressor in T-ALL through modulation of TAL1 transcriptional activity.
journal_name
Oncogenejournal_title
Oncogeneauthors
Fleskens V,Mokry M,van der Leun AM,Huppelschoten S,Pals CE,Peeters J,Coenen S,Cardoso BA,Barata JT,van Loosdregt J,Coffer PJdoi
10.1038/onc.2015.481subject
Has Abstractpub_date
2016-08-04 00:00:00pages
4141-8issue
31eissn
0950-9232issn
1476-5594pii
onc2015481journal_volume
35pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Neuroblastoma is the second most common pediatric malignancy, characterized by a high rate of unexplained spontaneous remissions. Much progress has been made in understanding neuroblastoma differentiation triggered by certain agents such as retinoic acid. However, little is known about the signalling pathways that lea...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208494
更新日期:2005-05-05 00:00:00
abstract::The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.93
更新日期:2014-03-20 00:00:00
abstract::We have previously reported that carboxyl terminal truncations of the normal human fyn gene, a member of the src subfamily, can transform immortal mouse fibroblasts to full malignancy. In search of evidence which suggests the possible activation of the human fyn gene, we have screened DNAs and RNAs from a number of hu...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::One prominent effect of IFNs is their cell growth-inhibitory activity. The mechanism behind this inhibition of proliferation is still not fully understood. In this study, the effect of IFN-alpha treatment on cell cycle progression has been analysed in three lymphoid cell lines, Daudi, U-266 and H9. Examination of the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202609
更新日期:1999-05-06 00:00:00
abstract::Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204097
更新日期:2000-12-27 00:00:00
abstract::Alterations affecting the epidermal growth factor (EGF)/transforming growth factor alpha (TGF alpha)-responsive mitogenic pathway are frequently detected in malignancies. In particular, the EGF-receptor (EGFR) molecule has been found overexpressed in a number of human tumors, and TGF alpha is produced by a large array...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent studies have indicated that...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.383
更新日期:2009-01-15 00:00:00
abstract::It is necessary to understand mechanisms by which differentiating agents influence tumor-initiating cancer stem cells. Toward this end, we investigated the cellular and molecular responses of glioblastoma stem-like cells (GBM-SCs) to all-trans retinoic acid (RA). GBM-SCs were grown as non-adherent neurospheres in grow...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.58
更新日期:2011-08-04 00:00:00
abstract::Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.145
更新日期:2011-10-27 00:00:00
abstract::Branching morphogenesis within the peripubertal mouse mammary gland is directed by progesterone (P). A role for the homeobox-containing transcription factor, Msx2, during branching morphogenesis is suggested from its ontogenic expression profile and hormonal regulation. Herein, we define the spatio-temporal control of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210555
更新日期:2007-11-29 00:00:00
abstract::Mcl-1 is an antiapoptotic member of the Bcl-2 family that can promote cell viability. We report here that Mcl-1 is a new substrate for caspases during induction of apoptosis. Mcl-1 cleavage occurs after Asp127 and Asp157 and generates four fragments of 24, 19, 17 and 12 kDa in both intact cells and in vitro, an effect...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208069
更新日期:2004-10-14 00:00:00
abstract::NIH sponsored a meeting of medical and veterinary pathologists with mammary gland expertise in Annapolis in March 1999. Rapid development of mouse mammary models has accentuated the need for definitions of the mammary lesions in genetically engineered mice (GEM) and to assess their usefulness as models of human breast...
