Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas.

abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively control expression of target genes in animals and plants. The microRNA-21 gene (mir-21) has been identified as the only miRNA commonly overexpressed in solid tumors of the lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pa...

journal_title：Oncogene

authors： Lu Z,Liu M,Stribinskis V,Klinge CM,Ramos KS,Colburn NH,Li Y

更新日期：2008-07-17 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:A search for protein tyrosine kinases expressed during murine cardiogenesis resulted in the isolation of a novel tyrosine kinase, designated tek, which maps to mouse chromosome 4 between the brown and pmv-23 loci. The deduced amino acid sequence of tek predicts that it encodes a putative receptor tyrosine kinase that ...

journal_title：Oncogene

authors： Dumont DJ,Yamaguchi TP,Conlon RA,Rossant J,Breitman ML

更新日期：1992-08-01 00:00:00

abstract：:The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...

journal_title：Oncogene

authors： Shamanna RA,Hoque M,Pe'ery T,Mathews MB

更新日期：2013-10-24 00:00:00

abstract：:Previous studies have shown that the adenovirus E1A oncoprotein can bind to and inactivate the retinoblastoma tumor suppressor protein (pRb) and the transcriptional coactivators CBP/p300. In this study, wild-type E1A12S or two deletion mutants (delN, which binds pRb but not CBP/p300; delCR2, which binds to CBP/p300 bu...

journal_title：Oncogene

authors： Chen Q,Ash JD,Branton P,Fromm L,Overbeek PA

更新日期：2002-02-07 00:00:00

abstract：:The MYCN gene has been implicated in certain neuronal tumours, such as neuroblastomas and retinoblastomas. These tumours express high levels of mRNA and protein of MYCN as a result of amplification. MYCN encodes a short-lived nuclear phosphoprotein whose function has not yet been elucidated. This study was undertaken ...

journal_title：Oncogene

authors： Hamann U,Wenzel A,Frank R,Schwab M

更新日期：1991-10-01 00:00:00

abstract：:Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular pathogenesis of NETs. In addition, NETs have become one of the most exciting settings for drug development. Two targeted agents for the management of advanced pancreat...

journal_title：Oncogene

authors： Capdevila J,Casanovas O,Salazar R,Castellano D,Segura A,Fuster P,Aller J,García-Carbonero R,Jimenez-Fonseca P,Grande E,Castaño JP

更新日期：2017-04-06 00:00:00

abstract：:A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This phenotype provides cancer cells, including those that participate in metastasis, a distinct competitive edge over n...

journal_title：Oncogene

authors： Mathupala SP,Ko YH,Pedersen PL

更新日期：2006-08-07 00:00:00

abstract：:Hec1 (highly expressed in cancer 1) or Nek2 (NIMA-related kinase 2) is often overexpressed in cancers with poor prognosis. Both are critical mitotic regulators, and phosphorylation of Hec1 S165 by Nek2 is required for proper chromosome segregation. Therefore, inactivation of Hec1 and Nek2 by targeting their interactio...

journal_title：Oncogene

authors： Hu CM,Zhu J,Guo XE,Chen W,Qiu XL,Ngo B,Chien R,Wang YV,Tsai CY,Wu G,Kim Y,Lopez R,Chamberlin AR,Lee EY,Lee WH

更新日期：2015-03-05 00:00:00

abstract：:Lymphoid cells and small intestinal epithelial (SIE) cells are among the most radiosensitive in the body. The factors that account for the differential sensitivity to gamma-radiation among different tissue-types remain poorly understood, but can only partly be explained by differences in rates of cell proliferation. H...

journal_title：Oncogene

authors： Kitada S,Krajewski S,Miyashita T,Krajewska M,Reed JC

更新日期：1996-01-04 00:00:00

abstract：:Paxillin is a focal-adhesion associated protein implicated in the regulation of integrin signaling and organization of the actin cytoskeleton. Paxillin associates with numerous signaling molecules including adaptor molecules (p130Cas, CRK), kinases (FAK, Pyk2, PAK and SRC), tyrosine phosphatases (PTP-PEST), ARF-GAP pr...

