Androgen regulation of soluble guanylyl cyclasealpha1 mediates prostate cancer cell proliferation.

abstract：:Fos-related antigen-1 (Fra-1) is a member of the Activator Protein-1 (AP-1) transcription factor superfamily that is overexpressed in a variety of cancers, including colon, breast, lung, bladder and brain. High Fra-1 levels are associated with enhanced cell proliferation, survival, migration and invasion. Despite its ...

journal_title：Oncogene

authors： Pakay JL,Diesch J,Gilan O,Yip YY,Sayan E,Kolch W,Mariadason JM,Hannan RD,Tulchinsky E,Dhillon AS

更新日期：2012-04-05 00:00:00

abstract：:The candidate proto-oncogene BCL3 was isolated through its involvement in the t(14;19) found in chronic lymphocytic leukemia and other B-cell neoplasms. As a member of the I kappaB family, BCL3 plays a role in the immune response by interactions with the NF-kappaB family of transcription factors. In order to study the...

journal_title：Oncogene

authors： Ong ST,Hackbarth ML,Degenstein LC,Baunoch DA,Anastasi J,McKeithan TW

更新日期：1998-05-07 00:00:00

abstract：:Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...

journal_title：Oncogene

authors： Lee YC,Huang CF,Murshed M,Chu K,Araujo JC,Ye X,deCrombrugghe B,Yu-Lee LY,Gallick GE,Lin SH

更新日期：2010-06-03 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:Casitas B-lineage lymphoma (CBL) protein family functions as multifunctional adaptor proteins and E3 ubiquitin ligases that are implicated as regulators of signaling in various cell types. Recent discovery revealed mutations of proto-oncogenic CBL in the linker region and RING finger domain in human acute myeloid neop...

journal_title：Oncogene

authors： Kang JM,Park S,Kim SJ,Hong HY,Jeong J,Kim HS,Kim SJ

更新日期：2012-12-13 00:00:00

abstract：:Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...

journal_title：Oncogene

authors： Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

更新日期：2011-02-10 00:00:00

abstract：:Tat protein is an early nonstructural protein necessary for virus replication, which is secreted by infected cells and taken up by uninfected cells. Extensive evidence indicates that Tat may be a cofactor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may incl...

journal_title：Oncogene

authors： De Falco G,Bellan C,Lazzi S,Claudio P,La Sala D,Cinti C,Tosi P,Giordano A,Leoncini L

更新日期：2003-09-18 00:00:00

abstract：:Liver metastasis remains a serious problem in the management of gastric cancer (GC). Our aims were to identify through transcriptome analysis a molecule that mediates hepatic metastasis in GC, and to evaluate its potential as a diagnostic marker and a therapeutic target. The effects of knocking out a relevant molecule...

journal_title：Oncogene

authors： Kanda M,Tanaka H,Shimizu D,Miwa T,Umeda S,Tanaka C,Kobayashi D,Hattori N,Suenaga M,Hayashi M,Iwata N,Yamada S,Fujiwara M,Kodera Y

更新日期：2018-09-01 00:00:00

abstract：:Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...

journal_title：Oncogene

authors： Kalari S,Jung M,Kernstine KH,Takahashi T,Pfeifer GP

更新日期：2013-07-25 00:00:00

abstract：:The crizotinib-resistant ALK(F1174L) mutation arises de novo in neuroblastoma (NB) and is acquired in ALK translocation-driven cancers, lending impetus to the development of novel anaplastic lymphoma kinase (ALK) inhibitors with different modes of action. The diaminopyrimidine TAE684 and its derivative ceritinib (LDK3...

journal_title：Oncogene

authors： Debruyne DN,Bhatnagar N,Sharma B,Luther W,Moore NF,Cheung NK,Gray NS,George RE

