Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation.

abstract：:Stimulation of resting W53 cells (lymphoid murine cells expressing prolactin (PRL) receptor) by PRL induced expression of growth-related immediate-early genes (IEG), and proliferation through activation of the Src kinases. Since IEG are essential for cell cycle progression, we have studied how PRL controls expression ...

journal_title：Oncogene

authors： Domínguez-Cáceres MA,García-Martínez JM,Calcabrini A,González L,Porque PG,León J,Martín-Pérez J

更新日期：2004-09-23 00:00:00

abstract：:PSP94, for prostatic secretory protein of 94 amino acids, is secreted by the prostate gland and functions as a suppressor of tumor growth and metastasis. The expression of PSP94 is lost in advanced, hormone-refractory prostate cancer and this correlates with an increased expression of the Polycomb protein EZH2 (enhanc...

journal_title：Oncogene

authors： Beke L,Nuytten M,Van Eynde A,Beullens M,Bollen M

更新日期：2007-07-05 00:00:00

abstract：:We previously described the oral-esophageal tissue-specific expression of cyclin D1 with the Epstein-Barr virus ED-L2 promoter in transgenic mice, and resulting dysplasia. Given the evidence for an interplay between environmental and genetic factors in esophageal squamous carcinogenesis, the aim of this study was to d...

journal_title：Oncogene

authors： Jenkins TD,Mueller A,Odze R,Shahsafaei A,Zukerberg LR,Kent R,Stoner GD,Rustgi AK

更新日期：1999-01-07 00:00:00

abstract：:Radicicol, a macrocyclic anti-fungal antibiotic, has the ability to suppress transformation by diverse oncogenes such as Src, Ras and Mos. Despite this useful property, the mechanism by which radicicol exerts its anti-transformation effects is currently unknown. To understand the transformation-suppressing effects of ...

journal_title：Oncogene

authors： Sharma SV,Agatsuma T,Nakano H

更新日期：1998-05-01 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:The p53 gene is frequently mutated in cancers and it is vital for cell cycle control, homeostasis and carcinogenesis. We describe a novel p53 mutational spectrum, different to those generally observed in human and murine tumors. Our study shows a high prevalence of nonsense mutations in the p53 N terminus of 2-acetyla...

journal_title：Oncogene

authors： Melis JP,Hoogervorst EM,van Oostrom CT,Zwart E,Breit TM,Pennings JL,de Vries A,van Steeg H

更新日期：2011-04-14 00:00:00

abstract：:Mdm2, a regulator of the p53 tumor suppressor, is frequently overexpressed in lymphomas, including lymphomas that have inactivated p53. However, the biological consequences of Mdm2 overexpression in lymphocytes are not fully resolved. Here, we report that increased expression of Mdm2 in B cells augmented proliferation...

journal_title：Oncogene

authors： Wang P,Lushnikova T,Odvody J,Greiner TC,Jones SN,Eischen CM

更新日期：2008-03-06 00:00:00

abstract：:The acute contractile function of the heart is controlled by the effects of released nonepinephrine (NE) on cardiac adrenergic receptors. NE can also act in a more chronic fashion to induce cardiomyocyte growth, characterized by cell enlargement (hypertrophy), increased protein synthesis, alterations in gene expressio...

journal_title：Oncogene

authors： Adams JW,Brown JH

更新日期：2001-03-26 00:00:00

abstract：:The current model for colorectal tumorigenesis defines four specific mutations (activation of a ras proto-oncogene and inactivation of the APC, p53 and DCC tumor-suppressor genes) that accumulate in a colonic epithelial cell as it progresses towards a carcinoma. However, further mutations must be needed for progressio...

journal_title：Oncogene

authors： Young J,Leggett B,Ward M,Thomas L,Buttenshaw R,Searle J,Chenevix-Trench G

更新日期：1993-03-01 00:00:00

abstract：:It is presently unclear if ovarian cancers arise through malignant transformation of pre-existing benign tumours. The apparent rarity of loss of heterozygosity (LOH) reported for benign tumours has led to speculation that they lack malignant potential and represent a biological entity distinct from ovarian carcinoma. ...

