Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.

abstract：:Cyclin D1, a putative G1 cyclin, has been implicated in cell cycle control. The human cyclin D1 gene is located on chromosome 11q13 where DNA rearrangement and amplification have been detected in several types of human cancer. Previous studies demonstrated that the cyclin D1 gene is not only rearranged or amplified bu...

journal_title：Oncogene

authors： Jiang W,Kahn SM,Zhou P,Zhang YJ,Cacace AM,Infante AS,Doi S,Santella RM,Weinstein IB

更新日期：1993-12-01 00:00:00

abstract：:Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...

journal_title：Oncogene

authors： Cao T,Jiang Y,Wang Z,Zhang N,Al-Hendy A,Mamillapalli R,Kallen AN,Kodaman P,Taylor HS,Li D,Huang Y

更新日期：2019-07-01 00:00:00

abstract：:p73 and p63 are two recently discovered p53 homologs. Like p53, these proteins can recognize canonical p53 DNA-binding sites and, when overproduced, can activate p53-responsive target genes and induce apoptosis. Unlike p53, these genes undergo complex alternative splicing which, at least in the case of p63, yields pro...

journal_title：Oncogene

authors： Kaelin WG Jr

更新日期：1999-12-13 00:00:00

abstract：:Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...

journal_title：Oncogene

authors： Lin J,Tang H,Jin X,Jia G,Hsieh JT

更新日期：2002-05-02 00:00:00

abstract：:Menin, the product of the MEN1 tumor suppressor gene, binds to the AP1 transcription factor JunD and represses JunD transcriptional activity. The effects of human or mouse JunD missense mutations upon menin interaction were studied by random and alanine scanning mutagenesis of the menin binding region of JunD (amino a...

journal_title：Oncogene

authors： Knapp JI,Heppner C,Hickman AB,Burns AL,Chandrasekharappa SC,Collins FS,Marx SJ,Spiegel AM,Agarwal SK

更新日期：2000-09-28 00:00:00

abstract：:p53 is involved in several DNA repair pathways. Some of these require the specific transactivation of p53-dependent genes and others involve direct interactions between the p53 protein and DNA repair associated proteins. Previously, we have shown that p53 acts directly in Base Excision Repair (BER) when assayed under ...

journal_title：Oncogene

authors： Offer H,Milyavsky M,Erez N,Matas D,Zurer I,Harris CC,Rotter V

更新日期：2001-02-01 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the no...

journal_title：Oncogene

authors： Mäueler W,Raulf F,Schartl M

更新日期：1988-05-01 00:00:00

abstract：:We isolated three related cDNA clones from a mouse cerebellar library; the type I cDNA was identical to the gene encoding the apoptosis-associated tyrosine kinase (AATYK), whose expression in myeloid precursor cells is increased during growth arrest or apoptosis. Low levels of AATYK mRNA expression were seen in adult ...

journal_title：Oncogene

authors： Tomomura M,Fernandez-Gonzales A,Yano R,Yuzaki M

更新日期：2001-03-01 00:00:00

abstract：:The genetically heterogeneous triple-negative breast cancer (TNBC) continues to be an intractable disease, due to lack of effective targeted therapies. Gene amplification is a major event in tumorigenesis. Genes with amplification-dependent expression are being explored as therapeutic targets for cancer treatment. In ...

journal_title：Oncogene

authors： He J,McLaughlin RP,van der Beek L,Canisius S,Wessels L,Smid M,Martens JWM,Foekens JA,Zhang Y,van de Water B

更新日期：2020-05-01 00:00:00

abstract：:Expression of constitutively activated M-Ras in normal murine bone-marrow cells was sufficient to induce the factor-independent, in vitro growth and differentiation of colonies of macrophages and neutrophils, and the generation of immortal lines of factor-independent mast cells, and, upon in vivo injection of the tran...

