Genotoxic exposure: novel cause of selection for a functional ΔN-p53 isoform.

abstract：:Individuals affected with the Gorlin syndrome inherit a germ-line mutation of the patched (Ptc1) developmental gene and, analogously to Ptc1 heterozygous mice, show an increased susceptibility to spontaneous tumor development. Human and mouse Ptc1 heterozygotes (Ptc1(+/-)) are also hypersensitive to ionizing radiation...

journal_title：Oncogene

authors： Pazzaglia S,Mancuso M,Atkinson MJ,Tanori M,Rebessi S,Majo VD,Covelli V,Hahn H,Saran A

更新日期：2002-10-24 00:00:00

abstract：:Induction of interstrand crosslinks (ICLs) in chromosomal DNA is considered a major reason for the antiproliferative effect of psoralen plus ultraviolet A (PUVA). It is unclear as to whether PUVA-induced cell cycle arrest is caused by ICLs mechanically stalling replication forks or by triggering cell cycle checkpoints...

journal_title：Oncogene

authors： Joerges C,Kuntze I,Herzinger T

更新日期：2003-09-18 00:00:00

abstract：:Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

journal_title：Oncogene

authors： Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

更新日期：2008-07-17 00:00:00

abstract：:There have been few studies on the specific signaling pathways involved in the transformation of epithelial cells by oncogenic protein tyrosine kinases. Here we investigate the requirement of MAP (MAPK) and phosphatidylinositol 3- (PI3K) kinases in the transformation of rat intestinal epithelial (RIE) cells by oncogen...

journal_title：Oncogene

authors： Nguyen KT,Wang WJ,Chan JL,Wang LH

更新日期：2000-11-09 00:00:00

abstract：:The MRN (MRE11-RAD50-NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit MRE11 cause the hereditary cancer-susceptibility disease ataxia-telangiectasia-like disorder (ATLD). Here we show that MRE11 directly interacts with PIH1D1, a subun...

journal_title：Oncogene

authors： von Morgen P,Burdova K,Flower TG,O'Reilly NJ,Boulton SJ,Smerdon SJ,Macurek L,Hořejší Z

更新日期：2017-08-24 00:00:00

abstract：:SALL4, a zinc-finger transcriptional factor for embryonic stem cell self-renewal and pluripotency, has been suggested to be involved in tumorigenesis. The role of SALL4 in human gastric cancer, however, remains largely unknown. In this study, we demonstrated that SALL4 was aberrantly expressed at both mRNA and protein...

journal_title：Oncogene

authors： Zhang L,Xu Z,Xu X,Zhang B,Wu H,Wang M,Zhang X,Yang T,Cai J,Yan Y,Mao F,Zhu W,Shao Q,Qian H,Xu W

更新日期：2014-11-27 00:00:00

abstract：:Overexpression of the receptor tyrosine kinase ERBB2 (also known as HER2) occurs in around 15% of breast cancers and is driven by amplification of the ERBB2 gene. ERBB2 amplification is a marker of poor prognosis, and although anti-ERBB2-targeted therapies have shown significant clinical benefit, de novo and acquired ...

journal_title：Oncogene

authors： Shiu KK,Wetterskog D,Mackay A,Natrajan R,Lambros M,Sims D,Bajrami I,Brough R,Frankum J,Sharpe R,Marchio C,Horlings H,Reyal F,van der Vijver M,Turner N,Reis-Filho JS,Lord CJ,Ashworth A

更新日期：2014-01-30 00:00:00

abstract：:Loss of the tumor suppressive effect of transforming growth factor-beta (TGF-beta) has been commonly found at later stages in carcinogenic progression. Although the genes encoding TGF-beta receptors and Smads have been found genetically altered in certain human cancers, no mutation in Smad3 has been observed. Therefor...

journal_title：Oncogene

authors： Han SU,Kim HT,Seong DH,Kim YS,Park YS,Bang YJ,Yang HK,Kim SJ

更新日期：2004-02-19 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...

journal_title：Oncogene

authors： Malek SN

更新日期：2013-06-06 00:00:00

abstract：:Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...

journal_title：Oncogene

authors： German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z

更新日期：2016-09-22 00:00:00

abstract：:The candidate proto-oncogene BCL3 was isolated through its involvement in the t(14;19) found in chronic lymphocytic leukemia and other B-cell neoplasms. As a member of the I kappaB family, BCL3 plays a role in the immune response by interactions with the NF-kappaB family of transcription factors. In order to study the...

