Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells.

abstract：:A proportion of familial breast cancer has recently been shown by genetic linkage analysis to map to chromosome l3q12 (Wooster et al, 1994). This locus contains a tumor suppressor gene BRCA2, mutations in which lead to tumorigenesis. Genetic alterations at this locus have also been shown in pancreatic adenocarcinoma a...

journal_title：Oncogene

authors： Jacob AN,Kandpal G,Kandpal RP

更新日期：1996-07-04 00:00:00

abstract：:Following discovery of c-Cbl, a cellular form of the transforming retroviral protein v-Cbl, multiple Cbl-related proteins have been identified in vertebrate and invertebrate organisms. c-Cbl and its homologues are capable of interacting with numerous proteins involved in cell signaling, including various molecular ada...

journal_title：Oncogene

authors： Tsygankov AY,Teckchandani AM,Feshchenko EA,Swaminathan G

更新日期：2001-10-01 00:00:00

abstract：:During tumor initiation, oncogene-induced senescence (OIS) is proposed to limit the progression of preneoplasms to invasive carcinoma unless circumvented by the acquisition of certain tumor suppressor mutations. Using a variety of biomarkers, OIS has been previously reported in a wide range of human and murine precurs...

journal_title：Oncogene

authors： Caldwell ME,DeNicola GM,Martins CP,Jacobetz MA,Maitra A,Hruban RH,Tuveson DA

更新日期：2012-03-22 00:00:00

abstract：:We have studied the relationship between ras-GAP and G protein coupled receptors in a proliferative setting comprised of NIH3T3 expressing transfected muscarinic receptors (mAChRs). GAP expression plasmids were engineered to encode wild-type GAP, its carboxyl-terminal catalytic domain, a mutant lacking a portion of th...

journal_title：Oncogene

authors： Xu N,McCormick F,Gutkind JS

更新日期：1994-02-01 00:00:00

abstract：:The RAD17 gene product of S. Pombe is an essential component of the checkpoint control pathway which responds to both DNA damage and disruption of replication. We have identified a human cDNA that encodes a polypeptide which is structurally conserved with the S. Pombe Rad17 protein. The human gene, designated hRAD17, ...

journal_title：Oncogene

authors： Li L,Peterson CA,Kanter-Smoler G,Wei YF,Ramagli LS,Sunnerhagen P,Siciliano MJ,Legerski RJ

更新日期：1999-03-04 00:00:00

abstract：:The Src family kinases c-Src, and its downstream effectors, the Rho family of small GTPases RhoA and Jun N-terminal kinase (JNK) have a significant role in tumorigenesis. In this report, using the Drosophila wing disc epithelium as a model system, we demonstrate that the actin-Capping Protein (CP) αβ heterodimer, whic...

journal_title：Oncogene

authors： Fernández BG,Jezowska B,Janody F

更新日期：2014-04-17 00:00:00

abstract：:Mammalian Mip/LIN-9 is a cell cycle regulatory protein that is negatively regulated by CDK4/cyclin D. It has been demonstrated that Mip/LIN-9 collaborates with B-Myb during S and G(2)/M in the induction of cyclins A and B, and CDK1. The ortholog of Mip/LIN-9 in Drosophila, Mip130, is part of a large multisubunit prote...

journal_title：Oncogene

authors： Pilkinton M,Sandoval R,Colamonici OR

更新日期：2007-11-29 00:00:00

abstract：:The chicken c-ets-1 locus encodes two transcription factors, p54c-ets-1 and p68c-ets-1 that differ in their N-termini, encoded respectively by the I54 and alpha beta exons. p68c-ets-1 equivalents are only found in birds and reptiles while p54c-ets-1 is widely conserved in vertebrates, from amphibians to mammals. Thus,...

journal_title：Oncogene

authors： Albagli O,Soudant N,Ferreira E,Dhordain P,Dewitte F,Begue A,Flourens A,Stehelin D,Leprince D