更新日期：2016-07-14 00:00:00

abstract：:LIM domain factors and associated cofactors are important developmental regulators in pattern formation and organogenesis. In addition, overexpression of two LIM-only factors (LMOs) causes acute lymphocytic leukemia. The more recently discovered LMO factor LMO4 is highly expressed in proliferating epithelial cells, an...

journal_title：Oncogene

authors： Wang N,Kudryavtseva E,Ch'en IL,McCormick J,Sugihara TM,Ruiz R,Andersen B

更新日期：2004-02-26 00:00:00

abstract：:Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some melanomas. c-Kit signalling activates the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways an...

journal_title：Oncogene

authors： Todd JR,Scurr LL,Becker TM,Kefford RF,Rizos H

更新日期：2014-01-09 00:00:00

abstract：:Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine with the capability to act as tumour suppressor or tumour promoter depending on the cellular context. TGF-beta receptor type-2 (TGFBR2) is the ligand-binding receptor for all members of the TGF-β family. Data from mouse model experiments demonstrated th...

journal_title：Oncogene

authors： Busch S,Acar A,Magnusson Y,Gregersson P,Rydén L,Landberg G

更新日期：2015-01-02 00:00:00

abstract：:Small-cell lung cancer (SCLC) is an aggressive, rapidly metastasizing neoplasm. The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) is constitutively secreted by marrow stromal cells and plays a key role for homing of hematopoietic cells to the marrow. Here, we report that tumor cells from patients with SCLC ex...

journal_title：Oncogene

authors： Burger M,Glodek A,Hartmann T,Schmitt-Gräff A,Silberstein LE,Fujii N,Kipps TJ,Burger JA

更新日期：2003-11-06 00:00:00

abstract：:Deregulation of Wnt signalling has recently been implicated in human renal cancer. Here, we directly test this association by using a Cre-LoxP strategy to inactivate the Adenomatous Polyposis Coli (Apc) gene in the murine renal epithelium. Mice homozygous for a conditional Apc allele were intercrossed with mice transg...

journal_title：Oncogene

authors： Sansom OJ,Griffiths DF,Reed KR,Winton DJ,Clarke AR

更新日期：2005-12-08 00:00:00

abstract：:Seventy lung tumors from 53 patients were analysed for alterations of myc family oncogenes, c-myc, N-myc and L-myc, to evaluate when activation of these genes occurs during tumor development. The 53 cases were 17 small cell carcinomas (SCCs), 18 adenocarcinomas, 12 squamous cell carcinomas (SqCs), 4 large cell carcino...

journal_title：Oncogene

authors： Yokota J,Wada M,Yoshida T,Noguchi M,Terasaki T,Shimosato Y,Sugimura T,Terada M

更新日期：1988-06-01 00:00:00

abstract：:Retinoic acid receptor-beta (RAR beta) and signal transducer and activator of transcription 1 (STAT1) are important mediators of the antiproliferative and apoptotic actions of retinoids and cytokines/growth factors, respectively. Expression of both RAR beta and STAT1 is lost in most breast cancer cell lines but it can...

journal_title：Oncogene

authors： Shang Y,Baumrucker CR,Green MH

更新日期：1999-11-18 00:00:00

abstract：:Small-molecule agonists at Toll-like receptor 7 (TLR7) and TLR8 have sparked a vivid interest in cancer research owing to their profound antitumoral activity. The lead compound of the imidazoquinoline family, imiquimod, is marketed as a topical formulation. It is efficacious against many primary skin tumors and cutane...

journal_title：Oncogene

authors： Schön MP,Schön M

更新日期：2008-01-07 00:00:00

abstract：:To appreciate the involvement of known or potential susceptibility genes in sporadic breast tumors, we have searched for chromosomal deletions by studying loss of heterozygosity (LOH) at 43 microsatellite (CA)n markers from human chromosomes 10, 11 and 17, in 115 unselected consecutive samples of breast carcinoma with...

