Abstract：
:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1 week before infection decreased mammary tumor incidence and number, and significantly increased tumor incidence and number, and significantly increased tumor latency. Reduction in tumorigenesis was observed to a lesser degree if mice were OVX at the time of or after infection, indicating that ovarian hormones are mainly required for tumor initiation. Tumor incidence was also reduced with increasing age; OVX prior to infection at older ages drastically reduced tumor development. Treatment of OVX adult mice with estrogen + progesterone for 1-3 weeks prior to infection was unable to restore tumorigenesis to the level observed in intact mice. Thus, in contrast to adolescent mice, the continued presence of ovarian hormones after infection was required for maximal tumorigenesis in adult mice. The decreased tumorigenesis observed in older animals is not likely due to increased differentiation since late pregnant mice with well differentiated mammary glands remained highly susceptible to tumorigenesis. At 10 days post infection, the levels of viral genomes were moderately high and similar in all experimental groups. Early viral protein and middle T-associated kinase levels were undetectable in infected tissues in all experimental conditions. However, high levels were found in tumors, perhaps reflecting a high dosage requirement for oncogenesis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Rondinelli RH,Haslam SZ,Fluck MMsubject
Has Abstractpub_date
1995-11-02 00:00:00pages
1817-27issue
9eissn
0950-9232issn
1476-5594journal_volume
11pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts wi...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Recent evidence suggests that squamous cell carcinoma of the vulva may have more than one etiology, with only some tumors associated with human papillomavirus (HPV). Cells infected with HPV produce a viral protein (E6) which binds to and causes rapid degradation of p53, possibly contributing to cellular transformation...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:Cancer development results from deregulated control of stem cell populations and alterations in their surrounding environment. Notch signaling is an important form of direct cell-cell communication involved in cell fate determination, stem cell potential and lineage commitment. The biological function of this pathway ...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2008.225
更新日期：2008-09-01 00:00:00
abstract：:Mouse malignant T-lymphoma CS-21 cells grow in vitro in the presence of CA-12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA-12 stromal cells. In the course of examining the nursing effects of CA-12 stromal cells, we found that these cells provided some soluble factors that supp...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-11-21 00:00:00
abstract：:Individuals with germline mutations in the tumour-suppressor gene CYLD are at high risk of developing disfiguring cutaneous appendageal tumours, the defining tumour being the highly organised cylindroma. Here, we analysed CYLD mutant tumour genomes by array comparative genomic hybridisation and gene expression microar...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.133
更新日期：2011-10-13 00:00:00
abstract：:We previously reported the presence of mitotic check-point impairment in about 40% of lung cancer cell lines. To gain an insight into the molecular basis of this impairment, we examined 49 lung cancer specimens for alterations in the hMAD1 mitotic checkpoint gene and identified a somatic, non-conservative missense mut...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203141
更新日期：1999-11-25 00:00:00
abstract：:We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement. This rearrangement is similar to one we characterized recently in an independent adenoma. In these two, plus a third partially characterized adenoma, one allele of the PTH gene, on 11p...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:Induction of interstrand crosslinks (ICLs) in chromosomal DNA is considered a major reason for the antiproliferative effect of psoralen plus ultraviolet A (PUVA). It is unclear as to whether PUVA-induced cell cycle arrest is caused by ICLs mechanically stalling replication forks or by triggering cell cycle checkpoints...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206613
更新日期：2003-09-18 00:00:00
abstract：:To ensure that their mRNAs are translated and that the viral proteins necessary for assembling the next generation of infectious progeny are produced, viruses must effectively seize control of the translational machinery within their host cells. In many cases, the ability to productively engage host translational comp...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209053
更新日期：2005-11-21 00:00:00
abstract：:Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men in the western world. Mutations in tumor suppressor genes and in oncogenes are important for PCa progression, whereas the role of stem cell proteins in prostate carcinogenesis is insufficiently examined. This study investigates the role o...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.325
更新日期：2017-03-01 00:00:00
abstract：:To investigate a possible role for c-Jun homodimers in c-Jun-mediated transformation, we designed two chimeric c-Jun derivatives, called c-Juneb1 and c-Jungcn4. In these chimeric derivatives the natural dimerization domain of c-Jun was replaced by the heterologous homodimerization domain of the Epstein-Barr virus EB1 ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209147