journal_title：Oncogene

authors： Wade R,Bohl J,Vande Pol S

更新日期：2002-01-03 00:00:00

abstract：:Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in about 5% of carriers after a long latent period. After its infection, HTLV-I promotes the clonal proliferation of HTLV-I infected cells in vivo by actions of encoded viral proteins, including Tax. However, leukemic cells frequently lack ...

journal_title：Oncogene

authors： Matsuoka M

更新日期：2003-08-11 00:00:00

abstract：:The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...

journal_title：Oncogene

authors： Miyata Y,Yahara I

更新日期：2000-03-09 00:00:00

abstract：:Nuclear-targeted high molecular weight 24 kDa fibroblast growth factor 2 (FGF-2) may induce specific cell functions through intracrine mechanisms. The role of nuclear FGF-2 on the metastatic potential of carcinoma cells was examined by conditional FGF-2 expression, which demonstrated that spontaneous metastasis in nud...

journal_title：Oncogene

authors： Thomas-Mudge RJ,Okada-Ban M,Vandenbroucke F,Vincent-Salomon A,Girault JM,Thiery JP,Jouanneau J

更新日期：2004-06-10 00:00:00

abstract：:The p53 family of proteins play instrumental roles in mediating the cellular response to stress. The p53-related gene product, p73, occurs as two distinct protein isoforms, referred to as alpha and beta, which differ in the length of the C-terminal region and arise through alternative splicing of the p73 RNA. Here, we...

journal_title：Oncogene

authors： Lee CW,La Thangue NB

更新日期：1999-07-22 00:00:00

abstract：:The myb proto oncogene product (c-Myb) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis. It has been shown [Venturelli, D., Travali, S. & Calabretta, B. (1990). Proc. Natl. Acad. Sci. USA, 87, 5963-5967] that inhibition of T-cell pro...

journal_title：Oncogene

authors： Sudo T,Miyazawa H,Hanaoka F,Ishii S

更新日期：1992-10-01 00:00:00

abstract：:An integrative functional genomics study of multiple forms of data are vital for discovering molecular drivers of cancer development and progression. Here, we present an integrated genomic strategy utilizing DNA methylation and transcriptome profile data to discover epigenetically regulated genes implicated in cancer ...

journal_title：Oncogene

authors： Mondal B,Patil V,Shwetha SD,Sravani K,Hegde AS,Arivazhagan A,Santosh V,Kanduri M,Somasundaram K

更新日期：2017-01-05 00:00:00

abstract：:We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...

journal_title：Oncogene

authors： Avila MA,Velasco JA,Cho C,Lupu R,Wen D,Notario V

更新日期：1995-03-02 00:00:00

abstract：:The mixed lineage leukemia (MLL) gene at chromosome band 11q23 is commonly involved in reciprocal translocations that are detected in acute leukemias. Evidence suggests that the resulting MLL fusion genes contribute to leukemogenesis. AF9 is a common MLL fusion partner in acute myeloid leukemia. The AF9 protein functi...

journal_title：Oncogene

authors： Srinivasan RS,de Erkenez AC,Hemenway CS

更新日期：2003-05-29 00:00:00

abstract：:The breast cancer-associated protein, BARD1, colocalizes with BRCA1 in nuclear foci in the S phase and after DNA damage, and the two proteins form a stable heterodimer implicated in DNA repair, protein ubiquitination, and control of mRNA processing. BARD1 has a BRCA1-independent proapoptotic activity; however, little ...

journal_title：Oncogene

authors： Rodriguez JA,Schüchner S,Au WW,Fabbro M,Henderson BR

更新日期：2004-03-11 00:00:00

abstract：:Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 rec...

