PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

abstract：:The tumor suppressor p53 has been found to be the most commonly mutated gene in human cancers; however, the frequency of p53 mutations varies from 10 to 70% across different cancer types. This variability can partly be explained by inactivating mechanisms aside from direct genomic polymorphisms. The p53 gene encodes 1...

journal_title：Oncogene

authors： Takahashi R,Giannini C,Sarkaria JN,Schroeder M,Rogers J,Mastroeni D,Scrable H

更新日期：2013-06-27 00:00:00

abstract：:The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes. However, it is not clear which genes are the biological targets of WT1, nor which cellular pathway(s) is critically altered in tumors as a result of WT1 muta...

journal_title：Oncogene

authors： Udtha M,Lee SJ,Alam R,Coombes K,Huff V

更新日期：2003-06-12 00:00:00

abstract：:The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in one of several ways, that is, cell cycle arrest, senescence or programmed cell death (apoptosis). Mutations in...

journal_title：Oncogene

authors： Lim YP,Lim TT,Chan YL,Song AC,Yeo BH,Vojtesek B,Coomber D,Rajagopal G,Lane D

更新日期：2007-03-08 00:00:00

abstract：:Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target gene...

journal_title：Oncogene

authors： Niida A,Hiroko T,Kasai M,Furukawa Y,Nakamura Y,Suzuki Y,Sugano S,Akiyama T

更新日期：2004-11-04 00:00:00

abstract：:The phosphatase Cdc25A was shown to be a target of the transcription factor c-Myc. Myc-induced apoptosis appeared dependent on Cdc25A expression and Cdc25A over-expression could substitute for Myc-triggered apoptosis. These findings suggested that an important downstream component of Myc-mediated apoptosis was identif...

journal_title：Oncogene

authors： Fuhrmann G,Leisser C,Rosenberger G,Grusch M,Huettenbrenner S,Halama T,Mosberger I,Sasgary S,Cerni C,Krupitza G

更新日期：2001-07-27 00:00:00

abstract：:Heregulins (neuregulins) are a family of proteins known to interact and activate the receptor tyrosine kinases ErbB2 in association with ErbB3 or ErbB4. Using immunofluorescence microscopy, electron microscopy autoradiography, and SDS-PAGE analysis of nuclear fractions, we show that the heregulin-beta1(1-244) isoform ...

journal_title：Oncogene

authors： Li W,Park JW,Nuijens A,Sliwkowski MX,Keller GA

更新日期：1996-06-06 00:00:00

abstract：:Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...

journal_title：Oncogene

authors： Ghamrasni SE,Cardoso R,Li L,Guturi KK,Bjerregaard VA,Liu Y,Venkatesan S,Hande MP,Henderson JT,Sanchez O,Hickson ID,Hakem A,Hakem R

更新日期：2016-09-15 00:00:00

abstract：:c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II,...

journal_title：Oncogene

authors： Kanazawa S,Soucek L,Evan G,Okamoto T,Peterlin BM

更新日期：2003-08-28 00:00:00

abstract：:Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors while current therapeutic approaches show little effect of prolonging the survival of patients with PCA. Thus, a deeper understanding of the patho-molecular mechanisms underlying the disease progression in PCA is crucial to identify n...

journal_title：Oncogene

authors： Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY,Li CR,Lin CY,Huang SP,Chen LT,Tsai KK

更新日期：2019-02-01 00:00:00

abstract：:The E2F1 transcription factor binds to sites within the promoters of a number of cell cycle regulated genes through a basic-helix-loop-helix motif (bHLH). It is shown here that the basic region of E2F1 is distinct from that of all other bHLH proteins. The center of the basic region contains a helix breaking proline-gl...

journal_title：Oncogene

authors： Jordan KL,Haas AR,Logan TJ,Hall DJ

更新日期：1994-04-01 00:00:00

abstract：:SPARC, also termed osteonectin, BM-40 and 43K protein, is an acidic, cysteine-rich component of the extracellular matrix that has been shown to be directly regulated by progesterone and dexamethasone and indirectly by cytokines. By RNA fingerprinting technique, we cloned a SPARC homolog from the normal human ovarian s...

journal_title：Oncogene

authors： Mok SC,Chan WY,Wong KK,Muto MG,Berkowitz RS

更新日期：1996-05-02 00:00:00

abstract：:The diverse checkpoint responses to DNA damage may reflect differential sensitivities by molecular components of the damage-signalling network to the type and amount of lesions. Here, we determined the kinetics of activation of the checkpoint kinases ATM and Chk2 (the latter substrate of ATM) in relation to the initia...

journal_title：Oncogene

authors： Buscemi G,Perego P,Carenini N,Nakanishi M,Chessa L,Chen J,Khanna K,Delia D

更新日期：2004-10-07 00:00:00

abstract：:The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...

journal_title：Oncogene

authors： Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

更新日期：1999-01-07 00:00:00

abstract：:DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture and animal models as well as analyses of clinical specimens show that activation of numerous oncogenes and loss...

journal_title：Oncogene

authors： Bartek J,Bartkova J,Lukas J

更新日期：2007-12-10 00:00:00

abstract：:Most human lymphomas originate from transformed germinal center (GC) B lymphocytes. While activating mutations and translocations of MYC, BCL2 and BCL6 promote specific GC lymphoma subtypes, other genetic and epigenetic modifications that contribute to malignant progression in the GC remain poorly defined. Recently, a...