更新日期：2006-02-16 00:00:00
abstract：:Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1208081
更新日期：2004-10-18 00:00:00
abstract：:NUP98 has been involved in multiple recurrent chromosome rearrangements in leukemia. We identified a novel fusion between NUP98 and IQ motif containing G (IQCG) gene from a de novo acute T-lymphoid/myeloid leukemia harboring t(3;11)(q29q13;p15)del(3)(q29). IQCG has two putative coiled-coil domains and one IQ domain. T...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210999
更新日期：2008-05-29 00:00:00
abstract：:There is currently a great interest in delayed chromosomal and other damaging effects of low-dose exposure to a variety of pollutants which appear collectively to act through induction of stress-response pathways related to oxidative stress and ageing. These have been studied mostly in the radiation field but evidence...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209399
更新日期：2006-06-08 00:00:00
abstract：:The v-src gene of Rous sarcoma virus (RSV) encodes pp60v-src, a tyrosine kinase that can initiate cellular transformation. High levels of v-src gene expression can either be cytotoxic or the cause of altered expression of cellular genes. Examination of cytotoxic thresholds is difficult because cells expressing high le...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-10-19 00:00:00
abstract：:Menin, the product of the MEN1 tumor suppressor gene, binds to the AP1 transcription factor JunD and represses JunD transcriptional activity. The effects of human or mouse JunD missense mutations upon menin interaction were studied by random and alanine scanning mutagenesis of the menin binding region of JunD (amino a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203832
更新日期：2000-09-28 00:00:00
abstract：:Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX, USA) arrays showed that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integrated HPV-16 DNA compared to the normal cerv...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210919
更新日期：2008-04-17 00:00:00
abstract：:Sal-like protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-expressed by an unknown mechanism in poor prognosis hepatocellular carcinoma (HCC), often associated with chronic hepatitis B virus (HBV) infection. Herein, we investigated the mechanism of SALL4 re-expression in HBV-related HCCs. We p...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2016.399
更新日期：2017-04-27 00:00:00
abstract：:Human hematopoietic progenitor cells (TF-1) undergo apoptosis upon deprivation of their dependent cytokine. In this report, we have isolated and characterized some spontaneously derived cytokine-independent variants from TF-1 cells. Analysis of several signaling molecules known to be activated by the GM-CSF pathway re...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1200884
更新日期：1997-02-13 00:00:00
abstract：:Hypoxia induces transcription of a range of physiologically important genes including erythropoietin and vascular endothelial growth factor. The transcriptional activation is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric member of the basic helix-loop-helix PAS family, composed of alpha and beta ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203938
更新日期：2000-11-16 00:00:00
abstract：:Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:A dual role of transforming growth factor β (TGF-β), to both suppress and promote tumor progression and metastasis, has been well established, but its molecular basis has remained elusive. In this review, we focus on Smad proteins, which are central mediators of the signal transduction of TGF-β family members. We desc...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2012.191
更新日期：2013-03-28 00:00:00
abstract：:Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry because of insuffici...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.232
更新日期：2010-08-26 00:00:00
abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208688
更新日期：2005-07-28 00:00:00
abstract：:Retinoic acid receptor alpha (RARα) has a critical role in the differentiation process of osteosarcoma cells induced by all-trans retinoic acid (ATRA). However, degradation of RARα through ubiquitin proteasome pathway weakens the differentiation efficiency of osteosarcoma cells. In this study, we discover that murine ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2015.503
更新日期：2016-08-18 00:00:00
abstract：:Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell motility. Our previous studies have identified that PHLPP2 participates in in...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0374-1
更新日期：2018-10-01 00:00:00
abstract：:Ultraviolet light (UV) induced DNA lesions efficiently block transcript elongation and induce the p53 response. Although p53 contributes to transcriptional activation of the p21waf1 and bax genes, accumulation of these proteins requires that these genes are free of UV induced pyrimidine dimers. We assessed the level o...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201963
更新日期：1998-08-06 00:00:00
abstract：:Ferritin is the major intracellular iron storage protein that sequesters excess free iron to minimize generation of iron-catalysed reactive oxygen species. We previously demonstrated that expression of ferritin heavy chain (ferritin H) was induced by pro-oxidants, which is a part of cellular antioxidant response to pr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208901
更新日期：2005-11-17 00:00:00
abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-08-15 00:00:00