journal_title：Oncogene

authors： Ong ST,Hackbarth ML,Degenstein LC,Baunoch DA,Anastasi J,McKeithan TW

更新日期：1998-05-07 00:00:00

abstract：:Constitutive telomerase activity maintains telomere length and confers immortal phenotypes to human cancers. The prevalence of telomerase, rather than a homologous recombination-based mechanism, in telomere length maintenance suggests that telomerase also has auxiliary roles in tumorigenesis. Here, we investigate grow...

journal_title：Oncogene

authors： Fleisig HB,Wong JM

更新日期：2012-02-23 00:00:00

abstract：:Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...

journal_title：Oncogene

authors： Busch S,Acar A,Magnusson Y,Gregersson P,Rydén L,Landberg G

更新日期：2015-01-02 00:00:00

abstract：:Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...

journal_title：Oncogene

authors： Koike C,Mizutani T,Ito T,Shimizu Y,Yamamichi N,Kameda T,Michimukai E,Kitamura N,Okamoto T,Iba H

更新日期：2002-04-18 00:00:00

abstract：:Sal-like protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-expressed by an unknown mechanism in poor prognosis hepatocellular carcinoma (HCC), often associated with chronic hepatitis B virus (HBV) infection. Herein, we investigated the mechanism of SALL4 re-expression in HBV-related HCCs. We p...

journal_title：Oncogene

authors： Fan H,Cui Z,Zhang H,Mani SK,Diab A,Lefrancois L,Fares N,Merle P,Andrisani O

更新日期：2017-04-27 00:00:00

abstract：:Uveal melanoma (UM) is a currently untreatable form of melanoma with a 50% mortality rate. Characterization of the essential signaling pathways driving this cancer is critical to develop target therapies. Activating mutations in the Gαq signaling pathway at the level of GNAQ, GNA11, or rarely CYSLTR2 or PLCβ4 are cons...

journal_title：Oncogene

authors： Ma J,Weng L,Bastian BC,Chen X

更新日期：2021-01-01 00:00:00

abstract：:Amplification of HER-2 oncogene was analysed in DNAs obtained from 291 primary human mammary carcinomas. 52/291 (18%) were found to contain amplified HER-2 oncogene. Moderate amplification (2- to 5-fold) was noted in 36/291 (12%). Thirteen tumors (4.5%) had a copy number of 5 to 10. A 10- to 20-fold and greater than 2...

journal_title：Oncogene

authors： Zeillinger R,Kury F,Czerwenka K,Kubista E,Sliutz G,Knogler W,Huber J,Zielinski C,Reiner G,Jakesz R

更新日期：1989-01-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive tumor of the brain. NF1, a tumor suppressor gene and RAS-GTPase, is one of the highly mutated genes in GBM. Dysregulated NF1 expression promotes cell invasion, proliferation, and tumorigenesis. Loss of NF1 expression in glioblastoma is associated with increased aggressiveness ...

journal_title：Oncogene

authors： Fadhlullah SFB,Halim NBA,Yeo JYT,Ho RLY,Um P,Ang BT,Tang C,Ng WH,Virshup DM,Ho IAW

更新日期：2019-07-01 00:00:00

abstract：:O6-methylguanine-DNA methyltransferase (MGMT) repairs the cytotoxic and mutagenic O6-alkylguanine produced by alkylating agents such as chemotherapeutic agents and mutagens. Recent studies have shown that in a subset of tumors, MGMT expression is inversely linked to hypermethylation of the CpG island in the promoter r...

journal_title：Oncogene

authors： Nakagawachi T,Soejima H,Urano T,Zhao W,Higashimoto K,Satoh Y,Matsukura S,Kudo S,Kitajima Y,Harada H,Furukawa K,Matsuzaki H,Emi M,Nakabeppu Y,Miyazaki K,Sekiguchi M,Mukai T

更新日期：2003-12-04 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/AKT and RAS oncogenic signalling modules are frequently mutated in sporadic human cancer. Although each of these pathways has been shown to play critical roles in driving tumour growth and proliferation, their activation in normal human cells can also promote cell senescence. A...

journal_title：Oncogene

authors： Astle MV,Hannan KM,Ng PY,Lee RS,George AJ,Hsu AK,Haupt Y,Hannan RD,Pearson RB

更新日期：2012-04-12 00:00:00

abstract：:The molecular interactions implicated in the mammalian G1/S cell cycle phase transition comprise a highly nonlinear network which can produce seemingly paradoxical results and make intuitive interpretations unreliable. A new approach to this problem is presented, consisting of (1) a convention of unambiguous reaction ...