journal_title:Oncogene
pub_type: 共识发展会议,杂志文章,评审
doi:10.1038/sj.onc.1203277
更新日期:2000-02-21 00:00:00
abstract::The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform myelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204071
更新日期:2001-01-11 00:00:00
abstract::Promoter methylation is an important pathway in transcriptional silencing of known and candidate tumor suppressor genes in Head and Neck Squamous Cell Carcinoma (HNSCC). In order to study the association of tumor suppressor gene promoter methylation in HNSCC with patient clinical characteristics, especially alcohol co...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205528
更新日期:2002-06-20 00:00:00
abstract::Retinoids (natural and synthetic derivatives of vitamin A) signal potent differentiation and growth-suppressive effects in diverse normal, premalignant, and malignant cells. A strong rationale exists for the use of retinoids in cancer treatment and chemoprevention based on preclinical, epidemiological, and early clini...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206936
更新日期:2003-10-20 00:00:00
abstract::A novel oncogene, rsc (rabbit squamous cell carcinoma), has been identified from a DMBA-induced rabbit squamous cell carcinoma using gene transfer and the nude mouse tumorigenesis assay. A full-length cDNA has been isolated and sequenced. rsc has potent tumorigenic activity in nude mice (latency <4 weeks), but does no...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200950
更新日期:1997-03-20 00:00:00
abstract::Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.132
更新日期:2013-02-28 00:00:00
abstract::Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; howev...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2015.318
更新日期:2016-05-12 00:00:00
abstract::Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210786
更新日期:2008-03-06 00:00:00
abstract::Loss of Fanconi anemia (FA) proteins activity by recessive inherited mutations in one of the FA genes leads to a disease characterized by bone marrow failure, myeloid leukemia and DNA damage hypersensitivity. The aim of this work was to improve our understanding of the FA syndrome defining the transcription profile of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207677
更新日期:2004-06-24 00:00:00
abstract::The transforming potential of adenovirus E1A oncogene products derives largely from the formation of complexes with cellular proteins, including the p105Rb tumor suppressor and a related p107 species, p130 and p300 proteins, and cyclin A (p60cycA). Extensive quantitative analyses using E1A deletion mutants identified ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-02-01 00:00:00
abstract::Constitutive expression of the activated Rap1A protein inhibits differentiation of myogenic C2 cells whereas the inactivated Rap1A protein favours cell differentiation and induces late endocytic compartments clustering. Although the role of Rap1A in MAPK activation has been analysed in various cell types, the signalli...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203984
更新日期:2000-12-07 00:00:00
abstract::TSC1 and TSC2 are responsible for the tumor suppressor gene syndrome tuberous sclerosis (TSC). Mammalian TSC genes have been shown to be involved in cell cycle regulation. Recently, in Drosophila, these data have been confirmed and TSC genes have further been demonstrated to affect cell size control. Here we provide s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206776
更新日期:2003-07-31 00:00:00
abstract::L-ascorbate (L-ascorbic acid, vitamin C) clearly has an inhibitory effect on cancer cells. However, the mechanism underlying differential sensitivity of cancer cells from same tissue to L-ascorbate is yet to be clarified. Here, we demonstrate that L-ascorbate has a selective killing effect, which is influenced by sodi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.176
更新日期:2013-03-21 00:00:00
abstract::A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Although activation of the STAT3 pathway has been associated with tumor progression in a wide variety of cancer types (including ovarian cancer), the precise mechanism of invasion and metastasis due to STAT3 are not fully delineated in ovarian cancer. We found that pSTAT3 Tyr705 is constitutively activated in patient ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.197
更新日期:2017-01-12 00:00:00
abstract::To investigate the relationship between the local configuration of a gene and its level of expression, we constructed a rat cell line, Hy5, carrying a mutant polyomavirus middle T oncogene (pmt) whose overexpression converted the cells to the transformed state. The structure of the transgene was such that pmt was able...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::Lin28b is an RNA-binding protein that inhibits biogenesis of let-7 microRNAs. LIN28B is overexpressed in diverse cancers, yet a specific role in the molecular pathogenesis of colon cancer has to be elucidated. We have determined that human colon tumors exhibit decreased levels of mature let-7 isoforms and increased ex...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.131
更新日期:2011-10-06 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency to the identification of new pathway dependencies and ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0965-5
更新日期:2019-09-01 00:00:00
abstract::Sex-determining region Y box 6 (SOX6) has been described as a tumor-suppressor gene in several cancers. Our previous work has suggested that SOX6 upregulated p21(Waf1/Cip1)(p21) expression in a p53-dependent manner; however, the underlying mechanism has remained elusive. In this study, we confirmed that SOX6 can suppr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.234
更新日期:2016-03-31 00:00:00