journal_title：Oncogene

authors： Roy WJ Jr,Watson RH,Hitchcock A,Campbell IG

更新日期：1997-10-23 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:The E1a gene of group C adenoviruses is one of the most studied transforming genes of DNA tumor viruses. These transforming genes have been conventionally considered as dominant oncogenes since they transform cells in vitro and many of the resulting transformed cell lines induce tumors in experimental animals. It now ...

journal_title：Oncogene

authors： Chinnadurai G

更新日期：1992-07-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase in the insulin receptor superfamily. We recently demonstrated that the growth factors pleiotrophin (PTN) and midkine (MK) are ligands for ALK and that upon ALK activation, insulin receptor substrate-1 (IRS-1) and other substrates are phosphor...

journal_title：Oncogene

authors： Kuo AH,Stoica GE,Riegel AT,Wellstein A

更新日期：2007-02-08 00:00:00

abstract：:cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90% similarity with rat fra-1 protein...

journal_title：Oncogene

authors： Matsui M,Tokuhara M,Konuma Y,Nomura N,Ishizaki R

更新日期：1990-03-01 00:00:00

abstract：:Epidemiological studies have demonstrated a close association of type 2 diabetes and hepatocellular carcinoma (HCC). Exenatide (Ex-4), a potent diabetes drug targeting glucagon-like peptide-1 receptor (GLP-1R), is protective against non-alcoholic fatty liver disease (NAFLD). However, the Ex-4 function and GLP-1R statu...

journal_title：Oncogene

authors： Zhou M,Mok MT,Sun H,Chan AW,Huang Y,Cheng AS,Xu G

更新日期：2017-07-20 00:00:00

abstract：:Histone deacetylase inhibitors (HDACis) are a promising class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a panel of 17 gastric...

journal_title：Oncogene

authors： Zhu Y,Das K,Wu J,Lee MH,Tan P

更新日期：2014-03-20 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with highly aggressive and metastatic potential in which distant metastasis is the main reason for treatment failure. Till present, the underlying molecular mechanisms of NPC metastasis remains poorly understood. Here, we identified S100 calcium-binding p...

journal_title：Oncogene

authors： Meng DF,Sun R,Liu GY,Peng LX,Zheng LS,Xie P,Lin ST,Mei Y,Qiang YY,Li CZ,Xu L,Peng XS,Hu H,Lang YH,Liu ZJ,Wang MD,Guo LL,Xie DH,Shu DT,Li HF,Luo FF,Niu XT,Huang BJ,Qian CN

更新日期：2020-07-01 00:00:00

abstract：:We have found that the differentiation inducer butyric acid causes the synthesis of a cellular protein(s) that mediates a rapid decline in the level of myc RNA in SW837, a cell line derived from a human adenocarcinoma of the rectum. This effect was dose-dependent and was maximal at 1 mM. Among the short chain fatty ac...

journal_title：Oncogene

authors： Herold KM,Rothberg PG

更新日期：1988-10-01 00:00:00

abstract：:Bladder cancer is one of the most common causes of death in industrialized countries. New tumor markers and therapeutic approaches are still needed to improve the management of bladder cancer patients. Choline kinase-alpha (ChoKalpha) is a metabolic enzyme that has a role in cell proliferation and transformation. Inhi...

journal_title：Oncogene

authors： Hernando E,Sarmentero-Estrada J,Koppie T,Belda-Iniesta C,Ramírez de Molina V,Cejas P,Ozu C,Le C,Sánchez JJ,González-Barón M,Koutcher J,Cordón-Cardó C,Bochner BH,Lacal JC,Ramírez de Molina A

更新日期：2009-07-02 00:00:00

abstract：:Defects in a developmental signaling pathway involving the mammalian homologue of the Drosophila segment polarity gene, patched are associated with human tumors such as basal cell carcinoma, medulloblastoma and squamous cell carcinoma. Loss of heterozygosity (LOH) in some of these tumor cells suggests that patched fun...