journal_title：Oncogene

authors： Kerangueven F,Eisinger F,Noguchi T,Allione F,Wargniez V,Eng C,Padberg G,Theillet C,Jacquemier J,Longy M,Sobol H,Birnbaum D

更新日期：1997-01-23 00:00:00

abstract：:In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...

journal_title：Oncogene

authors： Bianchi T,Rufer N,MacDonald HR,Migliaccio M

更新日期：2006-07-06 00:00:00

abstract：:Polyoma virus (Py) differs from other small DNA tumor viruses in not encoding a protein that inactivates p53. The complete Py early region encoding the large T-antigen (PyLT), middle T-antigen (PyMT) and small T-antigen (PyST) will transform primary rodent cells and REF52 cells, but PyMT, the main Py oncogene, by itse...

journal_title：Oncogene

authors： Lomax M,Fried M

更新日期：2001-08-16 00:00:00

abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...

journal_title：Oncogene

authors： Leung N,Turbide C,Olson M,Marcus V,Jothy S,Beauchemin N

更新日期：2006-09-07 00:00:00

abstract：:Many anticancer drugs exert their cytotoxicity through DNA damage and induction of apoptosis. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) have different sensitivity to treatment with radiation and chemotherapeutic agents with SCLC being more sensitive than NSCLC both in vitro and in vivo...

journal_title：Oncogene

authors： Joseph B,Ekedahl J,Lewensohn R,Marchetti P,Formstecher P,Zhivotovsky B

更新日期：2001-05-24 00:00:00

abstract：:We report here the nucleic acid sequence and deduced amino acid sequence of a cDNA for TIS7, a gene induced by mitogens in 3T3 cells and by nerve growth factor in PC12 pheochromocytoma cells. A fragment of the TIS7 gene has previously been cloned from murine fibroblast cells infected with Newcastle Disease Virus. The ...

journal_title：Oncogene

authors： Varnum BC,Lim RW,Herschman HR

更新日期：1989-10-01 00:00:00

abstract：:There is an emerging body of evidence implicating iron in carcinogenesis and in particular colorectal cancer, but whether this involves Wnt signalling, a major oncogenic signalling pathway has not been studied. We aimed to determine the effect of iron loading on Wnt signalling using mutant APC (Caco-2 and SW480) and w...

journal_title：Oncogene

authors： Brookes MJ,Boult J,Roberts K,Cooper BT,Hotchin NA,Matthews G,Iqbal T,Tselepis C

更新日期：2008-02-07 00:00:00

abstract：:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...

journal_title：Oncogene

authors： Rondinelli RH,Haslam SZ,Fluck MM

更新日期：1995-11-02 00:00:00

abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

journal_title：Oncogene

authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

更新日期：2004-04-15 00:00:00

abstract：:Delta(9)-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers,...

journal_title：Oncogene

authors： Preet A,Ganju RK,Groopman JE

更新日期：2008-01-10 00:00:00

abstract：:Steroid receptor co-activator-3 (SRC-3/AIB1) is an oncogene that is amplified and overexpressed in many human cancers. However, the molecular mechanisms that regulate 'activated SRC-3 oncoprotein' turnover during tumorigenesis remain to be elucidated. Here, we report that speckle-type POZ protein (SPOP), a cullin 3 (C...

journal_title：Oncogene

authors： Li C,Ao J,Fu J,Lee DF,Xu J,Lonard D,O'Malley BW

更新日期：2011-10-20 00:00:00

abstract：:Human hematopoietic progenitor cells (TF-1) undergo apoptosis upon deprivation of their dependent cytokine. In this report, we have isolated and characterized some spontaneously derived cytokine-independent variants from TF-1 cells. Analysis of several signaling molecules known to be activated by the GM-CSF pathway re...

journal_title：Oncogene

authors： Chao JR,Chen CS,Wang TF,Tseng LH,Tsai JJ,Kuo ML,Yen JJ,Yang Yen HF

更新日期：1997-02-13 00:00:00