journal_title：Oncogene

authors： Dawson DW,Hong JS,Shen RR,French SW,Troke JJ,Wu YZ,Chen SS,Gui D,Regelson M,Marahrens Y,Morse HC 3rd,Said J,Plass C,Teitell MA

更新日期：2007-06-21 00:00:00

abstract：:It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host immunosurveillance and neoplastic progression is revealed in cases where the immune response becomes compromised due to genetic or other pathological conditions, r...

journal_title：Oncogene

authors： Stewart TJ,Abrams SI

更新日期：2008-10-06 00:00:00

abstract：:To investigate the role of protein kinase C (PKC) in apoptotic signaling induced by cytokine withdrawal, we expressed PKC-alpha, -delta and -epsilon individually in the 32D myeloid progenitor cells. The parental and PKC-delta- and PKC-epsilon-transfected 32D cells underwent apoptosis within 24 h in the absence of inte...

journal_title：Oncogene

authors： Li W,Zhang J,Flechner L,Hyun T,Yam A,Franke TF,Pierce JH

更新日期：1999-11-11 00:00:00

abstract：:LIM-kinase 2 (LIMK2) belongs to the LIMK family of proteins, which comprises LIMK1 and LIMK2. Both proteins regulate actin polymerization through phosphorylation and inactivation of the actin depolymerizing factor cofilin. In this study, we show that the level of LIMK2 protein is increased in neuroblastoma, BE(2)-C ce...

journal_title：Oncogene

authors： Po'uha ST,Shum MS,Goebel A,Bernard O,Kavallaris M

更新日期：2010-01-28 00:00:00

abstract：:The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...

journal_title：Oncogene

authors： Wang W,Abbruzzese JL,Evans DB,Chiao PJ

更新日期：1999-08-12 00:00:00

abstract：:It is well known that intracellular antioxidant glutathione (GSH) plays major roles in the maintenance of redox status and defense of oxidative stress. Ras, a small GTP-binding protein, may send growth-stimulating message to the nucleus through downstream Rac oncoprotein and superoxide (O(2*-)). These findings led us ...

journal_title：Oncogene

authors： Chuang JI,Chang TY,Liu HS

更新日期：2003-03-06 00:00:00

abstract：:BRCA1 is a tumour suppressor gene implicated in the predisposition to early onset breast and ovarian cancer. We have generated cell lines with inducible expression of BRCA1 to evaluate its role in mediating the cellular response to various chemotherapeutic drugs commonly used in the treatment of breast and ovarian can...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Gilmore PM,McWilliams S,Andrews H,Gervin C,McCabe N,McKenna S,White P,Song YH,Maheswaran S,Liu E,Haber DA,Johnston PG,Harkin DP

更新日期：2001-09-27 00:00:00

abstract：:Deregulated expression of c-Myc has been shown to induce or enhance apoptosis in various different cell types. c-Myc requires p53 for apoptosis in some but not all the cell types, indicating heterogeneous mechanisms for c-Myc-induced apoptosis. In B lymphoma line WEHI-231, stable expression of c-Myc has been demonstra...

journal_title：Oncogene

authors： Hagiyama H,Adachi T,Yoshida T,Nomura T,Miyasaka N,Honjo T,Tsubata T

更新日期：1999-07-15 00:00:00

abstract：:A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This phenotype provides cancer cells, including those that participate in metastasis, a distinct competitive edge over n...

journal_title：Oncogene

authors： Mathupala SP,Ko YH,Pedersen PL

更新日期：2006-08-07 00:00:00

abstract：:Previously, we cloned two gene fragments encoding novel protein tyrosine phosphatases, termed PTP-U1 and PTP-U2. Here, we report the full-length sequence, expression, and chromosomal localization of the PTP-U2 gene. The cDNA for PTP-U2, which was obtained from a human normal kidney library, predicts a protein of 1216 ...

journal_title：Oncogene

authors： Seimiya H,Sawabe T,Inazawa J,Tsuruo T

更新日期：1995-05-04 00:00:00

abstract：:Wild-type human p53 protein is able to self-associate and consists predominantly of homotetramers in solution. In earlier work we identified the protein sequence motifs involved in p53 quaternary structure and showed that while monomeric p53 protein retains tumour suppressor function, monomeric tumour mutant p53 lacks...

journal_title：Oncogene

authors： Tarunina M,Jenkins JR

更新日期：1993-11-01 00:00:00

abstract：:Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...

journal_title：Oncogene

authors： McIlroy D,Sakahira H,Talanian RV,Nagata S

更新日期：1999-08-05 00:00:00

abstract：:Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...

journal_title：Oncogene

authors： Roberts T,Cowell JK

更新日期：1997-02-27 00:00:00

abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

journal_title：Oncogene

authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

更新日期：1997-03-27 00:00:00

abstract：:In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, pr...

journal_title：Oncogene

authors： Tsang NM,Nagasawa H,Li C,Little JB

更新日期：1995-06-15 00:00:00

abstract：:The breast cancer susceptibility gene 1 (Brca1) has a key role in both hereditary and sporadic mammary tumorigenesis. However, the reasons why Brca1-deficiency leads to the development of cancer are not clearly understood. Activation of Akt kinase is one of the most common molecular alterations associated with human m...

journal_title：Oncogene

authors： Xiang T,Jia Y,Sherris D,Li S,Wang H,Lu D,Yang Q

更新日期：2011-05-26 00:00:00