journal_title：Oncogene

authors： Dirmeier U,Hoffmann R,Kilger E,Schultheiss U,Briseño C,Gires O,Kieser A,Eick D,Sugden B,Hammerschmidt W

更新日期：2005-03-03 00:00:00

abstract：:The mechanisms of ras activation by mutations in residue 61 and in the NKXD guanine nucleotide-binding consensus sequence (ras residues 116-119) have been evaluated. Weakly transforming mutations that either reduce intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activities (61P) or enhance guanine nucl...

journal_title：Oncogene

authors： Patel G,MacDonald MJ,Khosravi-Far R,Hisaka MM,Der CJ

更新日期：1992-02-01 00:00:00

abstract：:The Kruppel-like transcription factor KLF6 is a novel tumor-suppressor gene mutated in a significant fraction of human prostate cancer. It is localized to human chromosome 10p14-15, a region that displays frequent loss of heterozygosity in glioblastoma multiforme (GBM). Indeed, mutations of the KLF6 gene have recently...

journal_title：Oncogene

authors： Kimmelman AC,Qiao RF,Narla G,Banno A,Lau N,Bos PD,Nuñez Rodriguez N,Liang BC,Guha A,Martignetti JA,Friedman SL,Chan AM

更新日期：2004-06-24 00:00:00

abstract：:Due to its high proclivity to metastasize, and despite the recent development of targeted and immune therapy strategies, melanoma is still the deadliest form of skin cancer. Therefore, understanding the molecular mechanisms underlying melanoma invasion remains crucial. We previously characterized Tspan8 for its abilit...

journal_title：Oncogene

authors： El Kharbili M,Agaësse G,Barbollat-Boutrand L,Pommier RM,de la Fouchardière A,Larue L,Caramel J,Puisieux A,Berthier-Vergnes O,Masse I

更新日期：2019-05-01 00:00:00

abstract：:Rel/NF-kappaB transcription factors form homo- and heterodimers with different DNA binding site specificities and DNA binding affinities. Several intracellular pathways evoked by a wide range of biological factors and environmental conditions can lead to the activation of Rel/NF-kappaB dimers by signaling degradation ...

journal_title：Oncogene

authors： Chen FE,Ghosh G

更新日期：1999-11-22 00:00:00

abstract：:In Dictyostelium discoideum, three ras genes (rasD, rasG and rasB) and one ras-related gene (rap1) have been previously isolated and characterized, and the deduced amino acid sequence of their predicted protein products share at least 50% sequence identity with the human H-Ras protein. We have now cloned and character...

journal_title：Oncogene

authors： Daniel J,Bush J,Cardelli J,Spiegelman GB,Weeks G

更新日期：1994-02-01 00:00:00

abstract：:Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...

journal_title：Oncogene

authors： Park TJ,Curran T

更新日期：2014-10-23 00:00:00

abstract：:Solid tumors frequently contain hypoxic subregions due to insufficient blood supply. In these domains, cells can undergo p53-dependent apoptosis. Therefore, hypoxia has been implicated as a physiological stimulus for p53 accumulation and activation. In such an environment, p53 mutant cells exhibit a selective growth a...

journal_title：Oncogene

authors： Pan Y,Oprysko PR,Asham AM,Koch CJ,Simon MC

更新日期：2004-06-24 00:00:00

abstract：:P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...

journal_title：Oncogene

authors： Zhang Y,Yan W,Chen X

更新日期：2014-03-20 00:00:00

abstract：:Ras oncogenes (Hras, Kras and Nras) are important drivers of carcinogenesis. However, tumors with Ras mutations often show loss of the corresponding wild-type (WT) allele, suggesting that proto-oncogenic forms of Ras can function as a suppressor of carcinogenesis. In vitro studies also suggest that WT Ras proteins can...

journal_title：Oncogene

authors： To MD,Rosario RD,Westcott PM,Banta KL,Balmain A

更新日期：2013-08-22 00:00:00