更新日期：1994-11-01 00:00:00

abstract：:Emerging evidence has shown that cancer stem cells (CSCs) are the cellular determinants to promote cancer invasion and metastasis. However, the mechanism underlying CSC invasion remains unknown. MicroRNAs are evolutionally conserved small noncoding RNAs that are critical for the regulation of gene expression, and thei...

journal_title：Oncogene

authors： Wang Z,Wang B,Shi Y,Xu C,Xiao HL,Ma LN,Xu SL,Yang L,Wang QL,Dang WQ,Cui W,Yu SC,Ping YF,Cui YH,Kung HF,Qian C,Zhang X,Bian XW

更新日期：2015-03-12 00:00:00

abstract：:Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. I...

journal_title：Oncogene

authors： Sánchez-Pérez T,Medema RH,López-Rivas A

更新日期：2015-01-29 00:00:00

abstract：:Approximately 80% of breast cancers express the estrogen receptor-alpha (ERalpha) and are treated with anti-estrogens. Resistance to these agents is a major cause of mortality. We have shown that estrogen inhibits Notch, whereas anti-estrogens or estrogen withdrawal activate Notch signaling. Combined inhibition of Not...

journal_title：Oncogene

authors： Hao L,Rizzo P,Osipo C,Pannuti A,Wyatt D,Cheung LW,Sonenshein G,Osborne BA,Miele L

更新日期：2010-01-14 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/AKT and RAS oncogenic signalling modules are frequently mutated in sporadic human cancer. Although each of these pathways has been shown to play critical roles in driving tumour growth and proliferation, their activation in normal human cells can also promote cell senescence. A...

journal_title：Oncogene

authors： Astle MV,Hannan KM,Ng PY,Lee RS,George AJ,Hsu AK,Haupt Y,Hannan RD,Pearson RB

更新日期：2012-04-12 00:00:00

abstract：:The p53 tumor suppressor is regulated by the MDM2 oncoprotein. Overexpression of MDM2 maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of tumors. We found that treatment with roscovitine and olomoucin, which were originally developed as cyclin-dependent kinase (CDK) inhibit...

journal_title：Oncogene

authors： Lu W,Chen L,Peng Y,Chen J

更新日期：2001-05-31 00:00:00

abstract：:Each step in the synthesis of functional transcript by RNA polymerase II provides a level at which gene expression can be regulated. Control over the elongation phase of transcription is a recognized regulatory mechanism in prokaryotes; however, only recently have examples of conditional transcription elongation block...

journal_title：Oncogene

authors： Spencer CA,Groudine M

更新日期：1990-06-01 00:00:00

abstract：:Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of autophagy in carcinogenesis is context dependent. As a tumor-suppressing mechanism in early-stage carcinogenesis, autophagy inhibits inflammation and ...

journal_title：Oncogene

authors： Wu WK,Coffelt SB,Cho CH,Wang XJ,Lee CW,Chan FK,Yu J,Sung JJ

更新日期：2012-02-23 00:00:00

abstract：:The clonality of lymphomas that originate in myc/pim-1 bitransgenic mice due to synergistic action of both oncogenes indicates the requirement of additional events for progression to full malignancy. To isolate genes that cooperate with both myc and pim-1, we have used provirus tagging with E mu L-myc/pim-1 double tra...

journal_title：Oncogene

authors： Zörnig M,Schmidt T,Karsunky H,Grzeschiczek A,Möröy T

更新日期：1996-04-18 00:00:00

abstract：:Matrilysin (MMP-7) is thought to contribute to invasive growth and metastasis of colon carcinoma and many other human cancers. The present study demonstrates that treatment of human colon carcinoma cells with active matrilysin induces cell aggregation in vitro and promotes liver metastasis in nude mice. When two kinds...