journal_title：Oncogene

authors： Kohn KW

更新日期：1998-02-26 00:00:00

abstract：:Within the superfamily of ras-related GTP-binding proteins, only ras itself has been shown to act as an oncogene. Seven other proteins, however, have greater than 50% amino acid identity to ras and one of them, rap1A, has been shown to interact with the ras GTPase activating protein, ras-GAP, and to inhibit ras functi...

journal_title：Oncogene

authors： Rey I,Taylor-Harris P,van Erp H,Hall A

更新日期：1994-03-01 00:00:00

abstract：:Although it has been demonstrated that transformed progenitor cell population can contribute to tumor initiation, factors contributing to this malignant transformation are poorly known. Using in vitro and xenograft-based models, previous studies demonstrated that miR-489 acts as a tumor suppressor miRNA by targeting v...

journal_title：Oncogene

authors： Patel Y,Soni M,Awgulewitsch A,Kern MJ,Liu S,Shah N,Singh UP,Chen H

更新日期：2019-01-01 00:00:00

abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder associated with an elevated incidence of cancers. The gene mutated in BS, BLM, encodes a RecQ helicase family member. BS cells exhibit genomic instability, including excessive homologous recombination and chromosomal aberrations. We reported previously that BS c...

journal_title：Oncogene

authors： Rassool FV,North PS,Mufti GJ,Hickson ID

更新日期：2003-11-27 00:00:00

abstract：:The retinoblastoma gene product (pRb) controls proliferation and differentiation processes in stratified epithelia. Importantly, and in contrast to other tissues, Rb deficiency does not lead to spontaneous skin tumor formation. As the cyclin-dependent kinase inhibitor p21 regulates proliferation and differentiation in...

journal_title：Oncogene

authors： Saiz-Ladera C,Lara MF,Garín M,Ruiz S,Santos M,Lorz C,García-Escudero R,Martínez-Fernández M,Bravo A,Fernández-Capetillo O,Segrelles C,Paramio JM

更新日期：2014-09-11 00:00:00

abstract：:CDX2 is a Drosophila caudal-related homeobox transcription factor that is important for the establishment and maintenance of intestinal epithelial cells. CDX2 is a marker of colon cancer, with strong staining in up to 90% of colonic adenocarcinomas. CDX2 heterozygous-null mice develop colonic neoplasms, which have sug...

journal_title：Oncogene

authors： Dang LH,Chen F,Ying C,Chun SY,Knock SA,Appelman HD,Dang DT

更新日期：2006-04-06 00:00:00

abstract：:Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3' kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Loss of PTEN expression in OPM2 and delta47 human myeloma lines led to high Akt activity toward insulin-like growth factor I (...

journal_title：Oncogene

authors： Choi Y,Zhang J,Murga C,Yu H,Koller E,Monia BP,Gutkind JS,Li W

更新日期：2002-08-08 00:00:00

abstract：:The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino a...

journal_title：Oncogene

authors： Tamagnone L,Partanen J,Armstrong E,Lasota J,Ohgami K,Tazunoki T,LaForgia S,Huebner K,Alitalo K

更新日期：1993-07-01 00:00:00

abstract：:Pin1 regulates a subset of phosphoproteins by isomerizing phospho-Ser/Thr-Pro motifs via a 'post-phosphorylation' mechanism. Here, we characterize TR3 as a novel Pin1 substrate, and the mitogenic function of TR3 depends on Pin1-induced isomerization. There are at least three phospho-Ser-Pro motifs on TR3 that bind to ...

journal_title：Oncogene

authors： Chen HZ,Li L,Wang WJ,Du XD,Wen Q,He JP,Zhao BX,Li GD,Zhou W,Xia Y,Yang QY,Hew CL,Liou YC,Wu Q

更新日期：2012-06-07 00:00:00

abstract：:Ki-1 lymphoma is a subtype of human malignant lymphoma characterized by the expression of CD30 (Ki-1) and a peculiar morphology. It is occasionally accompanied by a unique reciprocal chromosomal translocation t(2;5)(p23;q35). A Ki-1 lymphoma cell line, AMS3, was established by maintaining biopsied tumor cells in SCID ...

journal_title：Oncogene

authors： Shiota M,Fujimoto J,Semba T,Satoh H,Yamamoto T,Mori S

更新日期：1994-06-01 00:00:00