Abstract：
:Breast cancer is genetically and clinically heterogeneous. Triple negative breast cancer (TNBC) is a subtype of breast cancer that is usually associated with poor outcome and lack of benefit from targeted therapy. We used microarray analysis to perform a pathway analysis of TNBC compared with non-triple negative breast cancer (non-TNBC). Overexpression of several Wnt pathway genes, such as frizzled homolog 7 (FZD7), low density lipoprotein receptor-related protein 6 and transcription factor 7 (TCF7) was observed in TNBC, and we directed our focus to the Wnt pathway receptor, FZD7. To validate the function of FZD7, FZD7shRNA was used to knock down FZD7 expression. Notably, reduced cell proliferation and suppressed invasiveness and colony formation were observed in TNBC MDA-MB-231 and BT-20 cells. Study of the possible mechanism indicated that these effects occurred through silencing of the canonical Wnt signaling pathway, as evidenced by loss of nuclear accumulation of β-catenin and decreased transcriptional activity of TCF7. In vivo studies revealed that FZD7shRNA significantly suppressed tumor formation, through reduced cell proliferation, in mice bearing xenografts without FZD7 expression. Our findings suggest that FZD7-involved canonical Wnt signaling pathway is essential for tumorigenesis of TNBC, and thus, FZD7 shows promise as a biomarker and a potential therapeutic target for TNBC.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yang L,Wu X,Wang Y,Zhang K,Wu J,Yuan YC,Deng X,Chen L,Kim CC,Lau S,Somlo G,Yen Ydoi
10.1038/onc.2011.145subject
Has Abstractpub_date
2011-10-27 00:00:00pages
4437-46issue
43eissn
0950-9232issn
1476-5594pii
onc2011145journal_volume
30pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Adenovirus contains two nuclear oncogenes, the EIA and EIB genes, which cooperatively can transform cells through mechanisms that are not understood. The transcriptional activities of the E1A gene (transactivation and repression) are well studied. Using transient expression assays, we show here that the 19,000-Da E1B ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:There is an increasing interest in determining the role of ribosomal proteins (RPs) in the regulation of MDM2-p53 pathway in coordinating cellular response to stress. Herein, we report a novel regulatory role of ribosomal protein S25 (RPS25) in MDM2-mediated p53 degradation and a feedback regulation of S25 by p53. We ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.289
更新日期：2013-05-30 00:00:00
abstract：:To clarify the incidence, timing and pathogenetic significance of p53 gene alterations in the progression of small-cell lung carcinoma (SCLC), 17 primary tumors, 13 metastases and nine cell lines from 27 patients were analysed by a polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The transcription factor Snail has been recently proposed as an important mediator of tumour invasion because of its role in downregulation of E-cadherin and induction of epithelial-mesenchymal transitions (EMT). This behaviour has led to the consideration of Snail as a potential therapeutic target to block tumour pro...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209997
更新日期：2007-03-22 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is involved in diverse processes such as inflammation, carcinogenesis and apoptosis. As COX-2 inhibitors interfere with these processes, inhibition of COX-2 has been suggested as a promising anticancer treatment. However, the role of COX-2 in modulation of apoptosis as well as the death pathwa...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206837
更新日期：2003-09-11 00:00:00
abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-08-15 00:00:00
abstract：:There is now much evidence to suggest that the p53 tumour suppressor protein functions to monitor the integrity of the genome. When DNA damage is detected, p53 suppresses cell growth to allow repair or directs the cell into apoptosis. The mechanism of action of p53 is as yet unclear but recent evidence has accumulated...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-10-05 00:00:00
abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for many developmental process as well as homeostasis in the adult. Many lines of evidence also suggest that RA, acting through the RA receptors (RARs), can also suppress growth of tumors of diverse origin. To assess direct...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207682
更新日期：2004-07-08 00:00:00
abstract：:The MAP kinase pathway impinging on ERK2 has been shown to be integrally associated with mitogenic signalling in many cell types. Previously, we and others have demonstrated that oncogenic forms of Raf-1 kinase, when expressed in fibroblasts, lead to the constitutive activation of ERK2, the de-regulation of c-fos expr...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-11-16 00:00:00
abstract：:The c-myb gene is the normal cellular homolog of v-myb, the oncogenic component of Avian Myeloblastosis Virus (AMV). The c-myb gene has previously been shown to code for a single protein species of about 75 kd. However, accumulating evidence indicates that this gene could code for multiple mRNAs as a result of differe...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor, which upon activation, recruits downstream proteins by poly(ADP-ribosyl)ation (PARylation). However, it remains largely unclear how PARP1 activity is regulated. Interestingly, the data obtained through this study revealed that PARP1 was co-immunoprecipitate...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0506-7
更新日期：2019-02-01 00:00:00