journal_title：Oncogene

authors： Kioi M,Yamamoto K,Higashi S,Koshikawa N,Fujita K,Miyazaki K

更新日期：2003-11-27 00:00:00

abstract：:To investigate the possible role of the product of the retinoblastoma susceptibility gene, pRB, in leukemogenesis, we examined fresh leukemia cells from 56 cases of primary leukemia (AML, 32; ALL, 12; CML-BC, 9; CLL, 3) for expression of pRB by using an immunoblotting assay with anti-pRB monoclonal antibodies PMG 3-24...

journal_title：Oncogene

authors： Furukawa Y,DeCaprio JA,Belvin M,Griffin JD

更新日期：1991-08-01 00:00:00

abstract：:Activation of the mitogen-activated protein kinase (MAPK) cascade is a well documented mechanism for the G-protein-coupled receptors. Here, we have analysed the requirements for ERKs and p38 MAPK activation by thrombin in Jurkat T cells. We show that thrombin-mediated ERKs activation requires both PTK and PKC activiti...

journal_title：Oncogene

authors： Maulon L,Mari B,Bertolotto C,Ricci JE,Luciano F,Belhacene N,Deckert M,Baier G,Auberger P

更新日期：2001-04-12 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

journal_title：Oncogene

authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

更新日期：2004-04-15 00:00:00

abstract：:Signals received at the cell surface must be properly transmitted to critical targets within the cell to achieve the appropriate biological response. This process of signal transduction is often initiated by receptor tyrosine kinases (RTKs), which function as entry points for many extracellular cues and play a critica...

journal_title：Oncogene

authors： McKay MM,Morrison DK

更新日期：2007-05-14 00:00:00

abstract：:Juvenile myelomonocytic leukemia (JMML) is a malignant hematopoietic disorder whose proliferative component is a result of RAS pathway deregulation caused by somatic mutation in the RAS or PTPN11 oncogenes or in patients with underlying neurofibromatosis type 1 (NF-1), by loss of NF1 gene function. To search for poten...

journal_title：Oncogene

authors： Flotho C,Steinemann D,Mullighan CG,Neale G,Mayer K,Kratz CP,Schlegelberger B,Downing JR,Niemeyer CM

更新日期：2007-08-23 00:00:00

abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

journal_title：Oncogene

authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

更新日期：2008-01-03 00:00:00

abstract：:Promyelocytic leukemia (PML) nuclear bodies (PML NBs) are discrete subnuclear domains organized by the promyelocytic leukemia protein PML, a tumor suppressor essential for multiple apoptotic pathways. We have recently described a novel family of cellular factors, the THAP proteins, characterized by the presence at the...

journal_title：Oncogene

authors： Roussigne M,Cayrol C,Clouaire T,Amalric F,Girard JP

更新日期：2003-04-24 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform to mediate protein interactions with the DNA strand. Many proteins interact with PCNA through a small conserved motif with consensus QxxLxxFF. This work uses Schizosaccharomyces pombe and human cells to a...

journal_title：Oncogene

authors： Warbrick E

更新日期：2006-05-11 00:00:00

abstract：:Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...

journal_title：Oncogene

authors： Park TJ,Curran T

更新日期：2014-10-23 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...

journal_title：Oncogene

authors： Catalano A,Romano M,Martinotti S,Procopio A

更新日期：2002-04-25 00:00:00

abstract：:Multiple endocrine neoplasia type 2 (MEN 2) is an inherited cancer syndrome that includes pheochromocytoma. Germline mutations in RET are responsible for MEN 2 but the precise pathogenetic mechanisms of tumorigenesis are unknown. We have recently identified possible mechanisms of tumor formation in patients with MEN 2...

journal_title：Oncogene

authors： Koch CA,Huang SC,Zhuang Z,Stolle C,Azumi N,Chrousos GP,Vortmeyer AO,Pacak K

更新日期：2002-01-17 00:00:00

abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...

journal_title：Oncogene

authors： Shtrichman R,Sharf R,Kleinberger T

更新日期：2000-08-03 00:00:00