journal_title：Oncogene

authors： Guo X,Schrader KA,Xu Y,Schrader JW

更新日期：2005-03-31 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are caused by gain-of-function mutations in the Kit receptor tyrosine kinase. Most primary GIST patients respond to the Kit inhibitor imatinib, but this drug often becomes ineffective because of secondary mutations in the Kit kinase domain. The characteristic intracellular accum...

journal_title：Oncogene

authors： Obata Y,Horikawa K,Takahashi T,Akieda Y,Tsujimoto M,Fletcher JA,Esumi H,Nishida T,Abe R

更新日期：2017-06-29 00:00:00

abstract：:Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995). The fusion product between ELE1 and RET (RET/ PTC3) seems to be the prevailing type of rearrangement as s...

journal_title：Oncogene

authors： Klugbauer S,Lengfelder E,Demidchik EP,Rabes HM

更新日期：1996-09-05 00:00:00

abstract：:Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...

journal_title：Oncogene

authors： Takle LA,Knowles MA

更新日期：1996-03-07 00:00:00

abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

journal_title：Oncogene

authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

更新日期：1999-03-25 00:00:00

abstract：:One prominent effect of IFNs is their cell growth-inhibitory activity. The mechanism behind this inhibition of proliferation is still not fully understood. In this study, the effect of IFN-alpha treatment on cell cycle progression has been analysed in three lymphoid cell lines, Daudi, U-266 and H9. Examination of the ...

journal_title：Oncogene

authors： Sangfelt O,Erickson S,Castro J,Heiden T,Gustafsson A,Einhorn S,Grandér D

更新日期：1999-05-06 00:00:00

abstract：:PI3K/AKT pathway activation is thought to be a driving force in metastatic melanomas. Members of the pleckstrin homology (PH) domain leucine-rich repeat protein Ser/Thr specific phosphatase family (PHLPP1 and PHLPP2) can regulate AKT activation. By dephosphorylating specific serine residues in the hydrophobic motif, P...

journal_title：Oncogene

authors： Yu Y,Dai M,Lu A,Yu E,Merlino G

更新日期：2018-04-01 00:00:00

abstract：:Galectin-3 is a multifunctional carbohydrate-binding protein found in the nucleus, cytoplasm and the extracellular milieu. Nuclear galectin-3 expression is associated with cell proliferation, and its role in pre-mRNA splicing has been suggested. In this report, we investigated the role of galectin-3 on cyclin D(1) gen...

journal_title：Oncogene

authors： Lin HM,Pestell RG,Raz A,Kim HR

更新日期：2002-11-14 00:00:00

abstract：:The cellular response to ionizing radiation (IR) includes the induction of apoptosis. The p300/CBP proteins possess histone acetyltransferase activity and function as transcriptional coactivators of p53. We have prepared cells deficient in p300 or CBP to define the roles of these proteins in the cellular response to D...

journal_title：Oncogene

authors： Yuan ZM,Huang Y,Ishiko T,Nakada S,Utsugisawa T,Shioya H,Utsugisawa Y,Shi Y,Weichselbaum R,Kufe D

更新日期：1999-10-07 00:00:00

abstract：:Soft tissue sarcomas are a heterogeneous group of neoplasms with various histological subtypes. Up to now, no individual causal molecular markers for prognosis and therapeutic success have been identified. A tumorigenic connection between the oncogene product Mdm2 and tumor suppressor p53 is generally accepted, but th...

journal_title：Oncogene

authors： Würl P,Meye A,Schmidt H,Lautenschläger C,Kalthoff H,Rath FW,Taubert H

更新日期：1998-03-05 00:00:00

abstract：:Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...

journal_title：Oncogene

authors： Lee GH,Yoo KC,An Y,Lee HJ,Lee M,Uddin N,Kim MJ,Kim IG,Suh Y,Lee SJ

更新日期：2018-04-01 00:00:00

abstract：:Mesoderm formation in the frog, Xenopus laevis, is dependent on the activity of one or more members of the Src family kinases; the molecular interactions underlying this requirement are not well understood. The C-terminal Src Kinase (Csk) is a potent inhibitor of Src activity, and is required for normal mammalian deve...