abstract：:p73 encodes multiple functionally distinct isoforms. Proapoptotic TAp73 isoforms contain a transactivation (TA) domain, and like p53, have tumor suppressor properties and are activated by chemotherapies to induce cell death. In contrast, antiapoptotic DeltaNp73 isoforms lack the TA domain and are dominant-negative inh...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.59
更新日期：2009-05-14 00:00:00
abstract：:Tumor suppressor p53 forms a homo-tetramer through its COOH-terminal oligomerization domain and acts as a sequence-specific transcription factor. We have analysed the interrelation among the transcriptional activities, the structure and the cancer-related mutations in the oligomerization domain by using a comprehensiv...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208839
更新日期：2005-10-20 00:00:00
abstract：:Germline mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers. Current evidence demonstrates that mutations in BRCA1 do not directly result in tumor formation, but instead cause genetic instability, subjecting cells to high risks of malignant transformation. In an animal model in whic...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1203269
更新日期：2000-02-21 00:00:00
abstract：:Mutations of SMAD4/DPC4 are found in about 60% of human invasive pancreatic ductal adenocarcinomas (PDACs); yet, the manner in which SMAD4 deficiency enhances tumorigenesis remains elusive. Using a Cre-LoxP approach, we generated a mutant mouse carrying a targeted deletion of Smad4 in the pancreas. We showed that the ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.375
更新日期：2010-02-04 00:00:00
abstract：:We determined whether proteins encoded by the nm23/nucleoside diphosphate (NDP) kinase gene, a potential metastasis-suppressor gene, are expressed on the cell surface. Monoclonal antibodies (mAb) specific for nm23-H1 or H2 proteins were prepared using the corresponding fusion proteins with glutathione S-transferase (G...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signalling, perturbs differentiation and ultimately leads to neoplasia. Apc negatively regulates Wnt signalling but is also involved in organizing the cytoskeleton and may have a role in chromosome segregation. In vitro studies have implic...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.342
更新日期：2015-07-30 00:00:00
abstract：:The p53 gene is frequently mutated in cancers and it is vital for cell cycle control, homeostasis and carcinogenesis. We describe a novel p53 mutational spectrum, different to those generally observed in human and murine tumors. Our study shows a high prevalence of nonsense mutations in the p53 N terminus of 2-acetyla...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.552
更新日期：2011-04-14 00:00:00
abstract：:The VN-11 recombinant retroviruses, originally generated by co-transfection of the avian MH2 and AKRv viral genomes, were molecularly cloned from an infected mouse cell line named N11. The analysis of the proviral genome sequence from one of these recombinants showed a possible envAKR-mycMH2 fusion. Point mutations we...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0635-z
更新日期：2019-04-01 00:00:00
abstract：:Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused, for example, by downregulation of proapoptotic intracellular signaling molecules such as caspase-8. We found that the cytotoxic drugs methotrexate (MTX) and 5-...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210666
更新日期：2008-01-31 00:00:00
abstract：:Functional alterations or loss of tumor-suppressor genes are an important feature of neoplastic progression in humans. The employment of suitable animal model systems would greatly facilitate the detection and manipulation of such genes. We describe here an experimental approach to this problem based on the analysis o...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Loss of genetic material, including loss of loci on chromosome arms 6q, 9p, and 10q, occurs frequently in cutaneous melanoma but infrequently in benign melanocytic nevi or other melanocytic lesions, suggesting that these genetic alterations are important in the development and progression of melanoma. To examine wheth...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1200203
更新日期：1998-04-30 00:00:00
abstract：:The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT-PCR in 123 sp...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206040
更新日期：2002-12-05 00:00:00
abstract：:A selective switch from expression of Shc1 gene to Shc3 occurs with maturation of neuronal precursors into postmitotic neurons. Previous studies showed that in the embryo, Shc1 is maximally expressed in dividing CNS stem cells while it is silenced in mature neurons, where it is replaced by Shc3. Under normal condition...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208708
更新日期：2005-08-04 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209147
更新日期：2006-02-16 00:00:00
abstract：:Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202290
更新日期：1999-01-14 00:00:00
abstract：:The cyclin-dependent kinase inhibitor p27 is a key regulator of cell-cycle progression. Its expression and localization are altered in several types of malignancies, which has prognostic significance in cancers such as renal cell carcinoma (RCC). S-phase kinase-associated protein 2 (SKP-2) is an F-box protein that is ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.226
更新日期：2013-04-18 00:00:00
abstract：:High-grade gliomas (HGG) afflict both children and adults and respond poorly to current therapies. Epigenetic regulators have a role in gliomagenesis, but a broad, functional investigation of the impact and role of specific epigenetic targets has not been undertaken. Using a two-step, in vitro/in vivo epigenomic shRNA...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-1125-7
更新日期：2020-03-01 00:00:00