journal_title：Oncogene

authors： Koike C,Mizutani T,Ito T,Shimizu Y,Yamamichi N,Kameda T,Michimukai E,Kitamura N,Okamoto T,Iba H

更新日期：2002-04-18 00:00:00

abstract：:The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulat...

journal_title：Oncogene

authors： Sotoca AM,Prange KH,Reijnders B,Mandoli A,Nguyen LN,Stunnenberg HG,Martens JH

更新日期：2016-04-14 00:00:00

abstract：:Proteins containing a caveolin-binding domain (CBD), such as the Rho-GTPases, can interact with caveolin-1 (Cav1) through its caveolin scaffold domain. Rho-GTPases are important regulators of p130(Cas), which is crucial for both normal cell migration and Src kinase-mediated metastasis of cancer cells. However, althoug...

journal_title：Oncogene

authors： Arpaia E,Blaser H,Quintela-Fandino M,Duncan G,Leong HS,Ablack A,Nambiar SC,Lind EF,Silvester J,Fleming CK,Rufini A,Tusche MW,Brüstle A,Ohashi PS,Lewis JD,Mak TW

更新日期：2012-02-16 00:00:00

abstract：:Sal-like protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-expressed by an unknown mechanism in poor prognosis hepatocellular carcinoma (HCC), often associated with chronic hepatitis B virus (HBV) infection. Herein, we investigated the mechanism of SALL4 re-expression in HBV-related HCCs. We p...

journal_title：Oncogene

authors： Fan H,Cui Z,Zhang H,Mani SK,Diab A,Lefrancois L,Fares N,Merle P,Andrisani O

更新日期：2017-04-27 00:00:00

abstract：:Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Since surviving patients experience severe neurocognitive disabilities, better and more effective treatments are needed to enhance their quality of life. Casein kinase 2 (CK2) is known to regulate cell growth and survival in multiple cancers; how...

journal_title：Oncogene

authors： Nitta RT,Bolin S,Luo E,Solow-Codero DE,Samghabadi P,Purzner T,Aujla PS,Nwagbo G,Cho YJ,Li G

更新日期：2019-10-01 00:00:00

abstract：:Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. Immunoblotting or immunoprecipitation of fusion protein or in vitro translated protein, respect...

journal_title：Oncogene

authors： Drané P,Barel M,Balbo M,Frade R

更新日期：1997-12-18 00:00:00

abstract：:Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...

journal_title：Oncogene

authors： Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J

更新日期：2012-08-02 00:00:00

abstract：:The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...

journal_title：Oncogene

authors： Yu X,Wang R,Zhang Y,Zhou L,Wang W,Liu H,Li W

更新日期：2019-12-01 00:00:00

abstract：:Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin binding of the receptor and to identify AR target genes that may be important in the emergence of CRPC. We have established two sublines of LN...

journal_title：Oncogene

authors： Urbanucci A,Sahu B,Seppälä J,Larjo A,Latonen LM,Waltering KK,Tammela TL,Vessella RL,Lähdesmäki H,Jänne OA,Visakorpi T

更新日期：2012-04-26 00:00:00

abstract：:The discovery of constitutive nuclear factor-κB (NF-κB) activation in Hodgkin's lymphoma tumor cells almost two decades ago was one of the first reports that directly connected deregulated NF-κB signaling to human cancer. Subsequent studies demonstrated that enhanced NF-κB signaling is a common hallmark of many lympho...

journal_title：Oncogene

authors： Nagel D,Vincendeau M,Eitelhuber AC,Krappmann D

更新日期：2014-12-11 00:00:00

abstract：:The growth and progression of prostate cancer are dependent on androgens and androgen receptor (AR), which act by modulating gene expression. Utilizing a gene microarray approach, we have identified the alpha1-subunit gene of soluble guanylyl cyclase (sGC) as a novel androgen-regulated gene. A heterodimeric cytoplasmi...

journal_title：Oncogene

authors： Cai C,Chen SY,Zheng Z,Omwancha J,Lin MF,Balk SP,Shemshedini L

更新日期：2007-03-08 00:00:00