journal_title：Oncogene

authors： Song Y,Cohler AN,Weinstein DC

更新日期：2001-08-23 00:00:00

abstract：:The role of cbl-b in signaling by the epidermal growth factor receptor (EGFR) was studied and compared with c-cbl. We demonstrate in vivo, that cbl-b, like c-cbl, is phosphorylated and recruited to the EGFR upon EGF stimulation and both cbl proteins can bind to the Grb2 adaptor protein. To investigate the functional r...

journal_title：Oncogene

authors： Ettenberg SA,Keane MM,Nau MM,Frankel M,Wang LM,Pierce JH,Lipkowitz S

更新日期：1999-03-11 00:00:00

abstract：:Myc family proteins play an important role in cellular processes such as proliferation, differentiation, apoptosis and transformation. A number of interaction partners of Myc have been identified, such as Max, p107, TBP, YY1, Miz-1, AP-2 and Nmi. Both Max and Nmi also bind to MycN. In contrast to the well defined bind...

journal_title：Oncogene

authors： Bannasch D,Weis I,Schwab M

更新日期：1999-11-18 00:00:00

abstract：:Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 ...

journal_title：Oncogene

authors： Zhan X,Culpepper A,Reddy M,Loveless J,Goldfarb M

更新日期：1987-01-01 00:00:00

abstract：:Wnt genes encode a set of structurally related cell surface glycoproteins that appear to have roles in cell-cell signalling. The ectopic expression of several murine Wnt genes has been implicated in the transformation of mammary epithelial and the onset of mammary tumours. Wnt11 is expressed in the developing embryo i...

journal_title：Oncogene

authors： Christiansen JH,Monkley SJ,Wainwright BJ

更新日期：1996-06-20 00:00:00

abstract：:This study examines whether the serine/threonine protein kinase, Akt, is involved in the crosstalk between the ErbB2 and estrogen receptor-alpha (ER-alpha) pathways. Treatment of MCF-7 cells with 10(-9) M heregulin-beta1 (HRG-beta1) resulted in a rapid phosphorylation of Akt and a 15-fold increase in Akt activity. Akt...

journal_title：Oncogene

authors： Stoica GE,Franke TF,Wellstein A,Morgan E,Czubayko F,List HJ,Reiter R,Martin MB,Stoica A

更新日期：2003-04-10 00:00:00

abstract：:MicroRNAs (miRNAs) have been shown to have an important role in various cellular processes, such as apoptosis, differentiation and development. Recent studies have shown that miRNAs are mis-expressed in human cancers where they can exert their effect as oncogenes or tumor suppressors. Here, we review the potential for...

journal_title：Oncogene

authors： Trang P,Weidhaas JB,Slack FJ

更新日期：2008-12-01 00:00:00

abstract：:Medulloblastoma (MB) results from aberrant development of cerebellar neurons in which altered hedgehog (Hh) signalling plays a major role. We investigated the possible influence of Hh signalling on ErbB-receptor expression in MB, in particular that of the ErbB-4 CYT-1 and CYT-2 isoforms generated by alternative splici...

journal_title：Oncogene

authors： Ferretti E,Di Marcotullio L,Gessi M,Mattei T,Greco A,Po A,De Smaele E,Giangaspero F,Riccardi R,Di Rocco C,Pazzaglia S,Maroder M,Alimandi M,Screpanti I,Gulino A

更新日期：2006-11-23 00:00:00

abstract：:Histone acetylation has a central role in establishing an active chromatin environment. The functional contribution of histone acetylation to chromatin transcription is accomplished by a dominant action of histone acetyltransferases over repressive histone-modifying activities at gene promoters; misregulation of these...

journal_title：Oncogene

authors： Heo K,Kim JS,Kim K,Kim H,Choi J,Yang K,An W

更新日期：2013-05-16 00:00:00